DEVELOPMENT OF A DEVICE TO MEASURE THE BLADE TIP CLEARANCE OF AN AXIAL COMPRESSOR

Axial compressors, used in gas turbines, jet engines and also small scale power plants, are rotating, airfoil based compressors in which the working fluid flows parallel to the axis of rotation. There has been continuous struggle to maximize the efficiency of these compressors. One of the many ways to achieve the same is to minimize the tip clearance i.e. to reduce the distance between the blade tip and the housing. Experiments need to be conducted to measure the changes in the tip clearance while the  compressor is operating. Conventional devices to measure this tip clearance have proven to be costly if a small scale application is under consideration. Our aim in this project is to develop a device which will measure the blade tip clearance of an axial flow compressor economically. The literature review, development of the device, its working and results will be discussed in this paper

Genome editing in fruit, ornamental, and industrial crops

The advent of genome editing has opened new avenues for targeted trait enhancement in fruit, ornamental, industrial, and all specialty crops. In particular, CRISPR-based editing systems, derived from bacterial immune systems, have quickly become routinely used tools for research groups across the world seeking to edit plant genomes with a greater level of precision, higher efficiency, reduced off-target effects, and overall ease-of-use compared to ZFNs and TALENs. CRISPR systems have been applied successfully to a number of horticultural and industrial crops to enhance fruit ripening, increase stress tolerance, modify plant architecture, control the timing of flower development, and enhance the accumulation of desired metabolites, among other commercially-important traits. As editing technologies continue to advance, so too does the ability to generate improved crop varieties with non-transgenic modifications; in some crops, direct transgene-free edits have already been achieved, while in others, T-DNAs have successfully been segregated out through crossing. In addition to the potential to produce non-transgenic edited crops, and thereby circumvent regulatory impediments to the release of new, improved crop varieties, targeted gene editing can speed up trait improvement in crops with long juvenile phases, reducing inputs resulting in faster market introduction to the market. While many challenges remain regarding optimization of genome editing in ornamental, fruit, and industrial crops, the ongoing discovery of novel nucleases with niche specialties for engineering applications may form the basis for additional and potentially crop-specific editing strategies.The authors would like to acknowledge funding from MINECO, Spain (PGC2018-097655-B-I00 to P Christou), Generalitat de Catalunya Grant 2017 SGR 828 to the Agricultural Biotechnology and Bioeconomy Unit (ABBU). Work in the Dhingra lab in crop improvement is supported in part by Washington State University Agriculture Research Center Hatch grant WNP00011. ES and FR acknowledge the support received from the Department of Horticulture, BW was supported in part by a Research Assistantship from the Washington State University Graduate School. The authors would also like to thank Drs A. McHughen and H. Quemada for input and clarifications on US genome editing regulations. We would also like to thank the anonymous reviewers for their insightful comments

Photosensitizer Drug Delivery via an Optical Fiber

: An optical fiber has been developed with a maneuverable miniprobe tip that sparges O2 gas and photodetaches pheophorbide (sensitizer) molecules. Singlet oxygen is produced at the probe tip surface which reacts with an alkene spacer group releasing sensitizer upon fragmentation of a dioxetane intermediate. Optimal sensitizer photorelease occurred when the probe tip was loaded with 60 nmol sensitizer, where crowding of the pheophorbide molecules and self-quenching were kept to a minimum. The fiber optic tip delivered pheophorbide molecules and singlet oxygen to discrete locations. The 60 nmol sensitizer was delivered into petrolatum; however, sensitizer release was less efficient in toluene-d8 (3.6 nmol) where most had remained adsorbed on the probe tip, even after the covalent alkene spacer bond had been broken. The results open the door to a new area of fiber optic-guided sensitizer delivery for the potential photodynamic therapy of hypoxic structures requiring cytotoxic control

"Pointsource" Delivery of a Photosensitizer Drug and Singlet Oxygen: Eradication of Glioma Cells In Vitro

ABSTRACT We describe a pointsource sensitizer-tipped microoptic device for the eradication of glioma U87 cells. The device has a mesoporous fluorinated silica tip which emits singlet oxygen molecules and small quantities of pheophorbide sensitizer for additional production of singlet oxygen in the immediate vicinity. The results show that the device surges in sensitizer release and photokilling with higher rates about midway through the reaction. This was attributed to a self-amplified autocatalytic reaction where released sensitizer in the extracellular matrix provides positive feedback to assist in the release of additional sensitizer. The photokilling of the glioma cells was analyzed by global toxicity and live/dead assays, where a killing radius around the tip with~0.3 mm precision was achieved. The implication of these results for a new PDT tool of hard-to-resect tumors, e.g. in the brain, is discussed

Painful Lytic Lesions of the Foot : A Case Report

The presence of lytic lesions in the bones of foot raises a number of diagnostic possibilities ranging from infection, inflammatory pathology to neoplastic conditions. Although the radiological picture is not pathognomonic of any pathology, clinical history and histopathological examination can help to clinch the diagnosis. We present a case of multiple lytic lesions of the foot and discuss possible differential diagnoses. The patient was diagnosed as a case of madura foot and the lesions responded to surgical debridement and anti-fungal treatment with a good functional outcome. Madura foot is an uncommon, chronic granulomatous fungal or bacterial infection with a predilection in people who walk barefoot. Although known for a specific geographical distribution, madura foot should be kept as a possible diagnosis in patients presenting with lytic lesions of the foot due to population emigration across the world

Design and Analysis of Decentralized Dynamic Sliding Mode Controller for TITO Process

In this paper, a decentralized dynamic sliding mode control (DySMC) strategy is applied to a multivariable level control system. The time derivative of the control input of the DySMC is considered a new control variable for an augmented system which is composed of the original system and the integrator. This DySMC can transfer discontinuous terms to the first-order derivative of the control input and effectively reduce the chattering. The interactions between input/output variables are a common phenomenon and a challenging task in the design of multi-loop controllers for interacting multivariable processes. For reducing the interaction among variables, ideal decouplers are used. Independent diagonal controllers are designed for each decoupled subsystem, which is reduced to the first-order plus dead-time (FOPDT) model. A numerical simulation test has been carried out on a reactor system of the Industrial-Scale Polymerization (ISP). Experimental tests are performed to check the efficacy of the proposed controller using a laboratory-level coupled tank system.  A comparison of the proposed approach and sliding mode controller (SMC) is presented. Simulation and experiment results show that the DySMC approach reduces the chattering, and compensates for the effect of the external disturbances, and parametric uncertainties

REVIEW PAPER ON EFFECT OF ALUMINIUM DROSS ON PROPERTIES OF CONCRETE

The Bhima River is a main river in South India. It flows southeast for 861 kilometers (535 mi) through Maharashtra, Karnataka, and Telangana states, before inflowing the Krishna River. Along the river stretch there are about 7000 industries comprise Large, middling and little scale units according to CPCB. Most of the industry are located in the Maharashtra Industrial enlargement Corporation (MIDC). The river is 70% polluted by industries pollution and 30% by domestic wastewater. The following decision article presents the termination of the work approved out by the researchers in the past on the various River wate

S,S‐Chiral Linker Induced U Shape with a Syn‐facial Sensitizer and Photocleavable Ethene Group

There is a major need for light-activated materials for the release of sensitizers and drugs. Considering the success of chiral columns for the separation of enantiomer drugs, we synthesized an S,S-chiral linker system covalently attached to silica with a sensitizer ethene near the silica surface. First, the silica surface was modified to be aromatic rich, by replacing 70% of the surface groups with (3-phenoxypropyl)silane. We then synthesized a 3-component conjugate [chlorin sensitizer, S,S-chiral cyclohexane and ethene building blocks] in 5 steps with a 13% yield, and covalently bound the conjugate to the (3-phenoxypropyl)silane-coated silica surface. We hypothesized that the chiral linker would increase exposure of the ethene site for enhanced 1 O2-based sensitizer release. However, the chiral linker caused the sensitizer conjugate to adopt a U shape due to favored 1,2-diaxial substituent orientation; resulting in a reduced efficiency of surface loading. Further accentuating the U shape was p–p stacking between the (3-phenoxypropyl)silane and sensitizer. Semiempirical calculations and singlet oxygen luminescence data provided deeper insight into the sensitizer’s orientation and release. This study has lead to insight on modifications of surfaces for drug photorelease and can help lead to the development of miniaturized photodynamic devices.Fil: Ghosh, Goutam. City University of New York; Estados Unidos. Acadia University; CanadáFil: Belh, Sarah J.. City University of New York; Estados UnidosFil: Chiemezie, Callistus. City University of New York; Estados UnidosFil: Walalawela, Niluksha. City University of New York; Estados UnidosFil: Ghogare, Ashwini A.. City University of New York; Estados UnidosFil: Vignoni, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Thomas, Andrés Héctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: McFarland, Sherri A.. Acadia University; Canadá. University of North Carolina; Estados UnidosFil: Greer, Edyta M.. City University of New York; Estados UnidosFil: Greer, Alexander. City University of New York; Estados Unido

“Ene” Reactions of Singlet Oxygen at the Air–Water Interface

Prenylsurfactants [(CH₃)₂CCH­(CH₂)_<i>n</i>SO₃^– Na⁺ (<i>n</i> = 4, 6, or 8)] were designed to probe the “ene” reaction mechanism of singlet oxygen at the air–water interface. Increasing the number of carbon atoms in the hydrophobic chain caused an increase in the regioselectivity for a secondary rather than tertiary surfactant hydroperoxide, arguing for an orthogonal alkene on water. The use of water, deuterium oxide, and H₂O/D₂O mixtures helped to distinguish mechanistic alternatives to homogeneous solution conditions that include dewetting of the π bond and an unsymmetrical perepoxide transition state in the hydroperoxide-forming step. The prenylsurfactants and a photoreactor technique allowed a certain degree of interfacial control of the hydroperoxidation reaction on a liquid support, where the oxidant (airborne ¹O₂) is delivered as a gas