The effect of environmental index on mental health in nurses working in emergency and non emergency wards in Khorramabad hospitals

زمینه و هدف : یکی از دغدغه های ذهنی جوامع امروزی ، تامین سلامت و بهداشت روانی افراد به خصوص پرستاران است . پژوهش حاضر با هدف تعیین عوامل مرتبط با شاخص های محیط کار بر سلامت روان پرستاران شاغل در بیمارستان های شهر خرم آباد انجام گرفته است. روش بررسی: این یک مطالعه مقطعی است. جامعه آماری این پژوهش شامل کلیه پرستاران در بیمارستان مذکور که شامل 433 نفر و نمونه آماری شامل 207 نفر از پرستاران دو بخش بودند که در بیمارستان عشایر با روش نمونه گیری در دسترس و در بیمارستان تامین اجتماعی با روش سرشماری انتخاب شدند. ابزار جمع آوری اطلاعات عبارت بودند از : پرسشنامه اطلاعات جمعیت شناختی، پرسشنامه سلامت عمومی GHQ و نمره بندی تنش های محیط کار WES که پایایی و روایی آنها تایید شده است. برای آزمودن فرضیات از آزمون t مستقل ، تحلیل واریانس یک طرفه و ضریب همبستگی استفاده گردید. یافته ها : در تحقیق حاضر 119 زن و 88 مرد مورد مطالعه قرار گرفتند که 43.30 درصد پرستاران در بخش اورژانس و 57/69 درصد در سایر بخش ها مشغول به کار بودند. نتایج آزمون t مستقل نشان داد که تفاوت معناداری بین میانگین نمرات سلامت روان در پرستاران بخش اورژانس (71.14±19.29) در مقایسه با پرستاران سایر بخش ها (48.13±13.30) وجود ندارد (0.654=p). نتیجه گیری : ﭼﻨﺎن ﻛﻪ ﻧﺘﺎﻳﺞ مطالعه ﺣﺎﺿﺮ نشان می دهد ﻫﺮ ﭼﻨﺪ ﺷﺎﻏﻼن در ﺑﺨﺶ اورژاﻧﺲ ﺗﺮوﻣﺎی ﺑﻴﺸﺘﺮی را ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﺳﺎﺑﻘﻪ ی ﺣﻮادث ﺷﻐﻠﻲ ﺑﺮای ﺧﻮد و ﻫﻤﻜﺎرانشان تجربه کرده اند، تفاوت معنی داری بین اختلالات مرتبط با سلامت روان ناشی از فشار عصبی و روانی محیط کار در پرستاران بخش های اورژانس و غیر اورژانس در ﺑﻴﻤﺎرﺳﺘﺎن ﻳﺎﻓﺖ نشد

Psychological Violence in the Health Care Settings in Iran: A Cross-Sectional Study

Background: Psychological violence is the most common form of workplace violence that can affect professional performance and job satisfaction of health care workers. Although several studies have been conducted in Iran, but there is no consensus regarding current status of such violence. Objectives: This study aimed to investigate the prevalence of psychological violence among healthcare workers employed at teaching hospitals in Iran. Patients and Methods: In this cross-sectional study, 5874 health professionals were selected using multistage random sampling. Data were collected using a self-administered questionnaire developed by the International Labor Organization, International Council of Nurses, World Health Organization, and Public Services International. Descriptive statistics were used to analyze the data. Results: It was found that 74.7% of the participants were subjected to psychological violence during the past 12 months. Totally, 64.5% of psychological violence was committed by patients’ families, but 50.9% of participants had not reported the violence, and 69.9% of them believed that reporting was useless. Conclusions: The results are indicative of high prevalence of psychological violence against healthcare workers. Considering non-reporting of violence in more than half of participants, use of an appropriate reporting system and providing training programs for health professionals in order to prevent and manage workplace violence are essential

Antidiabetic potential of salvianolic acid B in multiple low-dose streptozotocin-induced diabetes

Context: Salvianolic acids are the most abundant water-soluble compounds extracted from the herb Salvia miltiorrhiza L. (Lamiaceae) with antioxidant and protective effects. Objective: This study evaluates the antidiabetic effect of salvianolic acid B (Sal B) in multiple low-dose streptozotocin (MLDS)-induced diabetes in rat. Materials and methods: Rats were divided into control, Sal B40-treated control, diabetic, Sal B20-, and Sal B40-treated diabetic groups. Sal B was daily administered at doses of 20 or 40 mg/kg (i.p.), started on third day post-STZ injection for 3 weeks. Serum glucose and insulin level and some oxidative stress markers in pancreas were measured in addition to the oral glucose tolerance test (OGTT), histological assessment, and apoptosis determination. Results: After 3 weeks, treatment of diabetic rats with Sal B20 and Sal B40 caused a significant decrease of the serum glucose (p<0.05-0.01) and improvement of OGTT. Meanwhile, serum insulin was significantly higher in Sal B20- and Sal B40-treated diabetics (p<0.01) and treatment of diabetics with Sal B40 significantly lowered malondialdehyde (MDA) (p<0.05), raised glutathione (GSH) (p<0.05), and activity of catalase (p<0.01) with no significant change of nitrite. Furthermore, the number of pancreatic islets (p<0.05) and their area (p<0.01) was significantly higher and apoptosis reactivity was significantly lower (p<0.05) in the Sal B40-treated diabetic group versus diabetics. Discussion and conclusion: Three-week treatment of diabetic rats with Sal B exhibited antidiabetic activity which is partly exerted via attenuation of oxidative stress and apoptosis and augmentation of antioxidant system. © 2015 Informa Healthcare USA, Inc

Is cyclooxygenase-1 involved in neuroinflammation?

Purpose: Reactive microglia are an important hallmark of neuroinflammation. Reactive microglia release various inflammatory mediators, such as cytokines, chemokines, and prostaglandins, which are produced by enzymes like cyclooxygenases (COX). The inducible COX‐2 subtype has been associated with inflammation, whereas the constitutively expressed COX‐1 subtype is generally considered as a housekeeping enzyme. However, recent evidence suggests that COX‐1 can also be upregulated and may play a prominent role in the brain during neuroinflammation. In this review, we summarize the evidence that supports this involvement of COX‐1. Methods: Five databases were used to retrieve relevant studies that addressed COX‐1 in the context of neuroinflammation. The search resulted in 32 articles, describing in vitro, in vivo, post mortem, and in vivo imaging studies that specifically investigated the COX‐1 isoform under such conditions. Results: Reviewed literature generally indicated that the overexpression of COX‐1 was induced by an inflammatory stimulus, which resulted in an increased production of prostaglandin E2. The pharmacological inhibition of COX‐1 was shown to suppress the induction of inflammatory mediators like prostaglandin E2. Positron emission tomography (PET) imaging studies in animal models confirmed the overexpression of COX‐1 during neuroinflammation. The same imaging method, however, could not detect any upregulation of COX‐1 in patients with Alzheimer's disease. Conclusion: Taken together, studies in cultured cells and living rodents suggest that COX‐1 is involved in neuroinflammation. Most postmortem studies on human brains indicate that the concentration of COX‐1‐expressing microglial cells is increased near sites of inflammation. However, evidence for the involvement of COX‐1 in neuroinflammation in the living human brain is still largely lacking

Pharmacokinetic Modeling of [11C]GSK-189254, PET Tracer Targeting H3 Receptors, in Rat Brain

[Image: see text] The histamine H(3) receptor has been considered as a target for the treatment of various central nervous system diseases. Positron emission tomography (PET) studies with the radiolabeled potent and selective histamine H(3) receptor antagonist [(11)C]GSK-189254 in rodents could be used to examine the mechanisms of action of novel therapeutic drugs or to assess changes of regional H(3) receptor density in animal models of neurodegenerative disease. [(11)C]GSK-189254 was intravenously administered to healthy Wistar rats (n = 10), and a 60 min dynamic PET scan was carried out. Arterial blood samples were obtained during the scan to generate a metabolite-corrected plasma input function. PET data were analyzed using a one-tissue compartment model (1T2k), irreversible (2T3k) or reversible two-tissue compartment models (2T4k), graphical analysis (Logan and Patlak), reference tissue models (SRTM and SRTM2), and standard uptake values (SUVs). The Akaike information criterion and the standard error of the estimated parameters were used to select the most optimal quantification method. This study demonstrated that the 2T4k model with a fixed blood volume fraction and Logan graphical analysis can best describe the kinetics of [(11)C]GSK-189254 in the rat brain. SUV(40–60) and the reference tissue-based measurements DVR(2T4k), BP(ND)(SRTM), and SUV ratio could also be used as a simplified method to estimate H(3) receptor availability in case blood sampling is not feasible

Large Exchange Bias, High Dielectric Constant, and Outstanding Ionic Conductivity in a Single Phase Spin Glass

The multigram synthesis of K [Fe S ] starting from K S and FeS is presented, and its electronic and magnetic properties are investigated. The title compound obtains a defect variant of the K[Fe Se ] structure type. Dielectric and impedance measurements indicate a dielectric constant of 1120 at 1 kHz and an outstanding ionic conductivity of 24.37 mS cm at 295 K, which is in the range of the highest reported value for potential solid state electrolytes for potassium ion batteries. The Seebeck coeffcient of the n type conductor amounts to amp; 8722;60 amp; 956;V K at 973 K. The mismatch of the measured electrical resistivity and the predicted metal like band structure by periodic quantum chemical calculations indicates Mott insulating behavior. Magnetometry demonstrates temperature dependent, large exchange biasfields of 35 mT, as a consequence of the coexistence of spin glass and antiferromagnetic orderings due to the iron vacancies in the lattice. In addition, the decreasing training effects of 34 in the exchange bias are identified at temperatures lower than 20 K. These results demonstrate the critical role of iron vacancies in tuning the electronic and magnetic properties and a multifunctional material from abundant and accessible element

Big data-driven fuzzy cognitive map for prioritising IT service procurement in the public sector

YesThe prevalence of big data is starting to spread across the public and private sectors however, an impediment to its widespread adoption orientates around a lack of appropriate big data analytics (BDA) and resulting skills to exploit the full potential of big data availability. In this paper, we propose a novel BDA to contribute towards this void, using a fuzzy cognitive map (FCM) approach that will enhance decision-making thus prioritising IT service procurement in the public sector. This is achieved through the development of decision models that capture the strengths of both data analytics and the established intuitive qualitative approach. By taking advantages of both data analytics and FCM, the proposed approach captures the strength of data-driven decision-making and intuitive model-driven decision modelling. This approach is then validated through a decision-making case regarding IT service procurement in public sector, which is the fundamental step of IT infrastructure supply for publics in a regional government in the Russia federation. The analysis result for the given decision-making problem is then evaluated by decision makers and e-government expertise to confirm the applicability of the proposed BDA. In doing so, demonstrating the value of this approach in contributing towards robust public decision-making regarding IT service procurement.EU FP7 project Policy Compass (Project No. 612133

Pancreatic beta cell protection/regeneration with phytotherapy

Although currently available drugs are useful in controlling early onset complications of diabetes, serious late onset complications appear in a large number of patients. Considering the physiopathology of diabetes, preventing beta cell degeneration and stimulating the endogenous regeneration of islets will be essential approaches for the treatment of insulin-dependent diabetes mellitus. The current review focused on phytochemicals, the antidiabetic effect of which has been proved by pancreatic beta cell protection/regeneration. Among the hundreds of plants that have been investigated for diabetes, a small fraction has shown the regenerative property and was described in this paper. Processes of pancreatic beta cell degeneration and regeneration were described. Also, the proposed mechanisms for the protective/regenerative effects of such phytochemicals and their potential side effects were discussed