Advanced Mid-Water Tools for 4D Marine Data Fusion and Visualization

Mapping and charting of the seafloor underwent a revolution approximately 20 years ago with the introduction of multibeam sonars -- sonars that provided complete, high-resolution coverage of the seafloor rather than sparse measurements. The initial focus of these sonar systems was the charting of depths in support of safety of navigation and offshore exploration; more recently innovations in processing software have led to approaches to characterize seafloor type and for mapping seafloor habitat in support of fisheries research. In recent years, a new generation of multibeam sonars has been developed that, for the first time, have the ability to map the water column along with the seafloor. This ability will potentially allow multibeam sonars to address a number of critical ocean problems including the direct mapping of fish and marine mammals, the location of mid-water targets and, if water column properties are appropriate, a wide range of physical oceanographic processes. This potential relies on suitable software to make use of all of the new available data. Currently, the users of these sonars have a limited view of the mid-water data in real-time and limited capacity to store it, replay it, or run further analysis. The data also needs to be integrated with other sensor assets such as bathymetry, backscatter, sub-bottom, seafloor characterizations and other assets so that a “complete” picture of the marine environment under analysis can be realized. Software tools developed for this type of data integration should support a wide range of sonars with a unified format for the wide variety of mid-water sonar types. This paper describes the evolution and result of an effort to create a software tool that meets these needs, and details case studies using the new tools in the areas of fisheries research, static target search, wreck surveys and physical oceanographic processes

Craig Goch Report No. 14 The production of juvenile Atlantic salmon (Salmo salar L.) in the Upper Wye, Wales

Apart from the work of Egglishaw (1970) there are few data available on the production of Atlantic salmon (Salmo salar L.) in freshwaters. Stream studies on salmon are generally confined to the enumeration of smolts (Elson, 1957a; Meister, 1962; Jessop, 1975). In contrast, the production of brown trout (S. trutta L.), brook trout (Salvelinus fontinalis Mitchill) and coho salmon (Oncorhynchus kisutch Walbaum) is well documented (Allen, 1951; Hunt 1974; Chapman, 1965). This paper reports estimates of salmon production (sensu Ivlev, 1966) in 16 study sites in 16 study sites in the upper catchment of the River Wye over a two year period and forms part of a broader study of fish populations in the Wye

Craig Goch Report No. 10 The effect of density on mortality in juvenile Atlantic salmon (Salmo salar L.)

Le Cren (1973) suggested that the most likely population-regulating process in salmonid populations is density-dependent territorial behaviour. Thus, in trout (Salmo trutta L.) populations aggressive territorial behaviour was manifested in density-dependent mortality and the size of the adult stock was largely dependent on the area of suitable rearing ground for the fry (Le Cren, 1973). Ricker (1954) also concluded that in most fish populations compensatory mortality in the juvenile stages, rather than in the mature stock, was of greatest importance as a regulator of population size. The nature of such regulating mechanisms in juvenile populations is, therefore, of fundamental importance in the understanding of the dynamics of fish populations and the implementation of management policies. This paper considers mortality rates of young Atlantic salmon (Salmo salar L.) in the upper catchment of the R. Wye over a two year period. The work forms part of a broader study of fish populations in the R. Wye

Craig Goch Report No. 10 The effect of density on mortality in juvenile Atlantic salmon (Salmo salar L.)

Le Cren (1973) suggested that the most likely population-regulating process in salmonid populations is density-dependent territorial behaviour. Thus, in trout (Salmo trutta L.) populations aggressive territorial behaviour was manifested in density-dependent mortality and the size of the adult stock was largely dependent on the area of suitable rearing ground for the fry (Le Cren, 1973). Ricker (1954) also concluded that in most fish populations compensatory mortality in the juvenile stages, rather than in the mature stock, was of greatest importance as a regulator of population size. The nature of such regulating mechanisms in juvenile populations is, therefore, of fundamental importance in the understanding of the dynamics of fish populations and the implementation of management policies. This paper considers mortality rates of young Atlantic salmon (Salmo salar L.) in the upper catchment of the R. Wye over a two year period. The work forms part of a broader study of fish populations in the R. Wye

Conference on the Magnetization of the Oceanic Crust Steers Future Research

Because marine magnetic anomalies arise from the combination of seafloor spreading and geomagnetic polarity reversals, they delineate a history of global plate motions and geomagnetic field behavior. Thirty years ago, interpretation of sea surface magnetometer profiles led to the plate tectonics revolution. Recent developments in high resolution magnetic studies are similarly changing our view of the structure and evolution of oceanic crust and beginning to answer basic questions concerning geomagnetic field behavior. In response to these developments, the Conference on the Magnetization of Oceanic Crust was held September 21-24,1996, on Orcas Island in Washington State. Forty-seven scientists representing 20 institutions in seven countries attended the conference, which was funded by the National Science Foundation, the Ridge Interdisciplinary Global Experiment (RIDGE), and the United States Science Advisory Committee (USSAC)

Central Anomaly Magnetization High documentation of crustal accretion along the East Pacific Rise (9°55′–9°25′N)

Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 9 (2008): Q04015, doi:10.1029/2007GC001611.Near-bottom magnetic data collected along the crest of the East Pacific Rise between 9°55′ and 9°25′N identify the Central Anomaly Magnetization High (CAMH), a geomagnetic anomaly modulated by crustal accretionary processes over timescales of ∼104 years. A significant decrease in CAMH amplitude is observed along-axis from north to south, with the steepest gradient between 9°42′ and 9°36′N. The source of this variation is neither a systematic change in geochemistry nor varying paleointensity at the time of lava eruption. Instead, magnetic moment models show that it can be accounted for by an observed ∼50% decrease in seismic Layer 2A thickness along-axis. Layer 2A is assumed to be the extrusive volcanic layer, and we propose that this composes most of the magnetic source layer along the ridge axis. The 9°37′N overlapping spreading center (OSC) is located at the southern end of the steep CAMH gradient, and the 9°42′–9°36′N ridge segment is interpreted to be a transition zone in crustal accretion processes, with robust magmatism north of 9°42′N and relatively low magmatism at present south of 9°36′N. The 9°37′N OSC is also the only bathymetric discontinuity associated with a shift in the CAMH peak, which deviates ∼0.7 km to the west of the axial summit trough, indicating southward migration of the OSC. CAMH boundaries (defined from the maximum gradients) lie within or overlie the neovolcanic zone (NVZ) boundaries throughout our survey area, implying a systematic relationship between recent volcanic activity and CAMH source. Maximum flow distances and minimum lava dip angles are inferred on the basis of the lateral distance between the NVZ and CAMH boundaries. Lava dip angles average ∼14° toward the ridge axis, which agrees well with previous observations and offers a new method for estimating lava dip angles along fast spreading ridges where volcanic sequences are not exposed.The research project was funded by National Science Foundation under grants OCE-9819261 and OCE- 0096468

Evaluation of the current knowledge limitations in breast cancer research: a gap analysis

BACKGROUND A gap analysis was conducted to determine which areas of breast cancer research, if targeted by researchers and funding bodies, could produce the greatest impact on patients. METHODS Fifty-six Breast Cancer Campaign grant holders and prominent UK breast cancer researchers participated in a gap analysis of current breast cancer research. Before, during and following the meeting, groups in seven key research areas participated in cycles of presentation, literature review and discussion. Summary papers were prepared by each group and collated into this position paper highlighting the research gaps, with recommendations for action. RESULTS Gaps were identified in all seven themes. General barriers to progress were lack of financial and practical resources, and poor collaboration between disciplines. Critical gaps in each theme included: (1) genetics (knowledge of genetic changes, their effects and interactions); (2) initiation of breast cancer (how developmental signalling pathways cause ductal elongation and branching at the cellular level and influence stem cell dynamics, and how their disruption initiates tumour formation); (3) progression of breast cancer (deciphering the intracellular and extracellular regulators of early progression, tumour growth, angiogenesis and metastasis); (4) therapies and targets (understanding who develops advanced disease); (5) disease markers (incorporating intelligent trial design into all studies to ensure new treatments are tested in patient groups stratified using biomarkers); (6) prevention (strategies to prevent oestrogen-receptor negative tumours and the long-term effects of chemoprevention for oestrogen-receptor positive tumours); (7) psychosocial aspects of cancer (the use of appropriate psychosocial interventions, and the personal impact of all stages of the disease among patients from a range of ethnic and demographic backgrounds). CONCLUSION Through recommendations to address these gaps with future research, the long-term benefits to patients will include: better estimation of risk in families with breast cancer and strategies to reduce risk; better prediction of drug response and patient prognosis; improved tailoring of treatments to patient subgroups and development of new therapeutic approaches; earlier initiation of treatment; more effective use of resources for screening populations; and an enhanced experience for people with or at risk of breast cancer and their families. The challenge to funding bodies and researchers in all disciplines is to focus on these gaps and to drive advances in knowledge into improvements in patient care

Magnetization of 0–29 Ma ocean crust on the Mid-Atlantic Ridge, 25°30′ to 27°10′N

Author Posting. © American Geophysical Union, 1998. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 103, No. B8 (1998): 17807–17826, doi:10.1029/98JB01394.A sea-surface magnetic survey over the west flank of the Mid-Atlantic Ridge from 0 to 29 Ma crust encompasses several spreading segments and documents the evolution of crustal magnetization in slowly accreted crust. We find that magnetization decays rapidly within the first few million years, although the filtering effect of water depth on the sea-surface data and the slow spreading rate (<13 km/m.y.) preclude us from resolving this decay rate. A distinctly asymmetric, along-axis pattern of crustal magnetization is rapidly attenuated off-axis, suggesting that magnetization dominated by extrusive lavas on-axis is reduced off-axis to a background value. Off-axis, we find a statistically significant correlation between crustal magnetization and apparent crustal thickness with thin crust tending to be more positively magnetized than thicker crust, indicative of induced magnetization in thin inside corner (IC) crust. In general, we find that off-axis segment ends show an induced magnetization component regardless of polarity and that IC segment ends tend to have slightly more induced component compared with outside corner (OC) segment ends, possibly due to serpentinized uppermost mantle at IC ends. We find that remanent magnetization is also reduced at segment ends, but there is no correlation with inside or outside corner crust, even though they have very different crustal thicknesses. This indicates that remanent magnetization off-axis is independent of crustal thickness, bulk composition, and the presence or absence of extrusives. Remanence reduction at segment ends is thought to be primarily due to alteration of lower crust in OC crust and a combination of crustal thinning and alteration in IC crust. From all these observations, we infer that the remanent magnetization of extrusive crust is strongly attenuated off-axis, and that magnetization of the lower crust may be the dominant source for off-axis magnetic anomalies.M. Tivey was supported by ONR grant N00014-94-1-0467 and NSF grant OCE-9200905 and B. Tucholke was supported by ONR grant N00014-94-1-0466 and NSF grant OCE-9503561. Data were collected under ONR grant N00014-90-JI612

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer's disease, and experimental data have demonstrated microglial proliferation as a significant component of the neuropathology. In this study, we tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 (JNJ-527) in the P301S mouse tauopathy model. We first demonstrated the anti-proliferative effects of JNJ-527 on microglia in the ME7 prion model, and its impact on the inflammatory profile, and provided potential CNS biomarkers for clinical investigation with the compound, including pharmacokinetic/pharmacodynamics and efficacy assessment by TSPO autoradiography and CSF proteomics. Then, we showed for the first time that blockade of microglial proliferation and modification of microglial phenotype leads to an attenuation of tau-induced neurodegeneration and results in functional improvement in P301S mice. Overall, this work strongly supports the potential for inhibition of CSF1R as a target for the treatment of Alzheimer's disease and other tau-mediated neurodegenerative diseases

Inflammatory biomarkers in Alzheimer&apos;s disease plasma

Introduction: Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a \u201cHoly Grail\u201d of AD research and intensively sought; however, there are no well-established plasma markers. Methods: A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed. Results: Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APO\u3b54 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71). Discussion: Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation