Exploratory studies of contact angle hysteresis, wetting of solidified rare gases and surface properties of mercury Final report

Contact angle hysteresis, wetting of solidified rare gases, and surface properties of mercur

PNNL - Using Matrix and Tensor Factorization for Analyzing Radiation Transport Data

The Disruptive Technologies Group in the National Security Directorate of Pacific Northwest National Laboratory teamed up with students at Embry-Riddle Aeronautical University on a research project that aims to develop quantitative methods for characterizing features in radiation transport simulation data and comparing features across different computational approaches. Understanding how radiation particles are transported throughout a system and interact with shielding is extremely computationally expensive. Reduced order models (ROMs) can be used to significantly increase the speed of these calculations. This project focuses on analysis of the simulated radiation transport for Cobalt-60, Cesium-137, and Technetium-99. A ROM may be developed from several formalisms and then analyzing the feature vectors of each. The methods considered here include principal component analysis (PCA), non-negative matrix factorization (NNMF), and CP tensor decomposition (CPT). By comparing the signal from fitted Lorentzian profiles to spectral features, we evaluate whether each ROM is capable of accurately displaying the radiation signal traces in the data

Police bail without charge: The human rights implications

Whilst the power of the police to release a person on bail prior to trial has existed for centuries, the power to release on bail a person suspected of but not charged with a criminal offence has been available to the police only since 1925. The power to attach conditions to pre-charge bail is of very recent origin, having been introduced for the first time in 2003 but rapidly expanded since then. Whilst imposing restrictions on the liberty of a person should, constitutionally, be reserved to the judiciary, the fact that it was originally conceived, in part at least, as a mechanism for enhancing liberty reduced the constitutional tension created by allowing members of the executive such powers. However, the changing role of arrest in the investigation of crime and the granting of extensive powers to the police to impose bail conditions means that the police now have the ability to place controls on people not charged with a criminal offence for extended periods of time. It is argued here that this is in breach of the right to liberty under Article 5 of the European Convention on Human Rights and, in practice, may also breach other Convention rights

INCREASING ENGAGEMENT IN ONLINE LEARNING

Motivated by the need to improve students’ engagement and learning outcomes, in 2018/2019 we implemented two engagement interventions to 1650 students in twelve online courses across Science, Education, Engineering and Accounting at a regional university. Both “click” data and video analytics were used to measure engagement. The first initiative applied findings from behavioural research to ‘nudge’ students toward early engagement with key learning resources and to create ‘teaching presence’ (Garrison, 2007). The second initiative was to help move ‘knowledge’ to ‘know-how’ by nudging videos to offer a sense of real-life expertise, application, motivation and advanced connection. We aimed to improve student learning outcomes and their online engagement by providing explicit guidance about which course resources were critical for students’ success. We were interested in interrogating the data in both learning management systems (Moodle®) and Video analytics (Vimeo®) to answer questions about learner engagement and to explore evidence of impact. The nudges successfully engaged students in the key online resources showing an 18% average increase in access and confirmed via student feedback. The project developed a Nudge Guidelines document that has been presented institutionally and nationally to enable academics to utilise the strategies in their courses

Continuing mortality of vultures in India associated with illegal veterinary use of diclofenac and a potential threat from nimesulide

AbstractThe collapse of South Asia's Gyps vulture populations is attributable to the veterinary use of the non-steroidal anti-inflammatory drug (NSAID) diclofenac. Vultures died after feeding on carcasses of recently-medicated animals. The governments of India, Nepal and Pakistan banned the veterinary use of diclofenac in 2006. We analysed results of 62 necropsies and 48 NSAID assays of liver and/or kidney for vultures of five species found dead in India between 2000 and 2012. Visceral gout and diclofenac were detected in vultures from nine states and three species: Gyps bengalensis, Gyps indicus and Gyps himalayensis. Visceral gout was found in every vulture carcass in which a measurable level of diclofenac was detected. Meloxicam, an NSAID of low toxicity to vultures, was found in two vultures and nimesulide in five vultures. Nimesulide at elevated tissue concentrations was associated with visceral gout in four of these cases, always without diclofenac, suggesting that nimesulide may have similar toxic effects to those of diclofenac. Residues of meloxicam on its own were never associated with visceral gout. The proportion of Gyps vultures found dead in the wild in India with measurable levels of diclofenac in their tissues showed a modest and non-significant decline since the ban on the veterinary use of diclofenac. The prevalence of visceral gout declined less, probably because some cases of visceral gout from 2008 onwards were associated with nimesulide rather than diclofenac. Veterinary use of nimesulide is a potential threat to the recovery of vulture populations.Financial support and assistance for the project from the Director, Indian Veterinary Research Institute (IVRI), the UK Government’s Darwin Initiative and the Royal Society for the Protection of Birds is gratefully acknowledged.This is the accepted manuscript. The final version is available from Cambridge University Press via http://dx.doi.org/10.1017/S003060531500037

Probing cosmic dawn with emission lines: predicting infrared and nebular line emission for ALMA and JWST

Infrared and nebular lines provide some of our best probes of the physics regulating the properties of the interstellar medium (ISM) at high-redshift. However, interpreting the physical conditions of high-redshift galaxies directly from emission lines remains complicated due to inhomogeneities in temperature, density, metallicity, ionisation parameter, and spectral hardness. We present a new suite of cosmological, radiation-hydrodynamics simulations, each centred on a massive Lyman-break galaxy that resolves such properties in an inhomogeneous ISM. Many of the simulated systems exhibit transient but well defined gaseous disks that appear as velocity gradients in [CII]~158.6$\mu$m emission. Spatial and spectral offsets between [CII]~158.6$\mu$m and [OIII]~88.33$\mu$m are common, but not ubiquitous, as each line probes a different phase of the ISM. These systems fall on the local [CII]-SFR relation, consistent with newer observations that question previously observed [CII]~158.6$\mu$m deficits. Our galaxies are consistent with the nebular line properties of observed $z\sim2-3$ galaxies and reproduce offsets on the BPT and mass-excitation diagrams compared to local galaxies due to higher star formation rate (SFR), excitation, and specific-SFR, as well as harder spectra from young, metal-poor binaries. We predict that local calibrations between H$\alpha$ and [OII]~3727$\AA$ luminosity and galaxy SFR apply up to $z>10$, as do the local relations between certain strong line diagnostics (R23 and [OIII]~5007$\AA$/H$\beta$) and galaxy metallicity. Our new simulations are well suited to interpret the observations of line emission from current (ALMA and HST) and upcoming facilities (JWST and ngVLA)

In vitro culture with gemcitabine augments death receptor and NKG2D ligand expression on tumour cells

Much effort has been made to try to understand the relationship between chemotherapeutic treatment of cancer and the immune system. Whereas much of that focus has been on the direct effect of chemotherapy drugs on immune cells and the release of antigens and danger signals by malignant cells killed by chemotherapy, the effect of chemotherapy on cells surviving treatment has often been overlooked. In the present study, tumour cell lines: A549 (lung), HCT116 (colon) and MCF-7 (breast), were treated with various concentrations of the chemotherapeutic drugs cyclophosphamide, gemcitabine (GEM) and oxaliplatin (OXP) for 24 hours in vitro. In line with other reports, GEM and OXP upregulated expression of the death receptor CD95 (fas) on live cells even at sub-cytotoxic concentrations. Further investigation revealed that the increase in CD95 in response to GEM sensitised the cells to fas ligand treatment, was associated with increased phosphorylation of stress activated protein kinase/c-Jun N-terminal kinase and that other death receptors and activatory immune receptors were co-ordinately upregulated with CD95 in certain cell lines. The upregulation of death receptors and NKG2D ligands together on cells after chemotherapy suggest that although the cells have survived preliminary treatment with chemotherapy they may now be more susceptible to immune cell-mediated challenge. This re-enforces the idea that chemotherapy-immunotherapy combinations may be useful clinically and has implications for the make-up and scheduling of such treatments

Detection of an intergalactic meteor particle with the 6-m telescope

On July 28, 2006 the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences recorded the spectrum of a faint meteor. We confidently identify the lines of FeI and MgI, OI, NI and molecular-nitrogen N_2 bands. The entry velocity of the meteor body into the Earth's atmosphere estimated from radial velocity is equal to 300 km/s. The body was several tens of a millimeter in size, like chondrules in carbon chondrites. The radiant of the meteor trajectory coincides with the sky position of the apex of the motion of the Solar system toward the centroid of the Local Group of galaxies. Observations of faint sporadic meteors with FAVOR TV CCD camera confirmed the radiant at a higher than 96% confidence level. We conclude that this meteor particle is likely to be of extragalactic origin. The following important questions remain open: (1) How metal-rich dust particles came to be in the extragalactic space? (2) Why are the sizes of extragalactic particles larger by two orders of magnitude (and their masses greater by six orders of magnitude) than common interstellar dust grains in our Galaxy? (3) If extragalactic dust surrounds galaxies in the form of dust (or gas-and-dust) aureoles, can such formations now be observed using other observational techniques (IR observations aboard Spitzer satellite, etc.)? (4) If inhomogeneous extragalactic dust medium with the parameters mentioned above actually exists, does it show up in the form of irregularities on the cosmic microwave background (WMAP etc.)?Comment: 9 pages, 6 EPS figure

Studies on the Removal of Fluorine from Drinking Waters in the State of Iowa

Our knowledge concerning the distribution of fluorine in drinking waters and the effect of such waters on the structure of the teeth has been appreciably expanded by the recent researches of Smith, Lantz, and Smith (1), Churchill (2), McKay (3), Kehr (4), Ostrem, Nelson, Greenwood, and Wilhelm (5), Boissevain (6), Dean (7), Sebrell, Dean, Elvove, and Breaux (8) and Boruff and Abbott (9). Smith, Lantz, and Smith (1), of the University of Arizona, were the first to show that mottled enamel is clue to fluorides in the drinking water; in fact, their analyses of waters from endemic areas show that the fluorine concentration in such waters is high

Aspirin Inhibits TGFβ2-Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells:Selective acetylation of K56 and K122 in histone H3

Posterior capsule opacification (PCO) is a complication after cataract surgery that can disrupt vision. The epithelial to mesenchymal transition (EMT) of lens epithelial cells (LECs) in response to transforming growth factor β2 (TGFβ2) has been considered an obligatory mechanism for PCO. In this study, we tested the efficacy of aspirin in inhibiting the TGFβ2-mediated EMT of human LECs, LECs in human lens capsular bags, and lensectomized mice. In human LECs, the levels of the EMT markers α-smooth muscle actin (α-SMA) and fibronectin were drastically reduced by treatment with 2 mM aspirin. Aspirin also halted the EMT response of TGFβ2 when introduced after EMT initiation. In human capsular bags, treatment with 2 mM aspirin significantly suppressed posterior capsule wrinkling and the expression α-SMA in capsule-adherent LECs. The inhibition of TGFβ2-mediated EMT in human LECs was not dependent on Smad phosphorylation or MAPK and AKT-mediated signaling. We found that aspirin significantly increased the acetylation of K56 and K122 in histone H3 of human LECs. Chromatin immunoprecipitation assays using acetyl-H3K56 or acetyl-H3K122 antibody revealed that aspirin blocked the TGFβ2-induced acetylation of H3K56 and H3K122 at the promoter regions of ACTA2 and COL1A1. After lensectomy in mice, we observed an increase in the proliferation and α-SMA expression of the capsule-adherent LECs, which was ameliorated by aspirin administration through drinking water. Taken together, our results showed that aspirin inhibits TGFβ2-mediated EMT of LECs, possibly from epigenetic down-regulation of EMT-related genes