Brain Amino Acids and Biogenic Amines Under Various Atmospheric Mixtures Semiannual Report, 1 Mar. 1965 - 30 Apr. 1966

Effects of exposure to different gaseous atmospheric mixtures on free amino acids and biogenic amines in rat brain

A high resolution scintillating fiber tracker with SiPM readout for the PEBS experiment

Using thin scintillating fibers with Silicon Photomultiplier (SiPM) readout a mo dular high-resolution charged-particle tracking detector has been designed. The fiber modules consist of 2 x 5 layers of 128 round multiclad scintillating fiber s of 0.250mm diameter. The fibers are read out by four SiPM arrays (8mm x 1mm) e ach on either end of the module.Comment: 6 pages, 5 figures, presented at the ICATPP 1

Charting the TeV Milky Way: H.E.S.S. Galactic plane survey maps, catalog and source populations

Very-high-energy (VHE, E>100 GeV) gamma-rays provide a unique view of the non-thermal universe, tracing the most violent and energetic phenomena at work inside our Galaxy and beyond. The latest results of the H.E.S.S. Galactic Plane Survey (HGPS) undertaken by the High Energy Stereoscopic System (H.E.S.S.), an array of four imaging atmospheric Cherenkov telescopes located in Namibia, are described here. The HGPS aims at the detection of cosmic accelerators with environments suitable for the production of photons at the highest energies and has led to the discovery of an unexpectedly large and diverse population of over 60 sources of TeV gamma rays within its current range of l = 250 to 65 degrees in longitude and |b|<3.5 degrees in latitude. The data set of the HGPS comprises 2800 hours of high-quality data, taken in the years 2004 to 2013. The sensitivity for the detection of point-like sources, assuming a power-law spectrum with a spectral index of 2.3 at a statistical significance of 5 sigma, is now at the level of 2% Crab or better in the core HGPS region. The latest maps of the inner Galaxy at TeV energies are shown alongside an introduction to the first H.E.S.S. Galactic Plane Survey catalog. Finally, in addition to an overview of the H.E.S.S. Galactic source population a few remarkable, recently discovered sources will be highlighted.Comment: 8 pages, 6 figures, in Proceedings of the 48th Rencontres de Moriond (2013), La Thuile (Italy

Mean-field approximations of networks of spiking neurons with short-term synaptic plasticity

Low-dimensional descriptions of neural network dynamics are an effective tool for bridging different scales of organization of brain structure and function. Recent advances in deriving mean-field descriptions for networks of coupled oscillators have sparked the development of a new generation of neural mass models. Of notable interest are mean-field descriptions of all-to-all coupled quadratic integrate-and-fire (QIF) neurons, which have already seen numerous extensions and applications. These extensions include different forms of short-term adaptation (STA) considered to play an important role in generating and sustaining dynamic regimes of interest in the brain. It is an open question, however, whether the incorporation of pre-synaptic forms of synaptic plasticity driven by single neuron activity would still permit the derivation of mean-field equations using the same method. Here, we discuss this problem using an established model of short-term synaptic plasticity at the single neuron level, for which we present two different approaches for the derivation of the mean-field equations. We compare these models with a recently proposed mean-field approximation that assumes stochastic spike timings. In general, the latter fails to accurately reproduce the macroscopic activity in networks of deterministic QIF neurons with distributed parameters. We show that the mean-field models we propose provide a more accurate description of the network dynamics, although they are mathematically more involved. Using bifurcation analysis, we find that QIF networks with pre-synaptic short-term plasticity can express regimes of periodic bursting activity as well as bi-stable regimes. Together, we provide novel insight into the macroscopic effects of short-term synaptic plasticity in spiking neural networks, as well as two different mean-field descriptions for future investigations of such networks

A Scintillating Fiber Tracker With SiPM Readout

We present a prototype for the first tracking detector consisting of 250 micron thin scintillating fibers and silicon photomultiplier (SiPM) arrays. The detector has a modular design, each module consists of a mechanical support structure of 10mm Rohacell foam between two 100 micron thin carbon fiber skins. Five layers of scintillating fibers are glued to both top and bottom of the support structure. SiPM arrays with a channel pitch of 250 micron are placed in front of the fibers. We show the results of the first module prototype using multiclad fibers of types Bicron BCF-20 and Kuraray SCSF-81M that were read out by novel 32-channel SiPM arrays from FBK-irst/INFN Perugia as well as 32-channel SiPM arrays produced by Hamamatsu. A spatial resolution of 88 micron +/- 6 micron at an average yield of 10 detected photons per minimal ionizig particle has been achieved.Comment: 5 pages, 7 figures, submitted as proceedings to the 11th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD08

"Wet-to-Dry" Conformational Transition of Polymer Layers Grafted to Nanoparticles in Nanocomposite

The present communication reports the first direct measurement of the conformation of a polymer corona grafted around silica nano-particles dispersed inside a nanocomposite, a matrix of the same polymer. This measurement constitutes an experimental breakthrough based on a refined combination of chemical synthesis, which permits to match the contribution of the neutron silica signal inside the composite, and the use of complementary scattering methods SANS and SAXS to extract the grafted polymer layer form factor from the inter-particles silica structure factor. The modelization of the signal of the grafted polymer on nanoparticles inside the matrix and the direct comparison with the form factor of the same particles in solution show a clear-cut change of the polymer conformation from bulk to the nanocomposite: a transition from a stretched and swollen form in solution to a Gaussian conformation in the matrix followed with a compression of a factor two of the grafted corona. In the probed range, increasing the interactions between the grafted particles (by increasing the particle volume fraction) or between the grafted and the free matrix chains (decreasing the grafted-free chain length ratio) does not influence the amplitude of the grafted brush compression. This is the first direct observation of the wet-to-dry conformational transition theoretically expected to minimize the free energy of swelling of grafted chains in interaction with free matrix chains, illustrating the competition between the mixing entropy of grafted and free chains, and the elastic deformation of the grafted chains. In addition to the experimental validation of the theoretical prediction, this result constitutes a new insight for the nderstanding of the general problem of dispersion of nanoparticles inside a polymer matrix for the design of new nanocomposites materials