BDE-209 in the Australian environment: desktop review

The commercial polybrominated diphenyl ether (PBDE) flame retardant mixture c-decaBDE is now being considered for listing on the Stockholm Convention on Persistent Organic Pollutants. The aim of our study was to review the literature regarding the use and detection of BDE-209, a major component of c-decaBDE, in consumer products and provide a best estimate of goods that are likely to contain BDE-209 in Australia. This review is part of a larger study, which will include quantitative testing of items to assess for BDE-209. The findings of this desktop review will be used to determine which items should be prioritized for quantitative testing. We identified that electronics, particularly televisions, computers, small household appliances and power boards, were the items that were most likely to contain BDE-209 in Australia. Further testing of these items should include items of various ages. Several other items were identified as high priority for future testing, including transport vehicles, building materials and textiles in non-domestic settings. The findings from this study will aid in the development of appropriate policies, should listing of c-decaBDE on the Stockholm Convention and Australia's ratification of that listing proceed

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial

Background Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects. Methods FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. Patients were randomly allocated fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimisation algorithm. The primary outcome was functional status, measured with the modified Rankin Scale (mRS), at 6 months. Patients, carers, health-care staff, and the trial team were masked to treatment allocation. Functional status was assessed at 6 months and 12 months after randomisation. Patients were analysed according to their treatment allocation. This trial is registered with the ISRCTN registry, number ISRCTN83290762. Findings Between Sept 10, 2012, and March 31, 2017, 3127 patients were recruited. 1564 patients were allocated fluoxetine and 1563 allocated placebo. mRS data at 6 months were available for 1553 (99·3%) patients in each treatment group. The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0·951 [95% CI 0·839–1·079]; p=0·439). Patients allocated fluoxetine were less likely than those allocated placebo to develop new depression by 6 months (210 [13·43%] patients vs 269 [17·21%]; difference 3·78% [95% CI 1·26–6·30]; p=0·0033), but they had more bone fractures (45 [2·88%] vs 23 [1·47%]; difference 1·41% [95% CI 0·38–2·43]; p=0·0070). There were no significant differences in any other event at 6 or 12 months. Interpretation Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function. Funding UK Stroke Association and NIHR Health Technology Assessment Programme

Occurrence and concentrations of halogenated natural products derived from seven years of passive water sampling (2007–2013) at Normanby Island, Great Barrier Reef, Australia

Polydimethylsiloxane (PDMS) based passive water samplers deployed at Normanby Island, Great Barrier Reef (Australia) from 2007 to 2013 were analyzed for halogenated natural products (HNPs). Altogether, 38 samples, typically deployed for 30 days, were studied. Five HNPs (Q1, 2′‑MeO-BDE 68, BC-10, 2,4‑dibromoanisole and 2,4,6‑tribromoanisole) were detected in all samples. Most samples (>90%) featured 2,2′‑diMeO-BB 80, 6‑MeO-BDE 47, 2′,6‑diMeO-BDE 68 and 2,4‑dibromophenol. In addition, tetrabromo‑N‑methylpyrrole (TBMP) was detected in ~80% and Cl-DBP in ~30% of the samples. Estimated time weighted maximum water concentrations were >150 pg Q1 and 60 pg 2′‑MeO-BDE 68 per L seawater. Typically, the concentrations were varying from year to year. Moreover, time weighted average water concentration estimates did not reveal consistent maximum trend levels within a given year. Additional screening analysis via GC/MS indicated the presence of several polyhalogenated 1′‑methyl‑1,2′‑bipyrroles (PMBPs), 1,1′‑dimethyl‑2,2′‑bipyrroles (PDBPs), and 1‑methylpyrroles (PMPs) along with four brominated N‑methylindoles and several other polyhalogenated compounds at Normanby Island

Environmental monitoring of selected pesticides and organic chemicals in urban stormwater recycling systems using passive sampling techniques

Water recycling via aquifers has become a valuable tool to augment urban water supplies in many countries. This study reports the first use of passive samplers for monitoring of organic micropollutants in Managed Aquifer Recharge (MAR). Five different configurations of passive samplers were deployed in a stormwater treatment wetland, groundwater monitoring wells and a recovery tank to capture a range of polar and non-polar micropollutants present in the system. The passive samplers were analysed for a suite of pesticides, polycyclic aromatic hydrocarbons (PAHs) and other chemicals. As a result, 17 pesticides and pesticide degradation products, 5 PAHs and 8 other organic chemicals including flame retardants and fragrances were detected in urban stormwater recharging Aquifer Storage and Recovery (ASR) and an Aquifer Storage Transfer and Recovery (ASTR) system. Of the pesticides detected, diuron, metolachlor and chlorpyrifos were generally detected at the highest concentrations in one or more passive samplers, whereas chlorpyrifos, diuron, metolachlor, simazine, galaxolide and triallate were detected in multiple samplers. Fluorene was the PAH detected at the highest concentration and the flame retardant Tris(1-chloro-2-propyl) phosphate was the chemical detected in the greatest abundance at all sites. The passive samplers showed different efficiencies for capture of micropollutants with the Empore disc samplers giving the most reliable results. The results indicate generally low levels of organic micropollutants in the stormwater, as the contaminants detected were present at very low ng/L levels, generally two to four orders of magnitude below the drinking water guidelines (NHMRC, 2011). The efficiency of attenuation of these organic micropollutants during MAR was difficult to determine due to variations in the source water concentrations. Comparisons were made between different samplers, to give a field-based calibration where existing lab-based calibrations were unavailable

Development and validation of a multi-residue method for the analysis of brominated and organophosphate flame retardants in indoor dust

Highlights - PBDEs and OPFRs were analysed in dust samples by one injection only, except for BDE 209. - The most efficient sorbent for OPFRs purification was found to be Envi-Carb cartridge. - LORs were 6.2–1000 ng/g and 0.14 −1100 ng/g for OPFRs and PBDEs, respectively. - Validation studies showed the good accuracy and reproducibility of the method. - SRM and real dust samples were analysed, with >50 detection frequency for most compounds. Flame retardants are associated to numerous adverse health effects, can accumulate in humans and have been used intensively worldwide. Recently, dust has been identified as a major human exposure route for flame retardants. The aim of this study was to develop a multi-residue method using a two-step SPE purification. It enabled us to effectively limit co-extracted matrix/interferets and therefore a simultaneous analysis of brominated and organophosphate flame retardants for indoor dust was achieved. The optimized method was validated according to standard protocol and achieved good accuracy and reproducibility (percent error ranged from −29% to 28%). Standard Reference Material (SRM) for dust was also analysed, and good agreement was found with reported brominated and organophosphate flame retardants (OPFRs) concentrations. The applicability of the validated method was demonstrated by the analysis of ten indoor dust samples from ten Australian homes. Overall 89% of the analytes were detected in these samples. The average concentrations of ∑OPFRs and ∑PBDEs in those samples were 41 and 3.6 μg/g, respectively. Tris(2-butoxyethyl) phosphate and tris(2-chloroisopropyl) phosphate were the most abundant OPFRs, accounting for 57–92% ∑OPFRs, while decabromodiphenyl ether dominated the Polybrominated diphenyl ethers (PBDE) congeners contributing between 71–94% to the ∑PBDE

Pandemic Perspectives: Reflections on the Post-Covid World: Introduction

This publication reflects papers from the first conference hosted by the Pandemic Perspectives group, an interdisciplinary network of scholars interested in Covid-19’s continued significance, and its manifold long-term consequences. Optimistically titled ‘Reflections on the Post-Covid World’, the conference united scholars from India, Canada, and across Europe and the UK in a discussion of the impact of the pandemic and their research and speculations into its long-term effects. The publication showcases the long-standing interest of the Pandemic Perspectives network in engaging in dialogue across cultural and disciplinary borders, with papers on topics widely ranging as the future of the office, women’s health, and classical reception

Pandemic Perspectives: Reflections on the Post-Covid World: Acknowledgements and Contributors

Between people buying groceries for their elderly, ill, or otherwise self-isolating neighbours, the British public applauding the NHS on Thursday evenings throughout 2020, and the increased popularity of quizzes taking place on digital platforms such as Zoom, the Covid-19 pandemic has continually highlighted the importance of community to individuals’ wellbeing and day-to-day activity. As such, the editors thought it fitting to give their thanks to the community that has made this edited collection possible