A six-year longitudinal study of neurocognitive problems in children with epilepsy

INTRODUCTION: This study describes the specific neuropsychological abnormalities among children with epilepsy (CH-E) living in Georgia. METHODS: A cohort of CH-E and children without epilepsy (CH-NoE), aged 6-13 years, admitted to the epilepsy center of the Institute of Neurology and Neuropsychology from 1st January 2010 to 31st December 2015, was selected and investigated with a structured protocol. Neurological/epileptological assessments were made and neuropsychological testing was done on all study subjects. RESULTS: Abnormalities in praxis, verbal functions, verbal learning, visual-spatial matching, visual-motor ability, and fine motor skills, working memory, and phonological memory span were often revealed in CH-E as compared to CH-NoE. Early age of seizure onset, epilepsy duration, and anti-seizure medication (ASM) use, in combination with brain structural abnormalities on neuroimaging, and structural etiology were independent predictors of impaired functioning in various neuropsychological domains. DISCUSSION: More than half of children with epilepsy have a variety of cognitive impairments, which may increase with ASM therapy, especially when the cause of seizures is structural damage to the brain. Therefore, in the process of diagnosing epilepsy, evaluation of cognitive functions should become an integral part to ensure effective management of the disorder

Stroke incidence and 30-day case-fatality in a suburb of Tbilisi: results of the first prospective population-based study in Georgia

BACKGROUND AND PURPOSE: Although stroke is one of the main public health problems worldwide, no study of stroke incidence has been performed in Georgia, and therefore, a population-based registry was established to determine the incidence and case-fatality rates of first-ever stroke. METHODS: We identified all first-ever strokes between November 2000 and July 2003 in a defined population of 51,246 residents in the Sanzona suburb of Tbilisi, the capital of Georgia, using overlapping sources of information and standard diagnostic criteria. RESULTS: A total of 233 first-ever strokes occurred during the study period. The crude annual incidence rate was 165 (95% CI, 145 to 188) per 100,000 residents. The corresponding rate adjusted to the standard "world" population was 103 (95% CI, 89 to 117). In terms of stroke subtype, the crude annual incidence rate per 100,000 inhabitants was 89 (95% CI, 74 to 106) for ischemic stroke, 44 (95% CI, 34 to 57) for intracerebral hemorrhage, 16 (95% CI, 10 to 25) for subarachnoidal hemorrhage, and 16 (95% CI, 10 to 25) for unspecified stroke, and the corresponding case-fatality rates at 1 month were 19.2%, 48.4%, 47.8%, and 69.6%. CONCLUSIONS: The overall stroke incidence rate in an urban population of Georgia is comparable to those reported in developed countries. As for the stroke subtypes, there is an excess of hemorrhagic strokes compared with other registries. Geographical and lifestyle variations may explain these findings, whereas inadequacy of the stroke care system in Georgia might contribute to the high case-fatality. [Authors]]]> Cerebrovascular Accident oai:serval.unil.ch:BIB_31770 2022-05-07T01:14:25Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_31770 La résurrection du Christ dans les apocryphes. Gounelle, R info:eu-repo/semantics/bookPart incollection 2004 Les premiers temps de l'Église. De saint Paul à saint Augustin (Folio Histoire 124), pp. 117-121 Baslez, M-F (ed.) oai:serval.unil.ch:BIB_31771 2022-05-07T01:14:25Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_31771 Le Christ des apocryphes. Gounelle, R info:eu-repo/semantics/bookPart incollection 2004 Les premiers temps de l'Église. De saint Paul à saint Augustin (Folio Histoire 124), pp. 242-245 Baslez, M-F (ed.) oai:serval.unil.ch:BIB_31771256CC87 2022-05-07T01:14:25Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_31771256CC87 Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment. info:doi:10.1016/S2213-8587(14)70102-0 info:eu-repo/semantics/altIdentifier/doi/10.1016/S2213-8587(14)70102-0 info:eu-repo/semantics/altIdentifier/pmid/24842598 Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration Danaei, G. Lu, Y. Singh, G.M. Carnahan, E. Stevens, G.A. Cowan, M.J. Farzadfar, F. Lin, J.K. Finucane, M.M. Rao, M. Khang, Y.H. Riley, L.M. Mozaffarian, D. Lim, S.S. Ezzati, M. Aamodt, G. Abdeen, Z. Abdella, N.A. Rahim, H.F. Addo, J. Aekplakorn, W. Afifi, M.M. Agabiti-Rosei, E. Salinas, C.A. Agyemang, C. Ali, M.K. Ali, M.M. Al-Nsour, M. Al-Nuaim, A.R. Ambady, R. Di Angelantonio, E. Aro, P. Azizi, F. Babu, B.V. Bahalim, A.N. Barbagallo, C.M. Barbieri, M.A. Barceló, A. Barreto, S.M. Barros, H. Bautista, L.E. Benetos, A. Bjerregaard, P. Björkelund, C. Bo, S. Bobak, M. Bonora, E. Botana, M.A. Bovet, P. Breckenkamp, J. Breteler, M.M. Broda, G. Brown, I.J. Bursztyn, M. de León, A.C. Campos, H. Cappuccio, F.P. Capuano, V. Casiglia, E. Castellano, M. Castetbon, K. Cea, L. Chang, C.J. Chaouki, N. Chatterji, S. Chen, C.J. Chen, Z. Choi, J.S. Chua, L. Cífková, R. Cobiac, L.J. Cooper, R.S. Corsi, A.M. Costanza, M.C. Craig, C.L. Dankner, R.S. Dastgiri, S. Delgado, E. Dinc, G. Doi, Y. Dong, G.H. Dorsi, E. Dragano, N. Drewnowski, A. Eggertsen, R. Elliott, P. Engeland, A. Erem, C. Esteghamati, A. Fall, C.H. Fan, J.G. Ferreccio, C. Fezeu, L. Firmo, J.O. Florez, H.J. Fornés, N.S. Fowkes, F.G. Franceschini, G. Frisk, F. Fuchs, F.D. Fuller, E.L. Getz, L. Giampaoli, S. Gómez, L.F. Gomez-Zumaquero, J.M. Graff-Iversen, S. Grant, J.F. Carvajal, R.G. Gulliford, M.C. Gupta, R. Gupta, P.C. Gureje, O. Gutierrez, H.R. Hansen, T.W. Hata, J. He, J. Heim, N. Heinrich, J. Hemmingsson, T. Hennis, A. Herman, W.H. Herrera, V.M. Ho, S. Holdsworth, M. Frisman, G.H. Hopman, W.M. Hussain, A. Husseini, A. Ibrahim, M.M. Ikeda, N. Jacobsen, B.K. Jaddou, H.Y. Jafar, T.H. Janghorbani, M. Jasienska, G. Joffres, M.R. Jonas, J.B. Kadiki, O.A. Kalter-Leibovici, O. Kamadjeu, R.M. Kaptoge, S. Karalis, I. Kastarinen, M.J. Katz, J. Keinan-Boker, L. Kelly, P. Khalilzadeh, O. Kiechl, S. Kim, K.W. Kiyohara, Y. Kobayashi, J. Krause, M.P. Kubínová, R. Kurjata, P. Kusuma, Y.S. Lam, T.H. Langhammer, A. Lawes, C.M. Le, C. Lee, J. Lévy-Marchal, C. Lewington, S. Li, Y. Li, Y. Lim, T.O. Lin, X. Lin, C.C. Lin, H.H. Lind, L. Lissner, L. Liu, X. Lopez-Jaramillo, P. Lorbeer, R. Ma, G. Ma, S. Macià, F. MacLean, D.R. Maggi, S. Magliano, D.J. Makdisse, M. Mancia, G. Mannami, T. Marques-Vidal, P. Mbanya, J.C. McFarlane-Anderson, N. Miccoli, R. Miettola, J. Minh, H.V. Miquel, J.F. Miranda, J.J. Mohamed, M.K. Mohan, V. Mohanna, S. Mokdad, A. Mollentze, W.F. Morales, D.D. Morgan, K. Muiesan, L.M. Muntoni, S. Nabipour, I. Nakagami, T. Nangia, V. Nemesure, B. Neovius, M. Nerhus, K.A. Nervi, F. Neuhauser, H. Nguyen, M. Ninomiya, T. Noale, M. Oh, S.W. Ohkubo, T. Olivieri, O. Önal, A.E. Onat, A. Oróstegui, M. Ouedraogo, H. Pan, W.H. Panagiotakos, D.B. Panza, F. Park, Y. Passos, V.M. Pednekar, M.S. Pelizzari, P.M. Peres, M.A. Pérez, C. Pérez-Fernández, R. Pichardo, R. Phua, H.P. Pistelli, F. Plans, P. Polakowska, M. Poulter, N. Prabhakaran, D. Qiao, Q. Rafiei, M. Raitakari, O.T. Ramos, L.R. Rampal, S. Rampal, L. Rasmussen, F. Reddy, K.K. Redon, J. Revilla, L. Reyes-García, V. Roaeid, R.B. Robinson, C.A. Rodriguez-Artalejo, F. Rojas-Martinez, R. Ronkainen, K. Rosero-Bixby, L. Roth, G.A. Sachdev, H.S. Sánchez, J.R. Sanisoglu, S.Y. Sans, S. Sarraf-Zadegan, N. Scazufca, M. Schaan, B.D. Schapochnik, N. Schelleman, H. Schneider, I.J. Schooling, C.M. Schwarz, B. Sekuri, C. Sereday, M.S. Serra-Majem, L. Shaw, J. Shera, A.S. Shi, Z. Shiri, R. Shu, X.O. Silva, D.A. Silva, E. Simons, L.A. Smith, M. Söderberg, S. Soebardi, S. Solfrizzi, V. Sonestedt, E. Soysal, A. Stattin, P. Stein, A.D. Stergiou, G.S. Stessman, J. Sudo, A. Suka, M. Sundh, V. Sundquist, K. Sundström, J. Swai, A.B. Tai, E.S. Tambs, K. Tesfaye, F. Thomas, G.N. Thorogood, M. Tilvis, R.S. Tobias, M. Torheim, L.E. Trenkwalder, P. Tuomilehto, J.O. Tur, J.A. Tzourio, C. Uhernik, A.I. Ukoli, F.A. Unwin, N. Hoorn, S.V. Vanderpump, M.P. Varo, J.J. Veierød, M.B. Velásquez-Meléndez, G. Verschuren, M. Viet, L. Villalpando, S. Vioque, J. Vollenweider, P. Volpato, S. Wang, N. Wang, Y.X. Ward, M. Waspadji, S. Welin, L.X. Whitlock, G. Wilhelmsen, L. Willeit, J. Woodward, M. Wormser, D. Xavier, A.J. Xu, F. Xu, L. Yamamoto, A. Yang, G. Yang, X. Yeh, L.C. Yoon, J.S. You, Q. Yu, Z. Zhang, J. Zhang, L. Zheng, W. Zhou, M. Ward, M. info:eu-repo/semantics/article article 2014-08</

Performance of the NA62 trigger system

The NA62 experiment at CERN targets the measurement of the ultra-rare K+ -&gt;pi+ nu nu decay, and carries out a broad physics programme that includes probes for symmetry violations and searches for exotic particles. Data were collected in 2016–2018 using a multi-level trigger system, which is described highlighting performance studies based on 2018 data

Physics beyond the standard model with kaons at NA62

The NA62 experiment at CERN Super Proton Synchrotron was designed to measure BR(K+ \u2192 \u3c0+\u3bdv\u304) with an in-fight technique, never used before for this measurement. This decay is characterised by a very precise prediction in the Standard Model. Its branching ratio, which is expected to be less than 10-10, is one of the best candidates to indicate indirect effects of new physics beyond SM at the highest mass scales. NA62 result on K+ \u2192 \u3c0+\u3bdv\u304 from the full 2016 data set is described. Also a search for an invisible dark photon A\u2032 has been performed, exploiting the efficient photon-veto capability and high resolution tracking of the NA62. The signal stems from the chain K+ \u2192 \u3c0+\u3c00 followed by \u3c00 \u2192 A\u2032\u3b3. No significant statistical excess has been identified. Upper limits on the dark photon coupling to the ordinary photon as a function of the dark photon mass have been set, improving on the previous limits over the mass range 60 - 110 MeV/c2

Search for π⁰ decays to invisible particles

The NA62 experiment at the CERN SPS reports a study of a sample of 4 × 109 tagged π0 mesons from K+ → π+π0(γ), searching for the decay of the π0 to invisible particles. No signal is observed in excess of the expected background fluctuations. An upper limit of 4.4 × 10−9 is set on the branching ratio at 90% confidence level, improving on previous results by a factor of 60. This result can also be interpreted as a model- independent upper limit on the branching ratio for the decay K+ → π+X, where X is a particle escaping detection with mass in the range 0.110–0.155 GeV/c2 and rest lifetime greater than 100 ps. Model-dependent upper limits are obtained assuming X to be an axion-like particle with dominant fermion couplings or a dark scalar mixing with the Standard Model Higgs boson

Searches for lepton number violating K+ decays

The NA62 experiment at CERN reports a search for the lepton number violating decays K+→π−e+e+ and K+→π−μ+μ+ using a data sample collected in 2017. No signals are observed, and upper limits on the branching fractions of these decays of 2.2 x 10^-10 and 4.2 x 10^-11 are obtained, respectively, at 90% confidence level. These upper limits improve on previously reported measurements by factors of 3 and 2, respectively

Recent results in kaon physics

A review of the present experimental status of the K → πνν (Kπνν) and other kaon decay analyses at experiments NA62 (CERN) and KOTO (J-PARC) is given. The Kπνν decay is one of the best candidates among the rare meson decays for indirect searches for new physics in the mass ranges complementary to those accessible by current accelerators. The Standard Model (SM) prediction of the branching fraction (B) of the Kπνν decay is lower than 10−10 in both neutral and charged modes. The NA62 experiment aims to measure the B of the charged mode with better than 10% precision. Three candidate events, compatible with the SM prediction, have been observed from a sample of 2.12×1012 K+ decays collected in 2016 and 2017 by NA62. More than twice the statistics is available in the 2018 dataset currently being analysed. The KOTO experiment in Japan aims to measure B(KL → π0νν) using a technique similar to NA62, but with much lower momentum. In the first dataset taken in 2015 zero signal candidate events were observed. The current status of the analysis of the 2016-2018 dataset with 1.4 times more data is presented. Finally, the most recent results of other physics analyses at the NA62 experiment are summarised

Measurement of the very rare K + → π+νν¯ decay

The NA62 experiment reports the branching ratio measurement BR(K+→π+νν¯)=(10.6−3.4+4.0|stat±0.9syst)×10−11 at 68% CL, based on the observation of 20 signal candidates with an expected background of 7.0 events from the total data sample collected at the CERN SPS during 2016–2018. This provides evidence for the very rare K+→π+νν¯ decay, observed with a significance of 3.4σ. The experiment achieves a single event sensitivity of (0.839 ± 0.054) × 10−11, corresponding to 10.0 events assuming the Standard Model branching ratio of (8.4 ± 1.0) × 10−11. This measurement is also used to set limits on BR(K+→ π+X), where X is a scalar or pseudo-scalar particle. Details are given of the analysis of the 2018 data sample, which corresponds to about 80% of the total data sample

Search for heavy neutral lepton production in K+ decays to positrons

A search for heavy neutral lepton (N) production in K+→e+N decays using the data sample collected by the NA62 experiment at CERN in 2017-2018 is reported. Upper limits of the extended neutrino mixing matrix element |Ue4|^2 are established at the level of 10^−9 over most of the accessible heavy neutral lepton mass range 144-462 MeV/c^2, with the assumption that the lifetime exceeds 50 ns. These limits improve significantly upon those of previous production and decay searches. The |Ue4|^2 range favoured by Big Bang Nucleosynthesis is excluded up to a mass of about 340 MeV/c^2

An investigation of the very rare K+ → π+ vv¯ decay

The NA62 experiment reports an investigation of the K+→π+ν ̄ν mode from a sample of K+ decays collected in 2017 at the CERN SPS. The experiment has achieved a single event sensitivity of (0.389±0.024)×10−10, corresponding to 2.2 events assuming the Standard Model branching ratio of (8.4±1.0)×10−11. Two signal candidates are observed with an expected background of 1.5 events. Combined with the result of a similar analysis conducted by NA62 on a smaller data set recorded in 2016, the collaboration now reports an upper limit of 1.78×10−10 for the K+→π+ν ̄ν branching ratio at 90% CL. This, together with the corresponding 68% CL measurement of (0.48+0.72−0.48)×10−10, are currently the most precise results worldwide, and are able to constrain some New Physics models that predict large enhancements still allowed by previous measurements