New data on naeva epigraphy (CIL II 1077-1080 & 1204)

Cuatro dibujos anónimos de un manuscrito del siglo XVI y otro de F. X. Delgado aportan nuevos datos de cinco inscripciones halladas en Cantillana, la antigua Naeva. Son todos altares, un tipo de monumento característico del paisaje epigráfico funerario del bajo Guadalquivir.Four anonymous drawings of a 16th century manuscript and another one by F. X. Delgado give us new data on five inscriptions found in Cantillana, the ancient Naeva. All of them are altars, a characteristic monument of the funerary epigraphic landscape of the lower Guadalquivir.España. Ministerio de Ciencia e Innovación HAR2009-12932-C02-01 HAR2009-12932-C02-0

VALIDACIÓN DE NUEVOS ESQUEMAS DE COORDINACIÓN TSO/DSO PARA FAVORECER LA INTEGRACIÓN DE ENERGÍAS RENOVABLES EN EL SISTEMA ELÉCTRICO EN EL HORIZONTE 2030+ - EL PROYECTO SMARTNET

El proyecto SmartNet se enmarca dentro del programa H2020 de la Comisión Europea. Con una duración de tres años y 22 socios entre Industria, Centros de Investigación y Universidades, tiene como objetivo el desarrollo e implementación de soluciones novedosas que permitan incrementar la proporción de energías renovables en el sistema eléctrico en el horizonte 2030+. Para ello, se han definido cinco esquemas de coordinación TSO/DSO orientados a definir la solución óptima para la provisión de servicios auxiliares desde las redes de distribución al sistema de transporte, así como los mecanismos de intercambio de información necesarios. Estos esquemas de coordinación se van a simular y, finalmente validar en tres pilotos en Italia, Dinamarca y España.European Commission's H202

Radiation hazard in soil from Ajaokuta North-central Nigeria

Background: Measurement of the radia�on dose distribu�on is important in assessing the health risk a popula�on and serve as reference in documen�ng changes to environmental radioac�vity in soil due to man-made ac�vi�es. Materials and Methods: The ac�vity concentra�on of 238U, 232Th and 40K in soil samples obtained from different loca�ons in Ajaokuta Local Government area was measured using Hyper Pure germanium Detec�on System (HPGe). Results: The calculated average concentra�on of the radionuclides ranged from 12 ± 1 Bqkg-1 to 59 ± 2 Bqkg-1 for 238U, 14 ± 1 Bqkg-1 to 78 ± 5 Bqkg-1 for 232Th and 49 ± 2 Bqkg-1 to 1272 ± 23 Bqkg-1 for 40K. In order to evaluate the radiological hazards due to natural radionuclides within Ajaokuta, the absorbed dose rate, gamma index, radium equivalent and excess life�me cancer risk were es�mated. According to measured data from the top soil (0-10 cm), the es�mated radium equivalent (Raeq) ranges from 55.7 Bqkg-1 at Steel Complex to 253.3 Bqkg-1 obtained from Forest samples. Conclusion: The mean absorbed dose rate, annual effec�ve dose and gamma radia�on index evaluated were 66.2 nGyh-1, 81.2 μSvy-1 and 1.05 respec�vely which are higher than the recommended limit for normal background radia�on. Thus, we conclude that people living in these loca�ons may be exposed to higher radia�on

High-resolution physical map for chromosome 16q12.1-q13, the Blau syndrome locus

BACKGROUND: The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region and consequently an unknown order of microsatellite markers, hampered us from further refining the genetic locus for the Blau syndrome. To address this problem, we constructed our own high-resolution physical map for the Blau susceptibility region. RESULTS: We generated a high-resolution physical map that provides more than 90% coverage of a refined Blau susceptibility region. The map consists of four contigs of sequence tagged site-based bacterial artificial chromosomes with a total of 124 bacterial artificial chromosomes, and spans approximately 7.5 Mbp; however, three gaps still exist in this map with sizes of 425, 530 and 375 kbp, respectively, estimated from radiation hybrid mapping. CONCLUSIONS: Our high-resolution map will assist genetic studies of loci in the interval from D16S3080, near D16S409, and D16S408 (16q12.1 to 16q13)

Market architecture for TSO-DSO interaction in the context of European regulation

Following the overall European political goals, massive efforts were recently made to promote an accelerated integration of renewable energy sources (RES) in Europe, creating several operational challenges. One of the key approaches to resolve these is to help harness RESs in an efficient and cost-effective way is to utilise flexibility which can be provided by Distributed Energy Resources (DERs) which include active demand participation, energy storage and electric vehicles. The present paper is based on results and learnings of H2020 project SmartNet (2016-2019), where five coordination schemes for TSO-DSO interaction, necessary for procurement and activation of ancillary services were developed and comparatively evaluated. The paper discusses how different coordination schemes all have specific benefits and attention points related to operation of the TSO and DSO grids, other market participants involved and the market operation in general

Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms

Abstract Background Abdominal aortic aneurysms are a common disorder with an incompletely understood etiology. We used Illumina and Affymetrix microarray platforms to generate global gene expression profiles for both aneurysmal (AAA) and non-aneurysmal abdominal aorta, and identified genes that were significantly differentially expressed between cases and controls. Results Affymetrix and Illumina arrays included 18,057 genes in common; 11,542 (64%) of these genes were considered to be expressed in either aneurysmal or normal abdominal aorta. There were 3,274 differentially expressed genes with a false discovery rate (FDR) ≤ 0.05. Many of these genes were not previously known to be involved in AAA, including SOST and RUNX3, which were confirmed using Q-RT-PCR (Pearson correlation coefficient for microarray and Q-RT-PCR data = 0.89; p-values for differences in expression between AAA and controls for SOST: 4.87 × 10-4 and for RUNX3: 4.33 × 10-5). Analysis of biological pathways, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), indicated extreme overrepresentation of immune related categories. The enriched categories included the GO category Immune Response (GO:0006955; FDR = 2.1 × 10-14), and the KEGG pathways natural killer cell mediated cytotoxicity (hsa04650; FDR = 5.9 × 10-6) and leukocyte transendothelial migration (hsa04670; FDR = 1.1 × 10-5). Conclusion Previous studies have provided evidence for the involvement of the immune system in AAA. The current expression analysis extends these findings by demonstrating broad coordinate gene expression in immunological pathways. A large number of genes involved in immune function were differentially expressed in AAA, and the pathway analysis gave these results a biological context. The data provide valuable insight for future studies to dissect the pathogenesis of human AAA. These pathways might also be used as targets for the development of therapeutic agents for AAA

Exploring multiple-discreteness in freight transport : a multiple discrete extreme value model application for grain consolidators in Argentina

There are some examples where freight choices may be of a multiple discrete nature, especially the ones at more tactical levels of planning. Nevertheless, this has not been investigated in the literature, although several discrete-continuous models for mode/vehicle type and shipment size choice have been developed in freight transport. In this work, we propose that the decision of port and mode of the grain consolidators in Argentina is of a discrete-continuous nature, where they can choose more than one alternative and how much of their production to send by each mode. The Multiple Discrete Extreme Value Model (MDCEV) framework was applied to a stated preference data set with a response variable that allowed this multiple-discreteness. To our knowledge, this is the only application of the MDCEV in regional freight context. Free alongside ship price, freight transport cost, lead-time and travel time were included in the utility function and observed and random heterogeneity was captured by the interaction with the consolidator’s characteristics and random coefficients. In addition, different discrete choice models were used to compare the forecasting performance, willingness to pay measures and structure of the utility function against

Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia

<p>Abstract</p> <p>Background</p> <p>In utero interactions between incompatible maternal and fetal genotypes are a potential mechanism for the onset or progression of pregnancy related diseases such as pre-eclampsia (PE). However, the optimal analytical approach and study design for evaluating incompatible maternal/offspring genotype combinations is unclear.</p> <p>Methods</p> <p>Using simulation, we estimated the type I error and power of incompatible maternal/offspring genotype models for two analytical approaches: logistic regression used with case-control mother/offspring pairs and the log-linear regression used with case-parent triads. We evaluated a real dataset consisting of maternal/offspring pairs with and without PE for incompatibility effects using the optimal analysis based on the results of the simulation study.</p> <p>Results</p> <p>We identified a single coding scheme for the incompatibility effect that was equally or more powerful than all of the alternative analysis models evaluated, regardless of the true underlying model for the incompatibility effect. In addition, the log-linear regression was more powerful than the logistic regression when the heritability was low, and more robust to adjustment for maternal or fetal effects. For the PE data, this analysis revealed three genes, lymphotoxin alpha (<it>LTA</it>), von Willebrand factor (<it>VWF</it>), and alpha 2 chain of type IV collagen (<it>COL4A2</it>) with possible incompatibility effects.</p> <p>Conclusion</p> <p>The incompatibility model should be evaluated for complications of pregnancy, such as PE, where the genotypes of two individuals may contribute to the presence of disease.</p

Immunohistochemical Analysis of the Natural Killer Cell Cytotoxicity Pathway in Human Abdominal Aortic Aneurysms

Our previous analysis using genome-wide microarray expression data revealed extreme overrepresentation of immune related genes belonging the Natural Killer (NK) Cell Mediated Cytotoxicity pathway (hsa04650) in human abdominal aortic aneurysm (AAA). We followed up the microarray studies by immunohistochemical analyses using antibodies against nine members of the NK pathway (VAV1, VAV3, PLCG1, PLCG2, HCST, TYROBP, PTK2B, TNFA, and GZMB) and aortic tissue samples from AAA repair operations (n = 6) and control aortae (n = 8) from age-, sex- and ethnicity-matched donors from autopsies. The results confirmed the microarray results. Two different members of the NK pathway, HCST and GRZB, which act at different steps in the NK-pathway, were actively transcribed and translated into proteins in the same cells in the AAA tissue demonstrated by double staining. Furthermore, double staining with antibodies against CD68 or CD8 together with HCST, TYROBP, PTK2B or PLCG2 revealed that CD68 and CD8 positive cells expressed proteins of the NK-pathway but were not the only inflammatory cells involved in the NK-pathway in the AAA tissue. The results provide strong evidence that the NK Cell Mediated Cytotoxicity Pathway is activated in human AAA and valuable insight for future studies to dissect the pathogenesis of human AAA