Critical Quantum Metrology with a Finite-Component Quantum Phase Transition

Physical systems close to a quantum phase transition exhibit a divergent susceptibility, suggesting that an arbitrarily high precision may be achieved by exploiting quantum critical systems as probes to estimate a physical parameter. However, such an improvement in sensitivity is counterbalanced by the closing of the energy gap, which implies a critical slowing down and an inevitable growth of the protocol duration. Here, we design different metrological protocols that exploit the superradiant phase transition of the quantum Rabi model, a finite-component system composed of a single two-level atom interacting with a single bosonic mode. We show that, in spite of the critical slowing down, critical quantum optical probes can achieve a quantum-enhanced time scaling of the sensitivity in frequency-estimation protocols

A Unified Interface Model for Dissipative Transport of Bosons and Fermions

We study the directed transport of bosons along a one dimensional lattice in a dissipative setting, where the hopping is only facilitated by coupling to a Markovian reservoir. By combining numerical simulations with a field-theoretic analysis, we investigate the current fluctuations for this process and determine its asymptotic behavior. These findings demonstrate that dissipative bosonic transport belongs to the KPZ universality class and therefore, in spite of the drastic difference in the underlying particle statistics, it features the same coarse grained behavior as the corresponding asymmetric simple exclusion process (ASEP) for fermions. However, crucial differences between the two processes emerge when focusing on the full counting statistics of current fluctuations. By mapping both models to the physics of fluctuating interfaces, we find that dissipative transport of bosons and fermions can be understood as surface growth and erosion processes, respectively. Within this unified description, both the similarities and discrepancies between the full counting statistics of the transport are reconciled. Beyond purely theoretical interest, these findings are relevant for experiments with cold atoms or long-lived quasi-particles in nanophotonic lattices, where such transport scenarios can be realized.Comment: comments welcom

The European citizen science landscape – a snapshot

Citizen science, the active participation of the public in scientific research projects, is a rapidly expanding field in open science and open innovation. It provides an integrated model of public knowledge production and engagement with science. As a growing worldwide phenomenon, it is invigorated by evolving new technologies that connect people easily and effectively with the scientific community. Catalysed by citizens’ wishes to be actively involved in scientific processes, as a result of recent societal trends, it also offers contributions to the rise in tertiary education. In addition, citizen science provides a valuable tool for citizens to play a more active role in sustainable development. This book identifies and explains the role of citizen science within innovation in science and society, and as a vibrant and productive science-policy interface. The scope of this volume is global, geared towards identifying solutions and lessons to be applied across science, practice and policy. The chapters consider the role of citizen science in the context of the wider agenda of open science and open innovation, and discuss progress towards responsible research and innovation, two of the most critical aspects of science today

Which medical disciplines diagnose and treat melanoma in Europe in 2019? A survey of experts from melanoma centres in 27 European countries

Background and objectives The incidence of melanoma is increasing. This places significant burden on societies to provide efficient cancer care. The European Cancer Organisation recently published the essential requirements for quality melanoma care. The present study is aimed for the first time to roughly estimate the extent to which these requirements have been met in Europe. Materials and methods A web-based survey of experts from melanoma centres in 27 European countries was conducted from 1 February to 1 August 2019. Data on diagnostic techniques, surgical and medical treatment, organization of cancer care and education were collected and correlated with national health and economic indicators and mortality-to-incidence ratio (MIR) as a surrogate for survival. Univariate linear regression analysis was performed to evaluate the correlations. SPSS software was used. Statistical significance was set at P < 0.05. Results The MIR was lower in countries with a high health expenditure per capita and with a higher numbers of general practitioners (GPs) and surgeons (SURG) per million inhabitants. In these countries, GPs and dermatologists (DER) were involved in melanoma detection; high percentage of DER used dermatoscopy and were involved in the follow-up of all melanoma stages; both medical oncologists (ONC) and dermato-oncologists administered systemic treatments; and patients had better access to sentinel lymph node biopsy and were treated within multidisciplinary tumour boards. Conclusion Based on these first estimates, the greater involvement of GPs in melanoma detection; the greater involvement of highly trained DER in dermatoscopy, dermatosurgery, follow-up and the systemic treatment of melanoma; and the provision of ongoing dermato-oncology training for pathologists, SURG, DER and ONC are necessary to provide an optimal melanoma care pathway. A comprehensive analysis of the melanoma care pathway based on clinical melanoma registries will be needed to more accurately evaluate these first insights

Potential effects of optical solar sail degredation on trajectory design

The optical properties of the thin metalized polymer films that are projected for solar sails are assumed to be affected by the erosive effects of the space environment. Their degradation behavior in the real space environment, however, is to a considerable degree indefinite, because initial ground test results are controversial and relevant inspace tests have not been made so far. The standard optical solar sail models that are currently used for trajectory design do not take optical degradation into account, hence its potential effects on trajectory design have not been investigated so far. Nevertheless, optical degradation is important for high-fidelity solar sail mission design, because it decreases both the magnitude of the solar radiation pressure force acting on the sail and also the sail control authority. Therefore, we propose a simple parametric optical solar sail degradation model that describes the variation of the sail film's optical coefficients with time, depending on the sail film's environmental history, i.e., the radiation dose. The primary intention of our model is not to describe the exact behavior of specific film-coating combinations in the real space environment, but to provide a more general parametric framework for describing the general optical degradation behavior of solar sails. Using our model, the effects of different optical degradation behaviors on trajectory design are investigated for various exemplary missions

Modifiable risk-factors for keratinocyte cancers in Australia: a case-control study

Keratinocyte cancer is the most common malignancy in Caucasians. The aim of this study was to investigate risk-factors responsible for development of keratinocyte cancer in Australia. A case-control study was conducted, including 112 cases of squamous cell carcinoma (SCC), 95 cases of basal cell carcinoma (BCC) and 122 controls. Freckling during adolescence (SCC: odds ratio (OR) 1.04, p < 0.01; BCC: OR 1.05, p < 0.01), propensity to sunburn (SCC: OR 2.75, p = 0.01, BCC: OR 2.68 p = 0.01) and high cumulative sun-exposure (SCC: OR 2.43, p = 0.04; BCC: OR 2.36 p = 0.04) were independent risk-factors for both SCC and BCC. This study provides further evidence that a sun-sensitive phenotype and excessive sun-exposure during adulthood contribute to the risk of developing keratinocyte cancer. Wearing a hat, long-sleeved shirts, and sunscreen did not significantly reduce the risk of keratinocyte cancer in this study

Comparisons between Canadian prairie MF radars, FPI (green and OH lines) and UARS HRDI systems

Detailed comparisons have been completed between the MF radars (MFR) in the Canadian prairies and three other systems: two ground-based Fabry-Perot interferometers (FPI) and the UARS high resolution Doppler imager (HRDI) system. The radars were at Sylvan Lake (52°N, 114°W), Robsart (49°N, 109°W) and the main continuing facility is at Saskatoon (52°N, 107°W). Statistical comparisons of hourly mean winds (1988–1992) for the Saskatoon MFR and FPI (557.7 nm green line) using scatter plots, wind speed-ratios, and direction-difference histograms show excellent agreement for Saskatoon. No serious biases in speeds or directions occur at the height of best agreement, 98 km. If anything, the MFR speeds appear bigger. The same applies to the Sylvan Lake MFR and Calgary FPI, where the best height is 88 km. In both cases these are close to the preferred heights for the emission layers. Differences between measurements seen on individual days are likely related to the influence of gravity waves (GW) upon the optical and radar systems, each of which have inherent spatial averaging (350, 50 km respectively), as well as the spatial difference between the nominal measurement locations. For HRDI, similar statistical comparisons are made, using single-overpass satellite winds and hourly means (to improve data quality) from MFR. Heights of best agreement, based upon direction-difference histograms, are shown; there is a tendency, beginning near 87 km, for these MFR heights to be 2 or 3 km greater than the HRDI heights. Speeds at these heights are typically larger for the satellite (MFR/HRDI = 0.7-0.8). Reasons for the differences are investigated. It is shown that the estimated errors and short-term (90 min) differences are larger for HRDI than for the MFR, indicating more noise or GW contamination. This leads to modest but significant differences in median speed-ratio (MFR/HRDI < 1). Also, comparison of the two systems is made under conditions when they agree best and when they show large disagreement. For the latter cases both systems show higher relative errors, and the HRDI vectors are frequently small. It is suggested that spatial or temporal GW wind fluctuations are the likely cause of the larger HRDI-MFR disagreement when wind speeds are small. No satisfactory explanation exists for the overall discrepancy is speeds between the MFR and HRDI.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47858/1/585_1997_Article_70151099.pd

The Contribution of National Spontaneous Reporting Systems to Detect Signals of Torsadogenicity: Issues Emerging from the ARITMO Project

Introduction: Spontaneous reporting systems (SRSs) are pivotal for signal detection, especially for rare events with a high drug-attributable component, such as torsade de pointes (TdP). Use of different national SRSs is rarely attempted because of inherent difficulties, but should be considered on the assumption that rare events are diluted in international databases. Objective: The aim was to describe TdP-related events associated with antipsychotics, H1-antihistamines and anti-infectives in three national SRSs (in Italy, Germany and France) and highlight potential signals of torsadogenicity through a combined literature evaluation. Methods: A common search strategy was applied to extract TdP-related events: (1) TdP, (2) QT interval abnormalities, (3) ventricular fibrillation/tachycardia, and (4) sudden cardiac death. Signals of disproportionate reporting (SDRs) were calculated for TdP + QT interval abnormalities and defined by a lower limit of the 95 % confidence interval of the reporting odds ratio (ROR) >1. Among SDRs with at least three cases without concomitant pro-arrhythmic drugs, we defined potential new signal of torsadogenicity as drugs with no published evidence from (a) the crediblemeds® website (http://www.crediblemeds.com, as of November 1st, 2014); (b) studies on the FDA Adverse Event Reporting System (FAERS); and (c) safety trials or pharmaco-epidemiological studies (as of December 16th, 2014). Results: Overall, 3505 cases were retrieved (1372, 1468, and 801 for France, Germany and Italy, respectively). Antipsychotics were mainly recorded in Germany (792 cases), whereas antibiotics peaked at 515 and 491 (France and Italy, respectively). Forty-one drugs met criteria for SDRs in at least one single source, of which 31 were detected only from one single SRS: 18, ten and three (French, German and Italian SRS, respectively). By contrast, only five SDRs were detected in all national data sources (amisulpride, aripiprazole, haloperidol, olanzapine, risperidone). Overall, five potential new signals of torsadogenicity were identified: flupentixol, ganciclovir, levocetirizine, oxatomide and tiapride. Conclusions: We found differences across and within national SRSs in the reporting of drug-induced TdP, which finally resulted in five potential new signals of torsadogenicity. These findings warrant targeted pharmacovigilance studies to formally assess the existence of actual drug–event associations