Comportamento sexual e infecções sexualmente transmissíveis em mulheres de apenados

Objetivo: analisar o comportamento sexual e estimar a prevalência de infecções sexualmente transmissíveis em mulheres de apenados. Método: estudo quantitativo transversal, com 349 mulheres parceiras de apenados. Para coleta de dados, foi utilizado o instrumento validado no Brasil, Estudo de Comportamento Sexual. Para análise estatística, utilizou-se o software Statistical Package for the Social Sciences, versão 20. Resultados: identificou-se que 41,2% das mulheres de apenados referiram que já tiveram algum tipo de infecção sexualmente transmissível. Há associação entre mulheres que tiveram mais de um parceiro nos últimos 12 meses (<0,006), que sofreram violência sexual (<0,001), praticaram sexo por dinheiro (<0,001), sob efeito de álcool (<0,001) e sob efeito de drogas (<0,005). Na Regressão Logística, as variáveis associadas às infecções sexualmente transmissíveis foram: mulheres que se relacionaram com mais de um parceiro nos últimos 12 meses, que referiram ter sofrido violência sexual, prática de sexo por dinheiro e sob efeito de álcool ou drogas. Conclusão: número de parceiros, violência sexual, sexo por dinheiro e sexo sob efeito de álcool ou drogas são comportamentos sexuais de risco que aumentam a prevalência de infecções sexualmente transmissíveis em mulheres de apenados.Objetivo: analizar el comportamiento sexual y estimar la prevalencia de Infecciones Sexualmente Trasmisibles en mujeres de condenados. Método: estudio cuantitativo transversal con 349 mujeres compañeras de condenados. Para recoger los datos fue utilizado el instrumento Estudio de Comportamiento Sexual (ECOS), validado en Brasil. Para el análisis estadístico, se utilizó el Programa Statistical Package for the Social Sciences versión 20. Resultados: se identificó que 41,2% de las mujeres de condenados mencionaron que ya tuvieron algún tipo de infección sexualmente trasmisible. Existe asociación entre mujeres que tuvieron más de un compañero en los últimos 12 meses (<0,006), que sufrieron violencia sexual (<0,001), practicaron sexo por dinero (<0,001), sobre efecto de alcohol (<0,001) y sobre efecto de drogas (<0,005). En la Regresión Logística las variables asociadas a infecciones sexualmente trasmisibles fueron mujeres que se relacionaron con más de un compañero en los últimos 12 meses, que mencionaron haber sufrido violencia sexual, practicado sexo por dinero y bajo efecto de alcohol o drogas. Conclusión: número de compañeros, la violencia sexual, sexo por dinero y sexo sobre efecto de alcohol o drogas son comportamientos sexuales de riesgo que aumentan la prevalencia de infecciones sexualmente trasmisibles en mujeres de condenados.Objective: to analyze the sexual behavior of the female partners of inmates and estimate the prevalence of sexually transmitted diseases. Method: cross-sectional, quantitative study involving 349 female partners of inmates. The Estudo de Comportamento Sexual [Sexual Behavior Study], an instrument validated in Brazil, was used to collect the data. The Statistical Package for the Social Sciences, version 20 was used in the statistical analysis. Results: 41.2% of the female partners of inmates reported a prior history of sexually transmitted disease. Association was found between having more than one partner in the last 12 months (<0.006), sexual violence (<0.001), having sex for money (<0.001), under the influence of alcohol (<0.001), and under the influence of drugs (<0.005). The variables associated with sexually transmitted infections in the logistic regression were: having more than one partner in the last 12 months, sexual violence, sex for money, and under the effect of alcohol or drugs. Conclusion: The number of partners, sexual violence, sex for money, and under the influence of alcohol or drugs are sexual risk behaviors that increase the prevalence of sexually transmitted infections among the female partners of inmates

Sífilis na gestante e congênita: perfil epidemiológico e prevalencia

Objective: To describe the epidemiological profile through sociodemographic, obstetric and partner characteristics of the notified cases of syphilis in pregnant women in the period of 2012 to 2016. Methods: This is a cross-sectional and descriptive study conducted at the 16th Apucarana Health Region of the State of Paraná through the compulsory notification sheets for syphilis in pregnant women and congenital syphilis inserted in the Notification System of Diseases and Diseases (SINAN). Results: It was recorded 257 cases of syphilis in pregnant women and 119 cases of congenital syphilis. The prevalent rate of syphilis was 0,97% and the incidence rate of congenital syphilis was 4,73%. Women with congenital syphilis (SG) and congenital syphilis (SC) were mostly white, young, with low schooling and living in urban areas. Untreated partners accounted for 40,8% and 47.05% of the mothers were considered with inadequate treatment. Among live births (NS) with SC, 69.7% did not undergo TT at 18 months and 81.5% did not do TNT in CSF. Conclusion: The health system must be reorganized ensuring the follow-up and follow-up of both the pregnant and the newborn.Objetivo: Describir el perfil epidemiológico a través de las características sociodemográficas, obstétricas y del compañero, de casos notificados de sífilis en gestantes y de sífilis congénita, en el período de 2012 a 2016. Métodos: Se trata de un estudio transversal y descriptivo realizado en la 16ª Regional de Salud de Apucarana, en el estado de Paraná, a través de las fichas de notificación compulsoria de sífilis en gestante y sífilis congénita, que constaban en el Sistema de Notificación de Perjuicios y Enfermedades (SINAN). Resultados: Fueron notificados 257 casos de sífilis en gestantes y 119 casos de sífilis congénita. La tasa de prevalencia de sífilis gestacional fue de 0,97% y la tasa de incidencia de sífilis congénita de 4,73%. Las mujeres notificadas como "sífilis en gestante" (SG) y con recién nacido (RN) con "sífilis congénita" (SC), eran en su mayoría, blancas, jóvenes, con baja escolaridad y residían en zona urbana. Los compañeros no tratados totalizaron 40,8%; las madres consideradas con tratamiento inadecuado fueron 47,05%. Entre los nacidos vivos (NV) con SC, 69,7% no realizaron el test treponémico (TT) a los 18 meses y 81,5% no hicieron el test no treponémico (TNT) en el líquido cefalorraquídeo. Conclusión: El sistema de salud debe ser reorganizado garantizando el seguimiento y acompañamiento tanto de la gestante como del recién nacido.Objetivo: Descrever o perfil epidemiológico através das características sociodemograficas, obstétricas e do parceiro dos casos notificados de sífilis em gestantes e de sífilis congênita no período de 2012 a 2016. Métodos: Trata-se de um estudo transversal e descritivo realizado na 16ª Regional de Saúde de Apucarana do estado do Paraná através das fichas de notificação compulsória de sífilis em gestante e sífilis congênita inseridas no Sistema de Notificação de Agravos e Doenças (SINAN). Resultados: Foram notificados 257 casos de sífilis em gestante e 119 casos de sífilis congênita. A taxa de prevalência de sífilis gestacional foi de 0.97% e a taxa de incidência de sífilis congênita de 4.73%. As mulheres notificadas com sífilis em gestante (SG) e com recém nascido (RN) portador de sífilis congênita (SC) eram em sua maioria, brancas, jovens, com baixa escolaridade e residiam em zona urbana. Parceiros não tratados totalizaram 40,8% e 47.05% das mães foram consideradas com tratamento inadequado. Entre os nascidos vivos (NV) com SC, 69,7% não realizaram o TT aos 18 meses e 81.5% não fizeram o TNT no líquor. Conclusão: O sistema de saúde deve ser reorganizado garantindo o seguimento e acompanhamento tanto da gestante quanto do recém-nascido

Comparison between two cancer registry quality check systems: functional features and differences in an Italian network of cancer registries dataset

PurposeThe aim of this study was to compare the functional characteristics of two computer-based systems for quality control of cancer registry data through analysis of their output differences. MethodsThe study used cancer incidence data from 22 of the 49 registries of the Italian Network of Cancer Registries registered between 1986 and 2017. Two different data checking systems developed by the WHO International Agency for Research on Cancer (IARC) and the Joint Research Center (JRC) with the European Network of Cancer Registries (ENCR) and routinely used by registrars were used to check the quality of the data. The outputs generated by the two systems on the same dataset of each registry were analyzed and compared. ResultsThe study included a total of 1,305,689 cancer cases. The overall quality of the dataset was high, with 86% (81.7-94.1) microscopically verified cases and only 1.3% (0.03-3.06) cases with a diagnosis by death certificate only. The two check systems identified a low percentage of errors (JRC-ENCR 0.17% and IARC 0.003%) and about the same proportion of warnings (JRC-ENCR 2.79% and IARC 2.42%) in the dataset. Forty-two cases (2% of errors) and 7067 cases (11.5% of warnings) were identified by both systems in equivalent categories. 11.7% of warnings related to TNM staging were identified by the JRC-ENCR system only. The IARC system identified mainly incorrect combination of tumor grade and morphology (72.5% of warnings). ConclusionBoth systems apply checks on a common set of variables, but some variables are checked by only one of the systems (for example, checks on patient follow-up and tumor stage at diagnosis are included by the JRC-ENCR system only). Most errors and warnings were categorized differently by the two systems, but usually described the same issues, with warnings related to "morphology" (JRC-ENCR) and "histology" (IARC) being the most frequent. It is important to find the right balance between the need to maintain high standards of data quality and the workability of such systems in the daily routine of the cancer registry

Mycobacterial and Human Ferrous Nitrobindins: Spectroscopic and Reactivity Properties

Structural and functional properties of ferrous Mycobacterium tuberculosis (Mt-Nb) and human (Hs-Nb) nitrobindins (Nbs) were investigated. At pH 7.0 and 25.0 °C, the unliganded Fe(II) species is penta-coordinated and unlike most other hemoproteins no pH-dependence of its coordination was detected over the pH range between 2.2 and 7.0. Further, despite a very open distal side of the heme pocket (as also indicated by the vanishingly small geminate recombination of CO for both Nbs), which exposes the heme pocket to the bulk solvent, their reactivity toward ligands, such as CO and NO, is significantly slower than in most hemoproteins, envisaging either a proximal barrier for ligand binding and/or crowding of H2O molecules in the distal side of the heme pocket which impairs ligand binding to the heme Fe-atom. On the other hand, liganded species display already at pH 7.0 and 25 °C a severe weakening (in the case of CO) and a cleavage (in the case of NO) of the proximal Fe-His bond, suggesting that the ligand-linked movement of the Fe(II) atom onto the heme plane brings about a marked lengthening of the proximal Fe-imidazole bond, eventually leading to its rupture. This structural evidence is accompanied by a marked enhancement of both ligands dissociation rate constants. As a whole, these data clearly indicate that structural-functional relationships in Nbs strongly differ from what observed in mammalian and truncated hemoproteins, suggesting that Nbs play a functional role clearly distinct from other eukaryotic and prokaryotic hemoproteins

Aborto em mulheres parceiras de apenados: prevalência e fatores associados

Objetivo: Analisar fatores e comportamentos associados à prevalência de aborto em mulheres parceiras de apenados.Métodos: Estudo descritivo, transversal de abordagem quantitativa realizado com 349 mulheres de apenados em três penitenciárias no Estado do Paraná. Para coleta dos dados foi utilizado instrumento validado ECOS – Estudo de Comportamento Sexual no Brasil. Processaram-se análises descritivas, e através de teste Qui-quadrado associou-se a ocorrência de aborto e as variáveis pesquisadas.Resultados: (38,3%) das mulheres referiram aborto ao longo da vida, houve associação entre mulheres com idade inferior a 30 anos (p=<0,001), que referiram tabagismo (p=<0,044), não uso de preservativo (p=<0,001), que sofreram violência sexual (p=<0,050) e que relataram diagnóstico de Infecções Sexualmente Transmissíveis (p=<0,001).Conclusão: O presente estudo evidenciou fatores associados para elevada prevalência de aborto em mulheres de apenados. O aborto é considerado importante problema de saúde pública e necessita ser tratado com prioridade pelas políticas públicas de saúde em diferentes grupos populacionais.Palavras-chave: Aborto. Saúde da mulher. Populações vulneráveis

Trends in Net Survival from Vulvar Squamous Cell Carcinoma in Italy (1990–2015)

Objective: In many Western countries, survival from vulvar squamous cell carcinoma (VSCC) has been stagnating for decades or has increased insufficiently from a clinical perspective. In Italy, previous studies on cancer survival have not taken vulvar cancer into consideration or have pooled patients with vulvar and vaginal cancer. To bridge this knowledge gap, we report the trend in survival from vulvar cancer between 1990 and 2015. (2) Methods: Thirty-eight local cancer registries covering 49% of the national female population contributed the records of 6274 patients. Study endpoints included 1- and 2-year net survival (NS) calculated using the Pohar-Perme estimator and 5-year NS conditional on having survived two years (5|2-year CNS). The significance of survival trends was assessed with the Wald test on the coefficient of the period of diagnosis, entered as a continuous regressor in a Poisson regression model. (3) Results: The median patient age was stable at 76 years. One-year NS decreased from 83.9% in 1990–2001 to 81.9% in 2009–2015 and 2-year NS from 72.2% to 70.5%. Five|2-year CNS increased from 85.7% to 86.7%. These trends were not significant. In the age stratum 70–79 years, a weakly significant decrease in 2-year NS from 71.4% to 65.7% occurred. Multivariate analysis adjusting for age group at diagnosis and geographic area showed an excess risk of death at 5|2-years, of borderline significance, in 2003–2015 versus 1990–2002. (4) Conclusions: One- and 2-year NS and 5|2-year CNS showed no improvements. Current strategies for VSCC control need to be revised both in Italy and at the global level

Relevance of Stereotyped B-Cell Receptors in the Context of the Molecular, Cytogenetic and Clinical Features of Chronic Lymphocytic Leukemia

Highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and heavy-chain complementarity determining region-3 (HCDR3), are expressed in a recurrent fraction of patients affected by chronic lymphocytic leukemia (CLL). We investigated the IGHV status of 1131 productive IG rearrangements from a panel of 1126 CLL patients from a multicenter Italian study group, and correlated the presence and class of HCDR3 stereotyped subsets with the major cytogenetic alterations evaluated by FISH, molecular prognostic factors, and the time to first treatment (TTFT) of patients with early stage disease (Binet A). Stereotyped HCDR3 sequences were found in 357 cases (31.7%), 231 of which (64.7%) were unmutated. In addition to the previously described subsets, 31 new putative stereotypes subsets were identified. Significant associations between different stereotyped HCDR3 sequences and molecular prognostic factors, such as CD38 and ZAP-70 expression, IGHV mutational status and genomic abnormalities were found. In particular, deletion of 17p13 was significantly represented in stereotype subset #1. Notably, subset #1 was significantly correlated with a substantially reduced TTFT compared to other CLL groups showing unmutated IGHV, ZAP-70 or CD38 positivity and unfavorable cytogenetic lesions including del(17)(p13). Moreover, subset #2 was strongly associated with deletion of 13q14, subsets #8 and #10 with trisomy 12, whereas subset #4 was characterized by the prevalent absence of the common cytogenetic abnormalities. Our data from a large and representative panel of CLL patients indicate that particular stereotyped HCDR3 sequences are associated with specific cytogenetic lesions and a distinct clinical outcome

Diversity and ethics in trauma and acute care surgery teams: results from an international survey

Background Investigating the context of trauma and acute care surgery, the article aims at understanding the factors that can enhance some ethical aspects, namely the importance of patient consent, the perceptiveness of the ethical role of the trauma leader, and the perceived importance of ethics as an educational subject. Methods The article employs an international questionnaire promoted by the World Society of Emergency Surgery. Results Through the analysis of 402 fully filled questionnaires by surgeons from 72 different countries, the three main ethical topics are investigated through the lens of gender, membership of an academic or non-academic institution, an official trauma team, and a diverse group. In general terms, results highlight greater attention paid by surgeons belonging to academic institutions, official trauma teams, and diverse groups. Conclusions Our results underline that some organizational factors (e.g., the fact that the team belongs to a university context or is more diverse) might lead to the development of a higher sensibility on ethical matters. Embracing cultural diversity forces trauma teams to deal with different mindsets. Organizations should, therefore, consider those elements in defining their organizational procedures. Level of evidence Trauma and acute care teams work under tremendous pressure and complex circumstances, with their members needing to make ethical decisions quickly. The international survey allowed to shed light on how team assembly decisions might represent an opportunity to coordinate team member actions and increase performance

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)