Roots of Etna volcano in faults of great earthquakes

International audienceResults from several seismic methods allow us to sketch the deep structure of Etna and its Ionian margin. Under Etna a volume of high velocity material is found in a structurally high position; the emplacement of this suggests spreading of the surrounding medium. Just offshore, down-to-the-east normal faults penetrate through the upper crust. The deeper crustal structure beneath appears upwarped from the basin towards Etna. Juxtaposed with the crust of Sicily, a thinner crust reaches from the Ionian Basin under Etna, and the mantle is upwarped. In such a structure, magma can then be viewed as a melted lens capping a mantle upwarp at shallow depth, rather than in an intracrustal chamber. This reduces the conflict between estimates of its volume from excess output of volatiles and short residence times. A link in time is indicated between volcanic and seismic activity at a large scale: over the millennium the reported ends of episodes of high output rates of magma are followed by the reported occurrences of magnitude 7 + earthquakes which caused destruction in southeastern Sicily. Several steep active normal fault have been imaged to a depth of 10 km the crust up to 30 km offshore of the cities of Catania and Augusta, which may be fault planes for such large earthquakes. They expand and prolongate the system of the Timpe faults on the eastern flank of Etna, thus linking large-scale tectonics offshore with the volcano. Etna developed together with normal faulting, upwarp, and spreading during the recent evolution of the former Ionian subduction. Activation of the material at depth at the lateral edge of the slab, by vertical motion with extension above, could produce the peculiar type of Etna magmatism

Restoration of T cell responses to Toxoplasma gondii after successful combined antiretroviral therapy in patients with AIDS with previous toxoplasmic encephalitis

Background: It is unknown whether a Toxoplasma gondii-specific T cell response is restored after successful combined antiretroviral therapy (cART) in patients with AIDS and current or previous toxoplasmic encephalitis (TE). Methods: We performed a multicenter cross-sectional study with 17 healthy T. gondii-positive human immunodeficiency virus (HIV)-1-uninfected individuals and 90 patients coinfected with HIV-1 and T. gondii distributed in 5 groups according to their CD4+ T cell counts and T. gondii infection (with or without current or previous TE). We investigated the lymphocyte proliferative response (LPR) and interferon (IFN)-γ production in response to T. gondii soluble antigen extract (SATg) and as CD4+ and CD8+ T cell subsets. Results: SATg-specific LPR and IFN-γ production were not observed in many of the most immunosuppressed patients (CD4+ T cell count, 200 cells/μL) who presented with TE and had already stopped secondary TE prophylaxis. Similar results were found in immunocompetent asymptomatic patients who did not receive TE prophylaxis. The predictors of SATgspecific T cell responses and IFN-γ production were a cART-mediated increase in CD4+ T cell count and LPR to phytohemagglutinin and viral suppression and a decrease in the activated (CD38+) CD8+ T cell count, respectively. Conclusions: cART restores T. gondii-specific CD4 T cell responses in most patients with AIDS who had previous TE. Our data support the safety of withdrawing TE prophylaxis when the CD4+ T cell count returns to levels >200 cells/μL. © The Author 2011.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

The Effects of Cinacalcet in Older and Younger Patients on Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial.

This article contains supplemental material online at http://cjasn. asnjournals.org/lookup/suppl/doi:10.2215/CJN.07730814/-/ DCSupplemental.BACKGROUND AND OBJECTIVES: The calcimimetic cinacalcet reduced the risk of death or cardiovascular (CV) events in older, but not younger, patients with moderate to severe secondary hyperparathyroidism (HPT) who were receiving hemodialysis. To determine whether the lower risk in younger patients might be due to lower baseline CV risk and more frequent use of cointerventions that reduce parathyroid hormone (kidney transplantation, parathyroidectomy, and commercial cinacalcet use), this study examined the effects of cinacalcet in older (≥65 years, n=1005) and younger (3-fold higher in younger relative to older patients and were more frequent in patients randomized to placebo. In older patients, the adjusted relative hazard (95% confidence interval) for the primary composite (CV) end point (cinacalcet versus placebo) was 0.70 (0.60 to 0.81); in younger patients, the relative hazard was 0.97 (0.86 to 1.09). Corresponding adjusted relative hazards for mortality were 0.68 (0.51 to 0.81) and 0.99 (0.86 to 1.13). Reduction in the risk of severe unremitting HPT was similar in both groups. CONCLUSIONS: In the EVOLVE trial, cinacalcet decreased the risk of death and of major CV events in older, but not younger, patients with moderate to severe HPT who were receiving hemodialysis. Effect modification by age may be partly explained by differences in underlying CV risk and differential application of cointerventions that reduce parathyroid hormone.The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) trial was funded by Amgen

Effcient generation of energetic ions in multi-ion plasmas by radio-frequency heating

We describe a new technique for the effcient generation of high-energy ions with electromagnetic ion cyclotron waves in multi-ion plasmas. The discussed 'three-ion' scenarios are especially suited for strong wave absorption by a very low number of resonant ions. To observe this effect, the plasma composition has to be properly adjusted, as prescribed by theory. We demonstrate the potential of the method on the world-largest plasma magnetic confinement device, JET (Joint European Torus, Culham, UK), and the high-magnetic-field tokamak Alcator C-Mod (Cambridge, USA). The obtained results demonstrate effcient acceleration of3He ions to high energies in dedicated hydrogen-deuterium mixtures. Simultaneously, effective plasma heating is observed, as a result of the slowing-down of the fast3He ions. The developed technique is not only limited to laboratory plasmas, but can also be applied to explain observations of energetic ions in space-plasma environments, in particular,3He-rich solar flares

Global scaling of the heat transport in fusion plasmas

A global heat flux model based on a fractional derivative of plasma pressure is proposed for the heat transport in fusion plasmas. The degree of the fractional derivative of the heat flux, α, is defined through the power balance analysis of the steady state. The model was used to obtain the experimental values of α for a large database of the Joint European Torus (JET) carbon-wall as well as ITER like-wall plasmas. The fractional degrees of the electron heat flux are found to be α<2, for all the selected pulses in the database, suggesting a deviation from the diffusive paradigm. Moreover, the results show that as the volume integrated input power is increased, the fractional degree of the electron heat flux converges to α∼0.8, indicating a global scaling between the net heating and the pressure profile in the high-power JET plasmas. The model is expected to provide insight into the proper kinetic description for the fusion plasmas and improve the accuracy of the heat transport predictions