6 research outputs found
Structural Insight v3: A stand-alone program for micro structural analysis of computed tomography volumes
Structural Insight is a software for the analysis of 3D quantitative computed
tomography volumes with a special weight for the analysis of the trabecular microstructure of human vertebrae.Sociedad Argentina de Informática e Investigación Operativa (SADIO
Structural Insight v3: A stand-alone program for micro structural analysis of computed tomography volumes
Structural Insight is a software for the analysis of 3D quantitative computed
tomography volumes with a special weight for the analysis of the trabecular microstructure of human vertebrae.Sociedad Argentina de Informática e Investigación Operativa (SADIO
Structural Insight v3: A stand-alone program for micro structural analysis of computed tomography volumes
Structural Insight is a software for the analysis of 3D quantitative computed
tomography volumes with a special weight for the analysis of the trabecular microstructure of human vertebrae.Sociedad Argentina de Informática e Investigación Operativa (SADIO
Multimodal [GdO]<sup>+</sup>[ICG]<sup>−</sup> Nanoparticles for Optical, Photoacoustic, and Magnetic Resonance Imaging
Multimodal contrast
agents with high biocompatibility and biodegradability,
as well as low material complexity, are in great demand for clinical
diagnostics at different scales of resolution and/or for translating
preclinical diagnosis into intraoperative imaging. Multimodality,
however, often results in multicomponent and multistructured materials
with complexity becoming a severe restriction for synthesis, approval,
and use in routine clinical practice. Here, we present sulfonate-based
saline [GdO]<sup>+</sup>[ICG]<sup>−</sup> (ICG, indocyanine
green) inorganic-organic hybrid nanoparticles (IOH-NPs with an inorganic
[GdO]<sup>+</sup> cation and an organic [ICG]<sup>−</sup> anion)
as a novel, multimodality contrast agent for optical, photoacoustic,
and magnetic resonance imaging (OI, PAI, MRI). [GdO]<sup>+</sup>[ICG]<sup>−</sup> IOH-NPs have a plain composition based on clinically
used constituents and are prepared as an insoluble saline compound
in water. The high [ICG]<sup>−</sup> content (81 wt %) ensures
intense near-infrared emission (780–840 nm) and a strong photoacoustic
signal. First, <i>in vitro</i> studies demonstrate longer
detectability and greater emission intensity for [GdO]<sup>+</sup>[ICG]<sup>−</sup> IOH-NP suspensions than for ICG solutions,
as well as a reduced toxicity compared to that of Gd-DTPA, a standard
MRI contrast agent. Conceptual <i>in vivo</i> studies confirm
the utility of the [GdO]<sup>+</sup>[ICG]<sup>−</sup> IOH-NPs
for optical and magnetic resonance imaging with a <i>T</i><sub>1</sub> relaxivity better than that of Gd-DTPA. Taken together,
[GdO]<sup>+</sup>[ICG]<sup>−</sup> represents a new compound
and nanomaterial that can be highly interesting as a multimodal contrast
agent