Cirugía micrográfica de Mohs : Estudio retrospectivo de los últimos trece años (1999-2011) en el Hospital de la Santa Creu i Sant Pau

El objetivo de este trabajo fue describir las características de los pacientes tratados con cirugía micrográfica de Mohs entre 1999-2011 y evaluar la eficacia de esta cirugía para el tratamiento de los carcinomas basocelulares. Durante este periodo se realizaron 560 cirugías de Mohs, el 95.36% de las cuales fueron de carcinomas basocelulares. Se observó una tasa de recidiva del 1.40% para los carcinomas basocelulares primarios y del 13.62% para los recurrentes, siendo la diferencia estadísticamente significativa (p 0.0001).L'objectiu d'aquest treball va ser descriure les característiques dels pacients tractats amb cirurgia microgràfica de Mohs entre 1999-2011 i avaluar l'eficàcia d'aquesta cirurgia per al tractament dels carcinomes basocel·lulars. Durant aquest període es van realitzar 560 cirurgies de Mohs, el 95.36% de les quals van ser de carcinomes basocel·lulars. Es va observar una taxa de recidiva del 1.40% per als carcinomes basocel·lulars primaris i del 13.62% per als recurrents, éssent la diferència estadísticament significativa (p 0.0001)

Castelló en festes

Interpretació del pasdoble " Castelló en festes" de Ramon Garcés Dualde, per la Banda Muncipal de Castelló, dirigida per Joan Garcés Queralt

Els materials arqueològics i epigràfics de Monteró (Camarasa, la Noguera, Lleida). Treballes anteriors a les excavacions de l'any 2002

A principis dels anys 80 les accions no legals d'uns aficionats als detectors de metalls conduïren a l'extracció de diversos objectes metàl·lics i ceràmics en el jaciment ibero-romà de Monteró (Camarasa, la Noguera). Posteriorment, una part d'aquestes peces foren donades al Gabinet Numismàtic o a la Secció d'Arqueologia de l'IEI, i una altra solament va ser mínimament documentada amb fotografies. La rellevància d'alguns objectes recuperats, tot i la lamentable manca de context estratigràfic, ha motivat el present estudi

Els materials arqueològics i epigràfics de Monteró (Camarasa, la Noguera, Lleida). Treballes anteriors a les excavacions de l'any 2002

A principis dels anys 80 les accions no legals d'uns aficionats als detectors de metalls conduïren a l'extracció de diversos objectes metàl·lics i ceràmics en el jaciment ibero-romà de Monteró (Camarasa, la Noguera). Posteriorment, una part d'aquestes peces foren donades al Gabinet Numismàtic o a la Secció d'Arqueologia de l'IEI, i una altra solament va ser mínimament documentada amb fotografies. La rellevància d'alguns objectes recuperats, tot i la lamentable manca de context estratigràfic, ha motivat el present estudi

Cirugía micrográfica de Mohs : Estudio retrospectivo de los últimos trece años (1999-2011) en el Hospital de la Santa Creu i Sant Pau

El objetivo de este trabajo fue describir las características de los pacientes tratados con cirugía micrográfica de Mohs entre 1999-2011 y evaluar la eficacia de esta cirugía para el tratamiento de los carcinomas basocelulares. Durante este periodo se realizaron 560 cirugías de Mohs, el 95.36% de las cuales fueron de carcinomas basocelulares. Se observó una tasa de recidiva del 1.40% para los carcinomas basocelulares primarios y del 13.62% para los recurrentes, siendo la diferencia estadísticamente significativa (p 0.0001).L'objectiu d'aquest treball va ser descriure les característiques dels pacients tractats amb cirurgia microgràfica de Mohs entre 1999-2011 i avaluar l'eficàcia d'aquesta cirurgia per al tractament dels carcinomes basocel·lulars. Durant aquest període es van realitzar 560 cirurgies de Mohs, el 95.36% de les quals van ser de carcinomes basocel·lulars. Es va observar una taxa de recidiva del 1.40% per als carcinomes basocel·lulars primaris i del 13.62% per als recurrents, éssent la diferència estadísticament significativa (p 0.0001)

Basal cell carcinoma treated with Mohs micrographic surgery in young Ibero-American patients

The incidence of basal cell carcinoma (BCC) in younger individuals has increased in recent decades. However, the characteristics of BCCs in this population, especially in Ibero-Latin American countries, have not been completely defined. To describe the demographic, clinical, and histopathological characteristics of BCCs in patients younger than 40 treated with Mohs Micrographic Surgery (MMS). A multicenter, retrospective study conducted between January 2009 and December 2014, in five Ibero-American countries, included biopsy-proven BCCs in patients younger than 40 that were treated with MMS. Demographic, clinical, histopathological, and surgical characteristics were described. The study included 301 tumors in 241 patients, of whom 61% were female. The most common Fitzpatrick phototype was III. The most common histological subtypes were nodular (37.5%) and infiltrative (18.9%). Perineural invasion was encountered in 1.7%, and tumor clearance was achieved in 87.4% within two stages of MMS. This is the first Ibero-Latin American transnational study describing the characteristics of BCCs in young patients treated with MMS. Despite darker skin phototypes in this population, BCCs can occur in early ages and may present with aggressive features. Therefore, MMS may be considered an appropriate first-line treatment option in this population

Role of POLE and POLD1 in familial cancer

Purpose: Germline pathogenic variants in the exonuclease domain (ED) of polymerases POLE and POLD1 predispose to adenomatous polyps, colorectal cancer (CRC), endometrial tumors, and other malignancies, and exhibit increased mutation rate and highly specific associated mutational signatures. The tumor spectrum and prevalence of POLE and POLD1 variants in hereditary cancer are evaluated in this study. Methods: POLE and POLD1 were sequenced in 2813 unrelated probands referred for genetic counseling (2309 hereditary cancer patients subjected to a multigene panel, and 504 patients selected based on phenotypic characteristics). Cosegregation and case-control studies, yeast-based functional assays, and tumor mutational analyses were performed for variant interpretation. Results: Twelve ED missense variants, 6 loss-of-function, and 23 outside-ED predicted-deleterious missense variants, all with population allele frequencies <1%, were identified. One ED variant (POLE p.Met294Arg) was classified as likely pathogenic, four as likely benign, and seven as variants of unknown significance. The most commonly associated tumor types were colorectal, endometrial and ovarian cancers. Loss-of-function and outside-ED variants are likely not pathogenic for this syndrome. Conclusions: Polymerase proofreading-associated syndrome constitutes 0.1-0.4% of familial cancer cases, reaching 0.3-0.7% when only CRC and polyposis are considered. ED variant interpretation is challenging and should include multiple pieces of evidence

Cova del Rinoceront (Castelldefels, Barcelona): a terrestrial record for the Last Interglacial period (MIS 5) in the Mediterranean coast of the Iberian Peninsula

The Cova del Rinoceront, a site in NE Iberia, contains a thick sedimentary fill preserving a faunal archive from the penultimate glacial and the the last interglacial periods. Layers I to III have been dated to between 74 and 147 ka, coinciding with MIS 5a to 5e, a period poorly represented in the Mediterranean terrestrial record. The results from Cova del Rinoceront are of broader interest for the reconstruction of ecological dynamics during warm stages and the understanding of the evolution and geographical variation of several taxa. The palaeoecological evidence suggests a landscape dominated by mixed wooded vegetation with mild climatic conditions, slightly more humid than today. Several vertebrate taxa, including Haploidoceros mediterraneus, Stephanorhinus hundsheimensis and Glis glis, are documented for the first time in the early Upper Pleistocene of Europe, showing that these species persisted across the region for longer than previously thought. In addition, the recovery of a small lithic assemblage indicates human presence in the surroundings of the site. The 11 m-thick stratigraphic section also provides an ideal setting in which to compare several geochronological methods. UeTh dating of the flowstones that cap the deposit, of speleothems formed along the cave walls, and of speleothems buried by the deposit at different elevations provides minimum and maximum ages of 74 and 175 ka, respectively, for the accumulation. The ages obtained by luminescence, electron spin resonance (ESR), amino acid racemisation (AAR), palaeomagnetism and U-series dating of bone are in good agreement with each other and are stratigraphically consistent. This well-dated faunal succession presents a unique opportunity to assess changes in the Pleistocene fauna of the Mediterranean coast over an interval of more than 100 ka

Incidence of melanoma in Catalonia, Spain, is rapidly increasing in the elderly population. A multicentric cohort study

The incidence of melanoma has been increasing worldwide during recent decades. The objective of the study was to analyse the trends in incidence for in situ and invasive melanoma in the Spanish region of Catalonia during the period of 2008-2017. We designed a cross-sectional study with an age-period-cohort analysis of melanoma patient data from the Network of Melanoma Centres in Catalonia. Our database covered a population of over seven million and included a total of 8626 patients with incident melanoma. The main outcome measures were crude and age-standardised incidence rates to the European 2013 standard population. Joinpoint regression models were used to evaluate the population trends. We observed an increase in the age-standardised incidence rate (per 100,000 population) of all melanoma subtypes from 11.56 in 2008 to 13.78 in 2017 with an average annual percent change (AAPC) of 3.5%. This incidence increase was seen exclusively in the older population. Moreover, the stratified analysis showed a statistically significant increase in the age-standardised incidence rate for invasive (AAPC 2.1%) and in situ melanoma (AAPC 6.5%). In conclusion, the incidence of melanoma has continued to increase in the elderly population over recent decades, with a rapidly increasing trend of in situ melanomas and the lentigo maligna subtype