Impacto de la salud oral en la calidad de vida de la gestante

Objetivo Identificar los factores determinantes de la calidad de vida relacionada con la salud oral (OHIP-14) en una población de mujeres embarazadas.Métodos En el estudio participaron 90 pacientes embarazadas, 45 inmigrantes y 45 españolas. Las participantes completaron el cuestionario de OHIP-14 (versión española) y se les exploró el índice CAOD (presencia de caries, ausencia de dientes por caries y dientes obturados) en el segundo trimestre de embarazo. Se realizó un estudio analítico bivariante y multivariante.Resultados La edad media de las participantes inmigrantes fue 30,2 años y de las españolas de 34,4. La puntuación media de OHIP-14 fue de 5,83±6,57, siendo en elgrupo de inmigrantes de 8,15 y en las nacionales de 3,51, manifestando una diferenciaestadísticamente significativa (p=0.001). Las puntuaciones más altas del OHIP-14se presentaron en los dominios de dolor (110), seguido del malestar psicológico (81). Tomando como punto de corte el valor de la mediana en la puntuación del OHIP-14 (≥3), el Odds ratio de sentir una salud oral que interfiere en la calidad de vida fue de 3,294y este riesgo se potenció con el padecimiento de caries (4,323) pero no con la edad.Conclusiones Dado que la experiencia de caries, pudiera ser uno de los determinantes en la valoración de percibir una peor calidad de vida oral durante el embarazo, se necesitarían más estudios que lo corroborasen, y así ampliar las expectativas preventivasen el desarrollo de la salud oral por parte de la política sanitaria.Objective To identify the factors that determine quality of life related to oral health (OHIP-14) in a population of pregnant women.Methods This study included ninety pregnant women, 45 immigrants and 45 from Spain. Participants completed the Oral Health Impact Profile questionnaire (OHIP-14) –Spanish version– and the DMFT index (decayed, missing, and filled teeth) was explored during the second trimester of pregnancy. A bivariate and multivariate analyticalstudy was performed.Results The average age of immigrant participants was 30.2, and of Spanish women 34.4. The mean OHIP-14 score was 5.83±6.57 (8.15 in the immigrant group and 3.51 in the Spanish group), showing a statistically significant difference (p=0.001). The highestOHIP-14 scores were related to pain (110), followed by psychological distress (81). Considering the median value in the OHIP-14 score as a cut-off (≥3), the odds ratio fororal health that interferes with quality of life was 3 294, and this risk was increased by caries (4 323) but not by age.Conclusions Since the DMFT could be one of the determining factors for worst quality of life in pregnant patients, more studies to corroborate this information are necessary in order to expand preventive expectations in the practice of oral health in relation to policies

Identification Of Mitotically Competent SOX2+ Cells In White Matter Of Normal Human Adult Brain

SOX2 expression is linked to the undifferentiated state of stem cells in mammalian neurogenic niches. While its expression has been reported in the adult human subventricular zone (SVZ), to date it has not been detected in adult human white matter. Here we describe a population of SOX2+ cells from the white matter of the adult human temporal lobe, which proliferate and express glial markers in vitro

Layered Interoperability for Collaborative IoT Applications

Peer reviewe

Actividad extracurricular en el ámbito de la Ingeniería para la competencia genérica de comunicación escrita

El objetivo de este trabajo es describir una actividad formativa extracurricular para la competencia de comunicación escrita, que puede ser fácilmente reproducida en otros centros y universidades. Para ello, en este trabajo se indica el marco en el que se pueden desarrollar las competencias genéricas y se analiza brevemente la actividad propuesta a través de sus resultados de aprendizaje, y cómo estos favorecen e influyen en otras competencias genéricas como la capacidad creativa y el aprendizaje para toda la vida.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1

Sarcomas are malignant tumors accounting for a high percentage of cancer morbidity and mortality in children and young adults. Surgery and radiation therapy are the accepted treatments for most sarcomas; however, patients with metastatic disease are treated with systemic chemotherapy. Many tumors display marginal levels of chemoresponsiveness, and new treatment approaches are needed. MAP17 is a small non-glycosylated membrane protein overexpressed in carcinomas. The levels of MAP17 could be used as a prognostic marker to predict the response to bortezomib in hematological malignancies and in breast tumors. Therefore, we analyzed the expression of this oncogene in sarcomas and its relationship with clinico-pathological features, as well as tested whether it can be used as a new biomarker to predict the therapeutic response to bortezomib and new therapies for sarcomas. We found that the levels of MAP17 were related to clinical features and poor survival in a cohort of 69 patients with different sarcoma types, not being restricted to any special subtype of tumor. MAP17 expression is associated with poor overall survival (p<0.001) and worse disease-free survival (p=0.002). Cell lines with high levels of MAP17 show a better response to bortezomib in vitro. Furthermore, patient-derived xenografts (PDX) with high levels of MAP17 respond to bortezomib in vivo. Our results showed that this response is due to the lower levels of NFκB and autophagy activation. Therefore, we suggest that MAP17 is a new biomarker to predict the efficacy of bortezomib as a new therapy for sarcomas.España, Consejeria de Ciencia e innovación CTS-6844 and CTS-1848Andalucia, Consejería de Salud PI-0029-2013Andalucia, Consejería de Salud PI-0096-2014Andalucia, Consejería de Salud PI-0306-201

An outdoor test facility for the Cherenkov Telescope Array mirrors

The Cherenkov Telescopes Array (CTA) is planned to be an Observatory for very high energy γ-ray astronomy and will consist of several tens of telescopes which account for a reflective surface of more than 10000 m2 . The mirrors of these telescopes will be formed by a set of facets. Different technological solutions are under test inside the CTA Consortium. Most of them involve composite structures whose behavior under real observing conditions is not yet fully tested. An outdoor test facility has been built in one of the candidate sites for CTA, in Argentina (San Antonio de los Cobres [SAC], 3600m a.s.l) in order to monitor the optical and mechanical properties of these facets exposed to the local atmospheric conditions for a given period of time. In this work we present the preliminary results of the first Middle Size Telescope (MST) mirror-monitoring campaign, started in 2013.Fil: Medina, Maria Clementina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Garcia, Beatriz Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Tecnología en Detección y Astropartículas. Comisión Nacional de Energía Atómica. Instituto de Tecnología en Detección y Astropartículas. Universidad Nacional de San Martín. Instituto de Tecnología en Detección y Astropartículas; ArgentinaFil: Maya, J.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Tecnología en Detección y Astropartículas. Comisión Nacional de Energía Atómica. Instituto de Tecnología en Detección y Astropartículas. Universidad Nacional de San Martín. Instituto de Tecnología en Detección y Astropartículas; ArgentinaFil: Mancilla, A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Tecnología en Detección y Astropartículas. Comisión Nacional de Energía Atómica. Instituto de Tecnología en Detección y Astropartículas. Universidad Nacional de San Martín. Instituto de Tecnología en Detección y Astropartículas; ArgentinaFil: Larrarte, Juan Jose. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Rasztocky, Emiliano. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Benitez, Martin Ezequiel. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Dipold, J.. Instituto de Física de Sao Carlos; BrasilFil: Platino, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Tecnología en Detección y Astropartículas. Comisión Nacional de Energía Atómica. Instituto de Tecnología en Detección y Astropartículas. Universidad Nacional de San Martín. Instituto de Tecnología en Detección y Astropartículas; ArgentinaFil: CTA Consortium. No especifíca;33rd International Cosmic Ray Conference (ICRC 2013): The Astroparticle Physics ConferenceRío de JaneiroBrasilCherenkov Telescope Array Consortiu

Dietary glycemic index and retinal microvasculature in adults: a cross-sectional study

[EN] Objective: To analyze the relationship between dietary glycemic index (GI) and retinal microvasculature in adults. Methods: This was a cross-sectional study of 300 subjects from the EVIDENT II study. Dietary GI was calculated using a validated, semi-quantitative food frequency questionnaire. Retinal photographs were digitized, temporal vessels were measured in an area 0.5–1 disc diameter from the optic disc and arteriolar-venular index (AVI) was estimated with semi-automated software. Results: AVI showed a significant difference between the tertiles of GI, after adjusting for potential confounders. The lowest AVI values were observed among subjects in the highest tertile of GI, whereas the greatest were found among those in the lowest tertile (estimated marginal mean of 0.738 vs. 0.768, p = 0.014). Conclusions: In adults, high dietary GI implies lowering AVI values regardless of age, gender and other confounding variables. Trial registration: Clinical Trials.gov Identifier: NCT02016014. Registered 9 December 2013

A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms

Background: Alterations in the DNA methylation pattern are a hallmark of leukemias and lymphomas. However, most epigenetic studies in hematologic neoplasms (HNs) have focused either on the analysis of few candidate genes or many genes and few HN entities, and comprehensive studies are required. Methodology/Principal Findings: Here, we report for the first time a microarray-based DNA methylation study of 767 genes in 367 HNs diagnosed with 16 of the most representative B-cell (n = 203), T-cell (n = 30), and myeloid (n = 134) neoplasias, as well as 37 samples from different cell types of the hematopoietic system. Using appropriate controls of B-, T-, or myeloid cellular origin, we identified a total of 220 genes hypermethylated in at least one HN entity. In general, promoter hypermethylation was more frequent in lymphoid malignancies than in myeloid malignancies, being germinal center mature B-cell lymphomas as well as B and T precursor lymphoid neoplasias those entities with highest frequency of gene-associated DNA hypermethylation. We also observed a significant correlation between the number of hypermethylated and hypomethylated genes in several mature B-cell neoplasias, but not in precursor B- and T-cell leukemias. Most of the genes becoming hypermethylated contained promoters with high CpG content, and a significant fraction of them are targets of the polycomb repressor complex. Interestingly, T-cell prolymphocytic leukemias show low levels of DNA hypermethylation and a comparatively large number of hypomethylated genes, many of them showing an increased gene expression. Conclusions/Significance: We have characterized the DNA methylation profile of a wide range of different HNs entities. As well as identifying genes showing aberrant DNA methylation in certain HN subtypes, we also detected six genes—DBC1, DIO3, FZD9, HS3ST2, MOS, and MYOD1—that were significantly hypermethylated in B-cell, T-cell, and myeloid malignancies. These might therefore play an important role in the development of different HNs

SALMANTICOR study. Rationale and design of a population-based study to identify structural heart disease abnormalities: a spatial and machine learning analysis

[EN]Introduction: This study aims to obtain data on the prevalence and incidence of structural heart disease in a population setting and, to analyse and present those data on the application of spatial and machine learning methods that, although known to geography and statistics, need to become used for healthcare research and for political commitment to obtain resources and support effective public health programme implementation. Methods and analysis: We will perform a cross-sectional survey of randomly selected residents of Salamanca (Spain). 2400 individuals stratified by age and sex and by place of residence (rural and urban) will be studied. The variables to analyse will be obtained from the clinical history, different surveys including social status, Mediterranean diet, functional capacity, ECG, echocardiogram, VASERA and biochemical as well as genetic analysis. Ethics and dissemination: The study has been approved by the ethical committee of the healthcare community. All study participants will sign an informed consent for participation in the study. The results of this study will allow the understanding of the relationship between the different influencing factors and their relative importance weights in the development of structural heart disease