43 research outputs found

    The complexity of epigenetic diseases

    Get PDF
    Over the past 30 years, a plethora of pathogenic mutations affecting enhancer regions and epigenetic regulators have been identified. Coupled with more recent genome‐wide association studies (GWAS) and epigenome‐wide association studies (EWAS) implicating major roles for regulatory mutations in disease, it is clear that epigenetic mechanisms represent important biomarkers for disease development and perhaps even therapeutic targets. Here, we discuss the diversity of disease‐causing mutations in enhancers and epigenetic regulators, with a particular focus on cancer. © 2015 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland

    Durable superhydrophobicity in embossed CYTOP fluoropolymer micro and nanostructures Durable Superhydrophobicity in Embossed CYTOP Fluoropolymer Micro and Nanostructures

    No full text
    Abstract: Micropillars, nanopillars and dual scale micro-nanopillars were fabricated out of an inherently hydrophobic amorphous CYTOP fluoropolymer by hot embossing. The resulting pillars were superhydrophobic with high apparent contact angles (θ > 160°) and low rolling angles. Abrasion experiments were performed using a novel rotary abrasive slurry setup. Due to their inherent hydrophobicity, CYTOP micro and nanopillars retained their superhydrophobic properties even after 4 hours of abrasion (900 rpm in 10 % slurry of 30 μm alumina particles), unlike control samples prepared out of fluoropolymer coated silicon
    corecore