Further development of an in vitro model for studying the penetration of chemicals through compromised skin

A new in vitro model based on the electrical resistance properties of the skin barrier has been established in this laboratory. The model utilises a tape stripping procedure in dermatomed pig skin that removes a specific proportion of the stratum corneum, mimicking impaired barrier function observed in humans with damaged skin. The skin penetration and distribution of chemicals with differing physicochemical properties, namely; Benzoic acid, 3-Aminophenol, Caffeine and Sucrose has been assessed in this model. Although, skin penetration over 24 h differed for each chemical, compromising the skin did not alter the shape of the time course profile, although absorption into receptor fluid was higher for each chemical. Systemic exposure (receptor fluid, epidermis and dermis), was marginally higher in compromised skin following exposure to the fast penetrant, Benzoic acid, and the slow penetrant Sucrose. The systemically available dose of 3-Aminophenol increased to a greater extent and the absorption of Caffeine was more than double in compromised skin, suggesting that Molecular Weight and Log Pow, are not the only determinants for assessing systemic exposure under these conditions. Although further investigations are required, this in vitro model may be useful for prediction of dermal route exposure under conditions where skin barrier is impaired

Geologic Evidence for Onshore Sediment Transport from the Inner Continental Shelf: Fire Island, New York

Schwab, W.C.; Baldwin, W.E.; Hapke, C.J.; Lentz, E.E.; Gayes, P.T.; Denny, J.F.; List, J.H., and Warner, J.C., 2013. Geologic evidence for onshore sediment transport from the inner continental shelf: Fire Island, New York. Sediment budget analyses along the south shore of Fire Island, New York, have been conducted and debated in the scientific and coastal engineering literature for decades. It is well documented that a primary component of sediment transport in this system is directed alongshore from E to W, but discrepancies in volumetric sediment budget calculations remain. An additional quantity of sand, averaging about 200,000 m3/y is required to explain the growth of the western segment of the barrier island, a prograding spit. Littoral sediment derived from updrift erosion of the coast, addition of beach nourishment fill, and onshore transport of inner continental shelf, shoreface sediments, or both have all been proposed as potential sources of the additional sediment needed to balance the sediment budget deficit. Analysis of high-resolution seafloor mapping data collected in 2011, including seismic reflection profiles and inteferometric sonar acoustic backscatter and swath bathymetry; comparison with seafloor mapping data collected in 1996–1997; and shoreline change analysis from 1933 to 2011 support previous suggestions that the inner-shelf Holocene sedimentary deposit is a likely source to resolve this sediment budget discrepancy

Modification of the Quaternary stratigraphic Framework of the Inner-continental Shelf by Holocene Marine Transgression: An Example Offshore of Fire Island, New York

The inner-continental shelf off Fire Island, New York was mapped in 2011 using interferometric sonar and high-resolution chirp seismic-reflection systems. The area mapped is approximately 50 km long by 8 km wide, extending from Moriches Inlet to Fire Island Inlet in water depths ranging from 8 to 32 m. The morphology of this inner-continental shelf region and modern sediment distribution patterns are determined by erosion of Pleistocene glaciofluvial sediments during the ongoing Holocene marine transgression; much of the shelf is thus an actively forming ravinement surface. Remnants of a Pleistocene outwash lobe define a submerged headland offshore of central Fire Island. East of the submerged headland, relatively older Pleistocene outwash is exposed over much of the inner-continental shelf and covered by asymmetric, sorted bedforms interpreted to indicate erosion and westward transport of reworked sediment. Erosion of the eastern flank of the submerged Pleistocene headland over the last ~ 8000 years yielded an abundance of modern sand that was transported westward and reworked into a field of shoreface-attached ridges offshore of western Fire Island. West of the submerged headland, erosion of Pleistocene outwash continues in troughs between the sand ridges, resulting in modification of the lower shoreface. Comparison of the modern sand ridge morphology with the morphology of the underlying ravinement surface suggests that the sand ridges have moved a minimum of ~ 1000 m westward since formation. Comparison of modern sediment thickness mapped in 1996–1997 and 2011 allows speculation that the nearshore/shoreface sedimentary deposit has gained sediment at the expense of deflation of the sand ridges