626 research outputs found

    Gauge Coupling Unification in E6 F-Theory GUTs with Matter and Bulk Exotics from Flux Breaking

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    We consider gauge coupling unification in E6 F-Theory Grand Unified Theories (GUTs) where E6 is broken to the Standard Model (SM) gauge group using fluxes. In such models there are two types of exotics that can affect gauge coupling unification, namely matter exotics from the matter curves in the 27 dimensional representation of E6 and the bulk exotics from the adjoint 78 dimensional representation of E6. We explore the conditions required for either the complete or partial removal of bulk exotics from the low energy spectrum. In the latter case we shall show that (miraculously) gauge coupling unification may be possible even if there are bulk exotics at the TeV scale. Indeed in some cases it is necessary for bulk exotics to survive to the TeV scale in order to cancel the effects coming from other TeV scale matter exotics which would by themselves spoil gauge coupling unification. The combination of matter and bulk exotics in these cases can lead to precise gauge coupling unification which would not be possible with either type of exotics considered by themselves. The combination of matter and bulk exotics at the TeV scale represents a unique and striking signature of E6 F-theory GUTs that can be tested at the LHC.Comment: 21 pages, 5 figure

    General mutation databases : analysis and review

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    Databases of mutations causing Mendelian disease play a crucial role in research, diagnostic and genetic health care and can play a role in life and death decisions. These databases are thus heavily used, but only gene or locus specific databases have been previously reviewed for completeness, accuracy, currency and utility. We have performed a review of the various general mutation databases that derive their data from the published literature and locus specific databases. Only two&mdash;the Human Gene Mutation Database (HGMD) and Online Mendelian Inheritance in Man (OMIM)&mdash;had useful numbers of mutations. Comparison of a number of characteristics of these databases indicated substantial inconsistencies between the two databases that included absent genes and missing mutations. This situation strengthens the case for gene specific curation of mutations and the need for an overall plan for collection, curation, storage and release of mutation data.<br /

    Energy from waste and the food processing industry

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    The provision of a secure, continuous energy supply is becoming an issue for all sectors of society and the foodprocessingindustry as a major energy user must address these issues. This paper identifies anaerobic digestion as an opportunity to go some way to achieving energy security in a sustainable manner. However, a number of energy management and waste reduction concepts must also be brought into play if the environmental, social and economic aspects of sustainability are to be balanced. The reporting of such activity will help to promote the green credentials of the industry. Cleaner production, supply chain and life cycle assessment approaches all have a part to play as tools supporting a new vision for integrated energy and waste management. Our reliance on high-energyprocessing, such as canning and freezing/chill storage, might also need re-assessment together with processing based on hurdle technology. Finally, the concepts of energy and power management for a distributed energy generation system must be brought into the foodprocessingindustry

    Interpreting the Outsider Tradition in British European Policy Speeches from Thatcher to Cameron

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    The article investigates how British European policy thinking has been informed by what it identifies as an ‘outsider’ tradition of thinking about ‘Europe’ in British foreign policy dating from imperial times to the presen. The article begins by delineating five phases in the evolution of the outsider tradition through a survey of the relevant historiography back to 1815. The article then examines how prime ministers from Margaret Thatcher to David Cameron have looked to various inflections of the outsider tradition to inform their European discourses. The focus in the speech data sections is on British identity, history and the realist appreciation of international politics that informed the leaders’ suggestions for EEC/EU reform. The central argument is that historically informed narratives such as those making up the outsider tradition do not determine opinion-formers’ outlooks, but that they can be deeply impervious to rapid change
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