Strategic orientations and digital marketing tactics in cross-border e-commerce: Comparing developed and emerging markets

In this article, the impact of strategic orientations on the use of digital marketing tactics and, subsequently, on the international business performance of small electronic retailers (e-retailers) in cross-border electronic commerce (e-commerce) is analysed. Furthermore, these relationships are compared between e-retailers originating in both developed and emerging e-commerce markets. Using a sample of 446 small business-to-consumer e-retailers from 20 European countries, we find that the deployment of digital marketing tactics has a positive effect on international business performance. Of the strategic orientations examined, foreign market orientation is most associated with the use of digital marketing tactics. Remarkably, growth orientation only has a positive effect on e-retailers from developed e-commerce markets, while customer orientation negatively affects e-retailers from emerging e-commerce markets. The differences between e-retailers from developed and emerging e-commerce markets are prominent and show that markets should not be considered as either uniform or generalisable

Katian GSSP and Carbonates of the Simpson and Arbuckle Groups in Oklahoma

This guidebook was written for the 2015 International Symposium on the Ordovician System (ISOS) as a synopsis of the recent work (e.g., Goldman et al. 2007; Carlucci et al. 2014, forthcoming work for the ISOS meeting) on Ordovician-Silurian rocks of south-central and south-eastern Oklahoma. This new research and past studies (e.g., Harris 1957; Longman 1976; Longman 1982a, b; Fay et al. 1982a; Fay et al. 1982b) underscore the scientific importance of this region. The global stratotype section and point for the Katian Stage of the Upper Ordovician Series is examined on this trip. The first appearances of important graptolites, conodonts and chitinozoans in that section are crucial for worldwide chronostratigraphic correlation. Vertical and lateral facies changes of the Simpson Group demonstrate the variety and intricacy of sedimentary cycles and the importance of updating depositional models with sequence stratigraphic data. Carbonate facies of the Arbuckle Group are of general interest to all geologists, as they demonstrate a wide variety of sedimentary structures and fabrics that were deposited in tropical epeiric seas. Arbuckle Group carbonates show a variety of peloidal, oolitic, fossiliferous, stromatolitic, and brecciated facies that provide important insights into the depositional history of the “Great American Carbonate Bank” (Taylor et al. 2012). Simply put, these deposits are an exceptional natural laboratory for the sedimentary geologist. Siliciclastic deposits are also common in the Simpson and Arbuckle Groups, with shoreface sands and siltstones forming “bookends” to formation boundaries. The scientific importance of the Arbuckle region also extends into the realm of structural geology, where geologic cross sections (Fig. 1) of the Ardmore Basin, Arbuckle Anticline, and Washita Valley demonstrate overturned strata, extensive reverse faulting, and a series of major synclines and anticlines at a variety of scales. Pennsylvanian age tectonic features are just another example of why the Arbuckle Mountains is an excellent natural laboratory for field geologists

Inferring stabilizing mutations from protein phylogenies : application to influenza hemagglutinin

One selection pressure shaping sequence evolution is the requirement that a protein fold with sufficient stability to perform its biological functions. We present a conceptual framework that explains how this requirement causes the probability that a particular amino acid mutation is fixed during evolution to depend on its effect on protein stability. We mathematically formalize this framework to develop a Bayesian approach for inferring the stability effects of individual mutations from homologous protein sequences of known phylogeny. This approach is able to predict published experimentally measured mutational stability effects (ΔΔG values) with an accuracy that exceeds both a state-of-the-art physicochemical modeling program and the sequence-based consensus approach. As a further test, we use our phylogenetic inference approach to predict stabilizing mutations to influenza hemagglutinin. We introduce these mutations into a temperature-sensitive influenza virus with a defect in its hemagglutinin gene and experimentally demonstrate that some of the mutations allow the virus to grow at higher temperatures. Our work therefore describes a powerful new approach for predicting stabilizing mutations that can be successfully applied even to large, complex proteins such as hemagglutinin. This approach also makes a mathematical link between phylogenetics and experimentally measurable protein properties, potentially paving the way for more accurate analyses of molecular evolution

Patients with suspected acute coronary syndrome in a university hospital emergency department: an observational study

BACKGROUND: It is widely considered that improved diagnostics in suspected acute coronary syndrome (ACS) are needed. To help clarify the current situation and the improvement potential, we analyzed characteristics, disposition and outcome among patients with suspected ACS at a university hospital emergency department (ED). METHODS: 157 consecutive patients with symptoms of ACS were included at the ED during 10 days. Risk of ACS was estimated in the ED for each patient based on history, physical examination and ECG by assigning them to one of four risk categories; I (obvious myocardial infarction, MI), II (strong suspicion of ACS), III (vague suspicion of ACS), and IV (no suspicion of ACS). RESULTS: 4, 17, 29 and 50% of the patients were allocated to risk categories I-IV respectively. 74 patients (47%) were hospitalized but only 19 (26%) had ACS as the discharge diagnose. In risk categories I-IV, ACS rates were 100, 37, 12 and 0%, respectively. Of those admitted without ACS, at least 37% could probably, given perfect ED diagnostics, have been immediately discharged. 83 patients were discharged from the ED, and among them there were no hospitalizations for ACS or cardiac mortality at 6 months. Only about three patients per 24 h were considered eligible for a potential ED chest pain unit. CONCLUSIONS: Almost 75% of the patients hospitalized with suspected ACS did not have it, and some 40% of these patients could probably, given perfect immediate diagnostics, have been managed as outpatients. The potential for diagnostic improvement in the ED seems large