Staff retention factors in the Not-for-profit sector: An examination of a Western Australian community organisation

In Australia today Not-for-profit organisations, like most other entities, are trying to respond effectively to challenges associated with the recruitment and retention of competent, experienced and committed staff. Unlike government and commercial entities, however, the poor resourcing of Not-for-profit organisations makes it necessary to approach the issue of recruitment and retention with more creativity than perhaps is required of organisations in the other two sectors of the Australian economy. This is particularly the case for Not-for-profit organisations operating in Western Australia where the economic conditions based on resource exploitation make recruitment and retention, even in the context of the recently reduced economic activity in the state, extremely difficult. In this article, the authors seek to communicate the results of a study focused upon the retention factors that staff considered to be important in a Not-for-profit organisation based in the northern periphery of Perth, Western Australia

Context-Gated Statistical Learning and Its Role in Visual-Saccadic Decisions

Adaptive behavior in a nonstationary world requires humans to learn and track the statistics of the environment. We examined the mechanisms of adaptation in a nonstationary environment in the context of visual-saccadic inhibition of return (IOR). IOR is adapted to the likelihood that return locations will be refixated in the near future. We examined 2 potential learning mechanisms underlying adaptation: (a) a local tracking or priming mechanism that facilitates behavior that is consistent with recent experience and (b) a mechanism that supports retrieval of knowledge of the environmental statistics based on the contextual features of the environment. Participants generated sequences of 2 saccadic eye movements in conditions where the probability that the 2nd saccade was directed back to the previously fixated location varied from low (.17) to high (.50). In some conditions, the contingency was signaled by a contextual cue (the shape of the movement cue). Adaptation occurred in the absence of contextual signals but was more pronounced in the presence of contextual cues. Adaptation even occurred when different contingencies were randomly intermixed, showing the parallel formation of multiple associations between context and statistics. These findings are accounted for by an evidence accumulation framework in which the resting baseline of decision alternatives is adjusted on a trial-by-trial basis. This baseline tracks the subjective prior beliefs about the behavioral relevance of the different alternatives and is updated on the basis of the history of recent events and the contextual features of the current environment

Gender and Medieval archaeology: storming the castle

Despite feminist critiques over three decades, Archaeological scholarship remains predominantly focused on exploring patriarchal narratives and is thereby complicit in reinforcing structural inequalities. Questions must be asked of how the construction of archaeological knowledge affects representation and impacts on our ‘archaeologies’. This paper explores the relative absence of gendered approaches within Archaeology through the lens of Later Medieval Archaeology in particular, and with a micro-focus on Castle-studies in Britain and Ireland. Is there a reason for the silence in relation to gender in the archaeology of the later middle ages

Metabolomic changes associated with frontotemporal lobar degeneration syndromes

Funder: Holt FellowshipFunder: Cambridge Centre for Parkinson plusFunder: National Institute for Health Research; doi: http://dx.doi.org/10.13039/501100000272Abstract: Objective: Widespread metabolic changes are seen in neurodegenerative disease and could be used as biomarkers for diagnosis and disease monitoring. They may also reveal disease mechanisms that could be a target for therapy. In this study we looked for blood-based biomarkers in syndromes associated with frontotemporal lobar degeneration. Methods: Plasma metabolomic profiles were measured from 134 patients with a syndrome associated with frontotemporal lobar degeneration (behavioural variant frontotemporal dementia n = 30, non fluent variant primary progressive aphasia n = 26, progressive supranuclear palsy n = 45, corticobasal syndrome n = 33) and 32 healthy controls. Results: Forty-nine of 842 metabolites were significantly altered in frontotemporal lobar degeneration syndromes (after false-discovery rate correction for multiple comparisons). These were distributed across a wide range of metabolic pathways including amino acids, energy and carbohydrate, cofactor and vitamin, lipid and nucleotide pathways. The metabolomic profile supported classification between frontotemporal lobar degeneration syndromes and controls with high accuracy (88.1–96.6%) while classification accuracy was lower between the frontotemporal lobar degeneration syndromes (72.1–83.3%). One metabolic profile, comprising a range of different pathways, was consistently identified as a feature of each disease versus controls: the degree to which a patient expressed this metabolomic profile was associated with their subsequent survival (hazard ratio 0.74 [0.59–0.93], p = 0.0018). Conclusions: The metabolic changes in FTLD are promising diagnostic and prognostic biomarkers. Further work is required to replicate these findings, examine longitudinal change, and test their utility in differentiating between FTLD syndromes that are pathologically distinct but phenotypically similar

‘Sons of athelings given to the earth’: Infant Mortality within Anglo-Saxon Mortuary Geography

FOR 20 OR MORE YEARS early Anglo-Saxon archaeologists have believed children are underrepresented in the cemetery evidence. They conclude that excavation misses small bones, that previous attitudes to reporting overlook the very young, or that infants and children were buried elsewhere. This is all well and good, but we must be careful of oversimplifying compound social and cultural responses to childhood and infant mortality. Previous approaches have offered methodological quandaries in the face of this under-representation. However, proportionally more infants were placed in large cemeteries and sometimes in specific zones. This trend is statistically significant and is therefore unlikely to result entirely from preservation or excavation problems. Early medieval cemeteries were part of regional mortuary geographies and provided places to stage events that promoted social cohesion across kinship systems extending over tribal territories. This paper argues that patterns in early Anglo-Saxon infant burial were the result of female mobility. Many women probably travelled locally to marry in a union which reinforced existing social networks. For an expectant mother, however, the safest place to give birth was with experience women in her maternal home. Infant identities were affected by personal and legal association with their mother’s parental kindred, so when an infant died in childbirth or months and years later, it was their mother’s identity which dictated burial location. As a result, cemeteries central to tribal identities became places to bury the sons and daughters of a regional tribal aristocracy

Plasmodium falciparum importation does not sustain malaria transmission in a semi-arid region of Kenya

Human movement impacts the spread and transmission of infectious diseases. Recently, a large reservoir of Plasmodium falciparum malaria was identified in a semi-arid region of northwestern Kenya historically considered unsuitable for malaria transmission. Understanding the sources and patterns of transmission attributable to human movement would aid in designing and targeting interventions to decrease the unexpectedly high malaria burden in the region. Toward this goal, polymorphic parasite genes (ama1, csp) in residents and passengers traveling to Central Turkana were genotyped by amplicon deep sequencing. Genotyping and epidemiological data were combined to assess parasite importation. The contribution of travel to malaria transmission was estimated by modelling case reproductive numbers inclusive and exclusive of travelers. P. falciparum was detected in 6.7% (127/1891) of inbound passengers, including new haplotypes which were later detected in locally-transmitted infections. Case reproductive numbers approximated 1 and did not change when travelers were removed from transmission networks, suggesting that transmission is not fueled by travel to the region but locally endemic. Thus, malaria is not only prevalent in Central Turkana but also sustained by local transmission. As such, interrupting importation is unlikely to be an effective malaria control strategy on its own, but targeting interventions locally has the potential to drive down transmission

Hormone Therapy and the Risk of Breast Cancer in BRCA1 Mutation Carriers

Background: Hormone therapy (HT) is commonly given to women to alleviate the climacteric symptoms associated with menopause. There is concern that this treatment may increase the risk of breast cancer. The potential association of HT and breast cancer risk is of particular interest to women who carry a mutation in BRCA1 because they face a high lifetime risk of breast cancer and because many of these women take HT after undergoing prophylactic surgical oophorectomy at a young age. Methods: We conducted a matched case-control study of 472 postmenopausal women with a BRCA1 mutation to examine whether or not the use of HT is associated with subsequent risk of breast cancer. Breast cancer case patients and control subjects were matched with respect to age, age at menopause, and type of menopause (surgical or natural). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated with conditional logistic regression. Statistical tests were two-sided. Results: In this group of BRCA1 mutation carriers, the adjusted OR for breast cancer associated with ever use of HT compared with never use was 0.58 (95% CI = 0.35 to 0.96; P =. 03). In analyses by type of HT, an inverse association with breast cancer risk was observed with use of estrogen only (OR = 0.51, 95% CI = 0.27 to 0.98; P =. 04); the association with use of estrogen plus progesterone was not statistically significant (OR = 0.66, 95% CI = 0.34 to 1.27; P =. 21). Conclusion: Among postmenopausal women with a BRCA1 mutation, HT use was not associated with increased risk of breast cancer; indeed, in this population, it was associated with a decreased risk

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]