Development Scenarios for Eastern European Cities and Regions in the New Europe

In this paper we focus on urban growth dynamics of Eastern European cities and regions in the past and in the new Europe. This work is a part of on-going research in the field of urban and regional development, carried out in Joint Research Centre (JRC) of the European Commission. Eastern European cities experienced similar and very turbulent historical and political development during 20th century. The policies during the communist period with planned economy has clearly reflected in the land use pattern development, e.g. the absence of large suburbs and underdeveloped transport networks around cities. In contrast to other European cities, no or very few commercial zones and commercial centres were built in suburban areas. In addition, satellite cities were built only on a limited scale. With the collapse of communist regimes cities and regions in Eastern Europe have entered into a new phase of urbanisation, which changes dramatically land use patterns. The liberalization of economy and the membership of the EU has led to the growing involvement to the European market and EU development schemes (e.g. TEN/T, ERDF, etc.). In spite of the expected decrease of population in the new EU countries the average gross domestic product is projected to triple and the number of households per capita is projected to double between 2000 and 2030 (EEA, 2005¬/4). Among the consequences of socio-economic development the continuous growth of urban areas can be foreseen. What shapes urban sprawl will take and will it cause new threads to sustainability remains to be seen. In this paper we focus on two study cases (1) the Dresden – Prague transport corridor in Germany and in the Czech Republic (Barredo et al, 2005) and (2) the Harjumaa region and the city of Tallinn in Estonia. The objective of this work is to test the impact of diverse economic development trends on urbanisation processes. Several development scenarios are produced in order to model the spatial pattern of urban land use. The MOLAND urban and regional growth simulation model (Lavalle et al, 2004), based on “cellular automata†(CA), is a key instrument in the forecasting land use development. The model operates at two levels. At the micro- level, the CA-based model determines the fate of individual land use cells based on the type of the activities in their neighbourhood. At the macro- level, various additional factors such as overall land use demand, effects of the transportation network as well as legislative, environmental and institutional characteristics (e.g. environmental protection, zoning) constrain the behaviour of the CA-model. This approach allowed us to integrate “physicalâ€, environmental, socio-economic development as well as institutional aspect of territorial development. The scenarios offer a useful approach to analysing and understanding urban land use dynamics and can also serve for landscape management at the local and regional scales, complementing existing policies and programmes. In both study cases we evaluate the impact newly developed motorways’ supported by EU Structural Funds. Very important feature of Dresden-Prague corridor is the extreme flood events in 2002. The increasing vulnerability to natural hazards due to rapid urban development in flood-prone area is also discussed in the paper.

The quantum-classical transition in thermally seeded parametric downconversion

We address the pair of conjugated field modes obtained from parametric-downconversion as a convenient system to analyze the quantum-classical transition in the continuous variable regime. We explicitly evaluate intensity correlations, negativity and entanglement for the system in a thermal state and show that a hierarchy of nonclassicality thresholds naturally emerges in terms of thermal and downconversion photon number. We show that the transition from quantum to classical regime may be tuned by controlling the intensities of the seeds and detected by intensity measurements. Besides, we show that the thresholds are not affected by losses, which only modify the amount of nonclassicality. The multimode case is also analyzed in some detail.Comment: 12 pages, 3 figure

The quantum-classical transition in thermally seeded parametric downconversion

We address the pair of conjugated field modes obtained from parametric-downconversion as a convenient system to analyze the quantum-classical transition in the continuous variable regime. We explicitly evaluate intensity correlations, negativity and entanglement for the system in a thermal state and show that a hierarchy of nonclassicality thresholds naturally emerges in terms of thermal and downconversion photon number. We show that the transition from quantum to classical regime may be tuned by controlling the intensities of the seeds and detected by intensity measurements. Besides, we show that the thresholds are not affected by losses, which only modify the amount of nonclassicality. The multimode case is also analyzed in some detail.Comment: 12 pages, 3 figure

An autoregulatory loop controls the expression of the transcription factor NF-Y

The heterotrimeric NF-Y complex is a pioneer factor that binds to CCAAT-genes and regulates their transcription. NF-Y cooperates with multiple transcription factors and co-regulators in order to positively or negatively influence gene transcription. The recruitment of NF-Y to CCAAT box is significantly enriched in cancer-associated gene promoters loci and positively correlates with malignancy. NF-Y subunits, in particular the DNA-binding subunit NF-YA and the histone-fold subunit NF-YC, appear overexpressed in specific types of cancer. Here we demonstrate that NF-Y subunits expression is finely regulated through transcriptional and post-translational mechanisms thus allowing control over basal expression levels. NF-Y negatively regulates the transcription of the genes encoding for its subunits. DNA pull-down/affinity purification assay coupled with Mass Spectrometry identified putative co-regulators, such as Lamin A, involved in NF-YA gene transcription level. We also evidentiate how the stability of the complex is severely affected by the absence of one subunit. Our results identified for the first time one of the mechanisms responsible for NF-Y expression, which may be involved in the aberrant expression and activity observed in tumor cells and other pathological conditions

Improved implementation of nonclassicality test for a single particle

Recently a test of nonclassicality for a single qubit was proposed [R. Alicki and N. Van Ryn, J. Phys. A: Math. Theor. 41, 062001 (2008)]. We present an optimized experimental realization of this test leading to a 46 standard deviation violation of classicality. This factor of 5 improvement over our previous result was achieved by moving from the infrared to the visible where we can take advantage of higher efficiency and lower noise photon detectors.Comment: 4 pages, 1 figur

Towards an Integrated Scenario Approach for Spatial Planning and Natural Hazards Mitigation

In the frame of the support to the conception, definition and implementation of European policies, the Land Management Unit of the Institute for Environment and Sustainability (Directorate General Joint Research Centre (DG-JRC) of the European Commission (EC)) is developing an integrated framework to evaluate and propose strategies for the sustainable management of the European territory. An important tool within this framework is the MOLAND (Monitoring Land Use/Cover Dynamics) model for urban and regional growth forecast. The model is part of an integrated methodology based on a set of spatial planning tools that can be used for assessing, monitoring and modelling the development of urban and regional environments. The MOLAND model has been specifically designed for urban and regional development assessment. It is based on a spatial dynamics bottom-up approach. The model takes as input several georeferenced datasets for the future simulation of urban areas and/or regions. Thus, future urban scenarios can be produced by taking into account land use development trends, population growth, socio-economic factors and spatial planning policies. Urban simulations offer a useful approach to understanding the consequences of current spatial planning policies. Among other causes the analysis of urban areas and their development has particular relevance because of their growing exposure to natural hazards, particularly floods and forest fires. Inappropriate regional and urban planning can exacerbate the negative effects of natural hazards. On the other hand, good land management and planning practices, including appropriate land use and development control in flood-prone areas, represent suitable non-structural solutions to minimise flood damage. The effects of urban and regional development on flood risk should be evaluated to support both flood protection and spatial planning policies. This work supports policies such as the 6th Environment Action Program (Thematic Strategy on the Urban Environment; Thematic Strategy on Soil Protection), the forthcoming Floods Directive “Reducing the risks of floods in Europe”, the ESPON (European Spatial Planning Observation Network) programme, and the growing awareness at local level amongst spatial policy-makers of the close connections between world-wide land degradation and global change, as underpinned by the European Climate Change Programme. The new regulations for renewed Structural Funds and instruments for the period 2007-2013, adopted by the EC on 14 July 2004, foresee specific measures for “developing plans and measures to prevent and cope with natural risks”.JRC.H.7-Land management and natural hazard

Is a Quantum Biosensing Revolution Approaching? Perspectives in NV‐Assisted Current and Thermal Biosensing in Living Cells

none8openPetrini, Giulia; Moreva, Ekaterina; Bernardi, Ettore; Traina, Paolo; Tomagra, Giulia; Carabelli, Valentina; Degiovanni, Ivo Pietro; Genovese, MarcoPetrini, Giulia; Moreva, Ekaterina; Bernardi, Ettore; Traina, Paolo; Tomagra, Giulia; Carabelli, Valentina; Degiovanni, Ivo Pietro; Genovese, Marc

Blending or Bonding? Mechanochromism of an Aggregachromic Mechanophore in a Thermoplastic Elastomer

A straightforward way for the preparation of mechanochromic polymers consists of incorporating a suitable content of a mechanophore in the polymeric matrix either by physical dispersion or via covalent functionalization. Although covalent incorporation may require demanding chemical efforts, this approach can offer significant advantages over physical dispersion. In this work, a common thermoplastic elastomer, styrene-b-(ethylene-co-butylene)-b-styrene triblock copolymer grafted with maleic anhydride (SEBS-MAH), was covalently functionalized with 1-aminomethylpyrene (AMP). MAH functional groups are covalently linked to the ethylene-co-butylene blocks, thus allowing a precise and selective confinement of the chromogenic AMP units in the soft block. Flat, fully conjugated pyrene units undergo the reversible formation of π-πaggregates, readily distinguishable by their red-shifted emission. These aggregates were heavily affected by the application of mechanical stimuli. Despite the low degree of mechanophore functionalization (about 1 wt %), uniaxial deformation of the polymer was reliably monitored via fluorescence and a clear drop in the excimer to monomer emission ratio (IE/IM) was observed starting from 50% of strain. The marked mechanochromism was confirmed by emission lifetime measurements and also by near-field investigations. In addition, the mechanoresponse showed good reversibility after repeated stress-relaxation cycles. Control experiments performed on formulations comprising a physical dispersion of pyrene in unfunctionalized SEBS showed faint excimer emission and a negligible mechanochromic response up to 5 wt % of doping, in substantial agreement with the scanning near-field optical microscopy analysis. An evident drop of the IE/IM ratio occurred for 10 wt % of pyrene, albeit the excimer emission remained predominant even at the highest deformation, being a smaller fraction of pyrene moieties involved. Overall, the covalent approach appeared as an elegant procedure to confine the chromogenic unit in the soft phase of block copolymers and thus to provide an elastomeric film showing a detectable and reversible mechanochromic response with a modest (i.e., ∼1 wt %) amount of pyrene molecules, i.e., 10 times smaller compared to the dispersed system