Women with Blood Hypertension: A Dialogical Reflection

The article reflects on the “philosophy of dialogue” of Martín Buber for the analysis of the relationship of women who live with arterial hypertension. With the theoretical proposal of Buber, considering the social context from the world view of the disease, this leads to relationships of suffering and anguish, but with dialogue among the people who live with this disease it is observed in specific cases of chronic disease. Likewise, the panorama of the problem is the interaction between the social being and the disease, in order to generate a dialogue between the disease and the women who live daily this condition

La situación laboral de los jóvenes españoles. Una perspectiva nacional, autonómica y europea

This TFG expounds a detailed study on young people´s situation in the Spanish labour market during recent years that serves to try to understand how a high youth unemployment rate was reached during the Great Recession. According to this purpose, we compare the main aspects that characterize young people´s employment situation with adult population´s one, and examine their reality at a different territorial levels. This study allows us to affirm that the crisis has aggravated young people´s situation more than the adults’ one, despite of their greater academic training. The circumstances of the young canaries are worse than those of the national average, and these, in turn, than those of the European´s one, being one of the causes the legislative framework. Having more academic training grants labour advantages, even though it does not guarantee an adequate job.En este TFG se desarrolla un estudio pormenorizado de la situación laboral de los jóvenes españoles en los últimos años, que sirve como base para tratar de entender cómo se llegó a alcanzar, durante la Gran Recesión, una tasa de paro juvenil tan elevada. Con este fin, se comparan los aspectos fundamentales que caracterizan la situación laboral de los jóvenes con los de la población adulta y se examina su realidad a distinto nivel territorial. Este estudio permite afirmar que la crisis ha agravado la situación de los jóvenes más que la de los adultos, a pesar de su mayor formación. Las circunstancias de los jóvenes canarios son peores que las de la media nacional, y estas, a su vez, que las de la media europea, siendo una de las causas el marco legislativo. Tener mayor formación otorga ventajas laborales aunque no garantiza un empleo acorde a la misma

Análisis de los estilos de aprendizaje, enseñanza y métodos de estudio transmitidos por los docentes de bachillerato del colegio campestre celestín freinet de la cuidad de piedecuesta santander

La presente investigación tuvo como finalidad analizar la relación entre los estilos de aprendizaje, enseñanza y métodos de estudio, se trabajó desde un enfoque de tipo cualitativo, con diseño descriptivo. La muestra que se utilizó está constituida por los estudiantes y docentes de bachillerato del colegio Campestre Celestín Freinet de la ciudad de Piedecuesta Santander, para poder llevar a cabo la investigación en relación con los métodos de estudio que manejaban los profesores, se realizó una entrevista semiestructurada que cuesta de 15 preguntas o ítems. Siendo el proceso de aprendizaje un factor importante en la vida del ser humano, se decide trabajar en este estudio ya que es un tema de interés, puesto que en el transcurso del proceso de enseñanza-aprendizaje, se ha generado la duda de que procedimientos o técnicas son las adecuadas para tener una buena obtención del conocimiento impartido, y estén acorde a esta relación profesor-estudiante, ya que son diversas las variables que se ven inmersas tanto por parte de los profesores, como de los alumnos.The purpose of this research was to analyze the relationship between learning styles, teaching and study methods, working from a qualitative approach, with a descriptive design. The sample that was used is made up of high school students and teachers from the Celestín Freinet Campestre school in the city of Piedecuesta Santander, in order to carry out the research in relation to the study methods used by the teachers, a semi-structured interview was conducted. which costs 15 questions or items. Being the learning process an important factor in the life of the human being, It is decided to work on this study since it is a topic of interest, since in the course of the teaching-learning process, the doubt has been generated that procedures or techniques are adequate to have a good obtaining of the imparted knowledge, and are according to this teacher-student relationship, since there are several variables that are immersed by both teachers and students.Resumen -- Abstract -- Introducción -- Planteamiento del problema -- Justificación -- Objetivos -- Objetivo General -- Objetivos Específicos -- Marco referencial -- Antecedentes investigativos -- Marco teórico -- Marco conceptual -- Marco legal -- Metodología -- Enfoque y diseño -- Participantes -- Instrumento -- Procedimiento -- Consideraciones Éticas -- Resultados -- Diagnostico sociodemográfico de la población participante -- Respuestas grupo poblacional A Entrevista Semiestructurada -- Discusión -- Conclusiones -- Recomendaciones -- Referencias -- Anexos

Angiotensin II requires an intact cardiac Thyrotropin-Releasing Hormone (TRH) system to Induce cardiac hypertrophy in mouse

Cardiac tyhrotropin-releasing hormone (TRH) is overexpressed in the hypertrophied left ventricle (LV) of spontaneously hypertensive rats (SHR) and its inhibition prevents both hypertrophy and fibrosis. In a normal heart, the TRH increase induces fibrosis and hypertrophy opening the question of whether TRH could be a common mediator of left ventricular hypertrophy (LVH). We used angiotensin II (AngII) as an inductor of LVH to evaluate if the blockade of LV-TRH prevents hypertrophy and fibrosis in mice. We challenged C57BL/6 adult male mice with an infusion of AngII (osmotic pumps; 2 mg/kg.day) to induce LVH. Groups of mice were injected with an intracardiac siRNA-TRH or scrambled siRNA (siRNA-Con). Body weight, water intake and systolic arterial blood pressure (SABP) were measured daily. AngII significantly increased water intake and SABP (p <.05). Cardiac hypertrophy (heart weight/body weight) was evident in the group with the normal cardiac TRH system. In fact, it was found an AngII-induced increase of TRH precursor mRNA (p <.05) in conjunction with elevated TRH levels measured by immunohistochemistry and western blot. These changes were not observed in the AngII + siRNA-TRH group. Furthermore, AngII increased significantly (p <.05) BNP (hypertrophic marker), collagens I and III and TGF-β (fibrosis markers) expression in the group with the native cardiac TRH system. These increases were attenuated in the groups with the TRH system blocked despite the high blood pressure. Similar and stronger results were observed “in vitro” with NIH3T3 and H9C2 cell culture models, where, when the TRH system is blocked, AngII stimulus was not able to induce the markers of its fibrotic and hypertrophic effects, so we believe that these effects are independent of any other physiological modifications. Our results point out that cardiac TRH is required for AngII-induced hypertrophic and fibrotic effects.Fil: Peres Diaz, Ludmila Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Schuman, Mariano Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Aisicovich, Maia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Toblli, Jorge Eduardo. Hospital Aleman; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Landa, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Garcia, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentin

Cardiac Thyrotropin-releasing Hormone Inhibition Improves Ventricular Function and Reduces Hypertrophy and Fibrosis After Myocardial Infarction in Rats

Background: Cardiac thyrotropin-releasing hormone (TRH) is a tripeptide with still unknown functions. We demonstrated that the left ventricle (LV) TRH system is hyperactivated in spontaneously hypertensive rats and its inhibition prevented cardiac hypertrophy and fibrosis. Therefore, we evaluated whether in vivo cardiac TRH inhibition could improve myocardial function and attenuate ventricular remodeling in a rat model of myocardial infarction (MI). Methods and Results: In Wistar rats, MI was induced by a permanent left anterior descending coronary artery ligation. A coronary injection of a specific small interfering RNA against TRH was applied simultaneously. The control group received a scrambled small interfering RNA. Cardiac remodeling variables were evaluated one week later. In MI rats, TRH inhibition decreased LV end-diastolic (1.049 ± 0.102 mL vs 1.339 ± 0.102 mL, P <.05), and end-systolic volumes (0.282 ± 0.043 mL vs 0.515 ± 0.037 mL, P <.001), and increased LV ejection fraction (71.89 ± 2.80% vs 65.69 ± 2.85%, P <.05). Although both MI groups presented similar infarct size, small interfering RNA against TRH treatment attenuated the cardiac hypertrophy index and myocardial interstitial collagen deposition in the peri-infarct myocardium. These effects were accompanied by attenuation in the rise of transforming growth factor-β, collagen I, and collagen III, as well as the fetal genes (atrial natriuretic peptide, B-type natriuretic peptide, and beta myosin heavy chain) expression in the peri-infarct region. In addition, the expression of Hif1α and vascular endothelial growth factor significantly increased compared with all groups. Conclusions: Cardiac TRH inhibition improves LV systolic function and attenuates ventricular remodeling after MI. These novel findings support the idea that TRH inhibition may serve as a new therapeutic strategy against the progression of heart failure.Fil: Schuman, Mariano Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Peres Diaz, Ludmila Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Aisicovich, Maia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Ingallina, Fernando Juan. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Toblli, Jorge Eduardo. Hospital Aleman; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Landa, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Garcia, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Hospital Aleman; Argentin

First report of cerebellar abiotrophy in an Arabian foal from Argentina

Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina.Fil: Sadaba, Sebastian Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Madariaga, Gonzalo Julián. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Corbi Botto, Claudia Malena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Carino, Mónica Herminia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Zappa, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Peral Garcia, Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; ArgentinaFil: Olguin, Silvia Andrea. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Massone, A.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Diaz, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentin

In silico Approach for Validating and Unveiling New Applications for Prognostic Biomarkers of Endometrial Cancer

Bioinformática; Cáncer de endometrio; Biomarcador pronósticoBioinformàtica; Càncer d'endometri; Biomarcador pronòsticBioinformatics; Endometrial cancer; Prognostic biomarkerEndometrial cancer (EC) mortality is directly associated with the presence of prognostic factors. Current stratification systems are not accurate enough to predict the outcome of patients. Therefore, identifying more accurate prognostic EC biomarkers is crucial. We aimed to validate 255 prognostic biomarkers identified in multiple studies and explore their prognostic application by analyzing them in TCGA and CPTAC datasets. We analyzed the mRNA and proteomic expression data to assess the statistical prognostic performance of the 255 proteins. Significant biomarkers related to overall survival (OS) and recurrence-free survival (RFS) were combined and signatures generated. A total of 30 biomarkers were associated either to one or more of the following prognostic factors: histological type (n = 15), histological grade (n = 6), FIGO stage (n = 1), molecular classification (n = 16), or they were associated to OS (n = 11), and RFS (n = 5). A prognostic signature composed of 11 proteins increased the accuracy to predict OS (AUC = 0.827). The study validates and identifies new potential applications of 30 proteins as prognostic biomarkers and suggests to further study under-studied biomarkers such as TPX2, and confirms already used biomarkers such as MSH6, MSH2, or L1CAM. These results are expected to advance the quest for biomarkers to accurately assess the risk of EC patients.This research was funded by grants from the Instituto de Salud Carlos III (ISCIII) grant number PI17/02155, PI20/00644, and the IFI19/00029 to E.C.-d.l.R., the Ministerio de ciencia, Innovación y Universidades through a RETOS Colaboración (RTC-2017-6261-1), both co-financed by the European Regional Development Fund (FEDER); from Fundación Científica Asociación Española Contra el Cáncer (AECC) grant number GCTRA1804MATI and CIBERONC network grant number CB16/12/00328; and Grups Consolidats de la Generalitat de Catalunya (2017SGR1661). E.C. is supported by an Investigator Grant from AECC (INVES20051COLA). E.M.-G. was supported by Televie grant F5/20/5-TLV/DD

Propuesta de Supply Chain Management y Logística para la Panadería La Europea S.A.S

La presente investigación se centra en el marco del diplomado de profundización en Supply Chain Management y Logística, en el cual enfoca un análisis y documentación de los procesos de producción, cadena de suministros y área logística de la Panadería La EUROPEA S.A.S, esta investigación pretende documentar los últimos avance tecnológicos, ideas innovadoras de marketing, las falencias de las empresas en la cadena de suministros y el área logística aplicándose en la panadería La EUROPEA S.A.S, para analizar esta problemática se trabajó en analizar y documentar por qué se hace necesario que la empresa configure su red estructural y el enfoque inteligente en los procesos Global Supply Chain Forum (GSCF) y APICS-SCOR, del cómo afecta la posición de Colombia frente a LPI del Banco Mundial y ante el CONPES 3982.This research focuses on the framework of the deepening diploma in Supply Chain Management and Logistics, which focuses on an analysis and documentation of the production processes, supply chain and logistics area of the Bakery La EUROPEA S.A.S, this research aims to document the latest technological advances, innovative marketing ideas, the shortcomings of companies in the supply chain and the logistics area applied in the bakery La EUROPEA S.A.S, to analyze this problem, we worked to analyze and document why it is necessary for the company to configure your structural network and the intelligent approach in the Global Supply Chain Forum (GSCF) and APICS-SCOR processes, how it affects the position of Colombia before LPI of the World Bank and before CONPES 3982