Red Educativa Telemática

Experiencia realizada en el centro educativo Escuelas San José - Jesuitas de Valencia y que consiste en la creación de una Comunidad Virtual en el centro con la finalidad de mejorar la comunicación entre el profesorado, las familias y los alumnos; mejorar la gestión documental; y mejorar la didáctica de los procesos de enseñanza-aprendizaje. Los autores analizan las causas que originaron el proyecto; realizan una descripción de los objetivos y ámbitos en los que se desarrolla el mismo; y, por último, exponen cuáles son, a su juicio, los factores que han contribuido al éxito de su implantación, entre los que destacan la formación del profesorado como elemento clave del proyecto

Diseño de un invernadero para la producción de planta hortícola en la comarca del Carracillo, en el término municipal de Cuéllar (Segovia)

El objetivo del presente proyecto es el diseño de un invernadero para producción de planta hortícola en la comarca del Carracillo, concretamente en el término municipal de Cuéllar (Segovia). La zona del Carracillo destaca por la horticultura al aire libre en régimen extensivo, principalmente el puerro, la zanahoria, la planta de fresa, el maíz dulce y la remolacha de mesa. Se trata de una zona con gran potencial, debido al tipo de suelo (arenoso) y sus recursos hídricos. En este proyecto se va a diseñar un invernadero para el abastecimiento de planta de puerro, tratando de cubrir las necesidades del mercado y de los horticultores que cultivan en régimen intensivo procurando rentabilizar la inversión haciendo uso del invernadero prácticamente durante todo el año. El proceso a seguir es la recepción de semilla y posterior siembra en bandejas o semilleros. Se trabajará en mesas donde se colocarán las bandejas. Una vez que la planta haya crecido y pueda ser comercializada, se recogerá para su venta en el mercado en bandejas. El invernadero es unimodular, la cubierta es recta y el material de cubierta es policarbonato. Las dimensiones del invernadero serán de 60x24 m.Grado en Ingeniería Agrícola y del Medio Rura

Integración de funcionalidades en las aplicaciones cliente y servidor del entorno virtual AIM-Mobile Learning Platform

Este Trabajo Fin de Máster consiste en el desarrollo software de una nueva versión de la plataforma e-learning AIM-Mobile Learning Platform para integrar nuevas funcionalidades en la aplicación cliente y en la aplicación servidora del entorno virtual de aprendizaje, centrándose principalmente en el desarrollo software de nuevas funcionalidades en la plataforma del alumno mediante el framework Sencha Touch para obtener una aplicación web accesible desde cualquier navegador web en cualquier momento y en cualquier lugar desde cualquier dispositivo móvil a través de Internet, así como una aplicación nativa en Android e iOS, en la que el alumno, además de visualizar el contenido generado por su profesor como en versiones anteriores de la plataforma de e-learning, puede generar sus propio contenido en forma de preguntas para mejorar el proceso de aprendizaje o también puede, entre otras nuevas funcionalidades, acceder a la base de datos de su elección independientemente del servidor en el que esté alojada para que cualquier centro de enseñanza pueda instalar su propia plataforma de e-learning AIM-Mobile Learning Platform.This Master’s Thesis consists of the software development of a new version of the AIM-Mobile Learning Platform e-learning platform to integrate new functionalities in the client application and in the server application of the virtual learning environment, focusing mainly on software development of new functionalities on the student’s platform through the Sencha Touch framework to obtain a web application accessible from any web browser anytime and anywhere from any mobile device through the Internet, as well as a native application on Android and iOS, in which the student, in addition to visualizing the content generated by your teacher as in previous versions of the e-learning platform, your own content in the form of questions can be generated to improve the learning process or, among other new functionalities, the database of your choice can be access regardless of the server on which it is hosted so that any educational institution can install its own AIM-Mobile Learning Platform e-learning platform.Departamento de Teoría de la Señal y Comunicaciones e Ingeniería TelemáticaMáster en Ingeniería de Telecomunicació

Strategies for GHG mitigation in Mediterranean cropping systems. A review

In this review we aimed to synthetize and analyze the most promising GHGs mitigation strategies for Mediterranean cropping systems. A description of most relevant measures, based on the best crop choice and management by farmers (i.e., agronomical practices), was firstly carried out. Many of these measures can be also efficient in other climatic regions, but here we provide particular results and discussion of their efficiencies for Mediterranean cropping systems. An integrated assessment of management practices on mitigating each component of the global warming potential (N2O and CH4 emissions and C sequestration) of production systems considering potential side-effects of their implementation allowed us to propose the best strategies to abate GHG emissions, while sustaining crop yields and mitigating other sources of environmental pollution (e.g. nitrate leaching and ammonia volatilization)

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Diseño de actividades de aprendizaje de robótica con LEGO Mindstorms en Bachillerato

[ES] Diseño de actividades de aprendizaje de robótica con LEGO Mindstorms en BachilleratoGilsanz Mir, A. (2013). Diseño de actividades de aprendizaje de robótica con LEGO Mindstorms en Bachillerato. http://hdl.handle.net/10251/179163Archivo delegad

Proteomic analysis reveals heat shock protein 70 has a key role in polycythemia Vera

Abstract JAK-STAT signaling through the JAK2V617F mutation is central to the pathogenesis of myeloproliferative neoplasms (MPN). However, other events could precede the JAK2 mutation. The aim of this study is to analyze the phenotypic divergence between polycytemia vera (PV) and essential thrombocytemia (ET) to find novel therapeutics targets by a proteomic and functional approach to identify alternative routes to JAK2 activation. Through 2D-DIGE and mass spectrometry of granulocyte protein from 20 MPN samples, showed differential expression of HSP70 in PV and ET besides other 60 proteins. Immunohistochemistry of 46 MPN bone marrow samples confirmed HSP70 expression. The median of positive granulocytes was 80% in PV (SD 35%) vs. 23% in ET (SD 34.25%). In an ex vivo model KNK437 was used as an inhibition model assay of HSP70, showed dose-dependent inhibition of cell growth and burst formation unit erythroid (BFU-E) in PV and ET, increased apoptosis in the erythroid lineage, and decreased pJAK2 signaling, as well as a specific siRNA for HSP70. These data suggest a key role for HSP70 in proliferation and survival of the erythroid lineage in PV, and may represent a potential therapeutic target in MPN, especially in PV.This research was supported by grants from the Spanish Health office FIS PI08402, FIS PI030345, PI071009 and PI12/01728 grants; RD12/10, Red de Cancer (Cancer Network of Excellence) from the Instituto de Salud Carlos III, Spain, Fundacion Mutua madrilène; Universidad Complutense groups CCG07-UCM/BIO-2555 (Santiago Barrio and Florinda Gilsanz), FMM and CRIS foundation for cancer research (Joaquin Martinez-Lopez). The Proteomics Facility of the Centro Nacional de Biotecnología is a member of ProteoRed-Spanish National Institute for Proteomics and follows the quality criteria set up by ProteoRed standards.Peer Reviewe

has a key role in polycythemia Vera

JAK-STAT signaling through the JAK2 V617F mutation is central to the pathogenesis of myeloproliferative neoplasms (MPN). However, other events could precede the JAK2 mutation. The aim of this study is to analyze the phenotypic divergence between polycytemia vera (PV) and essential thrombocytemia (ET) to find novel therapeutics targets by a proteomic and functional approach to identify alternative routes to JAK2 activation. Through 2D-DIGE and mass spectrometry of granulocyte protein from 20 MPN samples, showed differential expression of HSP70 in PV and ET besides other 60 proteins. Immunohistochemistry of 46 MPN bone marrow samples confirmed HSP70 expression. The median of positive granulocytes was 80 % in PV (SD 35%) vs. 23 % in ET (SD 34.25%). In an ex vivo model KNK437 was used as an inhibition model assay of HSP70, showed dose-dependent inhibition of cell growth and burst formation unit erythroid (BFU-E) in PV and ET, increased apoptosis in the erythroid lineage, and decreased pJAK2 signaling, as well as a specific siRNA for HSP70. These data suggest a key role for HSP70 in proliferation and survival of the erythroid lineage in PV, and may represent a potential therapeutic target in MPN, especially in PV

Revisión global de estrategias para la mitigación de gases de efecto invernadero en sistemas agrícolas mediterráneos

Revisión de las principales estrategias de reducción de GEI en sistemas agrícolas mediterráneos, tanto agronómicas como estructurales. Evaluación de barreras y oportunidades de implementación