16 research outputs found

    Instantaneous blowup and singular potentials on Heisenberg groups

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    In this paper we generalize the instantaneous blowup result from [3] and [15] to the heat equation perturbed by singular potentials on the Heisenberg group

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    Instantaneous blowup and singular potentials on Heisenberg groups

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    In this paper we generalize the instantaneous blowup result from previous papers by P. Baras, J.A. Goldstein and I. Kombe to the heat equation perturbed by singular potentials on the Heisenberg group

    Nevo displásico (nevo atípico) Dysplastic nevus (atypical nevus)

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    O nevo atípico (displásico) é considerado um fator importante associado com o risco aumentado de desenvolvimento do melanoma cutâneo. Acredita-se que nevos atípicos sejam lesões precursoras do melanoma cutâneo. Podem estar presentes em pacientes com múltiplos nevos melanocíticos (síndrome do nevo atípico) ou isolados e em poucas quantidades em um contexto não familial. Aparecem, geralmente, na puberdade e prevalecem em indivíduos jovens. Têm predileção por áreas expostas ao sol, especialmente, o tronco. O grande desafio em relação ao nevo atípico reside na controvérsia em se definir sua nomenclatura, diagnóstico clínico, critérios dermatoscópicos, diagnóstico histopatológico e aspectos moleculares. Esta revisão tem por objetivo trazer o conhecimento, facilitar o entendimento e responder às questões duvidosas concernentes ao nevo atípico.<br>Atypical nevum (dysplastic) is considered an important factor associated with increased risk of developing cutaneous melanoma. It is believed that atypical nevi are precursor lesions of cutaneous melanoma. They may be present in patients with multiple melanocytic nevi (atypical nevus syndrome) or isolated and in small numbers in a non-familial context. The disease usually begins at puberty and predominates in young people. It has a predilection for sun-exposed areas, especially the trunk. The major challenge in relation to atypical nevi lies in the controversy of defining its nomenclature, clinical diagnosis, dermoscopic criteria, histopathological diagnosis and molecular aspects. This review aims at bringing knowledge, facilitating comprehension and clarifying doubts about atypical nevus

    Gills of juvenile fish piaractus mesopotamicus as histological biomarkers for experimental sub-lethal contamination with the Organophosphorus Azodrin®400

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    Piaractus mesopotamicus is a freshwater native fish from rivers of the Paraná-Paraguay Basin and of the Pantanal region and has been used for repopulation programs in Brazil. Juvenile fishes were exposed to the sub-lethal dose of 1.08mg/L of the OP Azodrin®400 containing 0.43µL/L of the active principle monocrotophos for 96 h. A frequent pathology in the gills at all times of exposure was epithelial detachment, from minimal until 24 h of exposure, to intense after 48 h of contamination. Deformed pillar cells in the respiratory lamellae leading to irregular blood spaces and blood congestion, as well as hyperplasia and lamellar fusion were observed. These histopathologies suggested that 48 h after T0 was an important time when a reduction in the capability for gaseous exchange with consequent weakening of the fishes' condition could occur. This could impair growth and development of juveniles introduced in water bodies for repopulation programs.<br>Piaractus mesopotamicus é um peixe de água doce encontrado na Bacia Paraná-Paraguai e na região do Pantanal, tendo sido usado em programas de repovoamento no Brasil. Peixes juvenis foram expostos por 96 horas à dose sub-letal de 1.08mg/L do organofosforado (OP) Azodrin®400 que contém 0,43&micro;L/L do principio ativo monocrotofós. A patologia freqüente nas brânquias foi o descolamento epitelial que variou de mínimo nas primeiras 24 horas a severo ou intenso após 48 horas de contaminação. Deformações e degeneração de células pilares nas lamelas respiratórias levando à formação de espaços sanguíneos irregulares e congestão sanguínea, hiperplasia e fusão lamelar também foram observadas. Sugere-se que 48 horas após o T0 é um tempo crítico após exposição a níveis subletais de OP, pois a capacidade de trocas gasosas poderá ter diminuído, levando ao enfraquecimento dos peixes. Os sintomas poderão prejudicar o desenvolvimento dos juvenis introduzidos em corpos de água em programas de repovoamento

    Characterization of individuals at high risk of developing melanoma in Latin America: bases for genetic counseling in melanoma

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    Purpose: CDKN2A is the main high-risk melanoma-susceptibility gene, but it has been poorly assessed in Latin America. We sought to analyze CDKN2A and MC1R in patients from Latin America with familial and sporadic multiple primary melanoma (SMP) and compare the data with those for patients from Spain to establish bases for melanoma genetic counseling in Latin America. Methods: CDKN2A and MC1R were sequenced in 186 Latin American patients from Argentina, Brazil, Chile, Mexico, and Uruguay, and in 904 Spanish patients. Clinical and phenotypic data were obtained. Results: Overall, 24 and 14% of melanoma-prone families in Latin America and Spain, respectively, had mutations in CDKN2A. Latin American families had CDKN2A mutations more frequently (P = 0.014) than Spanish ones. Of patients with SMP, 10% of those from Latin America and 8.5% of those from Spain had mutations in CDKN2A (P = 0.623). The most recurrent CDKN2A mutations were c.-34G>T and p.G101W. Latin American patients had fairer hair (P = 0.016) and skin (P < 0.001) and a higher prevalence of MC1R variants (P = 0.003) compared with Spanish patients. Conclusion: The inclusion criteria for genetic counseling of melanoma in Latin America may be the same criteria used in Spain, as suggested in areas with low to medium incidence, SMP with at least two melanomas, or families with at least two cases among first-or second-degree relatives.GenoMEL, National Cancer Institute of the US National Institutes of Health, Fondo de Investigaciones Sanitarias, CIBER de Enfermedades Raras of the Instituto de Salud Carlos II, Catalan Government, European Commission, Instituto de Salud Carlos III, Consejo Nacional de Ciencia y Tecnologia (CONACYT), Fundacao para o Amparo da Pesquisa do Estado de Sao Paulo (FAPESP), Brazilian Post-Graduation Agency Capes (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior), Comision Honoraria de Lucha Contra el Cancer and Fundacion Manuel Perez, Montevide
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