57 research outputs found
Risk of suicide attempt repetition after an index attempt: A systematic review and meta-analysis
Objectives
To estimate the risk of suicide attempt repetition among individuals with an index attempt. It also aims to study the role of risk factors and prevention programme in repetition.
Methods
This systematic review and meta-analysis was conducted in keeping with the PRISMA 2020 guidelines. Studies on attempt repetition (both cohort studies and intervention studies) were searched from inception to 2022.
Results
A total of 110 studies comprising 248,829 attempters was reviewed. The overall repetition rate was 0.20 (0.17, 0.22). Repetition risk linearly increased over time. A higher risk of attempt repetition was associated with female sex and index attempts in which self-cutting methods were used. Moreover, a mental disorder diagnosis was associated with an increasing repetition risk (OR = 2.02, p < .01). The delivery of a preventive programme reduced the repetition risk, OR = 0.76, p < .05; however, this effect was significant for psychotherapy interventions, OR = 0.38, p < .01.
Conclusion
One in five suicide attempters will engage in a new suicide attempt. An elevated repetition risk is associated with being female, more severe index methods and psychiatric disorder diagnosis. Preventive programmes, particularly psychotherapy, may contribute to reducing repetition risk and eventually save lives.This study was supported by the Instituto de Salud Carlos III-FIS research grants (PI16/00187, PI19/00236, PI19/00569, PI19/00685, PI19/00941, PI19/00954, PI19/01027, PI19/01256, PI19/01484, PI20/00229), co-funded by the European Regional Development Fund (ERDF) “A Way to Build Europe”; the Government of the Principality of Asturias (grant ref.: PCTI-2018-2022 IDI/2018/235); Secretaria d'Universitats i Recerca from the Departament d'Economia i Coneixement (ref.: 2017SGR1365 and 2017SGR134), and Generalitat de Catalunya (Government of Catalonia), CERCA Programme
Transposable elements versus the fungal genome: impact on whole-genome architecture and transcriptional profiles
Incluye 10 ficheros de datosTransposable elements (TEs) are exceptional contributors to eukaryotic genome diversity.
Their ubiquitous presence impacts the genomes of nearly all species and mediates genome
evolution by causing mutations and chromosomal rearrangements and by modulating gene
expression. We performed an exhaustive analysis of the TE content in 18 fungal genomes,
including strains of the same species and species of the same genera. Our results depicted
a scenario of exceptional variability, with species having 0.02 to 29.8% of their genome consisting
of transposable elements. A detailed analysis performed on two strains of Pleurotus
ostreatus uncovered a genome that is populated mainly by Class I elements, especially
LTR-retrotransposons amplified in recent bursts from 0 to 2 million years (My) ago. The preferential
accumulation of TEs in clusters led to the presence of genomic regions that lacked
intra- and inter-specific conservation. In addition, we investigated the effect of TE insertions
on the expression of their nearby upstream and downstream genes. Our results showed
that an important number of genes under TE influence are significantly repressed, with
stronger repression when genes are localized within transposon clusters. Our transcriptional
analysis performed in four additional fungal models revealed that this TE-mediated
silencing was present only in species with active cytosine methylation machinery. We
hypothesize that this phenomenon is related to epigenetic defense mechanisms that are
aimed to suppress TE expression and control their proliferation.This work was supported by Spanish
National Research Plan (Projects AGL2011-30495
and AGL2014-55971-R) and FEDER funds; Public
University of Navarre; U.S.
Department of Energy Joint Genome Institute; and
Office of Science of the U.S. Department of Energy
under Contract No. DE-AC02-05CH11231.
Neurocognitive profile of the post-COVID condition in adults in Catalonia. A mixed method prospective cohort and nested case-control study: Study Protocol
The diagnosis of the post-COVID condition is usually achieved by excluding other diseases; however, cognitive changes are often found in the post-COVID disorder. Therefore, monitoring and treating the recovery from the post-COVID condition is necessary to establish biomarkers to guide the diagnosis of symptoms, including cognitive impairment. Our study employs a prospected cohort and nested case-control design with mixed methods, including statistical analyses, interviews, and focus groups. Our main aim is to identify biomarkers (functional and structural neural changes, inflammatory and immune status, vascular and vestibular signs and symptoms) easily applied in primary care to detect cognitive changes in post-COVID cases. The results will open up a new line of research to inform diagnostic and therapeutic decisions with special considerations for cognitive impairment in the post-COVID condition
TFG en Ingeniería Química: Un trampolín al mercado laboral
En este proyecto de innovación docente, se pretende mejorar la empleabilidad de los estudiantes tras la realización del Trabajo Fin de Grado e incrementar la motivación de los mismos por el emprendimiento. Para ello, han realizado actividades por parte de agentes provenientes de la Industria Química y expertos en emprendimiento y herramientas digitales
Infequus 2.0: Plataforma de enfermedades infecciosas en équidos
Depto. de Producción AnimalDepto. de Sanidad AnimalFac. de VeterinariaCentro de Vigilancia Sanitaria Veterinaria (VISAVET)FALSEsubmitte
Infequus: plataforma de enfermedades infecciosas equinas
Desarrollo de la herramienta de formación online Infequus, que ofrecerá a los alumnos y profesionales información actualizada sobre el diagnóstico y control de las enfermedades infecciosas en la especie equina
Discourse Analysis and Terminology in Languages for Specific Purposes
Aquest importantíssim recull conté estudis i reflexions sobre temes rellevants en la recerca sobre LSP: anglès mèdic, el llenguatge de la publicitat i periodístic, telecomunicacions i terminologia informàtica, llenguatge comercial i jurídic... Malgrat que gran part dels treballs aplegats es refereixen a l'anglès, també hi ha que tracten l'alemany, francès i altres llengües.
Conté textos en anglès, francés, portuguès i castellà
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