Methodological considerations for epidemiological studies of air pollution and the sars and COVID-19 coronavirus outbreaks

BACKGROUND: Studies have reported that ambient air pollution is associated with an increased risk of developing or dying from coronavirus-2 (COVID-19). Methodological approaches to investigate the health impacts of air pollution on epidemics should differ from those used for chronic dis-eases, but the methods used in these studies have not been appraised critically. OBJECTIVES: Our study aimed to identify and critique the methodological approaches of studies of air pollution on infections and mortality due to COVID-19 and to identify and critique the methodological approaches of similar studies concerning severe acute respiratory syndrome (SARS). METHODS: Published and unpublished papers of associations between air pollution and developing or dying from COVID-19 or SARS that were reported as of 10 May 2020 were identified through electronic databases, internet searches, and other sources. RESULTS: All six COVID-19 studies and two of three SARS studies reported positive associations. Two were time series studies that estimated associations between daily changes in air pollution, one was a cohort that assessed associations between air pollution and the secondary spread of SARS, and six were ecological studies that used area-wide exposures and outcomes. Common shortcomings included possible cross-level bias in ecological studies, underreporting of health outcomes, using grouped data, the lack of highly spatially resolved air pollution measures, inadequate control for confounding and evaluation of effect modification, not accounting for regional variations in the timing of outbreaks’ temporal changes in at-risk popu-lations, and not accounting for nonindependence of outcomes. DISCUSSION: Studies of air pollution and novel coronaviruses have relied mainly on ecological measures of exposures and outcomes and are suscepti-ble to important sources of bias. Although longitudinal studies with individual-level data may be imperfect, they are needed to adequately address this topic. The complexities involved in these types of studies underscore the need for careful design and for peer review

Introduction to the issue on nanophotonics

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Leptogenesis and Low-energy Observables

We relate leptogenesis in a class of theories to low-energy experimental observables: quark and lepton masses and mixings. With reasonable assumptions motivated by grand unification, one can show that the CP-asymmetry parameter takes a universal form. Furthermore the dilution mass is related to the light neutrino masses. Overall, these models offer a natural explanation for a lepton asymmetry in the early universe.Comment: 10 pages, revised discussion on light neutrino masse

Associations between incident breast cancer and ambient concentrations of nitrogen dioxide from a national land use regression model in the Canadian National Breast Screening Study

Background: Air pollution has been classified as a human carcinogen based largely on epidemiological studies of lung cancer. Recent research suggests that exposure to ambient air pollution increases the risk of female breast cancer especially in premenopausal women. Methods: Our objective was to determine the association between residential exposure to ambient nitrogen dioxide (NO2) and newly diagnosed cases of invasive breast cancer in a cohort of 89,247 women enrolled in the Canadian National Breast Screening Study between 1980 and 1985.

Genetic Algorithm in the Optimization of the Acoustic Attenuation System

[EN] It is well known that Genetic Algorithms (GA) is an optimization method which can be used in problems where the traditional optimization techniques are difficult to be applied. Sonic Crystals (SC) are periodic structures that present ranges of sound frequencies related with the periodicity of the structure, where the sound propagation is forbidden. This means that in the acoustic spectrum there are ranges of frequencies with high acoustic attenuation. This attenuation can be improved producing vacancies in the structure. In this paper we use a parallel implementation of a GA to optimize those structures, by means of the creation of vacancies in a starting SC, in order to obtain the best acoustic attenuation in a predetermined range of frequencies. The cost function used in GA is based on the Multiple Scattering Theory (MST), which is a self consistent method for calculating acoustic pressure in SCs. As a final result we achieve a quasi ordered structures that presents a high acoustic attenuation in a predetermined range of frequencies, independent of the periodicity of the SC.The authors acknowledge financial support provided by the Spanish MEC (Project No. MAT2006-03097) and by the Generalitat Valenciana (Spain) under Grant No. GV/2007/191. This work also has been partially supported by MEC (Spanish government) and FEDER funds: projects DPI2005-07835, DPI2004- 8383-C03-02 and GVA-026.Romero García, V.; Fuster García, E.; Sánchez Pérez, JV.; García Raffi, LM.; Blasco, X.; Herrero Durá, JM.; Sanchís Saez, J. (2007). Genetic Algorithm in the Optimization of the Acoustic Attenuation System. Lecture Notes in Computer Science. 4507:614-621. https://doi.org/10.1007/978-3-540-73007-1_74S6146214507Martínez-Sala, R., Sancho, J., Sánchez Pérez, J.V., Llinares, J., Meseguer, F.: Sound attenuation by sculpture. Nature (London) 387, 241 (1995)Hushwaha, M.S., Halevi, P., Martínez, G., Dobrynski, L., Djafari-Rouhani, B.: Theory of acoustic band structure of periodic elastic composites. Phys. Rev. B 49(4), 2313–2322 (1994)Liu, Z., Zhang, X., Mao, Y., Zhu, Y.Y., Yang, Z., Xhan, C.T., Sheng, P.: Locally resonatn sonic materials. Science 289, 1734 (2000)Hu, X., Chan, C.T., Zi, J.: Two dimensional sonic crystals with Helmholtz resonators. Phys. Rev. E 71, 055601 (2005)Umnova, O., Attenborough, K., Linton, C.M.: Effects of porous covering on sound attenuation by poriodi arrays of cylinders. J. Acoust. Soc. Am. 119, 278 (2006)Caballero, D., Sánchez-Dehesa, J., Martínez-Sala, R., Rubio, C., Sánchez Pérez, J.V.S., Sanchis, L., Meseguer, F.: Suzuki phase in two-dimensional sonic crystals. Phys. Rev. B 64, 064303 (2001)Hakansson, A., Sánchez-Dehesa, J., Sanchis, L.: Acoustic lens design by genetic algorithms. Phys. Rev. B 70, 214302 (2004)Romero-García, V., Fuster, E., García-Raffi, L.M., Sánchez-Pérez, E.A., Sopena, M., Llinares, J., Sánchez-Pérez, J.V.: Band gap creation using quasiordered strutures based on sonic crystals. Appl. Phys. Lett. 88, 174104-1 174104-3 (2006)Chen, Y.Y., Ye, Z.: Theoretical analysis of acoustic stop bands in two-dimensional periodic scattering arrays. Phys. Rev. E 64, 036616 (2001)Economou, E.N., Sigalas, M.M.: Classical wave propagation in periodic structures: Cermet versus network topology. Phys. Rev. B 48(18), 13434 (1993)Sigalas, M.M., Economou, E.N., Kafesaki, M.: Spectral gaps for electromagnietic and scalar waves: Possible explanation for certain differences. Phys. Rev. B 50(5), 3393 (1994)Goldberg, D.E.: Genetic Algorithms in search, optimization and machine learning. Addison-Wesley, London (1989)Bäck, T.: Evolutionaty Algorithms in theory and practice. Oxford University Press, New York (1996)Baker, J.E.: Reducing bias and inefficiency in the selection algorithm. In: Proc. Second International Conference on Genetic Algorithms (1987)Mühlenbein, H., Schlierkamp-Voosen, D.: Predictive Models for the Breeder Genetic Algorithm I. Continuous Parameter Optimization. Evolutionary Computation 1(1) (1993)Cantú-Paz, E.: A summary of resaearch on parallel genetic algorithms. Technical Report 95007, Illinois Genetic Algorithms Laboratory. IlliGAL (1995

Leptogenesis and neutrino parameters

We calculate the baryonic asymmetry of the universe in the baryogenesis-via-leptogenesis framework, assuming first a quark-lepton symmetry and then a charged-neutral lepton symmetry. We match the results with the experimentally favoured range. In the first case all the oscillation solutions to the solar neutrino problem, except the large mixing matter solution, can lead to the allowed range, but with fine tuning of the parameters. In the second case the general result is quite similar. Some related theoretical hints are discussed.Comment: RevTex, 21 pages with 8 figure

Diffusive Charge Transport in Graphene on SiO2

We review our recent work on the physical mechanisms limiting the mobility of graphene on SiO2. We have used intentional addition of charged scattering impurities and systematic variation of the dielectric environment to differentiate the effects of charged impurities and short-range scatterers. The results show that charged impurities indeed lead to a conductivity linear in density in graphene, with a scattering magnitude that agrees quantitatively with theoretical estimates [1]; increased dielectric screening reduces scattering from charged impurities, but increases scattering from short-range scatterers [2]. We evaluate the effects of the corrugations (ripples) of graphene on SiO2 on transport by measuring the height-height correlation function. The results show that the corrugations cannot mimic long-range (charged impurity) scattering effects, and have too small an amplitude-to-wavelength ratio to significantly affect the observed mobility via short-range scattering [3, 4]. Temperature-dependent measurements show that longitudinal acoustic phonons in graphene produce a resistivity linear in temperature and independent of carrier density [5]; at higher temperatures, polar optical phonons of the SiO2 substrate give rise to an activated, carrier density-dependent resistivity [5]. Together the results paint a complete picture of charge carrier transport in graphene on SiO2 in the diffusive regime.Comment: 28 pages, 7 figures, submitted to Graphene Week proceeding

Leptogenesis and low energy observables in left-right symmetric models

In the context of left-right symmetric models we study the connection of leptogenesis and low energy parameters such as neutrinoless double beta decay and leptonic CP violation. Upon imposition of a unitarity constraint, the neutrino parameters are significantly restricted and the Majorana phases are determined within a narrow range, depending on the kind of solar solution. One of the Majorana phases gets determined to a good accuracy and thereby the second phase can be probed from the results of neutrinoless double beta decay experiments. We examine the contributions of the solar and atmospheric mass squared differences to the asymmetry and find that in general the solar scale dominates. In order to let the atmospheric scale dominate, some finetuning between one of the Majorana phases and the Dirac CP phase is required. In this case, one of the Majorana phases is determined by the amount of CP violation in oscillation experiments.Comment: 18 pages, 6 figures. Matches version to appear in PR

The three-dimensional random field Ising magnet: interfaces, scaling, and the nature of states

The nature of the zero temperature ordering transition in the 3D Gaussian random field Ising magnet is studied numerically, aided by scaling analyses. In the ferromagnetic phase the scaling of the roughness of the domain walls, $w\sim L^\zeta$, is consistent with the theoretical prediction $\zeta = 2/3$. As the randomness is increased through the transition, the probability distribution of the interfacial tension of domain walls scales as for a single second order transition. At the critical point, the fractal dimensions of domain walls and the fractal dimension of the outer surface of spin clusters are investigated: there are at least two distinct physically important fractal dimensions. These dimensions are argued to be related to combinations of the energy scaling exponent, $\theta$, which determines the violation of hyperscaling, the correlation length exponent $\nu$, and the magnetization exponent $\beta$. The value $\beta = 0.017\pm 0.005$ is derived from the magnetization: this estimate is supported by the study of the spin cluster size distribution at criticality. The variation of configurations in the interior of a sample with boundary conditions is consistent with the hypothesis that there is a single transition separating the disordered phase with one ground state from the ordered phase with two ground states. The array of results are shown to be consistent with a scaling picture and a geometric description of the influence of boundary conditions on the spins. The details of the algorithm used and its implementation are also described.Comment: 32 pp., 2 columns, 32 figure

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but not Loss of Dopaminergic Neurons

Loss-of-function mutations in parkin are the major cause of early-onset familial Parkinson's disease. To investigate the pathogenic mechanism by which loss of parkin function causes Parkinson's disease, we generated a mouse model bearing a germline disruption in parkin. Parkin-/- mice are viable and exhibit grossly normal brain morphology. Quantitative in vivo microdialysis revealed an increase in extracellular dopamine concentration in the striatum of parkin-/- mice. Intracellular recordings of medium-sized striatal spiny neurons showed that greater currents are required to induce synaptic responses, suggesting a reduction in synaptic excitability in the absence of parkin. Furthermore, parkin-/- mice exhibit deficits in behavioral paradigms sensitive to dysfunction of the nigrostriatal pathway. The number of dopaminergic neurons in the substantia nigra of parkin-/- mice, however, is normal up to the age of 24 months, in contrast to the substantial loss of nigral neurons characteristic of Parkinson's disease. Steady-state levels of CDCrel-1, synphilin-1, and α-synuclein, which were identified previously as substrates of the E3 ubiquitin ligase activity of parkin, are unaltered in parkin-/- brains. Together these findings provide the first evidence for a novel role of parkin in dopamine regulation and nigrostriatal function, and a non-essential role of parkin in the survival of nigral neurons in mice