Implementing fencing as adapted physical activity in non-metastatic breast cancer patients: design and early rehabilitation strategy of the FENICE study protocol

background Improving prognosis of BC patients has drawn the attention of health care professionals on disease related long-term side effects and on the multiple treatments BC patients must undergo. despite advances in procedures, surgery still has multiple detrimental effects, including pain, edema, and limited mobility. For this reason, fostering adapted physical activity (APA) and healthy lifestyle (including a balanced diet and weight management) should become an everyday purpose of healthcare professionals. Fencing may be a well-suited activity to counteract fatigue, pain, and limited arm mobility. method and analysis The FENICE study is a mono-center, randomized clinical trial targeting women with BC stages I-III within four weeks from BC surgery. participants in the control arm will receive the usual recommendations based on the good clinical practice guidelines. In the study arm, participants will be treated with the usual clinical and therapeutic recommendations together with APA and correct lifestyle suggestions. objective the primary objective of the study is to compare whether implementation of APA and healthy lifestyle in BC patient after surgery will result in an overall improvement of physical and mental status. conclusion fencing and its early application in postoperative period may represent a feasible strategy to be implemented in the rehabilitation journey of BC patients. ethics and dissemination the study protocol FENICE has been approved by an italian ethics committee on May 2023 (R.S 100.23 5th May 2023)

Lo sviluppo della competenza acquatica

\u2018Lo sviluppo della competenza acquatica\u2019: un nuovo paradigma che va l\u2019oltre il mero insegnamento del nuoto ma che ha come fine ultimo il completo controllo dell\u2019ambiente e del proprio corpo in acqua. La possibilit\ue0 di saper risolvere qualsiasi problema possa capitare nell\u2019ambiente liquido \ue8 la premessa della completa sicurezza dell\u2019allievo in acqua e della possibilit\ue0 di affrontare qualsiasi tipo di sport acquatico. Un libro di testo universitario semplice e pragmatico impostato in maniera scientifica con informazioni e suggerimenti chiari e precisi. Il testo risponde a quattro domande fondamentali: perch\ue9 sia necessario proporle; chi ne deve beneficiare in modo adattato alle caratteristiche (fisiche, socio-cognitive ed emotivo-affettive) individuali e tipiche delle varie et\ue0; come insegnarle attraverso un\u2019analisi dei principali metodi, stili e strategie di insegnamento- apprendimento; infine dove proporle con riferimento esplicito ai vari contesti La trattazione si addice a coloro che scelgono di diventare insegnanti efficaci nell\u2019ambito delle attivit\ue0 psico-motorie e motorio-sportive: studenti e laureati in Scienze motorie o in Scienze della formazione primaria, ma anche maestri, docenti o istruttori alla ricerca di un aggiornamento delle loro conoscenze culturali e scientifich

ELEMENTI DI SCIENZE MOTORIE E SPORTIVE 2

IL VOLUME SI ARTICOLA IN DUE PARTI. NELLA PRIMA PARTE: LO SPORT, LE REGOLE E IL FAIRPLAY; NELLA SECONDA PARTE: RELAZIONE CON L'AMBIENTE NATURALE E TECNOLOGIC

ELEMENTI DI SCIENZE MOTORIE E SPORTIVE 1

iL TESTO SI ARTICOLA IN QUATTRO PARTI. NELLA PRIMA PARTE GLI ARGOMENTI TRATTATI SONO LO SPORT, LA SOCIETA' E LO STATO; NELLA SECONDA PARTE SI PARLA DI PERCEZIONE DI SE' E LO SVILUPPO DELLE CAPACITA' MOTORIE; NELLA TERZA PARTE: LOSPORT E IL FAIR PLAY; NELLA QUARTA - SALUTE, BENESSERE E PREVENZION

COVID-19 Vaccine and Death: Causality Algorithm According to the WHO Eligibility Diagnosis

The current challenge worldwide is the administration of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. Even if rarely, severe vascular adverse reactions temporally related to vaccine administration have induced diffidence in the population at large. In particular, researchers worldwide are focusing on the so-called “thrombosis and thrombocytopenia after COVID-19 vaccination”. This study aims to establish a practical workflow to define the relationship between adverse events following immunization (AEFI) and COVID-19 vaccination, following the basic framework of the World Health Organization (WHO). Post-mortem investigation plays a pivotal role to support this causality relationship when death occurs. To demonstrate the usefulness and feasibility of the proposed workflow, we applied it to two exemplificative cases of suspected AEFI following COVID-19 vaccination. Based on the proposed model, we took into consideration any possible causality relationship between COVID-19 vaccine administration and AEFI. This led us to conclude that vaccination with ChAdOx1 nCov-19 may cause the rare development of immune thrombocytopenia mediated by platelet-activating antibodies against platelet factor 4 (PF4), which clinically mimics heparin-induced autoimmune thrombocytopenia. We suggest the adoption of the proposed methodology in order to confirm or rule out a causal relationship between vaccination and the occurrence of AEFI

Effects of guidelines on adeno-tonsillar surgery on the clinical behaviour of otorhinolaryngologists in Italy

<p>Abstract</p> <p>Background</p> <p>Several guidelines on adeno-tonsillar disease have been proposed in recent years and some discrepancies in relation both to clinical manifestations and indications for surgical treatment have emerged. The aim of the study was to verify what influence (adeno)-tonsillectomy guidelines have had on the clinical behaviour of ENT specialists in Italy. Our study is a retrospective and multi-centre case series with chart review.</p> <p>Methods</p> <p>The survey involved 14,770 children, aged between the ages of 2 and 11, who had undergone adeno-tonsillar surgery between 2002 and 2008 in fourteen Italian tertiary and secondary referral centres. Anova test was used for the statistical analysis, assuming p < 0.05 as the minimum statistical significance value.</p> <p>Results</p> <p>The frequency of adeno-tonsillar surgeries did not change significantly (p>0.05) during the study period and following the Italian policy document publication. Overall, adeno-tonsillectomy was the most frequent intervention (64.1%), followed by adenoidectomy (31.1%) and tonsillectomy (4.8%). The indications for surgery did not change significantly for each of the operations (p>0.05), with the exception of adeno-tonsillectomy in case of feverish episodes due to acute recurrent tonsillitis ≥ 5 without nasal obstruction (decreased p= 0.010) , even when the feverish episodes due to acute recurrent tonsillitis were < 5 over the last year. Nasal obstruction was associated with feverish episodes due to acute recurrent tonsillitis in 65.2% of operated cases, while otitis media had been diagnosed in 43.3% of the patients studied.</p> <p>Conclusions</p> <p>The recommendations first developed in Italy in a 2003 policy document and then resumed in guidelines in 2008, were not implemented by ENT units involved in the survey. The study highlights the fact that the indications for adeno-tonsillar operations are based on the overall clinical presentation (comorbidity) rather than on a single symptom. Guidelines are necessary to give coherent recommendations based on both the findings obtained through randomized controlled trials and the data collected from observational studies.</p

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry. We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA. We replicated the nine previously reported signals, including known SNPs in the HLA-DQB1 and DEFA loci. The cumulative burden of risk alleles is strongly associated with age at disease onset. Most loci are either directly associated with risk of inflammatory bowel disease (IBD) or maintenance of the intestinal epithelial barrier and response to mucosal pathogens. The geospatial distribution of risk alleles is highly suggestive of multi-locus adaptation, and genetic risk correlates strongly with variation in local pathogens, particularly helminth diversity, suggesting a possible role for host-intestinal pathogen interactions in shaping the genetic landscape of IgAN