Áreas de especialización productiva y pequeña empresa en Europa

Cet article presente deux aspects d'un travail en cours de réalisation a propos des aires périphériques et du role important que joue la petite entreprise. Un premier aspect correspond aux hypothèses de la recherche et un second aux premien resultats obtenus. L'aire de recherche englobe les divers pays de la Communauté Economique Européenne, afin de pouvoir comparer l'Italie à ces pays, ce qui est l'objectif primordial de la recherche.The article outlines two aspects of studies at present being undertaken on peripheral areas and the related role of smale scale enterprise. The first aspect consists of the hypothesis underlying the investigation, and the second is a first reading of the results obtained. The study area covers the European Community countries, with the prime objective of making comparisons to the Italian model.Aquest article presenta dos aspectes d'un treball en curs de realització referit a les àrees perifèriques i a l'important paper que juga la petita empresa. Un primer aspecte correspon a les hipòtesis de la investigació i un segon als primers resultats obtinguts. L'àmbit de la investigació inclou els paisos de la Comunitat Econòmica Europea, per tal de comparar-los amb Itàlia que és l'objectiu primordial de la recerca

Measurement of CP Observables in B- -\u3e D0 K- pi+ pi- Decays

The analysis of the 3 fb^-1 data set collected by the LHCb experiment in 2011 and 2012 located at the LHC, CERN, Geneva, Switzerland is presented. The data set is comprised of one third taken at center of mass energy sqrt(s) = 7 TeV and the remaining two thirds taken at sqrt(s) = 8 TeV. The data is analyzed for the decays B- → D0 K- π+ π- and B- → D0 π- π+ π-$, with the D0 &rarr K+π-, K+K-, π-π+ or K-π+. The CP violation sensitive observables R_(CP+), A_(CP+), and R_(d,s)^± are measured, which are sensitive to the CKM Angle gamma. Upper limits are reported for the values of R_s^± since the doubly Cabibbo suppressed decay B- → D0 K- π+ π- with D0 → K+π- is not observed

Proxying the socio-economic background through real estate values. An application on performances of university students

This study shows how the socio-economic background of students in tertiary education can influence their performances and, in particular, the obtained graduation mark. Relying on administrative records on graduated students of the University of Modena and Reggio Emilia (UNIMORE) and aggregated statistics from the Immobiliare.it website, we explore the role of socio-economic background on students’ performances through two different proxies. One refers to the group of the Italian indicator of the household equivalised economic situation (or ISEE) which the student belongs, while the other consists of the average real estate price featuring the postcode where the student resides. Econometric results show a positive influence of both proxies of the socio-economic background on the graduation mark. Specifically, we observe that belonging to highest ISEE groups has on the graduation mark a similar effect with respect to the average real estate price of the student’s postcode of residence. This evidence confirms that the latter may be an effective alternative dimension to proxy the individuals’ socio-economic background when income/wealth variables are not available, interval-censored, or also present relevant issues of reliability

O exemplo italiano

Starting from the study of the economic crisis and of the style of regional development, the paper moves to analyze the model of the fifties and sixties. The regional articulation of the productive system and the development of the periphery are shown, characterizing the model of the seventies. Then is studied the regional distribution of industrial activities during the seventies, describing and explaining the new pattern of industrial location. Finally, the problems related to regional development and local resources are approached with a decisive interrogation: Is there an autonomous path to development?Starting from the study of the economic crisis and of the style of regional development, the paper moves to analyze the model of the fifties and sixties. The regional articulation of the productive system and the development of the periphery are shown, characterizing the model of the seventies. Then is studied the regional distribution of industrial activities during the seventies, describing and explaining the new pattern of industrial location. Finally, the problems related to regional development and local resources are approached with a decisive interrogation: Is there an autonomous path to development

The role of non-coding RNAs as prognostic factor, predictor of drug response or resistance and pharmacological targets, in the cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma (CSCC) is the most common keratinocyte-derived skin cancer in the Caucasian population. Exposure to UV radiations (UVRs) represents the main risk carcinogenesis, causing a considerable accumulation of DNA damage in epidermal keratinocytes with an uncontrolled hyperproliferation and tumor development. The limited and rarely durable response of CSCC to the current therapeutic options has led researchers to look for new therapeutic strategies. Recently, the multi-omics approaches have contributed to the identification and prediction ofthe key role of non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), circularRNAs (circRNAs) and long non-coding RNAs (lncRNAs) in the regulation of several cellular processes in different tumor types, including CSCC. ncRNAs can modulate transcriptional and post-transcriptional events by interacting either with each other or with DNAand proteins, such as transcription factors and RNA-binding proteins.In this review, the implication of ncRNAs in tumorigenesis and their potential role as diagnostic biomarkers and therapeutic targets in human CSCC are reported

Search for Gravitational Waves from Binary Black Hole Inspiral, Merger and Ringdown

We present the first modeled search for gravitational waves using the complete binary black hole gravitational waveform from inspiral through the merger and ringdown for binaries with negligible component spin. We searched approximately 2 years of LIGO data taken between November 2005 and September 2007 for systems with component masses of 1-99 solar masses and total masses of 25-100 solar masses. We did not detect any plausible gravitational-wave signals but we do place upper limits on the merger rate of binary black holes as a function of the component masses in this range. We constrain the rate of mergers for binary black hole systems with component masses between 19 and 28 solar masses and negligible spin to be no more than 2.0 per Mpc^3 per Myr at 90% confidence

Beating the Spin-Down Limit on Gravitational Wave Emission from the Vela Pulsar

We present direct upper limits on continuous gravitational wave emission from the Vela pulsar using data from the Virgo detector\u27s second science run. These upper limits have been obtained using three independent methods that assume the gravitational wave emission follows the radio timing. Two of the methods produce frequentist upper limits for an assumed known orientation of the star\u27s spin axis and value of the wave polarization angle of, respectively, 1.9\ee{-24} and 2.2\ee{-24}, with 95% confidence. The third method, under the same hypothesis, produces a Bayesian upper limit of 2.1\ee{-24}, with 95% degree of belief. These limits are below the indirect {\it spin-down limit} of 3.3\ee{-24} for the Vela pulsar, defined by the energy loss rate inferred from observed decrease in Vela\u27s spin frequency, and correspond to a limit on the star ellipticity of $\sim 10^{-3}$. Slightly less stringent results, but still well below the spin-down limit, are obtained assuming the star\u27s spin axis inclination and the wave polarization angles are unknown

Onset of valganciclovir resistance in two infants with congenital cytomegalovirus infection

Ganciclovir and its prodrug valganciclovir are elective treatments for cCMV. Neonates with important symptoms undergo 6 months of therapy to ameliorate/prevent symptoms and late sequelae, but evidence of resistance is emerging. Over the last 5 years, we took care of 59 cCMV infants and experienced two cases of resistance among nine cCMV infants receiving long-term valganciclovir therapy. In the first case, valganciclovir therapy was prolonged beyond 6 months due to severity of symptoms, control of viral load, and absence of adverse events. Resistance was detected in the 8th month of therapy. In the second case, after a significant reduction following valganciclovir administration and no adverse events, CMV viral load suddenly increased in the 6th month of therapy due to resistance. Both events were associated with UL97 gene mutation. The cCMV infants, affected by severe symptoms, remained in a steady state during treatment, and their later neurological development was coherent with initial seriousness of diagnosis. Prolonged therapeutic exposure may therefore be a risk for resistance, suggesting that constant dosage/weight adjustments, monthly surveillance of viral load, and therapeutic drug monitoring could be proposed to monitor resistance onset and optimize the therapy regime. The risk–benefit ratio for long-term therapy, including the possibility of resistance onset, alongside SNHL and neurodevelopmental improvement, should also be evaluated