Padres y madres para siempre

Actualmente se han producido cambios en el ámbito social y familiar que han dado lugar a nuevas estructuras familiares, diferentes a la familia tradicional. Entre ellas se encuentran las familias monoparentales, constituidas por un proceso de divorcio, llevando éste implícito numerosos cambios. Para las familias que viven esta situación, el apoyo resulta fundamental. El objetivo fundamental de este trabajo es realizar un Programa de Intervención dirigido a padres y madres en situación de divorcio para orientarles en la redefinición de sus roles parentales y así favorecer el ejercicio de la coparentalidad aumentando la colaboración entre ambos progenitores procurando siempre el bienestar de los menores. Para llevarlo a cabo se utilizará una metodología activa, dinámica y flexible, trabajando con ambos progenitores durante nueve sesiones de una hora. Para comprobar su eficacia, y el cumplimiento de los objetivos propuestos, se realizará una evaluación al inicio y final del programa mediante la realización de un pre-test y post-test.Currently there have been several changes in the social and familiar sphere that have given rise to new family structures, different from the traditional family. Among these are single-parent families, constituted by a divorce process, taking this implicit numerous change. For families who live this situation, support is essential. The main purpose of this work is to conduct an Intervention Programme aimed at fathers and mothers in divorce situation to guide them in the redefinition of their parental roles and thus favour the exercise of co-parenting by increasing collaboration between both parents always seeking the children’s welfare. To carry it out, an active, dynamic and flexible methodology will be used, working with both parents during nine sessions of one hour. To verify its effectiveness, and the fulfilment of the proposed objectives an evaluation will be made at the beginning and at the end of the program by the realization of a pre-test and post-testUniversidad de Sevilla. Grado en Educación Primari

Caracterización dinámica y optimización de una guitarra española

En este documento se aborda el estudio de la tapa armónica de la guitarra española, que es la parte de la guitarra donde se produce prácticamente toda la sonoridad de la guitarra y el principal objeto de estudio de los luthiers. El estudio de la tapa se realizará mediante el software de elementos finitos Abaqus. Se construirán varios modelos donde se estudiará el comportamiento de las cuerdas que posteriormente será introducido en el modelo de la tapa. En el estudio de la tapa se estudiará el modelo clásico de Torres, donde se estudiará el funcionamiento de la guitarra y posteriormente se buscará un modelo que optimice el modelo de Torres.This document deals with the study of the soundboard of the Spanish guitar, which is the part of the guitar where practically all the sound of the guitar is produced and the main object of study by luthiers. The study of the soundboard will be carried out using the Abaqus finite element software. Several models will be built where the behavior of the ropes will be studied, which will later be introduced in the model of the cover. In the study of the cover, the classical model of Torres will be studied, where the operation of the guitar will be studied and later a model that optimizes the model of Torres will be found.Universidad de Sevilla. Grado en Ingeniería en las Tecnologías Industriale

Promotion of Direct Electron Transfer to Cytochrome c by Functionalized Thiophene-based Conducting Polymers

Controlling direct electron transfer (DET) to redox proteins is of great interest for fundamental studies on biochemical processes and the development of biotechnological devices, such as biosensors or enzymatic fuel cells. Cytochrome c is a classical model protein for studying DET reactions that plays a key role in the onset of cellular apoptosis and the mitochondrial respiratory chain. In this contribution, we explored DET between cyt c and conducting polymers bearing the chemical structure of thiophene, specifically PEDOT, and its OH-containing derivative, PHMeEDOT. The combination of electrochemistry and in situ FTIR spectroscopy allowed us to gain more insight into the inner mechanism of DET at physiological pH. Hydrophilic interactions favour the correct orientation of the heme crevice of cytochrome c towards the polymer surface. When a positive charge is injected into the conducting polymer, the increasing electrostatic repulsion between protein and surface induces the desorption of lysine residues near the heme group and stimulates protein flipping. This effect was more pronounced at PEDOT- than PHMeEDOT-modified electrodes since the latter shows stronger interactions with lysine residues, partially hindering protein rotation at moderate potential. The potential-induced reorientation process was similar on both polymer surfaces, only at high positive potentials.Financial support by Spanish Ministry of Science (projects TED2021-129894B-I00 and PDC2021-120884-I00), Generalitat Valenciana (projects GVA-THINKINAZUL/2021/015, MFA/2022/058 and CIPROM/2021/62) and European Union (NextGenerationEU PRTR-C17.I1) is gratefully acknowledged. A.G.-Q. acknowledges funding received from his Marie Skłodowska-Curie Postdoctoral Fellowship (Grant Number MSCA-IF-EF-ST 2020/101018277)

Comparative study of fluoride conversion coatings formed on biodegradable powder metallurgy Mg: The effect of chlorides at physiological level

The development of a biodegradable metallic implant demands a precisely defined degradation profile and adequate mechanical properties. Mg has been proposed for this purpose but it has an excessively high corrosion rate and insufficient yield strength. In the present work pure Mg mechanically reinforced by a powder metallurgy (Mg(PM)) route and treated with KF was used. The effect of chlorides, at the physiological level, on four fluoride conversion coatings (F-CC) formed on Mg(PM) was evaluated comparatively. The behavior of Mg(PM) during fluoride treatments (0.01 M–0.3 M fluoride-containing solutions) before and after the addition of chlorides (8 g L− 1 NaCl) was investigated by conventional corrosion techniques and by scanning electrochemical microscopy (SECM) complemented with SEM observations and EDX analysis. Results showed that the composition and the microstructural characteristics of the F-CCs as well as their corrosion behavior change with KF concentration and immersion time. Treatments in the 0.01 M–0.1 M KF range prove to be effective to protect Mg(PM) against corrosion in the absence of chlorides while higher KF solution concentration (0.3 M) adversely affects the corrosion resistance of this metal. In the presence of chloride ions the F-CCs progressively lose their fluoride content and their corrosion resistance at a rate that depends on the treatment conditions. Such temporary corrosion protection is appropriate for biodegradable implants.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicada

Retos del PATEC ante la comparativa de otras experiencias de acción tutorial universitaria

Tras más de una década de la puesta en marcha del Programa de Acción Tutorial en la Facultad de Económicas siguen persistiendo debilidades que tratan de resolverse año a año. En este sentido, el Programa se ha tratado de mejorar desde la creación de la Red de Tutores del PATEC en el curso 2013-2014. Del trabajo de la Red ha surgido el Manual del tutor, entendido como un recurso que recopila la información básica que va a necesitar el tutor para orientar a su alumnado; la idea de implantar la figura del alumno-tutor en la Facultad para acercar el Programa al conjunto del alumnado; y en el presente curso se ha planteado estudiar la acción tutorial en otras universidades españolas con el objetivo de recopilar buenas prácticas y analizar la posibilidad de implementarlas en la Facultad. Esta comunicación recoge el trabajo realizado por la Red y se estructura de la siguiente manera: en primer lugar, se identifican las prácticas de acción tutorial de diversas universidades españolas; en segundo lugar, se comparan con las actividades realizadas en el marco del PATEC; y, finalmente, se proponen acciones que contribuyan a mejorar el funcionamiento del PATEC

Red de tutores del Programa de Acción Tutorial de la Facultad de Económicas (PATEC)

El Plan de Acción Tutorial (PAT, PATEC en la Facultad de Ciencias Económicas y Empresariales) se viene desarrollando en la Universidad de Alicante (UA) desde el curso 2005-2006. Tras más de una década de su puesta en marcha en la Facultad de Ciencias Económicas y Empresariales, el PATEC se ha ido consolidando año a año y, aunque son muchas sus fortalezas, existen aún ciertas debilidades que persisten a las que hay que dar respuesta. Para ello, en el curso 2013-2014 surge la Red de Tutores del PATEC como un punto de encuentro en el que reflexionar sobre el funcionamiento del Programa. En el curso 2015-2016 su objetivo es doble. Por un lado, y continuando la labor que comenzó en el curso anterior referida a analizar experiencias de acción tutorial en otras universidades españolas, extraer las buenas prácticas que supongan un nuevo impulso para el PATEC. Por otro, conocer la experiencia de la primera promoción de alumnos-tutores de la Facultad

Philosophy, science, and cinema: Feminist perspectives

A lo largo del curso académico 2021-2022, el proyecto “Filosofía, Ciencia y Cine: perspectivas feministas” ha logrado coordinar el trabajo de un elevado número de personal docente y estudiantado que ha participado activamente en la organización de eventos académicos, algunos de ellos previstos en la propuesta original y otros muchos ideados a lo largo del curso. En total, se han llevado a cabo 11 actividades, incluyendo la grabación de dos podcasts, la realización de 8 cinefórums y la celebración de un simposio. Las actividades han obtenido un gran éxito de asistencia y participación y se han difundido ampliamente tanto en la Facultad de Filosofía como en las redes sociales de la Facultad y del proyecto.Depto. de Lógica y Filosofía TeóricaFac. de FilosofíaFALSEsubmitte

Accuracy of Xpert Ultra for the diagnosis of paediatric tuberculosis in a low TB burden country: a prospective multicentre study

[Introduction] Childhood pulmonary tuberculosis (TB) remains a diagnostic challenge. This study aimed to evaluate the performance of Xpert Ultra for the diagnosis of pulmonary TB in children in a low TB prevalence setting.[Methods] Prospective, multicentre, diagnostic accuracy study. Children with clinical or radiological suspicion of pulmonary TB were recruited at 11 paediatric units in Spain. Up to three gastric or sputum specimens were taken on 3 consecutive days, and analysed by Xpert MTB/RIF, Xpert Ultra and culture in parallel.[Results] 86 children were included (median age 4.9 years, IQR 2.0–10.0; 51.2% male). The final diagnosis was pulmonary TB in 75 patients (87.2%); 33 (44.0%) were microbiologically confirmed. A total of 219 specimens, comprising gastric aspirates (n=194; 88.6%) and sputum specimens (n=25; 11.4%), were analysed. Using culture as reference standard and comparing individual specimens, the sensitivity was 37.8% (14/37) for Xpert MTB/RIF and 81.1% (30/37) for Xpert Ultra (p<0.001); specificity was 98.4% (179/182) and 93.4% (170/182), respectively (p=0.02). In the per-patient analysis, considering positive results on any specimen, the sensitivity was 42.9% (9/21) for Xpert MTB/RIF and 81.0% for Xpert Ultra (17/21, p=0.01); specificity was 96.9% (63/65) and 87.7% (57/65, p=0.07), respectively.[Conclusions] In children with pulmonary TB in a low burden setting, Xpert Ultra has significantly higher sensitivity than the previous generation of Xpert assay and only marginally lower specificity. Therefore, in children undergoing evaluation for suspected pulmonary TB, Xpert Ultra should be used in preference to Xpert MTB/RIF whenever possible.This study did not receive any project-specific funding. DA-A was supported by the Spanish Ministry of Health – Instituto de Salud Carlos III (ISCIII) and cofunded by the European Union (FEDER) (Contrato Río Hortega CM18/00100). AN-J was supported by 'Subvencions per a la Intensificació de Facultatius Especialistes' (Departament de Salut de la Generalitat de Catalunya, Programa PERIS 2016-2020) (SLT008/18/00193). DBG was supported by the Spanish Ministry of Science and Innovation – Instituto de Salud Carlos III and Fondos FEDER by 'Contratos para la intensificación de la actividad investigadora en el Sistema Nacional de Salud, 2020 (INT20/00086)'. BS-G was supported by the Spanish Ministry of Health – Instituto de Salud Carlos III (ISCIII) and cofunded by the European Union (FEDER) (Contrato Juan Rodés JR16/00036).Peer reviewe

Oral saliva swab reverse transcription PCR for Covid-19 in the paediatric population

8Pág. Centro de Investigación en Sanidad Animal (CISA)To evaluate the performance of oral saliva swab (OSS) reverse transcription PCR (RT-PCR) compared with RT-PCR and antigen rapid diagnostic test (Ag-RDT) on nasopharyngeal swabs (NPS) for SARS-CoV-2 in children.The study was funded by: Project PI20/00095, from the Instituto de Salud Carlos III (Ministry of Economy, Industry and Competitiveness) and cofounded by the European Regional Development Fund, by Infanta Sofia University Hospital and Henares University Hospital Foundation for Biomedical Research and Innovation (FIIB HUIS HHEN), and by SERMAS-Fundación para la Investigación Biomédica del Hospital 12 de Octubre. EC-C is supported by the Spanish Society of Paediatrics (Asociación Española de Pediatría); Grant COVID-19 EPICO-AEP 2020. JMM is funded by SERMAS-Fundación para la Investigación Biomédica del Hospital Infanta Sofía y del Henares and by Universidad Europea de Madrid, Spain. MdlS is funded by Grant Cantera de Investigación Santander, Fundación Universidad Europea de Madrid, Spain. ED is funded by the Juan de la Cierva–Incorporación granted by the Spanish Ministry of Science and Innovation. DB-G is funded by the Spanish Ministry of Science and Innovation—Instituto de Salud Carlos III and Fondos FEDER by ’Contratos para la intensificación de la actividad investigadora en el Sistema Nacional de Salud, 2020 (INT20/00086)’.Peer reviewe

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues