Film and Television Production Location Scouting - An Online GIS Based Location Library

The film and television production industries are multibillion-dollar businesses for the State of California. When productions leave the state for other locations, the economic and workforce impacts on local communities relying on production business can be significant. The application of geographic information system (GIS) technology to the location scouting business is a novel approach to streamlining the location scouting process. Enhancing the site selection process by making it a web-based self-service endeavor, consolidating disparate data sources, and featuring local crew, talent, and filmfriendly businesses, the online location library assists the client in achieving key business efficiency objectives. The custom JavaScript online location library incorporates Esri, Inc. ArcGIS technology and simplifies the location scouting process for the client, makes it easier to find the right location, and highlights the Coachella Valley as an international production destination. This proof of concept web application demonstrates the use of web GIS technology that can be used by other local, regional, and state film offices

Biological treatment of the knee with platelet-rich plasma or bone marrow aspirate concentrates

ABSTRACT — Knee pathologies including focal cartilage injuries, osteoarthritis (OA), and ligament injuries are common. The poor regeneration and healing potential of cartilage has led to the search for other treatment modalities with improved healing capacity. Furthermore, with an increasing elderly population that desires to remain active, the burden of knee pathologies is expected to increase. Increased sports participation and the desire to return to activities faster is also demanding more effective and minimally invasive treatment options. Thus, the use of biologic agents in the treatment of knee pathologies has emerged as a potential option. Despite the increasing use of biologic agents for knee pathology, there are conflicting results on the efficacy of these products. Furthermore, strong data supporting the optimal preparation methods and composition for widely used biologic agents, such as platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC), largely remain absent from the literature. This review presents the literature on the most commonly employed biologic agents for the different knee pathologies

Carvedilol: Therapeutic Application and Practice Guidelines

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90381/1/j.1875-9114.1998.tb03895.x.pd

iDNA from terrestrial haematophagous leeches as a wildlife surveying and monitoring tool - prospects, pitfalls and avenues to be developed

Invertebrate-derived DNA (iDNA) from terrestrial haematophagous leeches has recently been proposed as a powerful non-invasive tool with which to detect vertebrate species and thus to survey their populations. However, to date little attention has been given to whether and how this, or indeed any other iDNA-derived data, can be combined with state-of-the-art analytical tools to estimate wildlife abundances, population dynamics and distributions. In this review, we discuss the challenges that face the application of existing analytical methods such as site-occupancy and spatial capture-recapture (SCR) models to terrestrial leech iDNA, in particular, possible violations of key assumptions arising from factors intrinsic to invertebrate parasite biology. Specifically, we review the advantages and disadvantages of terrestrial leeches as a source of iDNA and summarize the utility of leeches for presence, occupancy, and spatial capture-recapture models. The main source of uncertainty that attends species detections derived from leech gut contents is attributable to uncertainty about the spatio-temporal sampling frame, since leeches retain host-blood for months and can move after feeding. Subsequently, we briefly address how the analytical challenges associated with leeches may apply to other sources of iDNA. Our review highlights that despite the considerable potential of leech (and indeed any) iDNA as a new survey tool, further pilot studies are needed to assess how analytical methods can overcome or not the potential biases and assumption violations of the new field of iDNA. Specifically we argue that studies to compare iDNA sampling with standard survey methods such as camera trapping, and those to improve our knowledge on leech (and other invertebrate parasite) physiology, taxonomy, and ecology will be of immense future value

Object level footprint uncertainty quantification in infrastructure based sensing

We examine the problem of estimating footprint uncertainty of objects imaged using the infrastructure based camera sensing. A closed form relationship is established between the ground coordinates and the sources of the camera errors. Using the error propagation equation, the covariance of a given ground coordinate can be measured as a function of the camera errors. The uncertainty of the footprint of the bounding box can then be given as the function of all the extreme points of the object footprint. In order to calculate the uncertainty of a ground point, the typical error sizes of the error sources are required. We present a method of estimating the typical error sizes from an experiment using a static, high-precision LiDAR as the ground truth. Finally, we present a simulated case study of uncertainty quantification from infrastructure based camera in CARLA to provide a sense of how the uncertainty changes across a left turn maneuver.Comment: Submitted to IEEE Sensors journa

A Method for Revealing and Addressing Security Vulnerabilities in Cyber-physical Systems by Modeling Malicious Agent Interactions with Formal Verification

Several cyber-attacks on the cyber-physical systems (CPS) that monitor and control critical infrastructure were publically announced over the last few years. Almost without exception, the proposed security solutions focus on preventing unauthorized access to the industrial control systems (ICS) at various levels – the defense in depth approach. While useful, it does not address the problem of making the systems more capable of responding to the malicious actions of an attacker once they have gained access to the system. The first step in making an ICS more resilient to an attacker is identifying the cyber security vulnerabilities the attacker can use during system design. This paper presents a method that reveals cyber security vulnerabilities in ICS through the formal modeling of the system and malicious agents. The inclusion of the malicious agent in the analysis of an existing systems identifies security vulnerabilities that are missed in traditional functional model checking

Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized rats

Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized rats.BackgroundVasopeptidase inhibitors are a new class of cardiovascular compounds that inhibit both angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP). The aim of the present study was to explore the effects of omapatrilat, a vasopeptidase inhibitor, on renal function and pathology in subtotally nephrectomized (STNx) rats.MethodsSTNx rats were randomized to four groups and treated for 12 weeks: no treatment (N = 14); omapatrilat at a low dose of 10 mg/kg (L, N = 12) and at a high dose of 40 mg/kg (H, N = 10); or an ACE inhibitor, fosinopril, at a dose of 10 mg/kg (N = 12). Sham-operated rats were used as control animals (N = 12).ResultsElevated blood pressure in STNx rats (174 ± 9mm Hg) was reduced by omapatrilat in a dose-dependent manner (L, 121 ± 3mm Hg; H, 110 ± 3mm Hg) and by fosinopril (149 ± 5mm Hg). Proteinuria in STNx rats (246 ± 73 mg/day) was reduced by treatment with fosinopril (88 ± 21 mg/day) and was normalized by treatment with omapatrilat (L, 30 ± 4 mg/day; H, 20 ± 2 mg/day vs. control 25 ± 1 mg/day). Decreased glomerular filtration rates, elevated plasma urea and creatinine and glomerulosclerosis, and tubulointerstitial fibrosis were ameliorated by omapatrilat and fosinopril to a similar degree. Compared with fosinopril, omapatrilat treatment was associated with increased plasma renin activity and decreased renal ACE and NEP binding in a dose-dependent manner.ConclusionThese findings suggest that vasopeptidase inhibition may provide a useful strategy for the treatment of progressive renal disease

TRANSLIT : a large-scale name transliteration resource

Transliteration is the process of expressing a proper name from a source language in the characters of a target language (e.g. from Cyrillic to Latin characters). We present TRANSLIT, a large-scale corpus with approx. 1.6 million entries in more than 180 languages with about 3 million variations of person and geolocation names. The corpus is based on various public data sources, which have been transformed into a unified format to simplify their usage, plus a newly compiled dataset from Wikipedia. In addition, we apply several machine learning methods to establish baselines for automatically detecting transliterated names in various languages. Our best systems achieve an accuracy of 92\% on identification of transliterated pairs

Kepler Input Catalog: Photometric Calibration and Stellar Classification

We describe the photometric calibration and stellar classification methods used to produce the Kepler Input Catalog (KIC). The KIC is a catalog containing photometric and physical data for sources in the Kepler Mission field of view; it is used by the mission to select optimal targets. We derived atmospheric extinction corrections from hourly observations of secondary standard fields within the Kepler field of view. Repeatability of absolute photometry for stars brighter than magnitude 15 is typically 2%. We estimated stellar parameters Teff, log(g), log (Z), E_{B-V} using Bayesian posterior probability maximization to match observed colors to Castelli stellar atmosphere models. We applied Bayesian priors describing the distribution of solar-neighborhood stars in the color-magnitude diagram (CMD), in log (Z)$, and in height above the galactic plane. Comparisons with samples of stars classified by other means indicate that in most regions of the CMD, our classifications are reliable within about +/- 200 K and +/- 0.4 dex in log (g). It is difficult to assess the reliability of our log(Z) estimates, but there is reason to suspect that it is poor, particularly at extreme Teff. Of great importance for the Kepler Mission, for Teff <= 5400 K, the distinction between main-sequence stars and giants has proved to be reliable with better than 98% confidence. The KIC is available through the MAST data archive.Comment: 77 pages, 12 figures, 1 Table. Accepted by Astronomical Journal 24 July 201

Sex Chromosome Mosaicism and Hybrid Speciation among Tiger Swallowtail Butterflies

Hybrid speciation, or the formation of a daughter species due to interbreeding between two parental species, is a potentially important means of diversification, because it generates new forms from existing variation. However, factors responsible for the origin and maintenance of hybrid species are largely unknown. Here we show that the North American butterfly Papilio appalachiensis is a hybrid species, with genomic admixture from Papilio glaucus and Papilio canadensis. Papilio appalachiensis has a mosaic phenotype, which is hypothesized to be the result of combining sex-linked traits from P. glaucus and P. canadensis. We show that P. appalachiensis' Z-linked genes associated with a cooler thermal habitat were inherited from P. canadensis, whereas its W-linked mimicry and mitochondrial DNA were inherited from P. glaucus. Furthermore, genome-wide AFLP markers showed nearly equal contributions from each parental species in the origin of P. appalachiensis, indicating that it formed from a burst of hybridization between the parental species, with little subsequent backcrossing. However, analyses of genetic differentiation, clustering, and polymorphism based on molecular data also showed that P. appalachiensis is genetically distinct from both parental species. Population genetic simulations revealed P. appalachiensis to be much younger than the parental species, with unidirectional gene flow from P. glaucus and P. canadensis into P. appalachiensis. Finally, phylogenetic analyses, combined with ancestral state reconstruction, showed that the two traits that define P. appalachiensis' mosaic phenotype, obligatory pupal diapause and mimicry, evolved uniquely in P. canadensis and P. glaucus, respectively, and were then recombined through hybridization to form P. appalachiensis. These results suggest that natural selection and sex-linked traits may have played an important role in the origin and maintenance of P. appalachiensis as a hybrid species. In particular, ecological barriers associated with a steep thermal cline appear to maintain the distinct, mosaic genome of P. appalachiensis despite contact and occasional hybridization with both parental species