Principes fondamentaux et stratégies socioéducatives dans l’élaboration de l’histoire de vie concernant l’accueil en famille élargie

Kindship foster care is the most common child protection measure in Spain, which finds the appropriate elaboration of life stories between its main difficulties. If this reconstruction of life story, which usually contains dramatic situations, is not well carried out, it could generate identity problems and hinder children’s adequate development. This article analyses narratives as one of the key socio-educative strategies for the elaboration of life stories, based on the concepts of failed experience, reactive imaginative experience, and mirror stage, among others. Moreover, it proposes the use of autobiographies, lifebooks and literature as meaningful tools to foster identity development and resilience in children, in order to they may know their life stories in a coherent and positive way. El acogimiento en familia extensa es la medida de protección a la infancia más utilizada en nuestro país, que encuentra entre sus mayores dificultades la correcta elaboración de la historia de vida de los niños acogidos. Si esta construcción de la historia vital del niño, que generalmente contiene situaciones dramáticas, no se elabora adecuadamente, puede generar problemas identitarios susceptibles de obstaculizar un adecuado desarrollo. Este artículo analiza la narrativa como una de las principales estrategias socioeducativas para la elaboración de la historia de vida, a partir de los conceptos de experiencia fallida, experiencia imaginaria reactiva y del estadio del espejo, entre otros. Así mismo, propone la utilización de las autobiografías, el libro de vida y la literatura como herramientas para contribuir al desarrollo de la identidad del niño, el fomento de su resiliencia y el conocimiento de su historia de vida de una manera coherente y positiva.L’accueil en famille élargie est la mesure de protection de l’enfance la plus utilisée dans notre pays, dont l’une des plus grandes difficultés est l’élaboration adéquate de l’histoire de vie des enfants accueillis. Si cette construction de l’histoire de vie de l’enfant, qui contient généralement des situations dramatiques, ne s’élabore pas de manière adéquate, cela peut générer des problèmes identitaires susceptibles de devenir un obstacle au développement de l’enfant. Cet article analyse la narration comme l’une des principales stratégies socioéducatives pour l’élaboration de l’histoire de vie, à partir des concepts d’expérience échouée, expérience imaginaire réactive et du stade du miroir, entre autres. Ainsi, il propose de se fonder sur l’utilisation de l’autobiographie, du livre de vie et de la littérature comme outils utiles pour contribuer au développement de l’identité de l’enfant et encourager sa résilience, afin que, de cette manière, il puisse construire son histoire de vie de manière coherente et positif

Los Acogimientos en Familia Extensa en Madrid: Análisis del Perfil Familiar y Propuestas de Intervención

El acogimiento en familia extensa es la medida de protección de menores más utilizada en España. El objetivo del trabajo es establecer un perfil familiar en la ciudad de Madrid y proponer líneas intervención psicoeducativas. La metodología utilizada es descriptiva para analizar variables como edad de menores y acogedores, parentesco o medida de protección. Los resultados muestran que la principal acogedora es la abuela materna, el tipo de acogimiento mayoritario es el administrativo permanente y la medida que más se acuerda es la tutela. La intervención se encamina a reducir las diferencias intergeneracionales, mejorar las relaciones familiares y elaborar la historia vital de los niños

School counselling with families at psychosocial risk: analysis of educational alliance with kinship foster care

This article analyses the possibilities of creation of educational alliance in schools with families in psycho-social risk and, more specifically, with kinship foster care. Based on four dimensions of the System for Observing Family Therapy Alliances, it focus on the necessary engagement for which kinship caregivers and children feel recognized and welcomed, and stay in it; safety in the system, that allows the family trust in the counsellor and find in the common conversation an open and accessible space; emotional connection, that makes the family feel respected, valued and comprehended by the professional, who trust in their capabilities; and a shared feeling of purpose in the family, for what all the members conceive the orientation as a common issue that motivate to act, providing valuable resources for the success of intervention.Este artículo analiza las posibilidades de la creación de la alianza educativa en centros escolares con familias en riesgo psico-social y, más concretamente, con acogimientos en familia extensa. Partiendo de las cuatro dimensiones del Sistema de Observación de Alianza Terapéutica en Intervención Familiar, se aborda el enganche necesario para que acogedores y menores se sientan reconocidos y acogidos y se mantengan presentes en ella; la seguridad en el sistema, que permite que la familia confíe en el profesional y encuentre en la conversación común un espacio abierto y accesible; la conexión emocional, que posibilita que la familia se sienta respetada y comprendida por el profesional, que la valora y confía en sus capacidades; y el sentido de compartir el propósito de la orientación, para que todos sus miembros perciban la orientación como un asunto común que los interpela a actuar, aportando así más recursos para el éxito de la intervención

Carbon nanodot–based electrogenerated chemiluminescence biosensor for miRNA-21 detection

A simple carbon nanodot–based electrogenerated chemiluminescence biosensor is described for sensitive and selective detection of microRNA-21 (miRNA-21), a biomarker of several pathologies including cardiovascular diseases (CVDs). The photoluminescent carbon nanodots (CNDs) were obtained using a new synthesis method, simply by treating tiger nut milk in a microwave reactor. The synthesis is environmentally friendly, simple, and efficient. The optical properties and morphological characteristics of the CNDs were exhaustively investigated, confirming that they have oxygen and nitrogen functional groups on their surfaces and exhibit excitation-dependent fluorescence emission, as well as photostability. They act as co-reactant agents in the anodic electrochemiluminescence (ECL) of [Ru(bpy)3]2+, producing different signals for the probe (single-stranded DNA) and the hybridized target (double-stranded DNA). These results paved the way for the development of a sensitive ECL biosensor for the detection of miRNA-21. This was developed by immobilization of a thiolated oligonucleotide, fully complementary to the miRNA-21 sequence, on the disposable gold electrode. The target miRNA-21 was hybridized with the probe on the electrode surface, and the hybridization was detected by the enhancement of the [Ru(bpy)3]2+/DNA ECL signal using CNDs. The biosensor shows a linear response to miRNA-21 concentration up to 100.0 pM with a detection limit of 0.721 fM. The method does not require complex labeling steps, and has a rapid response. It was successfully used to detect miRNA-21 directly in serum samples from heart failure patients without previous RNA extraction neither amplification processThis study is funded by the Comunidad Autónoma de Madrid (Spain) projects (TRANSNANOAVANSENS, S2018/NMT-4349, CAM/B2017/BMD-3686) and Ministerio de Economía, Industria y Competitividad (Spanish Government) projects: CTQ2015-71955-REDT (ELECTROBIONET), CTQ2014-53334-C2-1-R and PID2020-116728RB-I0

Medios nativos digitales en América Latina. Enfoques, retos y experiencias

El panorama de los medios de comunicación ha cambiado: de las grandes empresas editoras de periódicos, generalmente propiedad de grupos familiares, a los medios nativos digitales financiados por los propios periodistas o por oenegés gracias a los aportes ciudadanos o iniciativas de recaudación de fondos y suscriptores. Este texto dibuja un panorama general de lo que significan los medios digitales y revisa las experiencias de algunos medios de Ecuador, Colombia, Perú y Argentina. En el caso ecuatoriano, se analiza la cobertura de un hecho particular -las movilizaciones de octubre de 2019- por parte de tres medios: Wambra EC, La Periódica y el Centro de Medios Virtuales de la Carrera de Comunicación de la UPS

Competencias cívico-sociales, inclusión y calidad de vida de las personas mayores. Una colaboración europea en innovación

Depto. de Estudios EducativosFac. de EducaciónFALSEsubmitte

Competencias cívico-sociales, inclusión y calidad de vida de las personas mayores. Una colaboración europea en innovación (II)

Este proyecto se centra en el desarrollo de competencias cívico-sociales y el fomento de la educación para la salud en situaciones de crisis sanitaria como la provocada por la COVID-19. Participa estudiantes de grado, de máster y personas mayores

Risk factors for non-diabetic renal disease in diabetic patients

Background. Diabetic patients with kidney disease have a high prevalence of non-diabetic renal disease (NDRD). Renal and patient survival regarding the diagnosis of diabetic nephropathy (DN) or NDRD have not been widely studied. The aim of our study is to evaluate the prevalence of NDRD in patients with diabetes and to determine the capacity of clinical and analytical data in the prediction of NDRD. In addition, we will study renal and patient prognosis according to the renal biopsy findings in patients with diabetes. Methods. Retrospective multicentre observational study of renal biopsies performed in patients with diabetes from 2002 to 2014. Results. In total, 832 patients were included: 621 men (74.6%), mean age of 61.7 6 12.8 years, creatinine was 2.8 6 2.2 mg/dL and proteinuria 2.7 (interquartile range: 1.2–5.4) g/24 h. About 39.5% (n ¼ 329) of patients had DN, 49.6% (n ¼ 413) NDRD and 10.8% (n ¼ 90) mixed forms. The most frequent NDRD was nephroangiosclerosis (NAS) (n ¼ 87, 9.3%). In the multivariate logistic regression analysis, older age [odds ratio (OR) ¼ 1.03, 95% CI: 1.02–1.05, P < 0.001], microhaematuria (OR ¼ 1.51, 95% CI: 1.03–2.21, P ¼ 0.033) and absence of diabetic retinopathy (DR) (OR ¼ 0.28, 95% CI: 0.19–0.42, P < 0.001) were independently associated with NDRD. Kaplan–Meier analysis showed that patients with DN or mixed forms presented worse renal prognosis than NDRD (P < 0.001) and higher mortality (P ¼ 0.029). In multivariate Cox analyses, older age (P < 0.001), higher serum creatinine (P < 0.001), higher proteinuria (P < 0.001), DR (P ¼ 0.007) and DN (P < 0.001) were independent risk factors for renal replacement therapy. In addition, older age (P < 0.001), peripheral vascular disease (P ¼ 0.002), higher creatinine (P ¼ 0.01) and DN (P ¼ 0.015) were independent risk factors for mortality. Conclusions. The most frequent cause of NDRD is NAS. Elderly patients with microhaematuria and the absence of DR are the ones at risk for NDRD. Patients with DN presented worse renal prognosis and higher mortality than those with NDRD. These results suggest that in some patients with diabetes, kidney biopsy may be useful for an accurate renal diagnosis and subsequently treatment and prognosis

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

A Solve-RD ClinVar-based reanalysis of 1522 index cases from ERN-ITHACA reveals common pitfalls and misinterpretations in exome sequencing

Purpose Within the Solve-RD project (https://solve-rd.eu/), the European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies aimed to investigate whether a reanalysis of exomes from unsolved cases based on ClinVar annotations could establish additional diagnoses. We present the results of the “ClinVar low-hanging fruit” reanalysis, reasons for the failure of previous analyses, and lessons learned. Methods Data from the first 3576 exomes (1522 probands and 2054 relatives) collected from European Reference Network for Intellectual disability, TeleHealth, Autism and Congenital Anomalies was reanalyzed by the Solve-RD consortium by evaluating for the presence of single-nucleotide variant, and small insertions and deletions already reported as (likely) pathogenic in ClinVar. Variants were filtered according to frequency, genotype, and mode of inheritance and reinterpreted. Results We identified causal variants in 59 cases (3.9%), 50 of them also raised by other approaches and 9 leading to new diagnoses, highlighting interpretation challenges: variants in genes not known to be involved in human disease at the time of the first analysis, misleading genotypes, or variants undetected by local pipelines (variants in off-target regions, low quality filters, low allelic balance, or high frequency). Conclusion The “ClinVar low-hanging fruit” analysis represents an effective, fast, and easy approach to recover causal variants from exome sequencing data, herewith contributing to the reduction of the diagnostic deadlock