Strategy to determine the foot plantar center of pressure of a person through deep learning neural networks

Some case studies treated by physiotherapists or orthopedists to measure the alignment of the lower extremities during a gait cycle are based on empirical methods of visual observation. This methodology does not guarantee total success, since it depends on the experience of the specialist, what can cause irreversible damage to patients, such as: hip displacement, wear and overload of the joints of a single lower limb. Although, this problem has been addressed in the investigation by means of devices implementation with sensors or methods of processing sequences of images and videos, this topic is still under investigation because the current methods depend on many external elements and data given by an expert in the area. Therefore, this paper proposes a partial solution to this problem by systematizing the experience of a specialist through a computational learning method

Recognition system for facial expression by processing images with deep learning neural network

The recognition systems of patterns in images are mechanisms that filter the information that provides an image to highlight the area of interest for the user. Usually, these mechanisms are based on mathematical transformations that allow the processor to perform interpretations based on the geometry or shape of the image. However, the strategies that implement mathematical transformations are limited, since the effectiveness of these techniques is reduced by changing the morphology or resolution of the image. This paper presents a partial solution to this limitation with a digital image processing technique based on a deep learning neural network (DNN). This technique incorporates a mechanism that allows the DNN to determine the facial expression of a person, based on the segmented information of the image of their face. By segmenting the image and processing its characteristics in parallel, the proposed technique increases the effectiveness of recognizing facial gestures in different images even when modifying their characteristics

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Strategy to determine the foot plantar center of pressure of a person through deep learning neural networks

Some case studies treated by physiotherapists or orthopedists to measure the alignment of the lower extremities during a gait cycle are based on empirical methods of visual observation. This methodology does not guarantee total success, since it depends on the experience of the specialist, what can cause irreversible damage to patients, such as: hip displacement, wear and overload of the joints of a single lower limb. Although, this problem has been addressed in the investigation by means of devices implementation with sensors or methods of processing sequences of images and videos, this topic is still under investigation because the current methods depend on many external elements and data given by an expert in the area. Therefore, this paper proposes a partial solution to this problem by systematizing the experience of a specialist through a computational learning method

Different outcomes for transplant-eligible newly diagnosed multiple myeloma patients in Latin America according to the public versus private management: a GELAMM study

The aim of this study was to describe clinical and survival characteristics of transplant-eligible multiple myeloma (MM) patients in Latin America (LA), with a special focus on differences between public and private healthcare facilities. We included 1293 patients diagnosed between 2010 and 2018. A great disparity in outcomes and survival between both groups was observed. Late diagnosis and low access to adequate frontline therapy and ASCT in public institutions probably explain these differences. Patients treated with novel drug induction protocols, followed by autologous stem cell transplantation (ASCT) and maintenance, have similar overall survival compared to that published internationally