La asociación para delinquir

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Derecho, leída en 1975.Fac. de DerechoTRUEProQuestpu

La asociación para delinquir

Tesis inédita de la Universidad Complutense de Madrid, Facultad de Derecho, leída en 1975.Fac. de DerechoTRUEProQuestpu

Artículos publicados en el diario El País sobre Antonio Fernández Alba

Artículos publicados sobre Antonio Fernández Alba en el diario El Paí

Critical review of technologies for the on-site treatment of hospital wastewater: From conventional to combined advanced processes

In this work, a raw and low cost mineral, ilmenite (FeTiO3), has been tested for the first time as a photocatalyst paired with peroxymonosulfate (HSO5-; PMS) for the inactivation of Enterococcus faecalis as an alternative to conventional treatments to disinfect wastewater for reuse. The influence of some operational parameters such as reagent dosage, catalyst concentration, initial pH, or flow rate was also studied and optimized. After several tests, the scarce pure photoactivity under UV-A was remarked by ilmenite because of its high iron content, which favors photogenerated charge recombination. However, ilmenite activity was highly promoted when combined with low concentrations of PMS and UV-A light, reaching total inactivation of Enterococcus faecalis in 120 min. Quenching tests were performed using methanol, tert-butyl alcohol, furfuryl alcohol, and Cu(II) to assess the main reactive species involved in the disinfection process determining the critical role of both HO·and SO4·- radicals in the process. Finally, the influence of the water matrix was also evaluated by studying the effect of water hardness and the presence of nutrients on the system. Overall, the PMS/Ilmenite/UV-A system yielded promising results with a total removal of Enterococcus faecalis in 120 min. However, it also showed the need for further study and understanding of the disinfection mechanism to achieve the same level of performance in real wastewaterThe "Comunidad de Madrid" supported this research through REMTAVARES S2013/MAE-2716 and S2018/EMT-434

Critical review of technologies for the on-site treatment of hospital wastewater: From conventional to combined advanced processes

This review aims to assess different technologies for the on-site treatment of hospital wastewater (HWW) to remove pharmaceutical compounds (PhCs) as sustances of emerging concern at a bench, pilot, and full scales from 2014 to 2020. Moreover, a rough characterisation of hospital effluents is presented. The main detected PhCs are antibiotics and psychiatric drugs, with concentrations up to 1.1 mg/L. On the one hand, regarding the presented technologies, membrane bioreactors (MBRs) are a good alternative for treating HWW with PhCs removal values higher than 80% in removing analgesics, anti-inflammatories, cardiovascular drugs, and some antibiotics. Moreover, this system has been scaled up to the pilot plant scale. However, some target compounds are still present in the treated effluent, such as psychiatric and contrast media drugs and recalcitrant antibiotics (erythromycin and sulfamethoxazole). On the other hand, ozonation effectively removes antibiotics found in the HWW (>93%), and some studies are carried out at the pilot plant scale. Even though, some families, such as the X-ray contrast media, are recalcitrant to ozone. Other advanced oxidation processes (AOPs), such as Fenton-like or UV treatments, seem very effective for removing pharmaceuticals, Antibiotic Resistance Bacteria (ARBs) and Antibiotic Resistance Genes (ARGs). However, they are not implanted at pilot plant or full scale as they usually consider extra reactants such as ozone, iron, or UV-light, making the scale-up of the processes a challenging task to treat high-loading wastewater. Thus, several examples of biological wastewater treatment methods combined with AOPs have been proposed as the better strategy to treat HWW with high removal of PhCs (generally over 98%) and ARGs/ARBs (below the detection limit) and lower spending on reactants. However, it still requires further development and optimisation of the integrated processes.Comunidad de Madri

Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma

Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver is a fusion gene, EWSR1-FLI1. Although the essential role of EWSR1-FLI1 protein in the regulation of oncogenesis, survival, and tumor progression processes has been described in-depth, little is known about the regulation of chimeric fusion-gene expression. Here, we demonstrate that the active nuclear HDAC6 in EWS modulates the acetylation status of specificity protein 1 (SP1), consequently regulating the SP1/P300 activator complex binding to EWSR1 and EWSR1-FLI1 promoters. Selective inhibition of HDAC6 impairs binding of the activator complex SP1/P300, thereby inducing EWSR1-FLI1 downregulation and significantly reducing its oncogenic functions. In addition, sensitivity of EWS cell lines to HDAC6 inhibition is higher than other tumor or non-tumor cell lines. High expression of HDAC6 in primary EWS tumor samples from patients correlates with a poor prognosis in two independent series accounting 279 patients. Notably, a combination treatment of a selective HDAC6 and doxorubicin (a DNA damage agent used as a standard therapy of EWS patients) dramatically inhibits tumor growth in two EWS murine xenograft models. These results could lead to suitable and promising therapeutic alternatives for patients with EWS.Research in the E.D.A. lab is supported by Asociación Española Contra el Cáncer (AECC), the Ministry of Science of Spain-FEDER (CIBERONC, PI1700464, PI2000003, RD06/0020/0059)S. D.G.D. and L.H.P. are supported by CIBERONC (CB16/12/00361). D.G.D., M.J.R. and L.H.P. are PhD researchers funded by the Consejería de Salud, Junta de Andalucía (PI-0197-2016, ECAI F2-0012-2018 and PI-0013-2018, respectively).Peer reviewe

La aportación de la Criminología

[ES] Actualmente a la Criminología, como ciencia interdisciplinar, corresponde coordinar los saberes sectoriales (biológicos, psicológicos y sociológicos) sobre el crimen y la victima, para estructurar un control social positivo que entienda y atienda a la nueva dimensión dinámica social.[EU] Gaur egun Kriminologiari, zientzi interdisziplinario bezala, krimena eta biktimari buruzko jakintza sektorialak (biologikoak, psikologikoak eta soziologikoak) koordinatzea dagokio, gizartearen izari dinamiko berria ulertu eta harrera egin dezakeen gizarte-kontrol positibo bat egituratzeko.[FR] Il correspond actuellement à la Criminologie, en tent que science interdisciplinaire, de coordonner les savoirs sectorielle (biologiques, phychologiques, sociologiques) sur le crime et la victime, afin de structurer un contrôle social positif qui comprenne et fasse attention à la nouvelle dimension dynamique sociale.[EN] At present, Criminology, as an interdisciplinary science, must coordinate sectional knowleges (biological, psychologiques and sociological) about crime and victim to construct a positive social control that undestunds and attends to the new social dynamic

La prevención del delito y los principales centros de interés de la moderna criminología

Crime prevention is one of the problems that concern the current empirical Criminology and Criminal Policy. But it should be noted, also, other no less relevant that complement the theme and priority criminological research centers. Other contemporary sources of interest are dealt with in the present: Victimology, criminological theories, punishment and social reaction.La prevención del delito es uno de los problemas que preocupan a la actual Criminología empírica, y a la Política Criminal. Pero cabe señalar, también, otros no menos relevantes que completan la temática y centros prioritarios de investigación criminológica. En el presente se abordan otros focos de interés contemporáneos: Victimología, teorías criminológica, la pena y la reacción social