Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Las identidades y las tensiones culturales de la modernidad Homenaje a la Xeneracion Nos

Ten volumesCentro de Informacion y Documentacion Cientifica (CINDOC). C/Joaquin Costa, 22. 28002 Madrid. SPAIN / CINDOC - Centro de Informaciòn y Documentaciòn CientìficaSIGLEESSpai

Lineamientos para una gestión integral de los residuos de artículos eléctricos y electrónicos (RAEE) para los hogares de la ciudad de Ibagué

Los residuos de aparatos eléctricos y electrónicos -RAEE por sus siglas en español- es un tema de creciente interés en la comunidad científica por sus múltiples retos, no solo a nivel nacional sino también internacional: su rápida tasa de crecimiento anual, los componentes tanto tóxicos como valiosos que los componen, y por el nivel de informalidad en cuanto a su manejo que es entre otras la principal causa para la contaminación ambiental y los problemas de salud humana. En Colombia se han hecho algunos estudios frente a la generación de este flujo de residuos, se han generado diferentes normativas que finalizaron en la Política Nacional de Gestión de RAEE. Sin embargo, a nivel municipal aún siguen existiendo muchos vacíos de información sobre esta problemática, conllevando a una disposición incorrecta de RAEE. Parte de esta desinformación radica en la ausencia de casos de estudio de centros urbanos que aborden sus particularidades geográficas, socioeconómicas, ambientales y político-administrativas. Es por ello por lo que este trabajo busca presentar un diagnóstico y finalmente unos lineamientos para el manejo integral de RAEE en la ciudad de Ibagué, para lo cual se recopiló información de diagnóstico de RAEE en Ibagué, se realizaron entrevistas y a partir de estadísticas descriptivas e inferenciales, se obtienen conclusiones y lineamientos desde la ecología y la gestión ambiental para encontrar las estrategias oportunas, efectivas y ajustadas al contexto de esta ciudad.The waste of electrical and electronic equipment -RAEE by its acronym in Spanish- is a subject of growing interest in the scientific community for its many challenges, not only at the national level but also internationally: its rapid annual growth rate, the toxic components as valuable that compose them, and for the level of informality in terms of their management which is, among others, the main cause for environmental pollution and human health problems. In Colombia, some studies have been made regarding the generation of this waste stream, different regulations have been generated that ended in the National WEEE Management Policy. However, at the municipal level there are still many information gaps about this problem, leading to an incorrect provision of WEEE. Part of this misinformation lies in the absence of case studies of urban centers that address their geographical, socioeconomic, environmental and political-administrative particularities. That is why this work seeks to present a diagnosis and finally guidelines for the comprehensive management of WEEE in the city of Ibagué, for which WEEE diagnostic information was collected in Ibagué, interviews were conducted and from descriptive statistics and Inferential, conclusions and guidelines are obtained from the ecology and environmental management to find the opportune strategies, effective and adjusted to the context of this city

ESICM LIVES 2016: part two : Milan, Italy. 1-5 October 2016.

Meeting abstrac