Stereoselective cycloaddition of 1-glucosyl-1,3-butadienes with tert-butyl 2H-azirine-3-carboxylate, glyoxylates and imines

Glucosyl dienes 1 have been reacted with the achiral 2H-azirine 4 and with glyoxylates, forming fused structures of type 5 and disaccharide-like compounds 7 with good to excellent selectivity. Glucosyl dienes 1 participated as dienophiles in reactions with Schiff bases derived from anilines forming isoquinolines 10 and 11. The diastereoselectivity of this reaction is poor.Fundação para a Ciência e Tecnologia - POCTI/32723/QUI/2000. FEDER

CYP2C8 status of patients with malaria influences selection of Plasmodium falciparum pfmdr1 Alleles after Amodiaquine-Artesunate treatment

info:eu-repo/semantics/publishedVersio

INFORMATION AND COMMUNICATION TECHNOLOGIES IN THE NATIONAL UNIVERSITY OF EDUCATION OF ECUADOR

El presente estudio es un avance parcial de una investigación en curso que tiene por objeto principal la creación, contribución y el análisis de indicadores culturales en el contexto universitario ecuatoriano. Este trabajo se enfoca específicamente en proveer una serie de indicadores sobre el equipamiento, uso y consumo de las TIC de los estudiantes de la Universidad Nacional de Educación de Ecuador (UNAE). La metodología usada es de orden cuantitativo/descriptiva, a partir de los datos recolectados en una encuesta aplicada a una muestra compuesta de 438 estudiantes del total del universo entre las diferentes carreras y ciclos ofertados por la UNAE. La muestra tiene un nivel de confianza del 95% y un 5% de margen de error. Los resultados obtenidos muestran un alto nivel de equipamiento, uso y consumo de diferentes dispositivos tecnológicos. También, esta población universitaria usa su tiempo en actividades académicas y de ocio con su celular, televisión, videos e internet.This study is a partial advance of ongoing research whose main objective is the creation, contribution, and analysis of cultural indicators in the Ecuadorian university context. This work focuses specifically on providing a series of indicators on the equipment, use, and consumption of the TIC of students of the National University of Education of Ecuador (UNAE). The methodology used is the quantitative of descriptive-analytical order, based on the data collected in a survey applied on a population sample, made up of 438 students of the total universe between the different careers and cycles offered by the UNAE. The sample has a margin of 95% reliability and an error of 5%. The obtained results showed a high level of equipment, use, and consumption of the different technological devices. Also, this university population spends daily hours in academic and free time activities in cellphones, television, videos, and internet

The Northern χ -Orionid meteoroid stream and possible association with the potentially hazardous asteroid 2008XM1

We present new orbital data and dynamic results pointing towards the origin of the Northern χ -Orionid meteoroid stream, which is a part of the Taurid meteoroid complex. A new software package was developed to establish the potential parent bodies of meteoroid streams based on the similarity of their orbits. The analysis of a Northern χ -Orionid fireball observed on 2011 December 6 identified two potential parent bodies: the near-Earth object (NEO) 2002XM35 (previously proposed as the parent of this meteoroid stream) and the more recently discovered potentially hazardous asteroid 2008XM1. The calculation of the evolution of the orbital elements performed by using the Mercury 6 symplectic integrator supports the idea that 2008XM1 is a better parent body. Our data sample was expanded by including also in the calculations the mean orbit of the χ -Orionid stream. The results are consistent with the fragmentation of a larger body in the past that could give rise to both NEOs and the Northern χ -Orionid stream. To confirm this, further observations to improve the orbital elements of these asteroids should be attempted before the objects are lost. The analysis of the emission spectrum recorded for this fireball supports a primitive nature for these meteoroids.Ministerio de Ciencia e Innovación AYA2009-13227, AYA2009-14000-C03- 01, AYA2011-26522CSIC 201050I043Junta de Andalucía P09-FQM-455

TECNOLOGÍAS DE LA INFORMACIÓN Y COMUNICACIÓN EN LA UNIVERSIDAD NACIONAL DE EDUCACIÓN DE ECUADOR

This study is a partial advance of ongoing research whose main objective is the creation, contribution, and analysis of cultural indicators in the Ecuadorian university context. This work focuses specifically on providing a series of indicators on the equipment, use, and consumption of the TIC of students of the National University of Education of Ecuador (UNAE). The methodology used is the quantitative of descriptive-analytical order, based on the data collected in a survey applied on a population sample, made up of 438 students of the total universe between the different careers and cycles offered by the UNAE. The sample has a margin of 95% reliability and an error of 5%. The obtained results showed a high level of equipment, use, and consumption of the different technological devices. Also, this university population spends daily hours in academic and free time activities in cellphones, television, videos, and internet.El presente estudio es un avance parcial de una investigación en curso que tiene por objeto principal la creación, contribución y el análisis de indicadores culturales en el contexto universitario ecuatoriano. Este trabajo se enfoca específicamente en proveer una serie de indicadores sobre el equipamiento, uso y consumo de las TIC de los estudiantes de la Universidad Nacional de Educación de Ecuador (UNAE). La metodología usada es de orden cuantitativo/descriptiva, a partir de los datos recolectados en una encuesta aplicada a una muestra compuesta de 438 estudiantes del total del universo entre las diferentes carreras y ciclos ofertados por la UNAE. La muestra tiene un nivel de confianza del 95% y un 5% de margen de error. Los resultados obtenidos muestran un alto nivel de equipamiento, uso y consumo de diferentes dispositivos tecnológicos. También, esta población universitaria usa su tiempo en actividades académicas y de ocio con su celular, televisión, videos e internet

Analysis of the September ε-Perseid outburst in 2013

We analyse the outburst experienced by the September ε-Perseid meteor shower on 2013 September 9. As a result of our monitoring, the atmospheric trajectory of 60 multistation events observed over Spain was obtained and accurate orbital data were derived from them. On the basis of these orbits, we have tried to determine the likely parent body of this meteoroid stream by employing orbital dissimilarity criteria. In addition, the emission spectra produced by two events belonging to this meteor shower were also recorded. The analysis of these spectra has provided information about the chemical nature of their progenitor meteoroids. We also present an estimation of the tensile strength for these particles.We acknowledge support from the Spanish Ministry of Science and Innovation (projects AYA2015-68646-P and AYA 2015-67175-P)

Cardiac tissue engineering for myocardial infarction treatment

Myocardial infarction is one of the major causes of morbidity and mortality worldwide. Current treatments can relieve the symptoms of myocardial ischemia but cannot repair the necrotic myocardial tissue. Novel therapeutic strategies based on cellular therapy, extracellular vesicles, non-coding RNAs and growth factors have been designed to restore cardiac function while inducing cardiomyocyte cycle re-entry, ensuring angiogenesis and cardioprotection, and preventing ventricular remodeling. However, they face low stability, cell engraftment issues or enzymatic degradation in vivo, and it is thus essential to combine them with biomaterial-based delivery systems. Microcarriers, nanocarriers, cardiac patches and injectable hydrogels have yielded promising results in preclinical studies, some of which are currently being tested in clinical trials. In this review, we cover the recent advances made in cellular and acellular therapies used for cardiac repair after MI. We present current trends in cardiac tissue engineering related to the use of microcarriers, nanocarriers, cardiac patches and injectable hydrogels as biomaterial-based delivery systems for biologics. Finally, we discuss some of the most crucial aspects that should be addressed in order to advance towards the clinical translation of cardiac tissue engineering approaches

Periodontal regeneration in clinical practice

The regeneration or restitution of lost supporting tissue has always been considered the ideal objective of periodontal therapy. However, attempts to convert this intention into solid clinical practice can become tremendously complex, the results of which are very different from the original intention. The aim of this article is to offer an up-to-date, general perspective on periodontal regeneration, orienting the clinician within the global strategy for oral treatment. To this end, we revise the healing process of periodontal injury, the different therapeutic approaches, the interpretation of the results, and finally, limiting factors in periodontal regeneration

Colon tumor CD31 expression is associated with higher disease-free survival in patients with metabolic syndrome

Metabolic syndrome (MS) is recognized as a risk factor for colon cancer (CC). However, how does the interplay between metabolic dysfunction caused by MS and its individual components affect CC microenvironment and prognosis remains unexplored. Angiogenesis and lymphangiogenesis are fundamental processes for tumor progression and dissemination, ensuring oxygen and nutrient delivery and supporting one of the most important pathways of tumor dissemination, contributing to metastasis. Thus, our aim was to evaluate whether the expression of molecular biomarkers involved in angiogenic and lymphangiogenic processes influenced CC clinicopathological features and prognosis in patients with MS. Clinical and pathological data of 300 patients submitted to CC surgical resection at a single tertiary hospital were retrospectively retrieved from hospital records. Tumor tissue microarrays of archived paraffin-embedded blocks were used to assess CD31, VEGF-A and D2–40 tissue expression by immunohistochemistry. The percentage of stained area was quantified by computerized morphometric analysis. No association between tissue expression of angiogenesis and lymphangiogenesis biomarkers and tumor clinical and pathological characteristics was found. However, in subgroup analysis of patients with MS, dysglycemia was associated with lower D2–40 expression (p = 0.007) and high waist-circumference was associated with higher D2–40 (p = 0.0029) and VEGF-A expression (p = 0.026). In an adjusted Cox proportional hazard model CD31 expression was significantly associated with greater disease-free survival (HR=0.62; 95% CI: 0.41–0.95, p = 0.028). No association was found between D2–40 and VEGF-A expression and CC prognosis. Our data reinforces previous reports that suggest the potential use of CD31 as a CC prognostic biomarker. Additionally, our data further supports the evidence for an interplay between metabolic dysfunction, tumor microenvironment, and vascularization pathways.info:eu-repo/semantics/publishedVersio

Decreased Prevalence of Plasmodium Falciparum Resistance Markers to Amodiaquine Despite its wide Scale use as ACT Partner Drug in Zanzibar.

Zanzibar has recently undergone a rapid decline in Plasmodium falciparum transmission following combined malaria control interventions with artemisinin-based combination therapy (ACT) and integrated vector control. Artesunate-amodiaquine (ASAQ) was implemented as first-line treatment for uncomplicated P. falciparum malaria in Zanzibar in 2003. Resistance to amodiaquine has been associated with the single nucleotide polymorphism (SNP) alleles pfcrt 76T, pfmdr1 86Y, 184Y and 1246Y. An accumulation of these SNP alleles in the parasite population over time might threaten ASAQ efficacy.The aim of this study was to assess whether prolonged use of ASAQ as first-line anti-malarial treatment selects for P. falciparum SNPs associated with resistance to the ACT partner drug amodiaquine. The individual as well as the combined SNP allele prevalence were compared in pre-treatment blood samples from patients with uncomplicated P. falciparum malaria enrolled in clinical trials conducted just prior to the introduction of ASAQ in 2002-2003 (n = 208) and seven years after wide scale use of ASAQ in 2010 (n = 122). There was a statistically significant decrease of pfcrt 76T (96-63%), pfmdr1 86Y (75-52%), 184Y (83-72%), 1246Y (28-16%) and the most common haplotypes pfcrt/pfmdr1 TYYD (46-26%) and TYYY (17-8%), while an increase of pfcrt/pfmdr1 KNFD (0.4-14%) and KNYD (1-12%). This is the first observation of a decreased prevalence of pfcrt 76T, pfmdr1 86Y, 184Y and 1246Y in an African setting after several years of extensive ASAQ use as first-line treatment for uncomplicated malaria. This may support sustained efficacy of ASAQ on Zanzibar, although it was unexpected considering that all these SNPs have previously been associated with amodiaquine resistance. The underlying factors of these results are unclear. Genetic dilution by imported P. falciparum parasites from mainland Tanzania, a de-selection by artesunate per se and/or an associated fitness cost might represent contributing factors. More detailed studies on temporal trends of molecular markers associated with amodiaquine resistance are required to improve the understanding of this observation