Muerte y Filosofía. Una lectura del Fedón.

Hay que realizar un ejercicio hermenéutico cuando se trabaja con textos de la Antigua Grecia. Trabajar directamente con traducciones de estos textos implica exponerse a errores y prejuicios derivados de intentar traducir una lengua tan compleja y alejada como la griega. En el caso de los diálogos de Platón hay que prestar atención también al hecho de que no son tratados filosóficos en prosa sino unas obras pertenecientes al género poético griego y han de ser entendidas como tal. Tomamos esto como punto de partida para hacer una lectura del Fedón de Platón en base al texto griego original y comparando dos traducciones, una inglesa y otra castellana, para ver la importancia del ejercicio hermenéutico. Esta forma de leer el Fedón hace que se abandonen las interpretaciones tradicionales y surjan nuevas reflexiones sobre la ψυχή y sobre la muerte en tanto que tema principal del Fedón. El εἶδος juega también un papel importante en el Fedón y habrá de ser entendido bajo esta nueva lectura y no bajo su traducción tradicional de “idea”.<br /

The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study

Polymorphisms in the fatty acid desaturase (FADS) genes influence the arachidonic (AA) and docosahexaenoic (DHA) acid concentrations (crucial in early life). Infants with specific genotypes may require different amounts of these fatty acids (FAs) to maintain an adequate status. The aim of this study was to determine the effect of an infant formula supplemented with AA and DHA on FAs of infants with different FADS genotypes. In total, 176 infants from the COGNIS study were randomly allocated to the Standard Formula (SF; n = 61) or the Experimental Formula (EF; n = 70) group, the latter supplemented with AA and DHA. Breastfed infants were added as a reference group (BF; n = 45). FAs and FADS polymorphisms were analyzed from cheek cells collected at 3 months of age. FADS minor allele carriership in formula fed infants, especially those supplemented, was associated with a declined desaturase activity and lower AA and DHA levels. Breastfed infants were not affected, possibly to the high content of AA and DHA in breast milk. The supplementation increased AA and DHA levels, but mostly in major allele carriers. In conclusion, infant FADS genotype could contribute to narrow the gap of AA and DHA concentrations between breastfed and formula fed infants.This research was funded by ORDESA Laboratories, S.L., Spanish Ministry of Economy, Industry and Competitiveness, NEOBEFOOD Project (2010–2013) and SMARTFOODS Project (2014–2018)—CIEN Strategy (Ministry of Innovation and Science-CDTI) through 2 different contracts established between Ordesa Laboratories and the University of Granada General Foundation (ref. nº3349 and nº4003, respectively) and between Ordesa Laboratories and the Bosch Gimpera Foundation/University of Barcelona (ref. n 306811 and 308516). The project was partially funded by EU Project DynaHEALTH (HORIZON 2020-GA No.633595)

The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition—The PREOBE Follow-Up

This study analyzed how maternal obesity affected fatty acids (FAs) in breast milk and their association with infant growth and cognition to raise awareness about the programming effect of maternal health and to promote a healthy prenatal weight. Mother–child pairs (n = 78) were grouped per maternal pre-pregnancy body mass index (BMI): normal-weight (BMI = 18.5–24.99), overweight (BMI = 25–29.99) and obese (BMI > 30). Colostrum and mature milk FAs were determined. Infant anthropometry at 6, 18 and 36 months of age and cognition at 18 were analyzed. Mature milk exhibited lower arachidonic acid (AA) and docosahexaenoic acid (DHA), among others, than colostrum. Breast milk of non-normal weight mothers presented increased saturated FAs and n6:n3 ratio and decreased a-linolenic acid (ALA), DHA and monounsaturated FAs. Infant BMI-for-age at 6 months of age was inversely associated with colostrum n6 (e.g., AA) and n3 (e.g., DHA) FAs and positively associated with n6:n3 ratio. Depending on the maternal weight, infant cognition was positively influenced by breast milk linoleic acid, n6 PUFAs, ALA, DHA and n3 LC-PUFAs, and negatively a ected by n6:n3 ratio. In conclusion, this study shows that maternal pre-pregnancy BMI can influence breast milk FAs and infant growth and cognition, endorsing the importance of a healthy weight in future generations.This research was funded by the European Commission (DynaHEALTH-HORIZON 2020GANo: 633595) and the Spanish Ministry of Economy and Competitiveness (BFU2012-40254-C03-02). Further support was obtained from, Spanish Ministry of Innovation and Science (Junta de Andalucía), Excellence Projects (P06-CTS-02341). ADLGP thanks the Mexican government and the National Council on Science and Technology (CONACYT) for her PhD grant. The funders had no role in the study design, data collection, data analysis, decision to publish, or preparation of the manuscript

Association of maternal weight with FADS and ELOVL genetic variants and fatty acid levels- The PREOBE follow-up.

Single nucleotide polymorphisms (SNPs) in the genes encoding the fatty acid desaturase (FADS) and elongase (ELOVL) enzymes affect long-chain polyunsaturated fatty acid (LC-PUFA) production. We aimed to determine if these SNPs are associated with body mass index (BMI) or affect fatty acids (FAs) in pregnant women. Participants (n = 180) from the PREOBE cohort were grouped according to pre-pregnancy BMI: normal-weight (BMI = 18.5-24.9, n = 88) and overweight/obese (BMI≥25, n = 92). Plasma samples were analyzed at 24 weeks of gestation to measure FA levels in the phospholipid fraction. Selected SNPs were genotyped (7 in FADS1, 5 in FADS2, 3 in ELOVL2 and 2 in ELOVL5). Minor allele carriers of rs174545, rs174546, rs174548 and rs174553 (FADS1), and rs1535 and rs174583 (FADS2) were nominally associated with an increased risk of having a BMI≥25. Only for the normal-weight group, minor allele carriers of rs174537, rs174545, rs174546, and rs174553 (FADS1) were negatively associated with AA:DGLA index. Normal-weight women who were minor allele carriers of FADS SNPs had lower levels of AA, AA:DGLA and AA:LA indexes, and higher levels of DGLA, compared to major homozygotes. Among minor allele carriers of FADS2 and ELOVL2 SNPs, overweight/obese women showed higher DHA:EPA index than the normal-weight group; however, they did not present higher DHA concentrations than the normal-weight women. In conclusion, minor allele carriers of FADS SNPs have an increased risk of obesity. Maternal weight changes the effect of genotype on FA levels. Only in the normal-weight group, minor allele carriers of FADS SNPs displayed reduced enzymatic activity and FA levels. This suggests that women with a BMI≥25 are less affected by FADS genetic variants in this regard. In the presence of FADS2 and ELOVL2 SNPs, overweight/obese women showed higher n-3 LC-PUFA production indexes than women with normal weight, but this was not enough to obtain a higher n-3 LC-PUFA concentration

Patient experience with clinical pharmacist services in Travis County Federally Qualified Health Centers

Background: Positive patient experiences with care have been linked to improved health outcomes. Patient experience surveys can provide feedback about the level of patient-centered care provided by clinical pharmacists and information about how to improve services. Objectives: Study objectives are: 1) To describe patient experience with clinical pharmacist services in a federally qualified health center (FQHC). 2) To determine if demographic or health-related factors were associated with patient experience. Methods: This cross-sectional survey included adult patients who were English or Spanish speaking, and completed a clinical pharmacist visit in March or April 2018. Patient experience was evaluated, on a 5-point Likert scale (1 = strongly disagree to 5 = strongly agree), with 10 items using four domains: pharmacist-patient interaction information provision, support for self-care, and involvement in decision making. In addition, one item was used to rate the overall experience. Demographic and health-related variables were also collected. Eligible patients completed the survey after their clinical pharmacist visit. Descriptive and inferential statistics, as well as Cronbach’s alpha for scale reliability, were employed. Results: Respondents (N=99) were 55.4 (SD=12.1) years and 53.1% were women. Overall, patients rated their experiences very high with the 10-item scale score of 4.8 (SD=0.4) out of 5 points and the overall experience rating of 4.9 (SD=0.4) out of 5 points. With the exception of race, there were no differences between patient experience and demographic and health-related variables. African Americans had significantly (p=0.0466) higher patient experience scores compared to Hispanics. Conclusions: Patients receiving care in a FQHC highly rated their experience with clinical pharmacists. This indicates that clinical pharmacists provided a high level of patient-centered care to a diverse group

All for the success of college algebra

An extensive support system placed at Texas A&M International University (TAMIU) for the success of students taking College Algebra course is quintessential, since this is the first mathematics course taken by those who were admitted or plan to seek admission to TAMIU. Additional focus has been given as this course is taken by the majority of students to meet the core mathematics requirement in the state of Texas. Apart from sections being taught by experienced faculty, the University Learning Center (ULC) provides walk-in tutoring for students, and each section has been assigned a supplemental instruction leader who provides additional sessions beyond the classroom teaching, on a weekly basis. The ALEKS software provides an online homework system. Furthermore, a marathon review session is planned for the final exam, an opportunity geared towards procrastinators. This paper elaborates on the extent of the involvement required for the success of this course

Isolation and characterization of yeasts associated with plants growing in heavy metal- and arsenic-contaminated soils

Yeasts were quantified and isolated from the rhizospheres of five plant species grown at two sites of a Mexican region contaminated with arsenic, lead, and other heavy metals. Yeast abundance was about 102 CFU g-1 soil and 31 isolates were obtained. Based on the phylogenetic analysis of 26S rRNA and ITS fragment, six species within five genera were identified, including Cryptococcus (80.64%), Rhodotorula (6.45%), Exophiala (6.45%), Trichosporon (3.22%), and Cystobasidium (3.22%). Cryptococcus spp. was the predominant group. Pectinases (51.6%), proteases (51.6%), and xylanases (41.9%) were the enzymes most common, while poor siderophores (16.1%) and Indole Acetic Acid (IAA) (9.67%) production was detected. Isolates of Rhodotorula mucilaginosa and Cystobasidium sloffiae could promote plant growth and seed germination in bioassay with Brassica juncea. Resistance of isolates by As and heavy metals was as follows: As3+ ≥100 mM; As5+ ≥30 mM; Zn2+ ≥2 mM; Pb2+ ≥1.2 mM, and Cu2+ ≥0.5 mM. Strains of Cryptococcus albidus were able to reduce Arsenate (As5+) into Arsenite (As3+), but no isolate was capable of oxidizing arsenite. This is the first study on the abundance and identification of rhizosphere yeasts and in a HM and arsenic-contaminated soil and in arsenate reduction by the species C. albidus.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author