Youth Policy And The Development of Quality Education As Factors In Reducing The Level of Radicalization In Society

The article is devoted to the consideration of youth and youth policy as factors of terrorism in the 21st century. The authors have identified factors that increase the effectiveness of recruiters of terrorist organizations in attracting young people, as well as formulated and justified the principles of improving the effectiveness of youth policy in the framework of anti-terrorist activities of the authorities. According to the authors, an important factor in the radicalization of young people is the low level of education in the country. The authors draw attention to the fact that the low level of education does not create opportunities for the development of young people. This, in turn, leads to a radicalization of the relationship between the authorities and students. If graduates are unable to find jobs that meet their expectations, then the risk of radicalization of young people increases. A good education not only allows the state to train qualified specialists, which effectively affects the social and economic development of society. Specialists in demand do not belong to social groups prone to violent and radical actions in relation to other citizens, both within the country and abroad. Therefore, it is necessary, on the one hand, to develop educational programs that allow college and university graduates to be in demand in the labor market, constantly improve their skills, and increase the level of knowledge. On the other hand, it is necessary to develop students' skills, such as critical thinking, creativity, respect for the institutions of society, and skills in solving social and professional problems

Educational Reforms in the Context of Contemporary Civilizational Changes

Analysis of educational system seems to be the most reasonable when the key points are reformation and modernization of education, since the mentioned processes are the response to transformations in adjacent social spheres caused in their turn by objective changes, which may include civilizational, transnational changes in education at national level. This article is devoted to the estimation of educational reforms in the context of contemporary civilizational changes. The research aimed to systematize the features of development of reforms in the field of education, to develop measures on coordination of activities among main participants in educational process, to determine its main features in the context of civilizational changes. It has been established that the key point is to detect balance between autonomous right of a university to render education and scientific studies for economy and society, and responsibility of state for assurance of quality, accountability, integrity, and availability of education. It has been proved that the education sector needs investment to improve learning and research conditions. Another issue is implementation of new forms of financing, including on competitive basis, to support interest and interaction between universities and business environment. It has been determined that new trends in cooperation should not only concern the development of innovations and commercialization but also attract employers to cooperation aiming at development of new or updating the existing learning programs

Interaction of Drugs Used for the Treatment of Cardiovascular Diseases

Combined therapy in cardiology is currently the most recognized method of treatment, especially in patients with hypertension. Approximately in 50 % of patients with hypertension, monotherapy is effective. However to achieve the desired effect in the remaining half of patients, simultaneous administration of two and sometimes three drugs is required. Numerous drugs with a fixed combination of two (and even three) antihypertensive drugs, often used in clinical practice, greatly simplify the dosage regimen of drugs and improve patients’ adherence to treatment. Unfortunately, simultaneous prescription of several drugs increases sharply the probability of inter-drug interaction with the increase in the number of prescribed drugs. The result of drug-drug intereaction may be unpredictable. Therefore, the ability to predict the possible adverse reactions in patients with cardiovascular diseases and to prescribe rationally combined pharmacotherapy is a guarantee of highly efficient and safe treatment.Currently, rational combinations of antihypertensive drugs of different groups make hypertension therapy more comfortable and increases patients’ adherence to treatment. The authors present topical combinations of antihypertensive drugs in one drug: angiotensin converting enzyme inhibitor + diuretic, β-adrenoblocker + diuretic; diuretic + angiotensin receptor antagonist; calcium antagonist + angiotensin receptor antagonist; calcium antagonist + β-adrenoblocker, and others.The article presents an overview of both rational (calcium antagonist + diuretic, β-adrenoblocker + diuretic,) and irrational (angiotensin converting enzyme Inhibitor + potassium-sparing diuretic, angiotensin receptor blocker + potassium-sparing diuretic) combinations of antihypertensive drugs. Combinations of some hypotensive and antianginal drugs with drugs of other groups with a high risk of adverse reactions are presented

Transformation of mechanisms of the university first-year students’ social adaptation: mathematical analysis tools

The article describes modern approaches to the transformation of the mechanisms of the first-year students’ social adaptation to study at the university, taking into account the requests of students. The theoretical prerequisites of the research are formulated on the basis of the analysis of modern publications of the knowledge-intensive Scopus database of Russian and foreign scientific articles. The theoretical model of transformation of adaptation mechanisms has become the basis of empirical research. The analysis of the process of social adaptation to the training of the modern generation of first-year students was carried out by the survey method using the electronic educational environment of the University of the North Caucasus (Stavropol Krai, Russia). A total of 1,278 people took part in the survey. The results of the study allow us to identify key areas for improving the educational process at the university: the development of alignment programs within the educational program of the level of knowledge in the most significant subject areas (Mathematics, Physics, Chemistry, Social Studies, etc.), entering into the educational rhythm of the university training format, a deeper understanding of the nature of professional activity and the organization of professional socialization. The obtained theoretical conclusions and empirical research data provide an understanding of the transformation of the mechanisms of social adaptation to university education

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Asymptotic methods for solving boundary value eigenvalue problems

The aim of the study is an approximate construction with a given accuracy of solutions of boundary value problems for eigenvalues under various types of boundary conditions. It is shown that the problem of finding approximate large eigenvalues of boundary value problems is reduced to the analysis and solution of singularly perturbed differential equations with variable coefficients. Methods used: asymptotic diagram method developed to construct the asymptotic behavior of solutions of singularly perturbed differential equations and systems; methods of numerical integration of boundary value problems. The main results obtained are: the asymptotics of the required accuracy are constructed in the analytical form for the eigenvalues and eigenfunctions of the boundary value problems under various boundary conditions; analysis of the computational capabilities of the practical use of the constructed asymptotics in comparison with the results of numerical integration

Plastids of embryoes of flowering plants

The investigation is concerned with the ovules and seeds of separate taxones of flowering plants ranked at different levels of evolutionary development. The object of investigation is formulation of the general characteristic of the phenomenon of chlorophyll-bearing capacity of embryoes of flowering plants classified as chloro- and leukoembryophytes. The researchers have pioneered in carrying out the monographic study on the genesis of plastids in the plant embryo and revealed the general regularities in the biogenesis of embryonal plastids. Investigation into embryonal plastids, as applied to the problem of development of seeds is a new trend in the sphere of phytoembryology. The investigators have obtained new data that deepen the knowledge about the embryo genital process and development and promote perfection of efforts in genetics and selective breeding and contribute to the disclosure of causes of abortion of numerous cross-breeding combinationsAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

Development of methodical approaches to hygienic control of content of N-nitrose-compounds in foodstuffs and investigation into regularities of formation thereof and methods of reducing rate of penetration thereof into organism of human being

Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio