2,015 research outputs found
Morpholinium perchlorate
In the title salt, C4H10NO+·ClO4
−, which has three independent formula units, the cations are linked into chains along [100] by N—H⋯O hydrogen bonds. Each cation acts both as a donor and as an acceptor, and every cation makes one N—H⋯O hydrogen bond with a ClO4
− anion. The crystal studied was an inversion twin
Speciation of heptavalent technetium in sulfuric acid: structural and spectroscopic studies
TUYERE FOR SUPPLY OF ACOUSTICALLY EXCITED GAS JETS TO WORKING SPACE OF POWER TECHNOLOGICAL UNITS
FIELD: power industry. SUBSTANCE: tuyere includes housing with water cooling and outlet nozzle of tuyere for acoustically excited gas. Inside the tuyere on one axis with it there located is gas jet acoustic radiator consisting of nozzle, resonator and reflector. Distance from the end of resonator to nozzle exit section of tuyere is 4-5 diameters of resonator. Nozzle exit section of tuyere has different orientation relative to its longitudinal axis within the angle range of 0-45° between axis of tuyere and axis of its nozzle. EFFECT: decreasing overall dimensions and cost of tuyere, and reducing the required gas medium flow rates for creation of sound oscillations. 2 dwg.Изобретение относится к области энерготехнологий и может быть использовано для осаждения пыли из газовых потоков и интенсификации тепломассообменных процессов и процессов горения в энерготехнологических агрегатах. Фурма содержит корпус с водяным охлаждением и сопло фурмы для выхода озвученного газа. Внутри фурмы на одной оси с ней расположен газовый струйный акустический излучатель, состоящий из сопла, резонатора и рефлектора. Расстояние от торца резонатора до выходного сечения сопла фурмы составляет 4-5 диаметров резонатора. Выходное сечение сопла фурмы имеет различную ориентировку относительно ее продольной оси в диапазоне угла 0-45° между осью фурмы и осью ее сопла. Использование изобретения обеспечивает уменьшение габаритов и стоимости фурмы и снижение требуемых расходов газовой среды на создание звуковых колебаний. 2 ил
New Preparative Approach to Purer Technetium-99 Samples—Tetramethylammonium Pertechnetate: Deep Understanding and Application of Crystal Structure, Solubility, and Its Conversion to Technetium Zero Valent Matrix
99Tc is one of the predominant fission products of 235U and an important component of nuclear industry wastes. The long half-life and specific activity of 99Tc (212,000 y, 0.63 GBq g−1) makes Tc a hazardous material. Two principal ways were proposed for its disposal, namely, long-term storage and transmutation. Conversion to metal-like technetium matrices is highly desirable for both cases and for the second one the reasonably high Tc purity was important too. Tetramethylammonium pertechnetate (TMAP) was proposed here as a prospective precursor for matrix manufacture. It provided with very high decontamination factors from actinides (that is imperative for transmutation) by means of recrystallisation and it was based on the precise data on TMAP solubility and thermodynamics accomplished in the temperature range of 3–68 °C. The structure of solid pertechnetates were re-estimated with precise X-ray structure solution and compared to its Re and Cl analogues and tetrabutylammonium analogue as well. Differential thermal and evolved gas analysis in a flow of Ar–5% H2 gas mixture showed that the major products of thermolysis were pure metallic technetium in solid matrix, trimethylammonium, carbon dioxide, and water in gas phase. High decontamination factors have been achieved when TMAP was used as an intermediate precursor for Tc
Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2.
BACKGROUND
Although recent epidemiological data suggest that pneumococci may contribute to the risk of SARS-CoV-2 disease, cases of co-infection with Streptococcus pneumoniae in COVID-19 patients during hospitalisation have been reported infrequently. This apparent contradiction may be explained by interactions of SARS-CoV-2 and pneumococcus in the upper airway, resulting in the escape of SARS-CoV-2 from protective host immune responses.
METHODS
Here, we investigated the relationship of these two respiratory pathogens in two distinct cohorts of a) healthcare workers with asymptomatic or mildly symptomatic SARS-CoV-2 infection identified by systematic screening and b) patients with moderate to severe disease who presented to hospital. We assessed the effect of co-infection on host antibody, cellular and inflammatory responses to the virus.
RESULTS
In both cohorts, pneumococcal colonisation was associated with diminished anti-viral immune responses, which affected primarily mucosal IgA levels among individuals with mild or asymptomatic infection and cellular memory responses in infected patients.
CONCLUSION
Our findings suggest that S. pneumoniae impairs host immunity to SARS-CoV-2 and raises the question if pneumococcal carriage also enables immune escape of other respiratory viruses and facilitates reinfection occurrence.
TRIALS REGISTRATION
ISRCTN89159899 for FASTER study and Clinicaltrials.gov identifier: NCT03502291 for LAIV study
Design, Performance and Calibration of the CMS Forward Calorimeter Wedges
We report on the test beam results and calibration methods using charged particles of the CMS Forward Calorimeter (HF). The HF calorimeter covers a large pseudorapidity region (3\l |\eta| \le 5), and is essential for large number of physics channels with missing transverse energy. It is also expected to play a prominent role in the measurement of forward tagging jets in weak boson fusion channels. The HF calorimeter is based on steel absorber with embedded fused-silica-core optical fibers where Cherenkov radiation forms the basis of signal generation. Thus, the detector is essentially sensitive only to the electromagnetic shower core and is highly non-compensating (e/h \approx 5). This feature is also manifest in narrow and relatively short showers compared to similar calorimeters based on ionization. The choice of fused-silica optical fibers as active material is dictated by its exceptional radiation hardness. The electromagnetic energy resolution is dominated by photoelectron statistics and can be expressed in the customary form as a/\sqrt{E} + b. The stochastic term a is 198% and the constant term b is 9%. The hadronic energy resolution is largely determined by the fluctuations in the neutral pion production in showers, and when it is expressed as in the electromagnetic case, a = 280% and b = 11%
Design, Performance, and Calibration of the CMS Hadron-Outer Calorimeter
The CMS hadron calorimeter is a sampling calorimeter with brass absorber and plastic scintillator tiles with wavelength shifting fibres for carrying the light to the readout device. The barrel hadron calorimeter is complemented with an outer calorimeter to ensure high energy shower containment in the calorimeter. Fabrication, testing and calibration of the outer hadron calorimeter are carried out keeping in mind its importance in the energy measurement of jets in view of linearity and resolution. It will provide a net improvement in missing \et measurements at LHC energies. The outer hadron calorimeter will also be used for the muon trigger in coincidence with other muon chambers in CMS
Language of Lullabies: The Russification and De-Russification of the Baltic States
This article argues that the laws for promotion of the national languages are a legitimate means for the Baltic states to establish their cultural independence from Russia and the former Soviet Union
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. Variant annotation was supported by software resources provided via the Caché Campus program of the InterSystems GmbH to Alexander Teumer
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