295 research outputs found

    Physics case for an LHCb Upgrade II - Opportunities in flavour physics, and beyond, in the HL-LHC era

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    The LHCb Upgrade II will fully exploit the flavour-physics opportunities of the HL-LHC, and study additional physics topics that take advantage of the forward acceptance of the LHCb spectrometer. The LHCb Upgrade I will begin operation in 2020. Consolidation will occur, and modest enhancements of the Upgrade I detector will be installed, in Long Shutdown 3 of the LHC (2025) and these are discussed here. The main Upgrade II detector will be installed in long shutdown 4 of the LHC (2030) and will build on the strengths of the current LHCb experiment and the Upgrade I. It will operate at a luminosity up to 2×1034 cm−2s−1, ten times that of the Upgrade I detector. New detector components will improve the intrinsic performance of the experiment in certain key areas. An Expression Of Interest proposing Upgrade II was submitted in February 2017. The physics case for the Upgrade II is presented here in more depth. CP-violating phases will be measured with precisions unattainable at any other envisaged facility. The experiment will probe b → sl+l−and b → dl+l− transitions in both muon and electron decays in modes not accessible at Upgrade I. Minimal flavour violation will be tested with a precision measurement of the ratio of B(B0 → μ+μ−)/B(Bs → μ+μ−). Probing charm CP violation at the 10−5 level may result in its long sought discovery. Major advances in hadron spectroscopy will be possible, which will be powerful probes of low energy QCD. Upgrade II potentially will have the highest sensitivity of all the LHC experiments on the Higgs to charm-quark couplings. Generically, the new physics mass scale probed, for fixed couplings, will almost double compared with the pre-HL-LHC era; this extended reach for flavour physics is similar to that which would be achieved by the HE-LHC proposal for the energy frontier

    LHCb upgrade software and computing : technical design report

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    This document reports the Research and Development activities that are carried out in the software and computing domains in view of the upgrade of the LHCb experiment. The implementation of a full software trigger implies major changes in the core software framework, in the event data model, and in the reconstruction algorithms. The increase of the data volumes for both real and simulated datasets requires a corresponding scaling of the distributed computing infrastructure. An implementation plan in both domains is presented, together with a risk assessment analysis

    Determination of quantum numbers for several excited charmed mesons observed in B- -> D*(+)pi(-) pi(-) decays

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    A four-body amplitude analysis of the B − → D * + π − π − decay is performed, where fractions and relative phases of the various resonances contributing to the decay are measured. Several quasi-model-independent analyses are performed aimed at searching for the presence of new states and establishing the quantum numbers of previously observed charmed meson resonances. In particular the resonance parameters and quantum numbers are determined for the D 1 ( 2420 ) , D 1 ( 2430 ) , D 0 ( 2550 ) , D ∗ 1 ( 2600 ) , D 2 ( 2740 ) and D ∗ 3 ( 2750 ) states. The mixing between the D 1 ( 2420 ) and D 1 ( 2430 ) resonances is studied and the mixing parameters are measured. The dataset corresponds to an integrated luminosity of 4.7     fb − 1 , collected in proton-proton collisions at center-of-mass energies of 7, 8 and 13 TeV with the LHCb detector

    Updated measurement of decay-time-dependent CP asymmetries in D-0 -> K+ K- and D-0 -> pi(+)pi(-) decays

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    A search for decay-time-dependent charge-parity (CP) asymmetry in D0 \u2192 K+ K 12 and D0 \u2192 \u3c0+ \u3c0 12 decays is performed at the LHCb experiment using proton-proton collision data recorded at a center-of-mass energy of 13 TeV, and corresponding to an integrated luminosity of 5.4 fb^ 121. The D0 mesons are required to originate from semileptonic decays of b hadrons, such that the charge of the muon identifies the flavor of the neutral D meson at production. The asymmetries in the effective decay widths of D0 and anti-D0 mesons are determined to be A_\u393(K+ K 12) = ( 124.3 \ub1 3.6 \ub1 0.5) 7 10^ 124 and A_\u393(\u3c0+ \u3c0 12) = (2.2 \ub1 7.0 \ub1 0.8) 7 10^ 124 , where the uncertainties are statistical and systematic, respectively. The results are consistent with CP symmetry and, when combined with previous LHCb results, yield A_\u393(K+ K 12) = ( 124.4 \ub1 2.3 \ub1 0.6) 7 10^ 124 and A_\u393(\u3c0+ \u3c0 12) = (2.5 \ub1 4.3 \ub1 0.7) 7 10^ 124

    Updated measurement of decay-time-dependent CP asymmetries in D-0 -> K+ K- and D-0 -> pi(+)pi(-) decays

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    A search for decay-time-dependent charge-parity (CP) asymmetry in D-0 -> K+ K- and D-0 -> pi(+)pi(-) eff decays is performed at the LHCb experiment using proton-proton collision data recorded at a center-of-mass energy of 13 TeV, and corresponding to an integrated luminosity of 5.4 fb(-1). The D-0 mesons are required to originate from semileptonic decays of b hadrons, such that the charge of the muon identifies the flavor of the neutral D meson at production. The asymmetries in the effective decay widths of D-0 and (D) over bar (0) mesons are determined to be A(Gamma)(K+ K-) = (-4.3 +/- 3.6 +/- 0.5) x 10(-4) and A(Gamma) (K+ K- ) = (2.2 +/- 7.0 +/- 0.8) x 10(-4), where the uncertainties are statistical and systematic, respectively. The results are consistent with CP symmetry and, when combined with previous LHCb results, yield A(Gamma) (K+ K-) = (-4.4 +/- 2.3 +/- 0.6) x 10(-4) and A(Gamma) (pi(+)pi(-))= (2.5 +/- 4.3 +/- 0.7) x 10(-4)

    Validity, reliability and utility of connected objects as a tool for clinicians

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    The development of consumer grade connected objects has the potential to change the way we detect and manage health in many diverse domains, such as cardiovascular, respiratory, neurological disease, diabetes, sleep disorders and post-operative care. Some of the most significant advantages that connected objects could provide to the medical field include early diagnosis of diseases and exacerbations, improved patient autonomy and behavior, and remote communication with healthcare providers. However, comprehensive studies on the validity and reliability of connected objects in medicine are still limited. More importantly, prospective trials exploring their impact on health outcomes are lacking. Nevertheless, connected tools offer low cost, accessibility and availability across a large community of users, allowing collection of big data in free-living settings. Continuous development in technology added to machine learning systems will further improve connected objects performance in medicine. With the development of this new technology arise new challenges to our society. Regulatory authorities must revise their approach to address digital health. Confidentiality and personal data are increasingly difficult to protect from cybercriminals. On the other hand, insuring patients' privacy without limiting the development of new potential beneficial technologies is challenging. An opportunity for improvement or a threat to our society, no matter what our opinion on connected objects is, we will have to adapt to them, as they are already everywhere

    Modifications des traitements médicamenteux chroniques lors d'une hospitalisation : le rôle des médecins internes, des praticiens et des patients

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    Des changements de médicaments sont effectués lors d'une hospitalisation et peuvent être délétères. Les modifications de médicaments chroniques, (prescrits pour [supérieur ou égal à] 30 jours) durant et peu après une hospitalisation dans un service de médecine interne des Hôpitaux Universitaires de Genève, ont été suivies chez 367 patients (âge moyen 64.3 ± 16.8 ans; 50.4% d'hommes). Des modifications de médicaments ont été observées en moyenne 5.6 fois par patients: duranrt l'hospitalisation (24.8% des médicaments supprimés, 34.7% ajoutés); lors des visites ultérieures chez le médecin traitant (15% des médicaments supprimés, 10% ajoutés); par les patients eux-mêmes (7% des médicaments supprimés, 8% ajoutés). Au final, le nombre moyen de médicaments a augmenté de 0,5 par patient. Une hospitalisation dans un service de médecine interne conduit à de multiples modifications de médicaments dont l'impact potentiel sur la compréhension que les patients ont de leur médicament et sur leur observance est proéccupant

    Update in hospital medicine 2008

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    Cet article résume une série d'études parues durant cette dernière année et qui, selon les auteurs, sont utiles à une pratique de médecine interne hospitalière, soit parce qu'elles sont susceptibles de la modifier, soit, au contraire, parce qu'elles confortent des attitudes déjà établies. Les thèmes revus incluent la pathologie cardiovasculaire, notamment la prise en charge de l'hypertension des sujets de plus de 80 ans, le blocage du système rénine-angiotensine-aldostérone et l'utilisation de biomarqueurs en cardiologie ; la pathologie neurovasculaire, spécifiquement le pronostic des accidents ischémiques transitoires et certains aspects concernant les accidents cardio-emboliques sur fibrillation auriculaire. Le pronostic de la pneumonie, la prise en charge du liquide d'ascite ou du choc septique, et un aspect de méthodologie sont également abordés.This paper summarizes several important studies published during the previous year that have an impact on the practice of inpatient internal medicine, because they either modify or reinforce current practices. The selected domains include cardiovascular disease, for example the management of hypertension in very old patients, the effects of blockade of the renin-angiotensin-aldosterone system, and the use of biomarkers in cardiology; neurovascular pathology, specifically the prognosis of transient ischemic attacks and some aspects of cardioembolic stroke due to atrial fibrillation. Other topics include pneumonia prognosis, the management of ascitis fluid or of septic shock, and methodology

    Admission rates in emergency departments in Geneva during tennis broadcasting: a retrospective study

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    Abstract Background Literature provides mixed results regarding the influence of large-scale sporting events on emergency department attendance. To contribute to the research on the subject, we sought to evaluate whether the broadcasting of major tennis tournaments, one of the most popular sports in Switzerland, has an impact on patient admission rates in emergency units in Geneva including 1) type of match 2) the role of a Swiss player, 3) degree of triage, 4) reason of attendance and 5) age of patients. Methods Admission rates between periods with tennis matches regarding the semi-finals and finals of 3 major tennis tournaments were compared to equivalent periods without matches from May 2013 to August 2017. Patient admission data was retrieved retrospectively from administrative databases of two Outpatient Emergency Units in Geneva. Patients’ admission rates in periods with and without a tennis match were investigated using a negative binomial regression model with mixed effects. Results We observed a statistically significant decrease (− 10%, 95% CI -17 to − 2, p = 0.015) in admission rates in periods with a tennis match compared to periods without a tennis match, more pronounced during finals (− 15%, 95% CI -26 to − 3, p = 0.017) than during semi-finals (− 7%, − 16 to 2, p = 0.13). In addition, this effect was more pronounced in patients aged between 26 to 64 years of age, a category representing professionnally active people. No modification in the admission rates was detected in the hours preceding and following the matches, nor in type of consultations (traumatology vs non traumatology related admissions). Conclusion Although modest, the results support the hypothesis that the broadcasting of large-scale sporting events such as tennis matches decreases admission rates in emergency units. Further research is required to explore for a potential causal relationship
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