The complete organelle genomes of Physochlaina orientalis: Insights into short sequence repeats across seed plant mitochondrial genomes

Short repeats (SR)play an important role in shaping seed plant mitochondrial genomes (mtDNAs). However, their origin, distribution, and relationships across the different plant lineages remain unresolved. We focus on the angiosperm family Solanaceae that shows great variation in repeat content and extend the study to a wide diversity of seed plants. We determined the complete nucleotide sequences of the organellar genomes of the medicinal plant Physochlaina orientalis (Solanaceae), member of the tribe Hyoscyameae. To understand the evolution of the P. orientalis mtDNA we made comparisons with those of five other Solanaceae. P. orientalis mtDNA presents the largest mitogenome (∼685 kb in size)among the Solanaceae and has an unprecedented 8-copy repeat family of ∼8.2 kb in length and a great number of SR arranged in tandem-like structures. We found that the SR in the Solanaceae share a common origin, but these only expanded in members of the tribe Hyoscyameae. We discuss a mechanism that could explain SR formation and expansion in P. orientalis and Hyoscyamus niger. Finally, the great increase in plant mitochondrial data allowed us to systematically extend our repeat analysis to a total of 136 seed plants to characterize and analyze for the first time families of SR among seed plant mtDNAs.Fil: Gandini, Carolina Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Garcia, Laura Evangelina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Abbona, Cinthia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina. Universidad Tecnologica Nacional. Facultad Reg.san Rafael. Instituto de Evolucion, Ecologia Historica y Ambiente. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Mendoza. Instituto de Evolucion, Ecologia Historica y Ambiente.; ArgentinaFil: Sánchez Puerta, María Virginia. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentin

Dating apps : the uncertainty of marketised love

Dating apps promise a ‘digital fix’ to the ‘messy’ matter of love by means of datafication and algorithmic matching, realising a platformisation of romance commonly understood through notions of a market’s rationality and efficiency. Reflecting on the findings of a small-scale qualitative research on the use of dating apps among young adults in London, we problematise this view and argue that the specific form of marketisation articulated by dating apps is entrepreneurial in kind, whereby individuals act as brands facing the structural uncertainty of interacting with ‘quasi-strangers’. In so doing, we argue, dating app users enact a Luhmanian notion of interpersonal trust, built on the assessment of the risk of interacting with unfamiliar others that is typical of digitally mediated contexts dominated by reputational logics. From a sociocultural perspective, dating apps emerge as sociotechnical apparatuses that remediate the demand to rationally choose a partner while at the same time reproducing the (im)possibility of doing so. In this respect, far from offering a new form of efficiency, they (re)produce the ontological uncertainty (Illouz, 2019) that characterises lovers as entrepreneurs

Productivity of Cinta Senese and Large White x Cinta Senese pigs reared outdoors in woodlands and indoors. 2. Slaughter and carcass traits

The aim of this paper was to study slaughter and carcass traits of Cinta Senese pigs, both pure and crossbred with LargeWhite, reared outdoors in woodland and indoors. Sixteen Cinta Senese (CS) and 16 Large White x Cinta Senese (LWxCS)pigs were reared outdoors (OUT) on woodland pastures with some food supplementation; 70 animals (29 CS, 29 LWxCSand 12 LW) were reared indoors (IN), allotted in pens for genetic type and sex. Pigs were slaughtered at about 140 kgof live weight and at an age greater than 8 months. After slaughter, carcass length, thorax depth, number of vertebraeand backfat thickness were measured, and carcasses were dissected into lean, fat and bone cuts. Average daily gain toslaughter differed markedly among the five GTxRS combinations (598; 512; 438; 338; 250 g/d, respectively for LW-IN;LWxCS-IN; CS-IN; LWxCS-OUT; CS-OUT). LWxCS-IN and LWxCS-OUT had respectively the highest and the lowest dressingpercentages (83.3% and 80.1%). A greater compactness of CS carcasses was evident from the length to depth ratio.In both farming systems CS pigs had the thickest backfat, and their differences with the other genetic types increasedproportionally according to a cranio-caudal gradient. Moreover, CS pigs showed lower percentage of lean cuts and a higherpercentage of fat cuts, than the other breeds. In the indoor system an additive effect was evident, with crossbred pigsshowing lean cuts yields (62.8%) of almost intermediate value with respect to the parental breeds (57.7% for CS and69.1% for LW). Some effects of the availability of woodland pastures on growth and carcass composition were alsoobserved, particularly showing CS-OUT pigs’ higher percentage of backfat and kidney fat, and lower percentage of loinand shoulder than the CS-IN ones

Interpelando a la Psicología Educacional

El presente artículo surge a partir del trabajo que viene realizando el equipo de adscriptas en la Cátedra Psicología Educacional (FaHCE, UNLP), a cargo de la Dra. Palacios Analia. En el campo de la Psicología Educacional, diversas miradas reconocieron que los modelos psicológicos no son aplicables a los emergentes escolares cotidianos (Coll, 2010; Castorina, 2007; Baquero y Terigi, 1996). Desde un enfoque de derechos e inclusión socioeducativa, resulta relevante preguntarse acerca de la función de la Psicología Educacional en contextos educativos inclusivos. Desde elmodelo social, se presenta una visión que permite correrse de las miradas médico-patológica de los aprendizajes, y comprender la diversidad de sujetos, atendiendo a todas las condiciones y dimensiones educativas del problema del aprendizaje, entre ellas la diversidad de contextos socioeducativos, que requieren, en primera instancia, del reconocimiento de un otro dentro del aula, diverso, singular.This article merges from the work carried out by the assistant team of Educational Psychology from the Faculty of Humanities and Educational Sciences, UNLP, headed by Dra. Analía Palacios. Different views from Educational Psychology recognize that psychological models are not applicable to everyday school emergencies (Coll, 2010; Castorina, 2007; Baquero& Terigi, 1996). From a socio-educational perspective that pays focal attention to rights and inclusion, it is important to question ourselves about the function of Educational Psychology in inclusive educational contexts.Trabajos libres: Psicología y educaciónFacultad de Psicologí

Interpelando a la Psicología Educacional

El presente artículo surge a partir del trabajo que viene realizando el equipo de adscriptas en la Cátedra Psicología Educacional (FaHCE, UNLP), a cargo de la Dra. Palacios Analia. En el campo de la Psicología Educacional, diversas miradas reconocieron que los modelos psicológicos no son aplicables a los emergentes escolares cotidianos (Coll, 2010; Castorina, 2007; Baquero y Terigi, 1996). Desde un enfoque de derechos e inclusión socioeducativa, resulta relevante preguntarse acerca de la función de la Psicología Educacional en contextos educativos inclusivos. Desde elmodelo social, se presenta una visión que permite correrse de las miradas médico-patológica de los aprendizajes, y comprender la diversidad de sujetos, atendiendo a todas las condiciones y dimensiones educativas del problema del aprendizaje, entre ellas la diversidad de contextos socioeducativos, que requieren, en primera instancia, del reconocimiento de un otro dentro del aula, diverso, singular.This article merges from the work carried out by the assistant team of Educational Psychology from the Faculty of Humanities and Educational Sciences, UNLP, headed by Dra. Analía Palacios. Different views from Educational Psychology recognize that psychological models are not applicable to everyday school emergencies (Coll, 2010; Castorina, 2007; Baquero& Terigi, 1996). From a socio-educational perspective that pays focal attention to rights and inclusion, it is important to question ourselves about the function of Educational Psychology in inclusive educational contexts.Trabajos libres: Psicología y educaciónFacultad de Psicologí

Interpelando a la Psicología Educacional

El presente artículo surge a partir del trabajo que viene realizando el equipo de adscriptas en la Cátedra Psicología Educacional (FaHCE, UNLP), a cargo de la Dra. Palacios Analia. En el campo de la Psicología Educacional, diversas miradas reconocieron que los modelos psicológicos no son aplicables a los emergentes escolares cotidianos (Coll, 2010; Castorina, 2007; Baquero y Terigi, 1996). Desde un enfoque de derechos e inclusión socioeducativa, resulta relevante preguntarse acerca de la función de la Psicología Educacional en contextos educativos inclusivos. Desde elmodelo social, se presenta una visión que permite correrse de las miradas médico-patológica de los aprendizajes, y comprender la diversidad de sujetos, atendiendo a todas las condiciones y dimensiones educativas del problema del aprendizaje, entre ellas la diversidad de contextos socioeducativos, que requieren, en primera instancia, del reconocimiento de un otro dentro del aula, diverso, singular.This article merges from the work carried out by the assistant team of Educational Psychology from the Faculty of Humanities and Educational Sciences, UNLP, headed by Dra. Analía Palacios. Different views from Educational Psychology recognize that psychological models are not applicable to everyday school emergencies (Coll, 2010; Castorina, 2007; Baquero& Terigi, 1996). From a socio-educational perspective that pays focal attention to rights and inclusion, it is important to question ourselves about the function of Educational Psychology in inclusive educational contexts.Trabajos libres: Psicología y educaciónFacultad de Psicologí

HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus

Human papillomavirus (HPV) 16 is the most oncogenic human papillomavirus, responsible for most papillomavirus-induced anogenital cancers. We have explored by sequencing and phylogenetic analysis the viral variant lineages present in 692 HPV16-monoinfected invasive anogenital cancers from Europe, Asia, and Central/South America. We have assessed the contribution of geography and anatomy to the differential prevalence of HPV16 variants and to the non-synonymous E6 T350G polymorphism. Most (68%) of the variance in the distribution of HPV16 variants was accounted for by the differential abundance of the different viral lineages. The most prevalent variant (above 70% prevalence) in all regions and in all locations was HPV16_A1-3, except in Asia, where HPV16_A4 predominated in anal cancers. The differential prevalence of variants as a function of geographical origin explained 9% of the variance, and the differential prevalence of variants as a function of anatomical location accounted for less than 3% of the variance. Despite containing similar repertoires of HPV16 variants, we confirm the worldwide trend of cervical cancers being diagnosed significantly earlier than other anogenital cancers (early fifties vs. early sixties). Frequencies for alleles in the HPV16 E6 T350G polymorphism were similar across anogenital cancers from the same geographical origin. Interestingly, anogenital cancers from Central/South America displayed higher 350G allele frequencies also within HPV16_A1-3 lineage compared with Europe. Our results demonstrate ample variation in HPV16 variants prevalence in anogenital cancers, which is partly explained by the geographical origin of the sample and only marginally explained by the anatomical location of the lesion, suggesting that tissue specialization is not essential evolutionary forces shaping HPV16 diversity in anogenital cancers

Vitamin D receptor expression is associated with improved overall survival in human glioblastoma multiforme

Vitamin D and its analogs have been shown to display anti-proliferative effects in a wide variety of cancer types including glioblastoma multiforme (GBM). These anticancer effects are mediated by its active metabolite, 1α, 25-dihydroxyvitamin D3 (calcitriol) acting mainly through vitamin D receptor (VDR) signaling. In addition to its involvement in calcitriol action, VDR has also been demonstrated to be useful as a prognostic factor for some types of cancer. However, to our knowledge, there are no studies evaluating the expression of VDR protein and its association with outcome in gliomas. Therefore, we investigated VDR expression by using immunohistochemical analysis in human glioma tissue microarrays, and analyzed the association between VDR expression and clinico-pathological parameters. We further investigated the effects of genetic and pharmacologic modulation of VDR on survival and migration of glioma cell lines. Our data demonstrate that VDR is increased in tumor tissues when compared with VDR in non-malignant brains, and that VDR expression is associated with an improved outcome in patients with GBM. We also show that both genetic and pharmacologic modulation of VDR modulates GBM cellular migration and survival and that VDR is necessary for calcitriol-mediated effects on migration. Altogether these results provide some limited evidence supporting a role for VDR in glioma progression.Fil: Salomón, Débora Gisele. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); ArgentinaFil: Fermento, María Eugenia. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); ArgentinaFil: Gandini, Norberto Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); ArgentinaFil: Ferronato, María Julia. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); ArgentinaFil: Arevalo, Julian. Hospital Municipal General de Agudos Doctor José Penna; ArgentinaFil: Blasco, J.. Hospital Int. Gral. de Agudos Dr. Jose Penna. Servicio de Patologia; ArgentinaFil: Andrés, Nancy Carolina. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); ArgentinaFil: Zenklusen, Jean C.. National Institutes of Health. National Cancer Institute; Estados UnidosFil: Curino, Alejandro Carlos. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); ArgentinaFil: Facchinetti, Maria Marta. Consejo Nacional de Investigaciones Cienti­ficas y Tecnicas. Centro Cientifico Tecnologico Bahi­a Blanca. Instituto de Investigaciones Bioquimicas Bahi­a Blanca (i); Argentin

Estudio preliminar sobre la producción científica en ingeniería de software en la Argentina

Se realiza un estudio preliminar en el cual se identifican y recopilan publicaciones de los años 2009 y 2010 de las siguientes eventos: Workshop de Investigadores en Ciencias de la Computación (WICC), Congreso Argentino de Ciencias de la Computación (CACIC), Jornadas Argentinas de Informática (JAIIO) relativos a la investigación en Ingeniería de Software en Argentina y en la región. Se toma como punto de partida la conceptualizacion de Ingeniería de Software propuesta por diferentes autores.Eje: Ingeniería de SoftwareRed de Universidades con Carreras en Informática (RedUNCI