Deep and Surface Sensor Modalities for Myo-intent Detection

Electromyography is the gold-standard among sensors for prosthetic control. However, stable and reliable myocontrol remains an unsolved problem in the community. Amid improvements currently under investigation, one focuses on alternative or complementary sensors. In this study, we compare different techniques, recording surface and deep muscle activity. Ten subjects were involved in an experiment in which three different modalities were attached on their forearm: force myography, electro-impedance tomography and ultrasound. They were asked to perform wrist and grasp movements. For the first time, we evaluate and compare in an offline analysis these three different modalities while recording several hand gestures

Complete Genome Sequence of Treponema paraluiscuniculi, Strain Cuniculi A: The Loss of Infectivity to Humans Is Associated with Genome Decay

Treponema paraluiscuniculi is the causative agent of rabbit venereal spirochetosis. It is not infectious to humans, although its genome structure is very closely related to other pathogenic Treponema species including Treponema pallidum subspecies pallidum, the etiological agent of syphilis. In this study, the genome sequence of Treponema paraluiscuniculi, strain Cuniculi A, was determined by a combination of several high-throughput sequencing strategies. Whereas the overall size (1,133,390 bp), arrangement, and gene content of the Cuniculi A genome closely resembled those of the T. pallidum genome, the T. paraluiscuniculi genome contained a markedly higher number of pseudogenes and gene fragments (51). In addition to pseudogenes, 33 divergent genes were also found in the T. paraluiscuniculi genome. A set of 32 (out of 84) affected genes encoded proteins of known or predicted function in the Nichols genome. These proteins included virulence factors, gene regulators and components of DNA repair and recombination. The majority (52 or 61.9%) of the Cuniculi A pseudogenes and divergent genes were of unknown function. Our results indicate that T. paraluiscuniculi has evolved from a T. pallidum-like ancestor and adapted to a specialized host-associated niche (rabbits) during loss of infectivity to humans. The genes that are inactivated or altered in T. paraluiscuniculi are candidates for virulence factors important in the infectivity and pathogenesis of T. pallidum subspecies

Use of artificial intelligence and neural networks for analysis and gesture detection in electrical impedance tomography

Artificial intelligence and neural networks are getting more and more relevant for several types of application. The field of prosthesis technology currently uses electromyography for controllable prosthesis. The precision of the control suffers from the use of EMG. More precise and more collected data with the help of EIT allows a much more precise analysis and control of the prosthesis. In this paper a neural network for gesture detection using EIT is developed and presented in a user-friendly way

Toward More Robust Hand Gesture Recognition on EIT Data

Leins D, Gibas C, Brück R, Haschke R. Toward More Robust Hand Gesture Recognition on EIT Data. Frontiers in Neurorobotics. 2021;15: 659311.Striving for more robust and natural control of multi-fingered hand prostheses, we are studying electrical impedance tomography (EIT) as a method to monitor residual muscle activations. Previous work has shown promising results for hand gesture recognition, but also lacks generalization across multiple sessions and users. Thus, the present paper aims for a detailed analysis of an existing EIT dataset acquired with a 16-electrode wrist band as a prerequisite for further improvements of machine learning results on this type of signal. The performed t-SNE analysis confirms a much stronger inter-session and inter-user variance compared to the expected in-class variance. Additionally, we observe a strong drift of signals within a session. To handle these challenging problems, we propose new machine learning architectures based on deep learning, which allow to separate undesired from desired variation and thus significantly improve the classification accuracy. With these new architectures we increased cross-session classification accuracy on 12 gestures from 19.55 to 30.45%. Based on a fundamental data analysis we developed three calibration methods and thus were able to further increase cross-session classification accuracy to 39.01, 55.37, and 56.34%, respectively

Hand Gesture Recognition with Electrical Impedance Tomography (Dataset)

Leins D, Gibas C, Brück R, Haschke R. Hand Gesture Recognition with Electrical Impedance Tomography (Dataset). Universität Bielefeld; 2020.This dataset consists of measurements using Electrical Impedance Tomography (EIT). An EIT system with 16 electrodes configured to a feed in signal of 50 kHz frequency and a 1 mA alternating current was used for the data acquisition. 12 Gestures were recorded from a total of 6 subjects, targeting different aspects of the data. For more information about the data structure and the recorded gestures refer to the `README.md` file included in the archive. An example of data extraction and classifier training with TensorFlow is available at [https://github.com/DavidPL1/eit_data_analysis](https://github.com/DavidPL1/eit_data_analysis). The data were recorded within the German Research Society project DEEP-HAND: deep sensing + deep learning for myocontrol of the upper limb, DFG project number 272314643

Wearable Pressure Sensing for Vojta Therapy Guidance

The authors propose a glove with pressure sensitive fingertips and muscle tension detection of the thumb to aid in the physiotherapy of infants, children and adults according to Vojta. The therapy has to be carried out at home by the parents of children with cerebral palsy, or other movement disturbances up to 4 times per day. Often, parents struggle to carry out the practices because of insecurities regarding the therapy’s proper application. The presented glove is tailored towards the specific needs of Vojta therapy, e.g. flexibility and small sensor size, and can help parents gather objective data on their therapy application at home. It has been tested in multiple therapy sessions on adult probands and seems to be a suitable tool to support parents and therapists in training alike. Additionally, the results of the accompanied therapy sessions provide arguments against what the critics have often cited about the painfulness of the therapy

Transcriptome Analysis Suggests That Starch Synthesis May Proceed via Multiple Metabolic Routes in High Yielding Potato Cultivars

<div><h3>Background</h3><p>Glucose-6-phosphate is imported into the amyloplast of potato tubers and thought to constitute the precursor for starch synthesis in potato tubers. However, recently it was shown that glucose-1-phosphate can also be imported into the amyloplast and incorporated into starch via an ATP independent mechanism under special conditions. Nonetheless, glucose-6-phosphate is believed to be the quantitatively important precursor for starch synthesis in potato.</p> <h3>Principal Finding</h3><p>Potato tubers of the high yielding cv Kuras had low gene expression of plastidial phophoglucomutase (PGM) and normal levels of transcripts for other enzymes involved in starch metabolism in comparison with medium and low yielding cultivars as determined by DeepSAGE transcriptome profiling. The decrease in PGM activity in Kuras was confirmed by measuring the enzyme activity from potato tuber extracts. Contrary to expectations, this combination lead to a higher level of intracellular glucose-1-phosphate (G1P) in Kuras suggesting that G1P is directly imported into plastids and can be quantitatively important for starch synthesis under normal conditions in high yielding cultivars.</p> <h3>Significance</h3><p>This could open entirely new possibilities for metabolic engineering of the starch metabolism in potato via the so far uncharacterized G1P transporter. The perspectives are to increase yield and space efficiency of this important crop. In the light of the increasing demands imposed on agriculture to support a growing global population this presents an exciting new possibility.</p> </div