Prediction of road accident severity using the ordered probit model

The ordered probit model is used to examine the contribution of several factors to the injury severity faced by motor-vehicle occupants involved in road accidents. The estimated results suggest that motor-vehicle occupants travelling in light-vehicles, at two-way roads, and on dry road surfaces tend to suffer more severe injuries than those who travel in heavy-vehicles, at one-way roads, and on wet road surfaces. Additionally, the driver's seat is clearly the safest seating position, urban areas seem to originate less serious accidents than rural areas, and women tend to be more likely to suffer serious or fatal injuries than men

Feminisation of Dentistry in Brazil from the Perspective of a MOOC-Type Distance Course - A Short Report

The Brazilian public healthcare system (SUS - Brazilian Healthcare System) provides free dental care, covering almost half of the Brazilian population. Providing continuing education to thousands of professionals is a difficult and expensive task given the country’s large size. SUS' Open University in partnership with public universities provides ongoing education to thousands of healthcare professionals using technological resources for distance learning. A distance learning course, in the MOOC (Massive Open Online Course) modality, was developed to provide continuing medical education for dental surgeons to assist patients with chronic diseases. The course is free and has registered 13,089 participants. Aim: The purpose of this study is to present the profile of the MOOC course participants. Methods: Secondary data were obtained from Federal Council of Dentistry, the National Registry of Health Facilities, the National Institute for Educational Studies and Research Anísio Teixeira and the Registry of Higher Education Institutions and Courses (e-MEC). Data of the MOOC course were collected in the Arouca Platform. Results: Dentists in Brazil are predominantly female. However, in some specialties there are more men than women. The majority of participants on the course were female 73.5% and in the age group of 21-40 years. Conclusion: This phenomenon is similar to other countries, and needs to be better investigated in Brazil, so that public policies of continuing education of healthcare professionals by means of distance learning, may take the profession's feminisation into consideration. &nbsp

An Electrochemical Outlook on Tamoxifen Biotransformation: Current and Future Prospects

Tamoxifen is a nonsteroidal antiestrogen that is currently and widely used in the treatment of breast cancer in all of its stages, in adjuvant therapy as a long-term suppressant of tumor recurrence and also as a chemopreventive agent in women that are in high risk of developing this type of estrogen-dependent cancer. From a toxicological and (bio)analytical point of view the knowledge of the metabolic pathways of a drug is found to be extremely important. So, in the present work the most important tamoxifen biotransformation steps were reviewed in the light of recent pharmacological data. This overview also includes the current controversy concerning tamoxifen DNA-damaging (genotoxic) versus non-genotoxic mechanisms. A special focus will be given to the putative application of electrochemical methods as a modern and reliable analytical tool for determination of tamoxifen and its metabolites. Moreover, the potential of DNA electrochemical sensors for detection of structural damage to DNA as a basis for toxicity screening is highlighted. Future prospects looking for the importance of developing new analytical methodologies are also discussed.info:eu-repo/semantics/publishedVersio

Serious Game for reading and spelling skills

This work describes an interactive child-friendly application focused on spelling, intended to promote sensibility to Portuguese orthography. A description of the game and its particularities are given, as well as preliminary results obtained in school environment.info:eu-repo/semantics/publishedVersio

Photoperiod and Melatonin Supplementation: Variable Effects on the Quality of Chilled Dog Semen

The addition of melatonin in seminal extenders due to its antioxidant properties and its beneficial role in sperm preservation has been previously described, especially in seasonal species. The aim of this study was to study a potential seasonal effect based on photoperiod duration when adding a physiological concentration of melatonin in the canine ejaculate. A total of 24 ejaculates were obtained from 10 healthy dogs during the increasing photoperiod (from December 21 to June 21), whereas 12 ejaculates were collected from five healthy individuals during the decreasing photoperiod (from June 22 to December 20). Each ejaculate was separated into two aliquots, and one of them remained as a control, whereas melatonin (100 pM) was added to the other one (C and M treatment groups, respectively). Diluted semen was refrigerated at 5°C. On days 0, 1, 2, 3, and 6, sperm motility analyses were performed using a CASA system and hypoosmotic swelling test (HOST), osmotic resistance test (ORT), and flow cytometry analysis. No effect of melatonin on motility was detected in either photoperiod. Negative effects of melatonin were found for acrosomal defects, apoptosis, and viability in the decreasing photoperiod. The addition of melatonin to sperm in the decreasing photoperiod could create such a high level that it would cause the described negative effects. We found a beneficial effect of melatonin in the increasing photoperiod on acrosomal defects and apoptosis during 0–6 days. Melatonin treatment also increased viability in the short term (days 1 and 2) for both photoperiods. Also, melatonin can provide certain beneficial effects on mitochondrial activity in the medium term (days 2 and 3) in the decreasing photoperiod

Mujer joven con neuralgia del trigémino y paralisis facial

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