The Major Yolk Protein Vitellogenin Interferes with the Anti-Plasmodium Response in the Malaria Mosquito Anopheles gambiae

Functional gene analysis in malaria mosquitoes reveals molecules underpinning the trade-off between efficient reproduction and the antiparasitic response

Ectromelia Virus Disease Characterization in the BALB/c Mouse: A Surrogate Model for Assessment of Smallpox Medical Countermeasures

In 2007, the United States– Food and Drug Administration (FDA) issued guidance concerning animal models for testing the efficacy of medical countermeasures against variola virus (VARV), the etiologic agent for smallpox. Ectromelia virus (ECTV) is naturally-occurring and responsible for severe mortality and morbidity as a result of mousepox disease in the murine model, displaying similarities to variola infection in humans. Due to the increased need of acceptable surrogate animal models for poxvirus disease, we have characterized ECTV infection in the BALB/c mouse. Mice were inoculated intranasally with a high lethal dose (125 PFU) of ECTV, resulting in complete mortality 10 days after infection. Decreases in weight and temperature from baseline were observed eight to nine days following infection. Viral titers via quantitative polymerase chain reaction (qPCR) and plaque assay were first observed in the blood at 4.5 days post-infection and in tissue (spleen and liver) at 3.5 days post-infection. Adverse clinical signs of disease were first observed four and five days post-infection, with severe signs occurring on day 7. Pathological changes consistent with ECTV infection were first observed five days after infection. Examination of data obtained from these parameters suggests the ECTV BALB/c model is suitable for potential use in medical countermeasures (MCMs) development and efficacy testing

A hierarchical model of health service quality: Scale development and investigation of an integrated model

This research developed and empirically validated a multidimensional hierarchical scale for measuring health service quality and investigated the scale's ability to predict important service outcomes, namely, service satisfaction and behavioral intentions. Data were collected from a qualitative study and three different field studies of health care patients in two different health care contexts: oncology clinics and a general medical practice. Service quality was found to conform to the structure of the hierarchical model in all three samples. The research identified nine subdimensions driving four primary dimensions, which in turn were found to drive service quality perceptions. The primary dimensions were interpersonal quality, technical quality, environment quality, and administrative quality. The subdimensions were interaction, relationship, outcome, expertise, atmosphere, tangibles, timeliness, operation, and support. The findings also support the hypothesis that service quality has a significant impact on service satisfaction and behavioral intentions and that service quality mediates the relationship between the dimensions and intentions

Charting the Tibet issue in the Sino-Indian border dispute

In official quarters in Beijing and New Delhi, the Tibet issue figures only as a bargaining chip to 'regulate' their bilateral relations, not as an issue that has an independent bearing on the intractability or resolution of the Sino-Indian border dispute. Scholars of the Sino-Indian border dispute either dismiss the relevance of the Tibet issue or treat it as only a prop in their framing of the dispute in terms of security, nationalism and great power rivalry. This article argues that the Tibet issue is more central to the border dispute than official and scholarly circles have recognised so far. The article demonstrates this through an examination of the historical roots of the border row, the centrality of Tibet and Tibetans in the boundary claims of both Beijing and New Delhi and the revelation of concurrent historical developments in the border dispute and the Sino-Tibetan conflict. On the place of Tibet in broader Sino-Indian relations, the article posits that while Tibet was a victim of India's moralistic-idealist policies toward China in the 1950s, it has now become a victim of the new realism pervading India's policy of engaging and emulating China in the post-Cold War era