Metabolic risk score indexes validation in overweight healthy people

The constellation of adverse cardiovascular disease (CVD) and metabolic risk factors, including elevated abdominal obesity, blood pressure (BP), glucose, and triglycerides (TG) and lowered high-density lipoprotein-cholesterol (HDL-C), has been termed the metabolic syndrome (MetSyn) [1]. A number of different definitions have been developed by the World Health Organization (WHO) [2], the National Cholesterol Education Program Adult Treatment Panel III (ATP III) [3], the European Group for the Study of Insulin Resistance (EGIR) [4] and, most recently, the International Diabetes Federation (IDF) [5]. Since there is no universal definition of the Metabolic Syndrome, several authors have derived different risk scores to represent the clustering of its components [6-11]

Effect of different exercise modalities plus a hypocaloric diet on inflammation markers in overweight patients

Summary Background & aims Inflammation markers (IM) have been associated with the development of chronic diseases. This study compares the effects on IM of three exercise programs combined with a hypocaloric diet. Methods 119 overweight participants (73 women, 46 men) aged 18–50 years were randomised into four treatment groups: strength training (S; n = 30), endurance training (E; n = 30), combined S + E (SE; n = 30), and a diet and physical activity recommendations group (D; n = 29). Energy intake, anthropometric variables (AV), training variables (VO2peak, strength index, dynamometric strength index [DSI]) and plasma IM were recorded at baseline and after 22 weeks of treatment. Results 84 participants completed the study. At 22 weeks, all groups showed a significantly reduced energy intake (P < 0.001) and improved AV (P < 0.001). VO2peak significantly increased in all groups (P < 0.01). DSI increased in the exercise groups only (P < 0.05). Plasma leptin fell significantly (P < 0.001) in the S and E groups, but not significantly in the SE group (P = 0.029) (no significant differences between these groups). Tumour necrosis factor-α (TNF-α), and C-reactive protein (CRP) concentrations decreased in all groups when examined together, but not when examined separately. No significant differences were seen in interleukin-6 (IL-6). Conclusions Combining strength or endurance training with a hypocaloric diet improved AV and reduced plasma leptin concentrations. No differences were seen between groups in terms of TNF-α, IL-6 or CRP reduction. This trial was registered at clinical trials.gov as NCT01116856. http://clinicaltrials.gov/

High Prevalence of Sarcopenia in Women with Osteoporotic Fractures

The aim of the present study was to assess the prevalence of sarcopenia in women with osteopenia/osteoporosiswith or without fragility fractures.Patients and methods: 112 ambulatory women with osteopenia/osteporosis were included. Body composition wasdetermined by DXA. Weight, height, body mass index (BMI), bone mineral density (BMD) of the total skeleton, totallean mass (LM), appendicular lean mass (ALM) and the index: appendicular lean mass/height² (ALM/h²) weredetermined. Grip strength and self-selected gait speed were assessed. Results: Average (X ± SD) results were: age70.9 ± 8.2 years, BMI: 23.1 ± 3.3 kg/h², total skeleton BMD T-Score:-1.7 ± 0.8, total LM 33.3 ± 3.8 kg, ALM 14.4 ±2.1kg and ALM/h²: 5.86 ± 0.68 kg/h². Walking speed 0.96±0.21m/s and handgrip: 18.8 ± 4.8 kg. The prevalence ofsarcopenia was: 24.7% (International Working Group criteria). Values for BMI, LM, ALM, ALM/h², gait speed andhand grip were significantly lower in sarcopenic vs. non-sarcopenic patients. 29 patients, average age: 70.5 ± 8.0years had osteoporotic fragility fractures (Fx). The prevalence of sarcopenia in the group of patients with Fx was41.4% vs. 19.3% in the non-Fx patients (n=83) (p<0.018).Conclusion: The prevalence of sarcopenia in women with osteopenia/osteoporosis was higher compared to thatusually reported in non-selected patients of similar age. Those with bone fractures had a significantly higherprevalence of sarcopenia compared to the non-fracture patients. The assessment of muscle mass and function inpatients with osteopenia/osteoporosis is recommended.Fil: Fernández, Candela. Centro de Osteopatías Médicas Dr Mautalen; ArgentinaFil: Oliveri, María Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Bagur, Alicia Cristina. Centro de Osteopatías Médicas Dr Mautalen; ArgentinaFil: Gomez Glorioso, Dolores. Centro de Osteopatías Médicas Dr Mautalen; ArgentinaFil: González, Diana. Centro de Osteopatías Médicas Dr Mautalen; ArgentinaFil: Mastaglia, Silvina Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Mautalen, Carlos Alfredo. Centro de Osteopatías Médicas Dr Mautalen; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Can the exercise mode determine lipid profile improvements in obese patients?

Influencia del modo de ejercicio sobre el perfil lipídic

Combined exercise effects on metabolic syndrome

Few randomized trials have examined the optimal mode of exercise or combination of modalities for specific cardiometabolic health benefits [1-3] . Therefore, questions remain unaddressed whether strength training or endurance training alone improves cardiometabolic health in overweight adults; whether a combination of both provides additional improvements [4, 5]

Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention

The β-2 and β-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18–50 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (p = 0.019, 2.5 kg) and BMI (p = 0.019, 0.88 kg/m2) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (p = 0.036), in addition to an interaction with exercise for fat mass (p = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (p = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles. </jats:p

In-situ co-design of Mobile Games using Design Thinking’s resources approach

The contribution of this paper is to explore how in-situ co-design of indoor spaces (e.g. building) of Location-based Mobile Games could be handle, by describing the learned lessons on this topic. This paper presents a conceptual framework for in-situ co-design of indoor spaces on Location-based Mobile Games to assist to carry out this kind of experience using useful resources (as Design Thinking's resources). An experience of in-situ co-design for an indoor space on a Location-based Mobile Game is presented using this framework; for some phases an authoring tool was used which allows in-situ co-design of relevant locations for an application. Based on this experience, the authoring tool was extended to create a specific kind of Location-based Mobile Game. This paper presents this extension along with a proof of concept that shows how an in-situ co-designed game created by this extension was used by end-users

Co-diseño in-situ de juegos móviles usando una aproximación con recursos de Design Thinking

El aporte de este trabajo es explorar cómo abordar experiencias de co-diseño in-situ de Juegos Móviles basados en posicionamiento en espacios cerrados (por ejemplo, un edificio), describiendo las lecciones aprendidas sobre esta temática. En este trabajo se presenta un framework conceptual para el co-diseño in-situ de Juegos Móviles basados en posicionamiento para espacios cerrados con el objetivo de ayudar a los facilitadores a abordar este tipo de experiencias con recursos útiles (por ejemplo, recursos de Design Thinking). Usando este framework, se presenta una experiencia de co-diseño in-situ de un Juego Móvil basado en posicionamiento en un espacio cerrado; para algunas etapas se utilizó una herramienta de autor que permite co-diseñar in-situ cuáles son los lugares relevantes para una aplicación. A partir de esta experiencia, se extendió la herramienta de autor para poder crear un tipo particular de Juego Móvil basado en posicionamiento. En este trabajo se presenta esta extensión junto con una prueba de conceptos que muestra cómo un juego co-diseñado in-situ con esta extensión fue usado por usuarios finales.The contribution of this paper is to explore how in-situ co-design of indoor spaces (e.g. building) of Location-based Mobile Games could be handle, by describing the learned lessons on this topic. This paper presents a conceptual framework for in-situ co-design of indoor spaces on Location-based Mobile Games to assist to carry out this kind of experience using useful resources (as Design Thinking’s resources). An experience of in-situ co-design for an indoor space on a Locationbased Mobile Game is presented using this framework; for some phases an authoring tool was used which allows in-situ co-design of relevant locations for an application. Based on this experience, the authoring tool was extended to create a specific kind of Location-based Mobile Game. This paper presents this extension along with a proof of concept that shows how an in-situ co-designed game created by this extension was used by end-users

In-situ co-design of mobile games using design thinking's resources approach

El aporte de este trabajo es explorar cómo abordar experiencias de co-diseño in-situ de Juegos Móviles basados en Posicionamiento en espacios cerrados (por ejemplo: un edificio); describiendo las lecciones aprendidas sobre esta temática. En este trabajo se presenta un framework conceptual para el co-diseño in-situ de Juegos Móviles basados en Posicionamiento para espacios cerrados; con el objetivo de ayudar a los facilitadores en el abordaje de este tipo de experiencias con recursos útiles (por ejemplo, recursos de Design Thinking). Usando este framework, se presenta una experiencia de codiseño in-situ de un Juego Móvil basado en Posicionamiento en un espacio cerrado; para algunas etapas se utilizó una herramienta de autor que permite co-diseñar in-situ cuáles son los lugares relevantes para una aplicación. A partir de esta experiencia, se extendió la herramienta de autor para poder crear un tipo particular de Juego Móvil basado en Posicionamiento. En este trabajo se presenta esta extensión junto con una prueba de conceptos que muestra cómo un juego co-diseñado in-situ con esta extensión fue usado por usuarios finales.The contribution of this paper is to explore how in-situ co-design of indoor spaces (as a building) of Location-based Mobile Games could be handled; the lessons learned about this topic are detailed. This paper presents a conceptual framework for in-situ co-design of indoor spaces on Location-based Mobile Games; to assist to carry out this kind of experience using useful resources (as Design Thinking´s resources). An experience of in-situ co-design for an indoor space on a Location-based Mobile Game is presented using this framework; for some phases, an authoring tool was used which allows in-situ co-design of relevant locations for an application. Based on this experience, the authoring tool was extended to create a particular kind of Location-based Mobile Game. This paper presents this extension along with a proof of concept that shows how an in-situ co-designed game created by this extension was used by end-users.Fil: Challiol, Cecilia. Universidad Nacional de La Plata. Facultad de Informática. Laboratorio de Investigación y Formación en Informática Avanzada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Borrelli, Franco Martín. Universidad Nacional de La Plata. Facultad de Informática. Laboratorio de Investigación y Formación en Informática Avanzada; ArgentinaFil: Goin Plexevi. Francisco. Universidad Nacional de La Plata. Facultad de Informática. Laboratorio de Investigación y Formación en Informática Avanzada; ArgentinaFil: Rouaux Servat, Candela Mariel. Universidad Nacional de La Plata. Facultad de Informática. Laboratorio de Investigación y Formación en Informática Avanzada; ArgentinaFil: Mendiburu, Facundo Ivan. Universidad Nacional de La Plata. Facultad de Informática. Laboratorio de Investigación y Formación en Informática Avanzada; ArgentinaFil: Gomez Torres, Estevan. Universidad Tecnológica Equinoccial. Facultad de Ciencias de la Ingeniería E Industrias.; Ecuador. Universidad Nacional de La Plata. Facultad de Informática; ArgentinaFil: Gordillo, Silvia Ethel. Universidad Nacional de La Plata. Facultad de Informática. Laboratorio de Investigación y Formación en Informática Avanzada; Argentin