Time-dependent attractors for non-autonomous nonlocal reaction-diffusion equations

In this paper, the existence and uniqueness of weak and strong solutions for a non-autonomous nonlocal reaction-diffusion equation is proved. Next, the existence of minimal pullback attractors in the L2 -norm in the frameworks of universes of fixed bounded sets and those given by a tempered growth condition, and some relationships between them are established. Finally, we prove the existence of minimal pullback attractors in the H1-norm and study relationships among these new families and those given previously in the L2 - context. The results are also new in the autonomous framework in order to ensure the existence of global compact attractors, as a particular case.Ministerio de Economía y CompetitividadFondo Europeo de Desarrollo RegionalJunta de Andalucí

Robustness of time-dependent attractors in H1-norm for nonlocal problems

In this paper, the existence of regular pullback attractors as well as their upper semicontinuous behaviour in H1-norm are analysed for a parameterized family of non-autonomous nonlocal reaction-diffusion equations without uniqueness, improving previous results [Nonlinear Dyn. 84 (2016), 35–50].Ministerio de Economía y CompetitividadFondo Europeo de Desarrollo RegionalJunta de Andalucí

Long-time behavior of a non-autonomous parabolic equation with nonlocal diffusion and sublinear terms

This paper is devoted to study the asymptotic behavior of a time-dependent parabolic equation with nonlocal diffusion and nonlinear terms with sublinear growth. Namely, we extend some previous results from the literature, obtaining existence, uniqueness, and continuity results, analyzing the stationary problem and decay of the solutions of the evolutionary problem, and finally, under more general assumptions, ensuring the existence of pullback attractors for the associated dynamical system in both L2L2 and H1H1 norms. Relationships among these objects are established using regularizing properties of the equation

Robustness of nonautonomous attractors for a family of nonlocal reaction–diffusion equations without uniqueness

In this paper, we consider a non-autonomous nonlocal reactiondiffusion equation with a small perturbation in the nonlocal diffusion term and the non-autonomous force. Under the assumptions imposed on the viscosity function, the uniqueness of weak solutions cannot be guaranteed. In this multi-valued framework, the existence of weak solutions and minimal pullback attractors in the L2-norm are analysed. In addition, some relationships between the attractors of the universe of fixed bounded sets and those associated to a universe given by a tempered condition are established. Finally, the upper semicontinuity property of pullback attractors w.r.t. the parameter is proved. Indeed, under suitable assumptions, we prove that the family of pullback attractors converges to the corresponding global compact attractor associated to the autonomous nonlocal limit problem when the parameter goes to zero.Fondo Europeo de Desarrollo Regional (FEDER)Ministerio de Economía y Competitividad (España)Junta de Andalucí

Global attractor for a nonlocal p-Laplacian equation without uniqueness of solution

In this paper, the existence of solution for a p-Laplacian parabolic equation with nonlocal diffusion is established. To do this, we make use of a change of variable which transforms the original problem into a nonlocal one but with local diffusion. Since the uniqueness of solution is unknown, the asymptotic behaviour of the solutions is analysed in a multi-valued framework. Namely, the existence of the compact global attractor in L2(Ω) is ensured.Ministerio de Economía y CompetitividadJunta de Andalucí

Full-term pregnancy in breast cancer survivor with fertility preservation: A case report and review of literature

A 43-year-old woman with an associated history of gynecological pathology and breast cancer with only one cryopreserved embryo wished to be a mother. Several factors that influenced the success of the pregnancy in this case were analyzed. Favorable factors included: triple positive breast cancer [positive hormone receptors and positive human epidermal growth factor receptor 2], which is more hormosensitive and chemosensitive; absence of metastasis; correct endometrium preparation; and the patient's optimistic attitude and strict health habits. In contrast, the factors against success were: breast cancer; adjuvant breast cancer therapy gonadotoxicity; the age of the patient (> 40-year-old); endometriosis; ovarian cyst; hydrosalpinx; submucosal fibroids and the respective associated surgery done for the above-mentioned pathology (all resolved prior to the embryo transfer); and a low quantity of ovules (low ovarian reserve) after ovarian stimulation. This is a very special clinical case of a patient with theoretically low pregnancy success probability due to the consecutive accumulation of gynecological and oncological pathologies, who nonetheless became pregnant and delivered a full-term infant and was able to provide adequate breastfeeding

P73 plays a role in erythroid differentiaion through GATA1 induction

The TP73 gene gives rise to transactivation domain-p73 isoforms (TAp73) as well as ΔNp73 variants with a truncated N terminus. Although TAp73α and -Β proteins are capable of inducing cell cycle arrest, apoptosis, and differentiation, ΔNp73 acts in many cell types as a dominant-negative repressor of p53 and TAp73. It has been proposed that p73 is involved in myeloid differentiation, and its altered expression is involved in leukemic degeneration. However, there is little evidence as to which p73 variants (TA or ΔN) are expressed during differentiation and whether specific p73 isoforms have the capacity to induce, or hinder, this differentiation in leukemia cells. In this study we identify GATA1 as a direct transcriptional target of TAp73α. Furthermore, TAp73α induces GATA1 activity, and it is required for erythroid differentiation. Additionally, we describe a functional cooperation between TAp73 and ΔNp73 in the context of erythroid differentiation in human myeloid cells, K562 and UT-7. Moreover, the impaired expression of GATA1 and other erythroid genes in the liver of p73KO embryos, together with the moderated anemia observed in p73KO young mice, suggests a physiological role for TP73 in erythropoiesis.Peer reviewe

Distribución y conservación de la ictiofauna continental en pequeños cursos de agua del campo de Gibraltar

La revista Almoraima nº27 recoge las actas de las V Jornadas de Flora, Fauna y Ecología del Campo de Gibraltar, celebradas en Los Barrios durante los días 19, 20, 21 de octubre de 2001Los peces continentales son, con toda probabilidad, el grupo de vertebrados peor conocido y con problemas de conservación más acuciantes de cuantos habitan la Península Ibérica. En la franja costera que va desde la duna de Valdevaqueros hasta la ciudad de Algeciras se localizan una serie de arroyos de escasa magnitud, a pesar de lo cual albergan cuatro especies de peces continentales: la anguila (Anguilla anguilla), la colmilleja (Cobitis paludica), el cachuelo (Squalius pyrenaicus) y el barbo (Barbus sclateri). Este último parece haber estado ampliamente distribuido en estas cuencas, pero recientemente se ha extinguido de varias de ellas. El importante aislamiento de estas poblaciones de peces, que constituyen Unidades Evolutivas Significativas (en inglés, ESU), hace que su pérdida sea irreparable desde el punto de vista del patrimonio genético, debiendo ser prioritaria su conservación. En este trabajo se presentan datos sobre la distribución y estado de conservación de la ictiofauna continental que aún persiste en la zona. Finalmente se discuten las causas que han podido conducir a la situación crítica en la que se encuentran estas poblaciones, así como posibles medidas de gestión que garanticen la conservación de estos recursos genéticos

An oxygen-sensitive toxin-antitoxin system

The Hha and TomB proteins from Escherichia coli form an oxygen-dependent toxin-antitoxin (TA) system. Here we show that YmoB, the Yersinia orthologue of TomB, and its single cysteine variant [C117S]YmoB can replace TomB as antitoxins in E. coli. In contrast to other TA systems, [C117S]YmoB transiently interacts with Hha (rather than forming a stable complex) and enhances the spontaneous oxidation of the Hha conserved cysteine residue to a -SOxH- containing species (sulfenic, sulfinic or sulfonic acid), which destabilizes the toxin. The nuclear magnetic resonance structure of [C117S]YmoB and the homology model of TomB show that the two proteins form a four-helix bundle with a conserved buried cysteine connected to the exterior by a channel with a diameter comparable to that of an oxygen molecule. The Hha interaction site is located on the opposite side of the helix bundle

Metabolic and mitochondria alterations induced by SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10

1 p.Antiviral signaling, immune response and cell metabolism in human body are dysregulated by SARS-CoV-2, the causative agent of COVID-19. However, the impacts of individual accessory proteins on host cell metabolic pathways are unknown.Here, SARS-CoV-2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10 were individually transduced into A549 lung carcinoma cells. Furthermore, by combining transcriptomic analysis with functional and metabolic data in accessory protein-specific GSMMs, several alterations were identified that may point to a putative target for investigating novel therapies. In this study, we showed that these accessory proteins induced a significant mitochondrial and metabolic reprogramming in A549 lung epithelial cells. ORF9b, ORF9c and ORF10 induced largely overlapping transcriptomes. In contrast, ORF3a induced a distinct transcriptome, including the downregulation of numerous genes with critical role in mitochondria function and morphology. On the other hand, while all four ORFs altered mitochondrial dynamics and function, only ORF3a and ORF9c induced a marked structural alteration in mitochondrial cristae. Genome-Scale Metabolic Models identified both metabolic flux reprogramming features shared across all accessory proteins and specific ones for each accessory protein. Notably, a downregulated amino acid metabolism was observed in ORF9b, ORF9c and ORF10, while an upregulated lipid metabolism was distinctly induced by ORF3a. Next, qMTA identified gene knock downs (KDs) that would have the potential to revert the metabolic reprogramming induced by each individual accessory protein, especially in ORF3a and ORF10. These findings reveal metabolic dependencies and vulnerabilities prompted by SARS-CoV-2 accessory proteins that may be exploited to identify new targets for intervention.Peer reviewe