Pancreas and islet cell transplantation

Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use of exogenous insulin can be achieved only with pancreas or islet cell transplantation. These means of restoring β-cell mass can completely maintain essentially normal long-term glucose homeostasis, although the need for powerful immunosuppressive regimens limits their application to only a subgroup of adult patients. Apart from the shortage of donors that has limited all kinds of transplantation, however, the widespread use of β-cell replacement has been precluded until recently by the drawbacks associated with both organ and islet cell transplantation. Although the study of recurrence of diabetes has generated attention, the fundamental obstacle to pancreas and islet transplantation has been, and remains, the alloimmune response. With a better elucidation of the mechanisms of alloengraftment achieved during the last 3 years, the stage has been set for further advances

Alton Gliedman correspondence with Grady M. Long, 1943 December 18

Letter from Alton Gliedman Jr. to Grady Long in which Gliedman discusses his possession of Leroy Sullivan's diaries. The letter includes a note from Sullivan to give them to Long in the event of Sullivan's death. Gliedman explains his hesitancy to mail them because of the Censorship Regulations but states he will send them to Long upon his return to Atlanta, Georgia. Glideman remebers Sullian as a "a dear friend" and states, "I miss him very much. His ready wit and everpresent smile made the burden lighter." Gliedman encloses as copy of a 1941 September 22 letter from Sullivan to Grady in which Sullivan explains that he is bequething the diaries to Grady in order to spare his mother the knowledge of the hardships of war