Metabolic and Endocrine Side Effects of Atypical Antipsychotic Drugs in Children and Adolescents

omorbid psychiatric disorders, frequent hospitalization, multiple outpatient treatment, prior history of hypertension, obesity and lipid dysregulation are associated with higher risk of metabolic syndrome in children. Side effects of antipsychotic drugs and their management have recently become a major subject of research due to enhanced antipsychotic drug usage in child and adolescents. Prevention strategies are usually preferred to secondary or tertiary strategies in the management of metabolic syndrome associated with antipsychotic drugs. Clinicians should present multidisciplinary approach to endocrine and metabolic side effects due to antipsychotic use in pediatric patient groups and avoid multiple drug use in such patients. In this paper, we briefly reviewed metabolic side effects of second generation antipsychotic drugs in child and adolescent population, possible mechanisms of susceptibility to metabolic syndrome and pharmacological and non pharmacological treatment approach to prevention of weight gain

Atomoxetine Induced Seperation Anxiety: A Case Report

Atomoxetine, a selective norepinephrine (NE) inhibitor, is introduced as a safe non-stimulant alternative treatment of children and adolescents with attention deficit hyperactivity disorder (ADHD), especially co-morbid ADHD and anxiety disorder and/or Tourette syndrome. Generally known side effects were including weight loss, decrease appetite, nausea and somnolence, exacerbation of tics. In this paper, we want to present an adolescent case with ADHD-inattention type who developed separation anxiety during Atomoxetine treatment. It will be discussed in light of current knowledge about possible neurotransmitter systems associated with side effects of Atomoxetine. Consequently, atomoxetine treatment may trigger anxiety or obsessional thoughts although without any premorbid psychopathology. However, it is unclear whether effects of genetic, gender or adolescence period are associated with this. [Cukurova Med J 2013; 38(3.000): 503-505

A judicial notification discrepancy: child marriage and pregnancy

WOS: 000414861000011Purpose: There may be some worries and discrepancies about of notification obligation for child marriage, child pregnancy. In this study, we aimed to determine the level of awareness of health workers about child marriage, child pregnancy and obligation of judicial notification. Material and Methods: We performed training for family doctors and nurses about child marriage, child pregnancy and judicial notification. Participants completed a questionnaire, which was prepared by authors, before and after the training. Results: While proportion of participants indicating they would not make judicial notification for child pregnancy was 75.9% (n=66) in the pre-test, it was 19.4% (n=12) in the post-test. The number of participants indicating they would make notification for both child pregnancy and marriage was 21 (24.1%) in the pre-test, 50 (80.6%) in the post-test. All participants indicating they would not make judicial notification for pregnancy (n=68), declared that they would not give permission to marry under age 18 if they had authority. 98.4% (n=60) of participants declared that they would make judicial notification for child marriage in the pre- and post-tests, although 50% (n=5) participants indicating they would not make notification in the pre- test, changed their opinion to make notification in the post-test. Conclusion: There is a discrepancy about judicial notification of child marriage and child pregnancy among participants. It seems like the presence of pregnancy lead to avoidance of judicial notification. To make a brief presentation about child marriage/pregnancy for health workers, can raise great awareness about this topic and can create sensitivity about notification

The role of methylphenidate in treatment of school refusal

WOS: 000406284600034

Periodic Fever and Hyperimmunoglobulin D Syndrome in a Boy with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Group A beta-Hemolytic Streptococcus

WOS: 000319256600011PubMed ID: 23647138

Problematic Internet Use in the Psychiatric Sample Compared Community Sample

WOS: 000282653800010Objective: The aim of this study is to determine the characteristics of internet use and Problematic Internet Use (PIU) in adolescents with and without psychiatric disorder. Methods: The present study was performed on 884 adolescents, who were in the age group of 12 to 18 years. Each o psychiatric sample (PS) and community sample (CS) included 442 age/gender matched adolescents. PS were patients at the child and adolescent psychiatry departments of Cukurova, Mersin and Akdeniz Universities. Online Cognition Scale (OCS) was used for PIU. Results: The most common diagnoses in PS were attention deficit hyperactivity disorder (ADHD; n: 260), followed by anxiety disorders (AD; n: 96), mood disorders (MD; n: 55), and other disorders (OD; n: 31, 7.0%). 23.3% of participants in PS and 10.6% in CS reported use of internet for more than 8 hours/week (p=0.0001). Additionally, mean OCS scores of participants in PS were significantly higher than those in CS (p=0.0001). The highest OCS score average was observed in the ADHD group and it was significantly higher than that in CS (p=0.0001). Conclusion: This study has supported the relationship between PIU and psychopathology among adolescents which is more pronounced in adolescents with ADHD. (Archives of Neuropsychiatry 2010;47:241-6

The prevalence of childhood psychopathology in Turkey: a cross-sectional multicenter nationwide study (EPICPAT-T).

Aim: The aim of this study was to determine the prevalence of childhood psychopathologies in Turkey

Prevalence of Childhood Affective disorders in Turkey: An epidemiological study

Aim: To determine the prevalence of affective disorders in Turkey among a representative sample of Turkish population. Methods: This study was conducted as a part of the "The Epidemiology of Childhood Psychopathology in Turkey" (EPICPAT-T) Study, which was designed by the Turkish Association of Child and Adolescent Mental Health. The inclusion criterion was being a student between the second and fourth grades in the schools assigned as study centers. The assessment tools used were the K-SADS-PL, and a sociodemographic form that was designed by the authors. Impairment was assessed via a 3 point-Likert type scale independently rated by a parent and a teacher. Results: A total of 5842 participants were included in the analyses. The prevalence of affective disorders was 2.5 % without considering impairment and 1.6 % when impairment was taken into account. In our sample, the diagnosis of bipolar disorder was lacking, thus depressive disorders constituted all the cases. Among depressive disorders with impairment, major depressive disorder (MDD) (prevalence of 1.06%) was the most common, followed by dysthymia (prevalence of 0.2%), adjustment disorder with depressive features (prevalence of 0.17%), and depressive disorder-NOS (prevalence of 0.14%). There were no statistically significant gender differences for depression. Maternal psychopathology and paternal physical illness were predictors of affective disorders with pervasive impairment. Conclusion: MDD was the most common depressive disorder among Turkish children in this nationwide epidemiological study. This highlights the severe nature of depression and the importance of early interventions. Populations with maternal psychopathology and paternal physical illness may be the most appropriate targets for interventions to prevent and treat depression in children and adolescents