How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions

[EN] The present work characterises how selection for reproduction (by comparing two generations - 16th and 36th - of the V line selected for litter size at weaning) or foundation for reproductive longevity (the LP line) can affect the blood lymphocytes populations of reproductive rabbit does under normal [conventional housing, average daily minimum and maximum temperatures of 14 degrees C and 20 degrees C, respectively] and heat stress conditions [climatic chamber, 25 degrees C and 36 degrees C] from the first to the second parturition. Housing under heat stress conditions significantly reduced the B lymphocytes counts in female rabbits (-34 x 10(6)/L; P < 0.05). The highest lymphocytes population value in blood (total, T CD5(+), CD4(+) and CD8(+)) was noted at the first parturition, while the B lymphocytes count was significantly lower at the second parturition (-61 x 10(6)/L; P < 0.05). Selection for litter size at weaning (V females) reduced the average counts of total and B lymphocytes in blood (-502 and -60 x 10(6)/L, respectively; P < 0.01), mainly because these populations in V36 females continuously lowered from the first to the second parturition under normal housing conditions. Thus, more selected females (V36) at the second parturition showed significantly lower counts in blood for total, T CD5(+) and CD25(+) lymphocytes (-1303, -446 and -33 x 10(6)/L, respectively; P < 0.05). The main differences in blood counts between V36 and V16 females disappeared when housed under heat stress conditions, except for T CD5(+) and CD25(+), which significantly increased (T CD5(+): +428 x 10(6)/L; CD25(+): +41 x 10(6)/L; P < 0.01) in the V16 vs. V36 females on day 10 post-partum. Under normal conditions, no differences between LP and V36 females were found for most lymphocyte populations; only higher counts were noted in CD25(+) (+20 x 10(6)/L; P < 0.05) for LP females. However, the lymphocytes counts [especially total (+1327 x 10(6)/L; P < 0.01) and T CD5(+) (+376 x 10(6)/L; P < 0.10)] of LP females increased under heat vs. normal conditions when lymphocytes populations presented the lowest values (second parturition), while V36 females' counts remained invariable. Positive correlations were found between feed intake (r = +0.51; P < 0.001) and females' perirenal fat thickness (r = +0.40; P < 0.001) with B lymphocytes counts in the blood of primiparous rabbit females in the week 2 of lactation. These results indicate that selection for litter size at weaning might diminish their immune system's response and adaptation capacity, while the foundation for reproductive longevity criteria leads to more robust rabbit females as they present greater modulation under heat stress conditions when the immune system is affected. (c) 2012 Elsevier B.V. All rights reserved.This study has been supported by grants from the CEU-Cardenal Herrera University (Banco Santander/CEU-UCH: Copernicus Program), Generalitat Valenciana (ACOMP/2009/207 and ACOMP/2010/062) and the Comision Interministerial de Ciencia y Tecnologia (AGL2008-00273/GAN, AGL2008-03274/GAN and AGL2011-30170-CO2-02). Grants for Selena Ferrian and Irene Guerrero from Generalitat Valenciana (the Santiago Grisolia programme) and from the Universidad CEU-Cardenal Herrera, respectively, are also gratefully acknowledged.Ferrian, S.; Guerrero, I.; Blas Ferrer, E.; García Diego, FJ.; Viana, D.; Pascual Amorós, JJ.; Corpa, JM. (2012). How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions. Veterinary Immunology and Immunopathology. 150(1-2):53-60. doi:10.1016/j.vetimm.2012.08.007S53601501-

Medidas para la mitigación y la adaptación al cambio climático en el planeamiento urbano. Guía metodológica

Las conclusiones del recién publicado informe científico del Grupo de Trabajo I del Panel Internacional del Cambio Climático no admiten dudas y se resumen en dos formulaciones categóricas dirigidas a los responsables de la toma de decisiones: el calentamiento del sistema climático es inequívoco, y la influencia humana en el sistema climático está clara. Desde esta perspectiva, el presente manual se ofrece principalmente como una guía para la acción con dos objetivos básicos: Ofrecer una herramienta operativa para orientar a los responsables municipales y a todos los actores implicados a escala local en los procesos urbanísticos y ambientales en la elaboración de políticas coherentes de lucha contra el cambio climático desde la óptica de la planificación. Contribuir a que el nivel de concienciación respecto al fenómeno del cambio climático se traduzca a términos cotidianos, es decir, que se entienda mejor su vinculación directa con todos los aspectos que caracterizan la vida urbana de nuestros municipios

Medidas para la mitigación y la adaptación al cambio climático en el planeamiento urbano. Guía metodológica

Las conclusiones del recién publicado informe científico del Grupo de Trabajo I del Panel Internacional del Cambio Climático no admiten dudas y se resumen en dos formulaciones categóricas dirigidas a los responsables de la toma de decisiones: el calentamiento del sistema climático es inequívoco, y la influencia humana en el sistema climático está clara. Desde esta perspectiva, el presente manual se ofrece principalmente como una guía para la acción con dos objetivos básicos: Ofrecer una herramienta operativa para orientar a los responsables municipales y a todos los actores implicados a escala local en los procesos urbanísticos y ambientales en la elaboración de políticas coherentes de lucha contra el cambio climático desde la óptica de la planificación. Contribuir a que el nivel de concienciación respecto al fenómeno del cambio climático se traduzca a términos cotidianos, es decir, que se entienda mejor su vinculación directa con todos los aspectos que caracterizan la vida urbana de nuestros municipios

MOOC on "Ultra-dense networks for 5G and its evolution": challenges and lessons learned

Proceeding of: 31st Annual Conference of the European Association for Education in Electrical and Information Engineering (EAEEIE 2022), Coimbra, Portugal, 26 June-1 July 2022Many of the new mobile communication devices will be things that power and monitor our homes, city infrastructure and transport. Controlling drones thousands of miles away, performing remote surgeries or being immersed in video with no latency will also be a huge game changer. Those are some of the few things that make the fifth generation (5G) a revolution expected to be a thrust to the economy. To that end, the design and density of deployment of new networks is also changing becoming more dense, what introduces new challenges into play. What else will it add to previous generations? The MOOC about Ultra-dense networks for 5G and its evolution has been prepared by the researchers of an European MSCA ITN, named TeamUp5G, and introduces the most important technologies that support 5G mobile communications, with an emphasis on increasing capacity and reducing power. The content spans from aspects of communication technologies to use cases, prototyping and the future ahead, not forgetting issues like interference management, energy efficiency or spectrum management. The aim of the MOOC is to fill the gap in graduation and post-graduation learning on content related to emerging 5G technologies and its applications, including the future 6G. The target audience involves engineers, researchers, practitioners and students. This paper describes the content and the learning outcomes of the MOOC, the main tasks and resources involved in its creation, the joint contributions from the academic and non-academic sector, and aspects like copyright compliance, quality assurance, testing and details on communication and enrollment, followed by the discussion of the lessons learned.This work has received funding from the European Union Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie ETN TeamUp5G, grant agreement No. 813391

Cultural Heritage in Europe: A commitment for socioeconomic change from managing our past II

Diseño web, apoyo RRSS: Empresa Jansá Cultura y Tecnología https://appcultura.comEl proyecto formará en el Patrimonio Cultural existente en la Unión Europea desde su gestión. Supone actividades como: 1. Conocer los bienes culturales desde la visión crítica de los procesos de patrimonialización hasta la catalogación e inventario. 2 Planificar su financiación, legislación o la ordenación urbanística y territorial. 3. Controlar las acciones ilícitas que pueden deteriorarlos, así como la venta o la transmisión de estos bienes. 4. Plantear su socialización desde la interpretación y la difusión en ámbitos formales e informales, desde estrategias de turismo, tecnológicas o de redes sociales, así como realizar procesos participativos, de implicación de la sociedad civil y organizaciones interesadas en la toma de decisiones sobre su tratamiento. 5. Ser capaces de evaluar a corto, largo y medio plazo y desde múltiples perspectivas, incluida la del impacto socioeconómico. De la importancia del tema habla por si sola la declaración del Parlamento Europeo para la celebración del Año 2018 y que reproducimos (http://www.consilium.europa.eu/es/press/press-releases/2017/02/09-cultural-heritage/): " Año Europeo del Patrimonio Cultural en 2018: celebración de la diversidad y la riqueza de nuestro patrimonio europeo, cuyos objetivos son: - Promover la diversidad cultural, el diálogo intercultural y la cohesión social; - Poner de relieve la contribución económica del patrimonio cultural a los sectores cultural y de la creación, en particular a las pequeñas y medianas empresas, y al desarrollo local y regional; - Hacer hincapié en el papel del patrimonio cultural en las relaciones exteriores de la UE, por ejemplo, en la prevención de conflictos, la reconciliación tras estos y la reconstrucción del patrimonio cultural destruido " Abordar estos temas requiere una formación transdisciplinar, que aporta el equipo de docentes de la Universidad Complutense de Madrid y de la Universidad Politécnica de Madrid pertenecientes a las siguientes áreas de conocimiento: historia, historia del arte, geografía, arqueología, economía, sociología, psicología, derecho, arquitectura, ingeniería de las telecomunicaciones y de caminos, canales y puertos. A ellos se le suma una trayectoria de cerca de 30 años en los temas referidos, siendo nuestros centros pioneros en España para impartir esa formación y sin lugar a dudas innovadores en la transversalidad con la que las hemos impulsado en nuestras distintas facultades y escuelas, donde no existe el área de conocimiento como tal. Participamos miembros de varios grupos de investigación, como el de Gestión del Patrimonio Cultural, Patrimonio Turismo y Desarrollo o Paisajes Culturales. Destacan responsabilidades y docencias en Másteres como el de Conservación y Restauración en Patrimonio Arquitectónico, de la UPM o el de Museos y Patrimonio Histórico Artístico de la UCM, lineas de doctorado en Turismo y Desarrollo, asignaturas de grado y posgrados como Patrimonio Urbano, Paisaje Cultural y Ordenación Territorial o la gestión del patrimonio arqueológico. Así mismo la mayoría de nosotros hemos sido evaluados positivamente por el programa Docentia, y hemos participado y dirigido otros proyectos de innovación como el que se encuentra en los antecedentes a este sobre Patrimonio Cultural en CIU y el del decanato de la Fac. Geografía e Historia de Living Unilab sobre APs y ecosistemas de aprendizaje. Iniciativas con las que continuaremos participando. Pero, sin lugar a dudas, ha sido el Máster Interuniversitario Patrimonio Cultural en el S.XXI: Gestión e investigación, un motor de arranque para iniciativas conjuntas entre este equipo, a través del Campus de Excelencia Internacional, y es justo este año cuando se pone en marcha y podremos allí explorar gran parte de nuestras innovaciones recogidas en este proyecto. A estos esfuerzos se suma el alumnado: 13 estudiantes de grados y posgrados comprometidxs con la oportunidad que nos ofrece el pasado. No hay mejor aval para nuestra propuesta.The Educational Innovation Project “Cultural Heritage in Europe: a commitment for socioeconomic change from managing our past” of the Complutense University of Madrid together with the Technical University of Madrid, took advantage of the celebration of the European Year of Cultural Heritage 2018 to open new paths of transversal and multidisciplinary knowledge in the field of Cultural Heritage by applying a type of classroom teaching that would allow students to offer projects that could have an impact on society and contribute to meeting the objectives set by the European Commission for this year's celebration. From a European perspective, the project has completed a triple aspect: researcher, education and public service when working and disseminating Cultural Heritage among the population of Madrid and Europe. The work has been done on disciplines as diverse as Architecture, History, Civil Engineering, Geography, Tourism, etc. to compose from the different subjects involved a speech that will contribute to this field.Depto. de Prehistoria, Historia Antigua y ArqueologíaFac. de Geografía e HistoriaFALSEAyuntamiento de Madrid/Foro de Empresas por Madridsubmitte

Genomic history of coastal societies from eastern South America

Sambaqui (shellmound) societies are among the most intriguing archaeological phenomena in pre-colonial South America, extending from approximately 8,000 to 1,000 years before present (yr bp) across 3,000 km on the Atlantic coast. However, little is known about their connection to early Holocene hunter-gatherers, how this may have contributed to different historical pathways and the processes through which late Holocene ceramists came to rule the coast shortly before European contact. To contribute to our understanding of the population history of indigenous societies on the eastern coast of South America, we produced genome-wide data from 34 ancient individuals as early as 10,000 yr bp from four different regions in Brazil. Early Holocene hunter-gatherers were found to lack shared genetic drift among themselves and with later populations from eastern South America, suggesting that they derived from a common radiation and did not contribute substantially to later coastal groups. Our analyses show genetic heterogeneity among contemporaneous Sambaqui groups from the southeastern and southern Brazilian coast, contrary to the similarity expressed in the archaeological record. The complex history of intercultural contact between inland horticulturists and coastal populations becomes genetically evident during the final horizon of Sambaqui societies, from around 2,200 yr bp, corroborating evidence of cultural change

The alpha-galactosidase A p.Arg118Cys variant does not cause a Fabry disease phenotype: data from individual patients and family studies

Lysosomal α-galactosidase A (α-Gal) is the enzyme deficient in Fabry disease (FD), an X-linked glycosphingolipidosis caused by pathogenic mutations affecting the GLA gene. The early-onset, multi-systemic FD classical phenotype is associated with absent or severe enzyme deficiency, as measured by in vitro assays, but patients with higher levels of residual α-Gal activity may have later-onset, more organ-restricted clinical presentations. A change in the codon 118 of the wild-type α-Gal sequence, replacing basic arginine by a potentially sulfhydryl-binding cysteine residue – GLA p.(Arg118Cys) –, has been recurrently described in large FD screening studies of high-risk patients. Although the Cys118 allele is associated with high residual α-Gal activity in vitro, it has been classified as a pathogenic mutation, mainly on the basis of theoretical arguments about the chemistry of the cysteine residue. However its pathogenicity has never been convincingly demonstrated by pathology criteria. We reviewed the clinical, biochemical and histopathology data obtained from 22 individuals of Portuguese and Spanish ancestry carrying the Cys118 allele, including 3 homozygous females. Cases were identified either on the differential diagnosis of possible FD manifestations and on case-finding studies (n=11; 4 males), or on unbiased cascade screening of probands’ close relatives (n=11; 3 males). Overall, those data strongly suggest that the GLA p.(Arg118Cys) variant does not segregate with FD clinical phenotypes in a Mendelian fashion, but might be a modulator of the multifactorial risk of cerebrovascular disease, since the allelic frequency in stroke patients was 0.0087 (p=0.0185 vs the general population). The Cys118 allelic frequency in healthy Portuguese adults (n=696) has been estimated as 0.001, therefore not qualifying for “rare” conditio

Aula itinerante de Patrimonio Cultural II

Memoria final del PIMCD UCM 2020/2021 número 31