Target product profiles for protecting against outdoor malaria transmission.

BACKGROUND\ud \ud Long-lasting insecticidal nets (LLINs) and indoor residual sprays (IRS) have decimated malaria transmission by killing indoor-feeding mosquitoes. However, complete elimination of malaria transmission with these proven methods is confounded by vectors that evade pesticide contact by feeding outdoors.\ud \ud METHODS\ud \ud For any assumed level of indoor coverage and personal protective efficacy with insecticidal products, process-explicit malaria transmission models suggest that insecticides that repel mosquitoes will achieve less impact upon transmission than those that kill them outright. Here such models are extended to explore how outdoor use of products containing either contact toxins or spatial repellents might augment or attenuate impact of high indoor coverage of LLINs relying primarily upon contact toxicity.\ud \ud RESULTS\ud \ud LLIN impact could be dramatically enhanced by high coverage with spatial repellents conferring near-complete personal protection, but only if combined indoor use of both measures can be avoided where vectors persist that prefer feeding indoors upon humans. While very high levels of coverage and efficacy will be required for spatial repellents to substantially augment the impact of LLINs or IRS, these ambitious targets may well be at least as practically achievable as the lower requirements for equivalent impact using contact insecticides.\ud \ud CONCLUSIONS\ud \ud Vapour-phase repellents may be more acceptable, practical and effective than contact insecticides for preventing outdoor malaria transmission because they need not be applied to skin or clothing and may protect multiple occupants of spaces outside of treatable structures such as nets or houses

Polyisobutylene-paclitaxel conjugates with pendant carboxylic acids and polystyrene chains: Towards multifunctional stent coatings with slow drug release

Drug-eluting stents are used in the treatment of atherosclerosis, where the incorporation of anti-proliferative or anti-inflammatory drugs decreases the rate of restenosis, the recurrence of artery narrowing. However, these stents can suffer from limitations such as drug depletion and delamination of the drug-eluting coating from the stent surface. Described here is an approach aimed at addressing these issues. Starting from a maleic anhydride adduct of polyisobutylene (PIB) prepared from butyl rubber, ring opening using paclitaxel (PTX) or a combination of PTX and polystyrene (PS) afforded covalent conjugates of PTX and PIB or PIB-PS graft copolymers bearing pendant carboxylic acids. When coated on stainless steel, the drug release was slower than that from a control coating that ressembles a clinical formulation comprising a physical mixture of a PS-PIB-PS triblock copolymer (SIBS) and PTX. The PTX conjugates also exhibited enhanced adhesion to stainless steel and increased tensile strength in comparison with the starting rubber. Cytotoxicity assays indicated that the materials did not leach toxic levels of PTX into cell culture media. Nevertheless, they were capable of inhibiting the adhesion and proliferation of C2C12 cells on their surfaces. These properties are advantageous for the potential application of the materials as stent coatings

Structure and soft magnetic properties of sputter deposited MnZn-ferrite films

In this paper we report the soft magnetic properties of thin films of sputtered MnZn ferrite deposited on thermally oxidized Si substrates. A high deposition temperature, 600¿°C, together with the addition of water vapor to the sputtering gas was found to improve the initial ac permeability, µ. The highest value obtained was approximately 30. For MnZn-ferrite films with much larger grain sizes, as obtained by deposition on a polycrystalline Zn-ferrite substrate, a µ of 100 was obtained. The results are discussed in terms of the so-called nonmagnetic grain boundary model

Performance optimisation of inertial confinement fusion codes using mini-applications

Despite the recent successes of nuclear energy researchers, the scientific community still remains some distance from being able to create controlled, self-sustaining fusion reactions. Inertial Confinement Fusion (ICF) techniques represent one possible option to surpass this barrier, with scientific simulation playing a leading role in guiding and supporting their development. The simulation of such techniques allows for safe and efficient investigation of laser design and pulse shaping, as well as providing insight into the reaction as a whole. The research presented here focuses on the simulation code EPOCH, a fully relativistic particle-in-cell plasma physics code concerned with faithfully recreating laser-plasma interactions at scale. A significant challenge in developing large codes like EPOCH is maintaining effective scientific delivery on successive generations of high-performance computing architecture. To support this process, we adopt the use of mini-applications -- small code proxies that encapsulate important computational properties of their larger parent counterparts. Through the development of a mini-application for EPOCH (called miniEPOCH), we investigate a variety of the performance features exhibited in EPOCH, expose opportunities for optimisation and increased scientific capability, and offer our conclusions to guide future changes to similar ICF codes

Mini-app driven optimisation of inertial confinement fusion codes

In September 2013, the large laser-based inertial confinement fusion device housed in the National Ignition Facility at Lawrence Livermore National Laboratory, was widely acclaimed to have achieved a milestone in controlled fusion – successfully initiating a reaction that resulted in the release of more energy than the fuel absorbed. Despite this success, we remain some distance from being able to create controlled, self-sustaining fusion reactions. Inertial Confinement Fusion (ICF) represents one leading design for the generation of energy by nuclear fusion. Since the 1950s, ICF has been supported by computing simulations, providing the mathematical foundations for pulse shaping, lasers, and material shells needed to ensure effective and efficient implosion. The research presented here focuses on one such simulation code, EPOCH, a fully relativistic particle-in-cell plasma physics code, developed by a leading network of over 30 UK researchers. A significant challenge in developing large codes like EPOCH is maintaining effective scientific delivery on successive generations of high-performance computing architecture. To support this process, we adopt the use of mini-applications – small code proxies that encapsulate important computational properties of their larger parent counterparts. Through the development of a miniapp for EPOCH (called miniEPOCH), we investigate known timestep scaling issues within EPOCH and explore possible optimisations: (i) Employing loop fission to increase levels of vectorisation; (ii) Enforcing particle ordering to allow the exploitation of domain specific knowledge and, (iii) Changing underlying data storage to improve memory locality. When applied to EPOCH, these improvements represent a 2.02× speed-up in the core algorithm and a 1.55× speed-up to the overall application runtime, when executed on EPCC’s Cray XC30 ARCHER platform

Dielectric multilayer waveguides for TE and TM mode matching

We analyse theoretically for the first time to our knowledge the perfect phase matching of guided TE and TM modes with a multilayer waveguide composed of linear isotropic dielectric materials. Alongside strict investigation into dispersion relations for multilayer systems, we give an explicit qualitative explanation for the phenomenon of mode matching on the basis of the standard one-dimensional homogenization technique, and discuss the minimum number of layers and the refractive index profile for the proposed device scheme. Direct applications of the scheme include polarization-insensitive, intermodal dispersion-free planar propagation, efficient fibre-to-planar waveguide coupling and, potentially, mode filtering. As a self-sufficient result, we present compact analytical expressions for the mode dispersion in a finite, N-period, three-layer dielectric superlattice.Comment: 13 pages with figure

λϕ4\lambda\phi^4 model and Higgs mass in standard model calculated by Gaussian effective potential approach with a new regularization-renormalization method

Basing on new regularization-renormalization method, the $\lambda\phi^4$ model used in standard model is studied both perturbatively and nonperturbatively (by Gaussian effective potential). The invariant property of two mass scales is stressed and the existence of a (Landau) pole is emphasized. Then after coupling with the SU(2)$\times$U(1) gauge fields, the Higgs mass in standard model (SM) can be calculated as $m_H\approx$138GeV. The critical temperature ($T_c$) for restoration of symmetry of Higgs field, the critical energy scale ($\mu_c$, the maximum energy scale under which the lower excitation sector of the GEP is valid) and the maximum energy scale ($\mu_{max}$, at which the symmetry of the Higgs field is restored) in the standard model are $T_c\approx$476 GeV, $\mu_c\approx 0.547\times 10^{15}$GeV and $\mu_{\max}\approx 0.873 \times 10^{15}$ GeVv respectively.Comment: 12 pages, LaTex, no figur

Advantages and Limitations of Commercially Available Electrocuting Grids for Studying Mosquito Behaviour.

Mosquito feeding behaviour plays a major role in determining malaria transmission intensity and the impact of specific prevention measures. Human Landing Catch (HLC) is currently the only method that can directly and consistently measure the biting rates of anthropophagic mosquitoes, both indoors and outdoors. However, this method exposes the participant to mosquito-borne pathogens, therefore new exposure-free methods are needed to replace it. Commercially available electrocuting grids (EGs) were evaluated as an alternative to HLC using a Latin Square experimental design in Dar es Salaam, Tanzania. Both HLC and EGs were used to estimate the proportion of human exposure to mosquitoes occurring indoors (πi), as well as its two underlying parameters: the proportion of mosquitoes caught indoors (Pi) and the proportion of mosquitoes caught between the first and last hour when most people are indoors (Pfl). HLC and EGs methods accounted for 69% and 31% of the total number of female mosquitoes caught respectively and both methods caught more mosquitoes outdoors than indoors. Results from the gold standard HLC suggest that An. gambiae s.s. in Dar es Salaam is neither exophagic nor endophagic (Pi ≈ 0.5), whereas An. arabiensis is exophagic (Pi < < 0.5). Both species prefer to feed after 10 pm when most people are indoors (Pfl > >0.5). EGs yielded estimates of Pi for An. gambiae s.s., An. arabiensis and An. coustani, that were approximately equivalent to those with HLC but significantly underestimated Pfl for An. gambiae s.s. and An. coustani. The relative sampling sensitivity of EGs declined over the course of the night (p ≤ 0.001) for all mosquito taxa except An. arabiensis. Commercial EGs sample human-seeking mosquitoes with high sensitivity both indoors and outdoors and accurately measure the propensity of Anopheles malaria vectors to bite indoors rather than outdoors. However, further modifications are needed to stabilize sampling sensitivity over a full nocturnal cycle so that they can be used to survey patterns of human exposure to mosquitoes

Choroidal structural changes correlate with neovascular activity in neovascular age related macular degeneration

PURPOSE. To correlate changes in choroidal thickness and vascularity index with disease activity in patients with neovascular age-related macular degeneration (nAMD). METHODS. Eyes diagnosed with AMD that had two sequential visits within 12 months and that had no choroidal neovascularization (CNV) or had inactive CNV at the first visit were included. Those that had active CNV at follow-up were enrolled as cases. Eyes that did not developed a CNV or that were still inactive at the second visit were enrolled as controls. Disease activity was based on optical coherence tomography (OCT) and fluorescein angiography findings. Subfoveal choroidal thickness (SCT), mean choroidal thickness (MCT), and choroidal vascularity index (CVI) were assessed on enhanced depth imaging OCT and compared between the baseline and follow-up visit. Subgroup analysis accounting for lesion type and previous treatment, if any, were performed. RESULTS. Sixty-five eyes from 60 patients (35 females) and 50 age-and sex-matched controls were included. At the active visit, cases had an increase from 164 +/- 67 mu m to 175 +/- 70 mu m in mean +/- SD SCT and from 144 +/- 45 mu m to 152 +/- 45 mu m in MCT (both P &lt; 0.0001). The mean CVI also increased at from 54.5% +/- 3.3% to 55.4% +/- 3.8% (P = 0.04). Controls did not show significant changes in choroidal measurements between the two visits. Mean SCT, MCT, and CVI values were similar for previously treated and treatment-naive eyes. CONCLUSIONS. Choroidal thickness and CVI significantly increased with active disease in nAMD eyes. Changes in choroidal thickness may predict CNV development or recurrence before they are otherwise evident clinically