4,075 research outputs found
Clinical and Pathophysiological Insights Into Immunological Mediated Glomerular Diseases in Childhood
The kidney is often the target of immune system dysregulation in the context of primary or systemic disease. In particular, the glomerulus represents the anatomical entity most frequently involved, generally as the expression of inflammatory cell invasion or circulant or in situ immune-complex deposition. Glomerulonephritis is the most common clinical and pathological manifestation of this involvement. There are no universally accepted classifications for glomerulonephritis. However, recent advances in our understanding of the pathophysiological mechanisms suggest the assessment of immunological features, biomarkers, and genetic analysis. At the same time, more accurate and targeted therapies have been developed. Data on pediatric glomerulonephritis are scarce and often derived from adult studies. In this review, we update the current understanding of the etiologic events and genetic factors involved in the pathogenesis of pediatric immunologically mediated primitive forms of glomerulonephritis, together with the clinical spectrum and prognosis. Possible new therapeutic targets are also briefly discussed
GIANO-TNG spectroscopy of red supergiants in the young star cluster RSGC3
The Scutum complex in the inner disk of the Galaxy has a number of young star
clusters dominated by red supergiants that are heavily obscured by dust
extinction and observable only at infrared wavelengths. These clusters are
important tracers of the recent star formation and chemical enrichment history
in the inner Galaxy. During the technical commissioning and as a first science
verification of the GIANO spectrograph at the Telescopio Nazionale Galileo, we
secured high-resolution (R=50,000) near-infrared spectra of five red
supergiants in the young Scutum cluster RSGC3. Taking advantage of the full
YJHK spectral coverage of GIANO in a single exposure, we were able to measure
several tens of atomic and molecular lines that were suitable for determining
chemical abundances. By means of spectral synthesis and line equivalent width
measurements, we obtained abundances of Fe and iron-peak elements such as Ni,
Cr, and Cu, alpha (O, Mg, Si, Ca, Ti), other light elements (C, N, F, Na, Al,
and Sc), and some s-process elements (Y, Sr). We found average half-solar iron
abundances and solar-scaled [X/Fe] abundance patterns for most of the elements,
consistent with a thin-disk chemistry. We found depletion of [C/Fe] and
enhancement of [N/Fe], consistent with standard CN burning, and low 12C/13C
abundance ratios (between 9 and 11), which require extra-mixing processes in
the stellar interiors during the post-main sequence evolution. We also found
local standard of rest V(LSR)=106 km/s and heliocentric V(HEL)=90 km/s radial
velocities with a dispersion of 2.3 km/s. The inferred radial velocities,
abundances, and abundance patterns of RSGC3 are very similar to those
previously measured in the other two young clusters of the Scutum complex,
RSGC1 and RSGC2, suggesting a common kinematics and chemistry within the Scutum
complex
Weight Loss and Hypertension in Obese Subjects
Arterial hypertension is strongly related to overweight and obesity. In obese subjects, several mechanisms may lead to hypertension such as insulin and leptin resistance, perivascular adipose tissue dysfunction, renal impairment, renin-angiotensin-aldosterone-system activation and sympathetic nervous system activity. Weight loss (WL) seems to have positive effects on blood pressure (BP). The aim of this review was to explain the mechanisms linking obesity and hypertension and to evaluate the main studies assessing the effect of WL on BP. We analysed studies published in the last 10 years (13 studies either interventional or observational) showing the effect of WL on BP. Different WL strategies were taken into account-diet and lifestyle modification, pharmacological intervention and bariatric surgery. Although a positive effect of WL could be identified in each study, the main difference seems to be the magnitude and the durability of BP reduction over time. Nevertheless, further follow-up data are needed: there is still a lack of evidence about long term effects of WL on hypertension. Hence, given the significant results obtained in several recent studies, weight management should always be pursued in obese patients with hypertension
Lines and continuum sky emission in the near infrared: observational constraints from deep high spectral resolution spectra with GIANO-TNG
Aims Determining the intensity of lines and continuum airglow emission in the
H-band is important for the design of faint-object infrared spectrographs.
Existing spectra at low/medium resolution cannot disentangle the true
sky-continuum from instrumental effects (e.g. diffuse light in the wings of
strong lines). We aim to obtain, for the first time, a high resolution infrared
spectrum deep enough to set significant constraints on the continuum emission
between the lines in the H-band. Methods During the second commissioning run of
the GIANO high-resolution infrared spectrograph at La Palma Observatory, we
pointed the instrument directly to the sky and obtained a deep spectrum that
extends from 0.97 to 2.4 micron. Results The spectrum shows about 1500 emission
lines, a factor of two more than in previous works. Of these, 80% are
identified as OH transitions; half of these are from highly excited molecules
(hot-OH component) that are not included in the OH airglow emission models
normally used for astronomical applications. The other lines are attributable
to O2 or unidentified. Several of the faint lines are in spectral regions that
were previously believed to be free of line emission. The continuum in the
H-band is marginally detected at a level of about 300
photons/m^2/s/arcsec^2/micron, equivalent to 20.1 AB-mag/arcsec^2. The observed
spectrum and the list of observed sky-lines are published in electronic format.
Conclusions Our measurements indicate that the sky continuum in the H-band
could be even darker than previously believed. However, the myriad of airglow
emission lines severely limits the spectral ranges where very low background
can be effectively achieved with low/medium resolution spectrographs. We
identify a few spectral bands that could still remain quite dark at the
resolving power foreseen for VLT-MOONS (R ~6,600).Comment: 7 pages, 4 figures, to be published in Astronomy & Astrophysic
IMU-based classification of resistive exercises for real-time training monitoring on board the international space station with potential telemedicine spin-off
The microgravity exposure that astronauts undergo during space missions lasting up to 6 months induces biochemical and physiological changes potentially impacting on their health. As a countermeasure, astronauts perform an in-flight training program consisting in different resistive exercises. To train optimally and safely, astronauts need guidance by on-ground specialists via a real-time audio/video system that, however, is subject to a communication delay that increases in proportion to the distance between sender and receiver. The aim of this work was to develop and validate a wearable IMU-based biofeedback system to monitor astronauts in-flight training displaying real-time feedback on exercises execution. Such a system has potential spin-offs also on personalized home/remote training for fitness and rehabilitation. 29 subjects were recruited according to their physical shape and performance criteria to collect kinematics data under ethical committee approval. Tests were conducted to (i) compare the signals acquired with our system to those obtained with the current state-of-the-art inertial sensors and (ii) to assess the exercises classification performance. The magnitude square coherence between the signals collected with the two different systems shows good agreement between the data. Multiple classification algorithms were tested and the best accuracy was obtained using a MultiLayer Perceptron (MLP). MLP was also able to identify mixed errors during the exercise execution, a scenario that is quite common during training. The resulting system represents a novel low-cost training monitor tool that has space application, but also potential use on Earth for individuals working-out at home or remotely thanks to its ease of use and portability
GIANO-TNG spectroscopy of red supergiants in the young star cluster RSGC2
The inner disk of the Galaxy has a number of young star clusters dominated by
red supergiants that are heavily obscured by dust extinction and observable
only at infrared wavelengths. These clusters are important tracers of the
recent star formation and chemical enrichment history in the inner Galaxy.
During the technical commissioning and as a first science verification of the
GIANO spectrograph at the Telescopio Nazionale Galileo, we secured
high-resolution (R~50,000) near-infrared spectra of three red supergiants in
the young Scutum cluster RSGC2. Taking advantage of the full YJHK spectral
coverage of GIANO in a single exposure, we were able to identify several tens
of atomic and molecular lines suitable for chemical abundance determinations.
By means of spectral synthesis and line equivalent width measurements, we
obtained abundances of Fe and other iron-peak elements such as V, Cr, Ni, of
alpha (O, Mg, Si, Ca and Ti) and other light elements (C, N, Na, Al, K, Sc),
and of some s-process elements (Y, Sr). We found iron abundances between half
and one third solar and solar-scaled [X/Fe] abundance patterns of iron-peak,
alpha and most of the light elements, consistent with a thin-disk chemistry. We
found a depletion of [C/Fe] and enhancement of [N/Fe], consistent with CN
burning, and low 12C/13C abundance ratios (between 9 and 11), requiring
extra-mixing processes in the stellar interiors during the post-main sequence
evolution. Finally, we found a slight [Sr/Fe] enhancement and a slight [Y/Fe]
depletion (by a factor of <=2), with respect to solar.Comment: Paper accepted on A&
Gradients of Variation in the At-Vessel Mortality Rate between Twelve Species of Sharks and Skates Sampled through a Fishery-Independent Trawl Survey in the Asinara Gulf (NW Mediterranean Sea)
Elasmobranchs are priority species for conservation due to their rapid decline determined by the unbalanced struggle between a fragile bio-ecology and strong anthropogenic impacts, such as bycatch from professional fishing. In this context, measuring species resistance to catch of poorly selective gear is of paramount importance. During June-October 2022, five experimental fishing campaigns were carried out in the Asinara Gulf (northern Sardinia) through 35 geographically and bathymetrically representative hauls of an area between 30 and 600 m in depth. Skates prevailed over sharks in the number of species, with seven and five species, respectively. We first evaluated the status of each individual with respect to stress due to the trawl's catch using a three-graded scale. We also recorded individual biometrics (total and disk length, weight and sex, and maturity for males) on board by implementing the best practices in manipulating individuals for physiological recovery and release at sea. After capture, skates resulted in generally better conditions than sharks, although deepwater species of both groups exhibited a worse state than coastal species. The estimated vitality rates also depended on the size of the individuals. This work provides standardized data on the intermingled effect of size, species type, and inhabited depth on the resistance response of some elasmobranch species against capture by trawl fishery activities
Kac-Moody Symmetries of Ten-dimensional Non-maximal Supergravity Theories
A description of the bosonic sector of ten-dimensional N=1 supergravity as a
non-linear realisation is given. We show that if a suitable extension of this
theory were invariant under a Kac-Moody algebra, then this algebra would have
to contain a rank eleven Kac-Moody algebra, that can be identified to be a
particular real form of very-extended D_8. We also describe the extension of
N=1 supergravity coupled to an abelian vector gauge field as a non-linear
realisation, and find the Kac-Moody algebra governing the symmetries of this
theory to be very-extended B_8. Finally, we discuss the related points for the
N=1 supergravity coupled to an arbitrary number of abelian vector gauge fields
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