Methodology for the metric restoration of the historical cartography applied to Francisco Coello's cartografic series of the Royal Site of Aranjuez

Hojas Kilométricas (Kilometric Sheets). Specifically, the study focuses on those sheets referring to the city centre and surrounding area of the Royal Site of Aranjuez, a town in the south of the Province of Madrid. The aim of this study is to restore the actual size and measurements of scanned images of the Hojas Kilométricas. This would allow us, among other things, to reestablish both the format and scale of the original plans. To achieve this goal it is necessary to rectify and then georeference these images, i.e. assign them a geographic reference system. This procedure is essential in the overlaying and comparison of the Hojas Kilométricas of the Royal Site with other historical cartography as well as other sources related to the same area from different time periods. Subsequent research would allow us, for example, to reconstruct the time-evolution of the urban area, to spot new construction and to pinpoint the locations of any altered or missing buildings or architectural features. In addition, this would allow us to develop and integrate databases for GIS models applicable to the management of our cultural heritage

Challenges to the Effective Implementation of Competition Policy in Regulated Sectors: The Case of Telecommunications in Mexico Symposium on Competition Law and Policy in Developing Countries

This article reviews Mexico\u27s competition law and policy, with particular emphasis on the challenges that the Federal Competition Commission ( CFC ) has faced in implementing an effective competition policy. Some of the difficulties analyzed are the loopholes in the current laws, the lack of cooperation between the CFC and other sectoral regulators, and the regulatory arbitrage by market participants. These challenges are then illustrated by the developments in the telecommunications sector. This sector is particularly interesting in the case of Mexico given the overwhelming power of the dominant firm and the overlapping and even conflicting mandates of the different government authorities overseeing the sector. The article concludes with a series of specific policy recommendations aimed at improving the effectiveness with which the competition authority in Mexico implements competition policy

Flame Spray Pyrolysis of Precursors as a Route to Nano-mullite Powder: Powder Characterization and Sintering Behavior

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66240/1/j.1151-2916.2001.tb00774.x.pd

PAR-2-induced colonic inflammation does not depend upon paracellular permeability and lymphocyte infiltration

PAR-2-induced colonic inflammation does not depend upon paracellular permeability and lymphocyte infiltration. 10th United European Gastroenterology Wee

Histological changes induced by the cynipid wasp Dryocosmus kuriphilus (Hymenoptera: Cynipidae) in leaves of the chestnut Castanea sativa (Fagaceae): Mechanisms of galling impact on host vigor

[EN] Dryocosmus kuriphilus (Hymenoptera: Cynipidae), the Asian chestnut gall wasp (ACGW), is an invasive pest that threatens native stands and orchards of European Sweet Chestnut (Castanea sativa Mill.). ACGW induces galls in stems, petioles, and midribs. These galls cause inhibition of tree growth and fruit production. An understanding of morphogenetic changes in host organs is important to evaluate how plant resources are redirected to galls. Structural divergences in C. sativa petioles, midribs, and respective galls were investigated. Larvae of D. kuriphilus are found in the central region of young petioles and midribs in the spring. They are positioned in the pith region of petioles and midribs, surrounded by vascular tissues. The increase in cell layers and volume is evident in the ground tissues of galls, i.e., parenchyma, collenchyma, and sclerenchyma that originate from ground meristem. Gall formation causes the separation of the original vascular system into several collateral and amphicribral vascular bundles. The vascular web branching likely favors the redirection of resources from developing leaf blades to the galls by compensatory hydraulic mechanisms. The rapid growth rates of galls are likely supported by an increased water supply to gall sites. Cytoplasmically dense and metabolically active nutritive linings of the larval chambers are the sole source of food for larvae. Nutritive cells are maintained by a rich vascular supply. The redifferentiation of mechanical tissue surrounding the nutritive tissue also requires energy and protects the D. kuriphilus larva until pupation. These vascular alterations impact the normal formation of tissues in distal regions of the leaf, which reduces the productivity of chestnut treesS

Análisis arqueosismológico del conjunto arqueológico romano de Mulva- Munigua (Sevilla, España). Resultados preliminares

El conjunto arqueológico romano de Mulva-Munigua (Sevilla, España) presenta daños en las edificaciones que pueden ser interpretadas como resultado de la ocurrencia de un evento sísmico (Efectos Arqueológicos de los Terremotos: EAEs) a finales del siglo III A.D., fecha coincidente con el inicio del periodo de declive económico de este asentamiento romano. Para intentar establecer el posible origen sísmico de las deformaciones, se ha procedido al inventario y análisis de las estructuras deformadas presentes en el yacimiento. No obstante, algunas de estas deformaciones también se pueden interpretar como resultado de procesos gravitaciones asociados a la ladera Este de la colina sobre la que se sitúa parte del yacimiento. Las direcciones de máxima deformación (ey) obtenidas del análisis de EAEs indica dos direcciones preferentes de la deformación (o movimiento preferente del terreno): NNO-SSE y ENEOSO. Aunque los datos presentan una dispersión importante, se puede establecer que la orientación principal NNO-SSE es compatible con un evento sísmico situado en el borde norte del Valle del Guadalquivir. La orientación ENE-OSO podría relacionarse con un evento posterior, o más seguramente con procesos de ladera de carácter cosísmico o no.The Roman archaeological site of Mulva-Munigua (Sevilla, Spain) displays building damage features suggesting a seismic origin (Earthquake Archaeological Effects: EAEs). The proposed seismic event could be tentatively dated in the late 3rd century AD, coinciding with the beginning of the economic fall of the Roman Empire at Iberia. However, some of the recorded EAEs can be also interpreted as a result of intervening slope movements in the eastern hillslope of this roman site. The inventory and analysis of the proposed EAEs make possible to discern between seismic oriented damage and other causes. In spite of the data show a significant dispersion, their analysis result in two different orientations of maximum deformation (ey) or preferential ground movement: NNW-SSE and ENE-WSW. The main ey orientation (NNW-SSE) can be tentatively related to a seismic event occurred in the environs of the northern border of the Guadalquivir Depression. The secondary orientation (ENE-WSW) can be interpreted as a consequence of latter slope movements triggered (or not) by other ancient earthquakes

Primary productivity and phytoplankton dynamics in a subtropical estuary: a multiple timescale approach

Temporal variability of physicochemical parameters and phytoplankton primary productivity, abundance and composition were investigated at Babitonga Bay, southern Brazil, using a hierarchical sampling design on the scales of months, weeks and days during spring 2012 and summer 2013. Only temperature, respiration rates and concentrations of dissolved oxygen and silicate exhibited significant differences in the greatest timescale (seasons: spring; summer). In contrast, most physicochemical parameters, such as salinity and the concentration of nitrogen compounds, varied mainly among weeks and days. This short-scale variability was similarly observed for the microphytoplankton abundance, ranging from 0.04 to 1.7.106 cells L–1 during a bloom of the diatom Skeletonema costatum. Two major phytoplankton assemblages were associated with high primary production rates: > 30 μm centric diatoms such as Cyclotella spp. and Cymatodiscus sp., in spring; and a summer assemblage dominated by smaller, bloom-forming diatoms (S. costatum and Eucampia cornuta). Primary production ranged from 10.5 to 1793 mg C m–2 d–1 and varied significantly between days and months, being associated with the photosynthetic active radiation level and weather conditions on the sampling day. Abundance of specific plankton taxa appeared controlled by trophic interactions, as revealed for the mixotrophic, toxic dinoflagellate Dinophysis acuminata complex and its prey, the ciliate Mesodinium rubrum

DRB1*03:01 Haplotypes: Differential Contribution to Multiple Sclerosis Risk and Specific Association with the Presence of Intrathecal IgM Bands

BACKGROUND: Multiple sclerosis (MS) is a multifactorial disease with a genetic basis. The strongest associations with the disease lie in the Human Leukocyte Antigen (HLA) region. However, except for the DRB1*15:01 allele, the main risk factor associated to MS so far, no consistent effect has been described for any other variant. One example is HLA-DRB1*03:01, with a heterogeneous effect across populations and studies. We postulate that those discrepancies could be due to differences in the diverse haplotypes bearing that allele. Thus, we aimed at studying the association of DRB1*03:01 with MS susceptibility considering this allele globally and stratified by haplotypes. We also evaluated the association with the presence of oligoclonal IgM bands against myelin lipids (OCMB) in cerebrospinal fluid. METHODS: Genotyping of HLA-B, -DRB1 and -DQA1 was performed in 1068 MS patients and 624 ethnically matched healthy controls. One hundred and thirty-nine MS patients were classified according to the presence (M+, 58 patients)/absence (M-, 81 patients) of OCMB. Comparisons between groups (MS patients vs. controls and M+ vs. M-) were performed with the chi-square test or the Fisher exact test. RESULTS: Association of DRB1*03:01 with MS susceptibility was observed but with different haplotypic contribution, being the ancestral haplotype (AH) 18.2 the one causing the highest risk. Comparisons between M+, M- and controls showed that the AH 18.2 was affecting only M+ individuals, conferring a risk similar to that caused by DRB1*15:01. CONCLUSIONS: The diverse DRB1*03:01-containing haplotypes contribute with different risk to MS susceptibility. The AH 18.2 causes the highest risk and affects only to individuals showing OCMB

An increase in erythromycin resistance in methicillin-susceptible Staphylococcus aureus from blood correlates with the use of macrolide/lincosamide/streptogramin antibiotics. EARS-Net Spain (2004–2020)

Objectives: To describe and analyse erythromycin resistance trends in blood isolates of Staphylococcus aureus (EARS-Net Spain, 2004–2020) and the association of these trends with the consumption of macrolide, lincosamide, and streptogramin B (MLSB) antibiotics. To assess molecular changes that could be involved in erythromycin resistance trends by whole genome analysis of representative isolates. Materials and methods: We collected antibiotic susceptibility data for all firstblood S. aureus isolates in patients from 47 Spanish hospitals according to EARS-Net criteria. MLSB antibiotic consumption was obtained from the Spanish Agency for Medicines and Medical Devices (2008–2020). We sequenced 137 representative isolates for core genome multilocus sequence typing, resistome and virulome analysis. Results: For the 36,612 invasive S. aureus isolates, methicillin resistance decreased from 26.4% in 2004 to 22.4% in 2020. Erythromycin resistance in methicillin-susceptible S. aureus (MSSA) increased from 13.6% in 2004 to 28.9% in 2020 (p < 0.001); however, it decreased from 68.7 to 61.8% (p < 0.0001) in methicillin-resistant S. aureus (MRSA). Total consumption of MLSB antibiotics increased from 2.72 defined daily doses per 1,000 inhabitants per day (DID) in 2014 to 3.24 DID in 2016. By WGS, the macrolide resistance genes detected were erm (59.8%), msrA (46%), and mphC (45.2%). The erm genes were more prevalent in MSSA (44/57, 77.2%) than in MRSA (38/80, 47.5%). Most of the erm genes identified in MSSA after 2013 differed from the predominant ermC gene (17/22, 77.3%), largely because ermT was significantly associated with MSSA after 2013 (11/29, 37.9%). All 13 ermT isolates in this study, except one, belonged to ST398 and came from 10 hospitals and six Spanish provinces. Conclusion: The significant increase in erythromycin resistance in blood MSSA correlated with the consumption of the MLSB antibiotics in Spain. These preliminary data seem support the hypothesis that the human ST398 MSSA clade with ermT-mediated resistance to erythromycin may be involved in this trend.This research was supported by CIBER—Consorcio Centro de Investigación Biomédica en Red (CB21/13/00095, CB21/13/00006, CB21/13/00054, CB21/13/00068, CB21/13/00084, CB21/13/00099 groups of CIBERINFEC; CB06/06/0058 group of CIBERES), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea-NextGenerationEU. This research was also supported by Personalized and precision medicine grant from the Instituto de Salud Carlos III (MePRAM Project, PMP22/00092), and by the Antibiotic Resistance and Staphylococcus aureus Surveillance Programs of the National Center for Microbiology, Instituto de Salud Carlos III.S